Article
Critical Care Medicine
Catherine Moermans, Chloe Brion, Gregory Bock, Sophie Graff, Sara Gerday, Haleh Nekoee, Christophe Poulet, Noemie Bricmont, Monique Henket, Virginie Paulus, Francoise Guissard, Renaud Louis, Florence Schleich
Summary: This study examined the biomarkers of remission after anti-IL-5 therapy in sputum samples of patients with severe eosinophilic asthma. The results suggest that sputum type 2 markers may potentially predict remission after anti-IL-5 therapy in these patients.
Article
Allergy
Michael Fricker, Ling Qin, Stephany Sanchez-Ovando, Jodie L. Simpson, Katherine J. Baines, Carlos Riveros, Hayley A. Scott, Lisa G. Wood, Peter AB. Wark, Nazanin Z. Kermani, Kian Fan Chung, Peter G. Gibson
Summary: In this study, RNASeq analysis was conducted on sputum macrophages from NA and NNA patients, revealing transcriptomic differences in NA macrophages. Pathway analysis indicated activation of inflammatory programs in NA macrophages, supporting NA as a specific endotype characterized by transcriptional activation of inflammatory pathways in cell types other than neutrophils.
Article
Respiratory System
Sara Gerday, Sophie Graff, Catherine Moermans, Francoise Guissard, Virginie Paulus, Monique Henket, Renaud Louis, Florence Schleich
Summary: Several clinical trials have shown that anti-IL-5(R) biologics can improve lung function, asthma control, and reduce exacerbations in eosinophilic asthmatic patients. However, there is variability in clinical responses to these biologics. Our study aimed to evaluate the role of baseline sputum eosinophils in identifying super-responders to mepolizumab and benralizumab. Our findings emphasize the importance of examining sputum eosinophils in severe asthma patients before starting biologic treatment as it is associated with the intensity of response to mepolizumab and benralizumab.
Article
Immunology
Leandro do Nascimento Camargo, Renato Fraga Righetti, Francine Maria de Almeida, Tabata Maruyama dos Santos, Silvia Fukuzaki, Nilo Arthur Bezerra Martins, Miguel Cantadori Barbeiro, Beatriz Mangueira Saraiva-Romanholo, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Edna Aparecida Leick, Carla Maximo Prado, Iolanda de Fatima Lopes Calvo Tiberio
Summary: Inhibiting IL-17 can modulate cell-associated cytokine production, extracellular matrix remodeling, and oxidative stress in ACO.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock, Kian Fan Chung
Summary: Levels of ACE2 and FURIN in severe asthma patients may be associated with neutrophilic inflammation, indicating a potential for greater morbidity and mortality from SARS-CoV-2 infection.
RESPIRATORY RESEARCH
(2021)
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Allergy
Dandan Chen, Yu Zhang, Can Yao, Binbin Li, Sinian Li, Wenwen Liu, Rongchang Chen, Fei Shi
Summary: This study compared patients with severe early-onset and late-onset asthma, finding that early-onset patients had a younger age, longer asthma duration, higher family history rate, and better small-airway function. Additionally, levels of serum IL-17 and sputum neutrophil percentage were significantly higher in early-onset asthma patients. Logistic regression analysis identified serum IL-17 as independently associated with severe early-onset asthma, and the combination of serum IL-17 and sputum neutrophil percentage showed high sensitivity and specificity for identifying these patients.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Tanaka Arthur Choto, Ian Makupe, Andrew Zolani Cakana, Elopy Nimele Sibanda, Takafira Mduluza
Summary: This study aimed to determine the lymphocyte and cytokine profiles associated with COVID-19 severity. The analysis of hospitalized COVID-19 patients revealed that severe cases exhibit reduced CD4(+) lymphocytes, increased neutrophils and immature granulocytes, and elevated expression of interleukin 17A (IL-17A). These results suggest that targeting neutrophils and blocking IL-17 production could be potential therapeutic strategies against severe COVID-19.
Article
Immunology
Masaya Matsuda, Miki Inaba, Junpei Hamaguchi, Hiro Tomita, Miyu Omori, Hayato Shimora, Harumi Sakae, Kazuyuki Kitatani, Takeshi Nabe
Summary: IL-10 can suppress eosinophil and neutrophil infiltration by inhibiting the proliferation of ICAM-1+ and VCAM1+ pulmonary vascular endothelial cells, resulting in inhibition of airway hyperresponsiveness in steroid-insensitive asthmatic mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Physiology
Ji-Su Shim, Hyun-Seung Lee, Hyuktae Kwon, Min-Hye Kim, Young-Joo Cho, Heung-Woo Park
Summary: Obesity disturbs glutamine metabolism, leading to enhanced inflammation by affecting immune cells. In this study, it was found that a high-fat diet induced airway hyperresponsiveness in obese mice by altering glutamine metabolism in macrophages and innate lymphoid cells. Moreover, plasma glutamine/glutamate ratios were higher in obese asthmatics compared to nonobese asthmatics.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Respiratory System
Clair Barber, Laurie Lau, Jonathan A. Ward, Thomas Daniels, Alastair Watson, Karl J. Staples, Tom M. A. Wilkinson, Peter H. Howarth
Summary: Sputum cytology is crucial for evaluating cellular inflammation in airways and phenotyping patients with airways diseases. Indirect blood eosinophil measures have been adopted in clinical care, but there are no good peripheral blood biomarkers for airway neutrophils. A cost-effective method of sputum processing, such as mechanical disruption, could provide a more sustainable means of monitoring the airway milieu.
