Subclinical Doses of ATP-Sensitive Potassium Channel Modulators Prevent Alterations in Memory and Synaptic Plasticity Induced by Amyloid-β

Exercise Prevents Amyloid-β-Induced Hippocampal Network Disruption by Inhibiting GSK3β Activation

(2016) Arturo G. Isla et al.   JOURNAL OF ALZHEIMERS DISEASE

Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer’s disease therapy

(2016) S Moriguchi et al.   MOLECULAR PSYCHIATRY

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Epilepsy, amyloid-β, and D1 dopamine receptors: a possible pathogenetic link?

(2016) Cinzia Costa et al.   NEUROBIOLOGY OF AGING

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

(2016) Ming Lei et al.   NEUROBIOLOGY OF DISEASE

Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ1−42

(2016) Xi Wang et al.   Frontiers in Neuroscience

AmyloidβEnhances Typical Rodent Behavior While It Impairs Contextual Memory Consolidation

(2015) Karla Salgado-Puga et al.   BEHAVIOURAL NEUROLOGY

Amyloid beta modulation of neuronal network activity in vitro

(2015) Hamid Charkhkar et al.   BRAIN RESEARCH

Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability

(2015) Masashi Tabuchi et al.   CURRENT BIOLOGY

The therapeutic potential of berberine against the altered intrinsic properties of the CA1 neurons induced by Aβ neurotoxicity

(2015) Masoud Haghani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

(2015) Shannon L. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism

(2015) Miroslav N. Nenov et al.   JOURNAL OF NEUROPHYSIOLOGY

Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism

(2015) C. Varin et al.   JOURNAL OF NEUROSCIENCE

Hypoglycemia-induced alterations in hippocampal intrinsic rhythms: Decreased inhibition, increased excitation, seizures and spreading depression

(2015) C.M. Florez et al.   NEUROBIOLOGY OF DISEASE

Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

(2015) Cui Lv et al.   NEUROPHARMACOLOGY

Preferential reduction of synaptic efficacy in the dentate gyrus of hippocampal slices from aged rats during reduced glucose availability

(2015) R.T. Jones et al.   NEUROSCIENCE

Preventing Effect of L-Type Calcium Channel Blockade on Electrophysiological Alterations in Dentate Gyrus Granule Cells Induced by Entorhinal Amyloid Pathology

(2015) Hamid Gholami Pourbadie et al.   PLoS One

Cellular and Network Mechanisms Underlying Memory Impairment Induced by Amyloid β Protein

(2015) Karla Salgado-Puga et al.   PROTEIN AND PEPTIDE LETTERS

Amyloid- -Induced Action Potential Desynchronization and Degradation of Hippocampal Gamma Oscillations Is Prevented by Interference with Peptide Conformation Change and Aggregation

(2014) F. R. Kurudenkandy et al.   JOURNAL OF NEUROSCIENCE

Metabolism Regulates the Spontaneous Firing of Substantia Nigra Pars Reticulata Neurons via K ATP and Nonselective Cation Channels

(2014) Andrew Lutas et al.   JOURNAL OF NEUROSCIENCE

GABAergic Neurogliaform Cells Represent Local Sources of Insulin in the Cerebral Cortex

(2014) G. Molnar et al.   JOURNAL OF NEUROSCIENCE

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Diazoxide Pretreatment Prevents Aβ1–42 Induced Oxidative Stress in Cholinergic Neurons Via Alleviating NOX2 Expression

(2014) Qingxi Fu et al.   NEUROCHEMICAL RESEARCH

Protective Effects of Bexarotene against Amyloid-�25-35-Induced Dysfunction in Hippocampal Neurons through the Insulin Signaling Pathway

(2014) Weiwei Dai et al.   Neurodegenerative Diseases

Persistent sodium currents contribute to Aβ1-42-induced hyperexcitation of hippocampal CA1 pyramidal neurons

(2014) Shuan-cheng Ren et al.   NEUROSCIENCE LETTERS

A mutation causing increased KATP channel activity leads to reduced anxiety in mice

