Article
Biochemical Research Methods
Yanjie Wang, Maurice Pasternak, Krishnan Sathiyamoorthy, Michael C. Kolios
Summary: In this study, targeted phase-transition polymeric nanoparticles were developed for imaging and treating HER2-positive breast cancer cells. The nanoparticles actively targeted HER2-positive cells with high efficacy, causing more damage to the targeted cells through laser-induced vaporization. These nanoparticles may offer better diagnostic imaging and therapeutic potential compared to current methods for treating HER2-positive breast cancer.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Psychiatry
Max M. Owens, Matthew D. Albaugh, Nicholas Allgaier, Dekang Yuan, Gabriel Robert, Renata B. Cupertino, Philip A. Spechler, Anthony Juliano, Sage Hahn, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rudiger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Sabina Millenet, Juliane H. Frohner, Michael N. Smolka, Henrik Walter, Robert Whelan, Scott Mackey, Gunter Schumann, Hugh Garavan
Summary: This study used Bayesian causal network (BCN) modeling to analyze the impact of adolescent cannabis use on brain development, and found that cannabis use accelerates prefrontal cortical thinning. Although BCN modeling alone does not prove a causal relationship, these findings are consistent with a body of animal and human research suggesting that adolescent cannabis use adversely affects brain development.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Environmental Sciences
Shawna Vreeke, David M. Faulkner, Robert M. Strongin, Echoleah Rufer
Summary: This paper presents a first-tier framework for conducting risk assessments of cannabis concentrate additives, providing a preliminary methodology for regulators, cannabis manufacturers, and consumers to evaluate the health risks associated with these additives. Scarce consumption data has made exposure assessment of cannabis concentrates difficult and variable.
Article
Acoustics
Weiqi Zhang, Hilde Metzger, Stavros Vlatakis, Amelia Claxton, M. Alejandra Carbajal, Leong Fan Fung, James Mason, K. L. Andrew Chan, Antonios N. Pouliopoulos, Roland A. Fleck, Paul Prentice, Maya Thanou
Summary: Phase-change nanodroplets, composed of a stabilising shell and a perfluorocarbon core, have recently gained attention as ultrasound theranostic nanoparticles. Nanodroplets can vaporise into echogenic microbubbles forming cavitation nuclei when exposed to ultrasound. However, methods to quantify the perfluorocarbon core in nanodroplets are lacking. In this study, nanodroplets were fabricated using lipids shell and perfluorocarbons, and the amount of perfluorocarbon in the core was assessed using 19F NMR and FTIR. The results showed that the fluorine signal accurately correlated with the perfluorocarbon concentration, allowing for quantification of the core. The study also found that different perfluorocarbons had varying rates of content loss and generated cavitation comparable to commercial contrast agent microbubbles.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Applied
Yoji Kato, Yui Kishi, Yayako Okano, Masaki Kawai, Michiyo Shimizu, Naoko Suga, Chisato Yakemoto, Mai Kato, Akika Nagata, Noriyuki Miyoshi
Summary: Reports on the thermal stability of manuka honey in terms of food processing have been limited. This study found that heating resulted in significant decreases in MGO and MAP in manuka honey. The mechanism for the decrease in MGO involves an amino-carbonyl reaction, while the decrease in MAP is influenced by the volume of headspace in a vessel. Additionally, heating can cause signature molecules in honey to vaporize.
Article
Engineering, Mechanical
Mao Ueda, Janet S. S. Wong, Hugh Spikes
Summary: This paper investigates the influence of appropriate blends of PAOs and PIBs on micropitting. The findings show that these blends can provide thick oil film thicknesses and reduce micropitting while maintaining low viscosity.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Environmental Studies
Christopher Dillis, Eric Biber, Hekia Bodwitch, Van Butsic, Jennifer Carah, Phoebe Parker-Shames, Michael Polson, Theodore Grantham
Summary: The cannabis industry in California is transitioning from illegal production to a legal market, with implications for local communities and the environment. Research shows that a small number of large farms dominate permitted cultivation areas, and the industry is moving towards two divergent paths of development.
Review
Microbiology
Carole Balthazar, David L. Joly, Martin Filion
Summary: This review discusses the opportunities and challenges of using beneficial Pseudomonas spp. bacteria as crop inoculants to improve cannabis yield. The prevalence and diversity of Pseudomonas strains within the cannabis microbiome are outlined, along with their potential mechanisms for promoting plant growth and stress tolerance. Specific aspects for hemp and marijuana crops in different production systems are emphasized. Factors influencing inoculant efficacy and strategies for strain selection, commercialization, and formulation design are also provided.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Antonella Casiraghi, Andrea Gentile, Francesca Selmin, Chiara Grazia Milena Gennari, Eleonora Casagni, Gabriella Roda, Gloria Pallotti, Pierangela Rovellini, Paola Minghetti
Summary: In the past 20 years, the interest in medicinal cannabis oily extracts has grown, leading to the need for high quality preparations. This study systematically investigated the use of an ultrasonic homogenizer as an alternative extraction method and found that it can provide equivalent content in CBD and THC compared to the traditional hot maceration method, with the advantage of a faster process. The qualitative characteristics of the oil remained constant for both treatments.
Article
Pharmacology & Pharmacy
Valentina Maggini, Lorenzo Calvi, Tommaso Pelagatti, Eugenia Rosaria Gallo, Celine Civati, Carlo Privitera, Flavio Squillante, Paolo Maniglia, Domenico Di Candia, Roberto Spampatti, Fabio Firenzuoli
Summary: The purpose of this analytical study was to develop an advanced formulation of medical Cannabis oil (MCO) by comparing the chemical profiles of different extracts obtained through three different extraction methods. The results showed that the new CERFIT method optimized the phytochemical profile of the MCO, offering a standardized high-level therapeutic product.
Article
Physics, Applied
Anqi Huang, Shizhe An, Yuebo Wang, Kangyi Feng, Haiyang Yu, Zhuonan Chen, Mingxi Wan, Yujin Zong
Summary: A spatiotemporally super-resolved ultrasound monitoring technique based on post-activation dynamics of high-bulk-boiling-point PCNDs was proposed. The technique allows for accurate monitoring and dose analysis of non-flowing extravascular PCNDs with high sensitivity and accuracy.
APPLIED PHYSICS LETTERS
(2023)
Article
Engineering, Environmental
Ce Wang, Yuling Lue, Chao Song, Jiakai Shi, Peng Zhang, Limin He
Summary: Condensate bubbles prepared by partial vaporization of low boiling point condensate can improve the efficiency of oil-water separation. The structure of the bubble is composed of a condensate film wrapped around the gas core of the vaporized portion. The contact angle between condensate bubble and oil surface is >150 degrees, showing great similarity-intermiscibility. The oil removal efficiency of condensate bubble flotation at the optimum temperature of 313 K can reach 85%.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Horticulture
Tiantian Ye, Xue Liu, Xiaojie Liang, Xueyan Zhu, Qian Bai, Shuchai Su
Summary: Heavy flower thinning in Camellia oleifera leads to increased fruit size and weight, as well as higher seed and dry kernel rate of fresh fruit, soluble protein and oil accumulation in seeds. However, it also decreases fruit yield, and certain fatty acids proportion in the oil composition like palmitic, palmitoleic, linoleic, and linolenic acid.
Article
Psychology, Biological
Jacqueline E. Smith, Elizabeth R. Aston, Samantha G. Farris
Summary: This study aimed to evaluate the feasibility of using a smart vaporizer and application to assess the use of cannabis oil vaporization. The findings showed that participants used cannabis oil vaporization an average of 1.79 times per day, with an average of 8.76 puffs per session and a session duration of 2.59 minutes. This method allows for the collection of objective momentary data, which is important for understanding the use behaviors of cannabis oil vaporization.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Eduarda Gomes Ferrarini, Rodrigo Sebben Paes, Gabriela Mantovani Baldasso, Pollyana Mendonca de Assis, Murilo Chaves Gouvea, Paola De Cicco, Nadia Rezende Barbosa Raposo, Raffaele Capasso, Eduardo Luiz Gasnhar Moreira, Rafael Cypriano Dutra
Summary: Broad-spectrum cannabis oil with low THC concentration has analgesic effects and can alleviate pain and depressive behavior in fibromyalgia models. Its analgesic effects may be attributed to its anti-inflammatory, neuroprotective, and immunomodulatory properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)