CLINICAL RESPIRATORY JOURNAL
(2021)
Article
Respiratory System
Mustafa Abdo, Mohib Uddin, Torsten Goldmann, Sebastian Marwitz, Thomas Bahmer, Olaf Holz, Anne-Marie Kirsten, Frederik Trinkmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Henrik Watz, Frauke Pedersen
Summary: The study identified a subset of asthma patients with excessive extracellular DNA production, which was associated with broad lung function impairments, poor symptom control, and increased risk of severe exacerbations.
RESPIRATORY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Melissa Simard, Volatiana Rakotoarivelo, Vincenzo Di Marzo, Nicolas Flamand
Summary: The CB2 receptor is expressed in a wide range of leukocytes and its activation has potential therapeutic effects for inflammatory and autoimmune diseases. Current research focuses on identifying immune cells expressing CB2 receptors and studying the consequences of receptor activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Noria Segueni, Muazzam Jacobs, Bernhard Ryffel
Summary: Studies on the innate immune response to Mycobacterium tuberculosis infection suggest that the IL-17 and IL-22 pathways play a limited role in infection control, and neutralizing IL-17 does not affect infection control.
BIOMEDICAL JOURNAL
(2021)
Article
Allergy
Ali Versi, Fransiskus Xaverius I. Ivan, Mahmoud Abdel-Aziz, Stewart Bates, John Riley, Frederic Baribaud, Nazanin Zounemat Kermani, Paolo Montuschi, Sven-Erik Dahlen, Ratko Djukanovic, Peter H. Sterk, Anke H. Maitland-Van Der Zee, Sanjay Chotirmall, Peter M. Howarth, Ian Adcock, Kian Fan Chung
Summary: The study analyzed the bacterial species in sputum of severe asthma patients and found altered airway microbiome in asthma. Haemophilus influenzae and Moraxella catarrhalis were more abundant in severe neutrophilic asthma, while Haemophilus influenzae and Tropheryma whipplei were highest in current or ex-smokers. The abundance of these bacteria correlated with the presence of inflammatory cells in the airways.
Article
Allergy
Melissa A. Rosenkranz, Douglas C. Dean, Barbara B. Bendlin, Nizar N. Jarjour, Stephane Esnault, Henrik Zetterberg, Amanda Heslegrave, Michael D. Evans, Richard J. Davidson, William W. Busse
Summary: Asthma is associated with neuroinflammation and neurodegeneration, particularly in severe cases. This study used dMRI and blood-based biomarkers to examine changes in brain structure and found widespread differences in asthma patients, indicating neuroinflammation and neurodegeneration. These changes were associated with glial activation and cognitive dysfunction.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Physiology
Pierre Tawfik, Muhammad K. Hayat Syed, Firas S. Elmufdi, Michael D. Evans, David J. Dries, John J. Marini
Summary: This study compared four different methods for measuring compliance and driving pressure and found that using plateau pressure for static measurements may underestimate the maximum pressure experienced by compromised lung units during dynamic inflation. Utilizing the pressure at zero flow or the inspiratory slope as dynamic measurements may provide a more accurate estimate of the maximum alveolar pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Alisa B. Nelson, Lisa S. Chow, David B. Stagg, Jacob R. Gillingham, Michael D. Evans, Meixia Pan, Curtis C. Hughey, Chad L. Myers, Xianlin Han, Peter A. Crawford, Patrycja Puchalska
Summary: This study investigates the effects of acute aerobic exercise on the metabolome in overweight and normal-weight individuals. The findings suggest that changes in fatty acid esters of hydroxy fatty acids (FAHFAs) may distinguish normal-weight from overweight individuals and predict maximum oxygen consumption (VO(2)max). These results provide insights into the impact of exercise on metabolism and its potential health implications.
Article
Urology & Nephrology
Sarah J. Kizilbash, Michael D. Evans, Blanche M. Chavers, Clifford Kashtan
Summary: There are racial disparities in age at transplant and long-term graft survival for patients with Alport syndrome in the United States. The age at transplant has increased over time for Whites, but not for Black and Hispanic patients.
CLINICAL NEPHROLOGY
(2022)
Article
Hematology
Shruti Chaturvedi, Ana G. Antun, Andrew M. Farland, Ryan Woods, Ara Metjian, Yara A. Park, Gustaaf de Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, J. Evan Sadler, Meera Sridharan, Ronald S. Go, Keith R. McCrae, Harsh Vardhan Upreti, Angela Liu, Ming Y. Lim, Radhika Gangaraju, X. Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Andrew Johnson, Elizabeth Davis, Michael D. Evans, Marshall A. Mazepa
Summary: This study evaluated the impact of race on mortality and relapse-free survival in immune-mediated thrombotic thrombocytopenic purpura (iTTP) patients and found racial disparities in treatment response and relapse risk.