(2014) Carolina Lahmann et al.   PHYSIOLOGY & BEHAVIOR

Glucose, relational memory, and the hippocampus

(2014) Brian Stollery et al.   PSYCHOPHARMACOLOGY

KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons

(2014) Maria S. Lemak et al.   Frontiers in Cellular Neuroscience

AMPK regulates KATP channel trafficking via PTEN inhibition in leptin-treated pancreatic β-cells

(2013) Sun-Hyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity

(2013) A.H. Alhebshi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthetic Aβ oligomers (Aβ1–42 globulomer) modulate presynaptic calcium currents: Prevention of Aβ-induced synaptic deficits by calcium channel blockers

(2013) David Hermann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability

(2013) K. Zhao et al.   JOURNAL OF NEUROSCIENCE

A Novel Nicotinic Mechanism Underlies  -Amyloid-Induced Neuronal Hyperexcitation

(2013) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Diazoxide and cyclosporin A protect primary cholinergic neurons against beta-amyloid (1-42)-induced cytotoxicity

(2013) Xianwei Zeng et al.   NEUROLOGICAL RESEARCH

Calcineurin Inhibition Rescues Early Synaptic Plasticity Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Virve Cavallucci et al.   NEUROMOLECULAR MEDICINE

Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons

(2013) Feiyang Liu et al.   NEUROSCIENCE LETTERS

Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model

(2013) Andrea Marcantoni et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Post-Hypoxic Recovery of Respiratory Rhythm Generation Is Gender Dependent

(2013) Alfredo J. Garcia et al.   PLoS One

Inhibitory Neuron and Hippocampal Circuit Dysfunction in an Aged Mouse Model of Alzheimer's Disease

(2013) Anupam Hazra et al.   PLoS One

Amyloid Beta Inhibits Olfactory Bulb Activity and the Ability to Smell

(2013) Reynaldo Alvarado-Martínez et al.   PLoS One

Severe Hypoglycemia in a Juvenile Diabetic Rat Model: Presence and Severity of Seizures Are Associated with Mortality

(2013) Margaret Maheandiran et al.   PLoS One

Multiple effects of β-amyloid on single excitatory synaptic connections in the PFC

(2013) Yun Wang et al.   Frontiers in Cellular Neuroscience

Amyloid-β induces synaptic dysfunction through G protein-gated inwardly rectifying potassium channels in the fimbria-CA3 hippocampal synapse

(2013) Mauricio O. Nava-Mesa et al.   Frontiers in Cellular Neuroscience

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Amyloid Beta 1-42 Inhibits Entorhinal Cortex Activity in the Beta-Gamma Range: Role of GSK-3

(2012) Fernando Pena-Ortega et al.   Current Alzheimer Research

An update on type 2 diabetes, vascular dementia and Alzheimer's disease

(2012) L.G. Exalto et al.   EXPERIMENTAL GERONTOLOGY

Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease

(2012) Sara E. Rubio et al.   FASEB JOURNAL

Glibenclamide Enhances Neurogenesis and Improves Long-Term Functional Recovery after Transient Focal Cerebral Ischemia

(2012) Francisco J Ortega et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration

(2012) Julia Schiemann et al.   NATURE NEUROSCIENCE

Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

(2012) Wei-Na Han et al.   NEUROBIOLOGY OF AGING

Effects of Abeta1–42 on the current of KATP channels in cultured cholinergic neurons

(2012) Shuhui Tan et al.   NEUROLOGICAL RESEARCH

BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures

(2012) Alfredo Giménez-Cassina et al.   NEURON

Protective effects of diazoxide against Aβ25–35-induced PC12 cell apoptosis due to prevention of endoplasmic reticulum stress

(2012) Min Kong et al.   NEUROREPORT

Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease

(2012) A. O. Ardiles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Too Many Cooks? Intrinsic and Synaptic Homeostatic Mechanisms in Cortical Circuit Refinement

(2011) Gina Turrigiano   Annual Review of Neuroscience

An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction

(2011) Maya K. Desai et al.   GLIA

Subsecond regulation of striatal dopamine release by pre-synaptic KATP channels

(2011) Jyoti C. Patel et al.   JOURNAL OF NEUROCHEMISTRY

Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis

(2011) Noemí Virgili et al.   Journal of Neuroinflammation

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

A new neuronal target for beta-amyloid peptide in the rat hippocampus

(2011) Vincent Villette et al.   NEUROBIOLOGY OF AGING

The protective roles of mitochondrial ATP-sensitive potassium channels during hypoxia–ischemia–reperfusion in brain

