Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 26, Issue 1, Pages 35-45Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2014.05.005
Keywords
Systemic juvenile idiopathic arthritis; Cytokine profile; Systemic inflammatory syndromes; Natural killer cells; Defective cytotoxicity
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Funding
- Fund for Scientific Research-Flanders (FWO-Vlaanderen) [G.0515.12]
- Regional Government of Flanders (GOA program) [GOA/13/014]
- Interuniversity Attraction Poles (IAP) [P7/39]
- FWO-Vlaanderen
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Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory childhood disorder, characterized by a specific pattern of systemic features and a typical cytokine profile. Patients are at risk to develop macrophage activation syndrome (MAS), an acute life-threatening condition defined by excessive proliferation and activation of macrophages and T cells. Defects of unknown cause in the natural killer (NK) cell cytotoxic capacity are presumed to underlie the pathogenesis of MAS and have been detected in sJIA patients. Here, we provide an overview of the cytokine profiles in sJIA and related mouse models. We discuss the influence of cytokines on NK cell function, and hypothesize that NK cell dysfunction in sJIA is caused by altered cytokine profiles. (C) 2014 Elsevier Ltd. All rights reserved.
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