Article
Cardiac & Cardiovascular Systems
Mark McGill, Kishore R. R. Raja, Michael Evans, Gurumurthy Hiremath, Rebecca Ameduri, Shanti Narasimhan
Summary: This study aimed to assess the correlation between serum N-terminal pro b-type natriuretic peptide levels and both non-invasive measurements and invasive mean right atrial pressure in paediatric heart transplant patients. The results showed a correlation between serum N-terminal pro b-type natriuretic peptide levels and inferior vena cava collapsibility index, inferior vena cava diameter index, and mean right atrial pressure. Non-invasive measurements can serve as a reliable tool in assessing right heart filling pressures and cardiac function in this population.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Pediatrics
Stephanie P. P. Kerkvliet, Carlos J. Perez J. Perez Kerkvliet, Ziou Jiang, Michael Evans, Sarah J. J. Kizilbash
Summary: In pediatric kidney transplant, recipients requiring interpreter services have fewer post-transplant interactions with their healthcare team (fewer hospitalizations and more no-show visits) and lower 5-year patient survival compared with recipients not requiring interpreters.
PEDIATRIC NEPHROLOGY
(2023)
Article
Immunology
Tithi Roy, Sergette Banang-Mbeumi, Samuel T. Boateng, Emmanuelle M. Ruiz, Roxane-Cherille N. Chamcheu, Lin Kang, Judy A. King, Anthony L. Walker, Bolni Marius Nagalo, Konstantin G. Kousoulas, Stephane Esnault, Shile Huang, Jean Christopher Chamcheu
Summary: Fisetin has potential therapeutic effects on refractory psoriasis by inhibiting abnormal immune response, promoting keratinocyte differentiation and autophagy, and reducing disease inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Elise F. Palzer, Erika S. Helgeson, Michael D. Evans, David M. Vock, Arthur J. Matas
Summary: In kidney donors, postdonation complications such as preeclampsia, gestational hypertension, or gestational diabetes are associated with long-term risks of developing hypertension or diabetes.
Article
Virology
Mark K. Devries, Yury A. Bochkov, Michael D. Evans, James E. Gern, Daniel J. Jackson
Summary: In 2014, enterovirus D68 (EV-D68), previously associated with mild respiratory illness, caused a severe outbreak of respiratory illness and paralysis. A comparison of viral binding and replication in different cell cultures showed that recent EV-D68 isolates had increased replication efficiency and induced a stronger inflammatory response compared to the prototype Fermon strain from 1962. However, host factors are likely the main determinants of illness severity.
Article
Dentistry, Oral Surgery & Medicine
Michelle C. Arnett, Danna R. Paulson, Michael D. Evans, Christine M. Blue, Yvette G. Reibel
Summary: Brief-motivational interviewing (MI) is more successful than traditional oral hygiene instructions (OHI) in promoting discussions on oral home care behaviors, oral diseases/conditions, lifestyle behaviors, nutrition, emotional/mental health, and general health.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2023)
Letter
Cardiac & Cardiovascular Systems
Matthew C. Tattersall, Stephane Esnault, Ron Stewart, David T. Vereide, Scott Swanson, Jue Zhang, John Steill, Nizar Jarjour, Kristin M. Hansen, Claudia E. Korcarz, Timothy B. Baker, James H. Stein
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Urology & Nephrology
Anne M. Kouri, Tiffany N. Caza, Laurence H. Beck Jr, Jason M. Misurac, Michael D. Evans, Carrie L. Phillips, Michael T. Eadon, Christopher P. Larsen, Sharon P. Andreoli, Lihong Bu, Michelle N. Rheault, Myda Khalid
Summary: PMN is uncommon in children and data on its clinical course are scarce. This study retrospectively analyzed the clinical presentation and outcomes data of 21 children with PMN and identified novel antigens in their biopsy specimens. Approximately 60% of pediatric PMN cases were positive for a novel antigen and the clinical prognosis was generally favorable.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Psychology, Multidisciplinary
Katherine Diaz Vickery, Becky R. Ford, Lillian Gelberg, Zobeida Bonilla, Ella Strother, Susan Gust, Edward Adair, Victor M. Montori, Mark Linzer, Michael D. Evans, John Connett, Michele Heisler, Patrick J. O'Connor, Andrew M. Busch
Summary: Compared to stably housed peers, individuals experiencing homelessness have poorer glycemic control and higher morbidity and mortality rates. The high prevalence of behavioral health comorbidities and trauma contribute to access barriers and poor outcomes. There is limited evidence on behavioral approaches to support individuals experiencing homelessness with diabetes.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Pediatrics
Sarah J. Kizilbash, Michael D. Evans, David M. Vock, Srinath Chinnakotla, Blanche M. Chavers
Summary: This study found that kidney transplantation in children under the age of 2 is associated with improved patient survival and reduced dialysis exposure compared to waiting until the age of 2 for transplantation.
PEDIATRIC TRANSPLANTATION
(2023)