(2011) Lin Wang et al.   NEUROSCIENCE LETTERS

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

(2011) Oscar Vadas et al.   Science Signaling

Blockade of presynaptic K ATP channels reduces the zinc-mediated posttetanic depression at hippocampal mossy fiber synapses

(2010) C.M. Matias et al.   BRAIN RESEARCH

Amyloid β Oligomers Decrease Hippocampal Spontaneous Network Activity in an Age-Dependent Manner

(2010) H. Balleza-Tapia et al.   Current Alzheimer Research

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

17β-Estradiol Rapidly Increases KATPActivity in GnRH via a Protein Kinase Signaling Pathway

(2010) Chunguang Zhang et al.   ENDOCRINOLOGY

Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats

(2010) Azza Baraka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prostaglandin E2-Induced Synaptic Plasticity in Neocortical Networks of Organotypic Slice Cultures

(2010) H. Koch et al.   JOURNAL OF NEUROSCIENCE

Decreased Rhythmic GABAergic Septal Activity and Memory-Associated   Oscillations after Hippocampal Amyloid-  Pathology in the Rat

(2010) V. Villette et al.   JOURNAL OF NEUROSCIENCE

Val8-glucagon-like peptide-1 protects against Aβ1–40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

(2010) X.H. Wang et al.   NEUROSCIENCE

Homeostatic Regulation of Neuronal Excitability by K+ Channels in Normal and Diseased Brains

(2010) Hiroaki Misonou   NEUROSCIENTIST

Beta-like hippocampal network activity is differentially affected by amyloid beta peptides

(2010) Alvaro Adaya-Villanueva et al.   PEPTIDES

A New Target for Amyloid Beta Toxicity Validated by Standard and High-Throughput Electrophysiology

(2010) Kucku Varghese et al.   PLoS One

Burrowing: A sensitive behavioural assay, tested in five species of laboratory rodents

(2009) R.M.J. Deacon   BEHAVIOURAL BRAIN RESEARCH

Cardioprotective effects of propofol in isolated ischemia-reperfused guinea pig hearts: role of KATP channels and GSK-3β

(2009) Noriko Kamada et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Patents related to therapeutic activation of KATPand K2Ppotassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anesthetics

(2009) Susan IV Judge et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+Channels

(2009) Ke Ning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient reduction of spontaneous neuronal network activity by sublethal amyloid β (1–42) peptide concentrations

(2009) Philipp Görtz et al.   JOURNAL OF NEURAL TRANSMISSION

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Dissociating  -Amyloid from  7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes  7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain

(2009) H.-Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Pharmacology of the Intracellular Pathways Activated by Amyloid Beta Protein

(2009) Hugo Balleza-Tapia et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine

(2009) Igor Klyubin et al.   NEUROBIOLOGY OF AGING

Gap junctions and memory: An investigation using a single trial discrimination avoidance task for the neonate chick

(2009) L.J. Verwey et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Diazoxide Reverses the Enhanced Expression of KATP Subunits in Cholinergic Neurons Caused by Exposure to Aβ1-42

(2009) Guozhao Ma et al.   NEUROCHEMICAL RESEARCH

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Sulphonylurea therapy improves cognition in a patient with the V59M KCNJ11 mutation

(2008) A. S. Slingerland et al.   DIABETIC MEDICINE

Amyloid   Oligomers (A 1-42 Globulomer) Suppress Spontaneous Synaptic Activity by Inhibition of P/Q-Type Calcium Currents

(2008) V. Nimmrich et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Medial septal β-amyloid 1-40 injections alter septo-hippocampal anatomy and function

(2008) Luis V. Colom et al.   NEUROBIOLOGY OF AGING

Effects of Aβ1–42 on the Subunits of KATP Expression in Cultured Primary Rat Basal Forebrain Neurons

(2008) Guozhao Ma et al.   NEUROCHEMICAL RESEARCH

Involvement of hippocampal CA3 KATP channels in contextual memory

(2008) Alexandre Betourne et al.   NEUROPHARMACOLOGY

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE