Article
Rheumatology
Satomi Kobayashi, Yasuo Nagafuchi, Mai Okubo, Yusuke Sugimori, Hiroaki Hatano, Saeko Yamada, Masahiro Nakano, Ryochi Yoshida, Yusuke Takeshima, Mineto Ota, Yumi Tsuchida, Yukiko Iwasaki, Keigo Setoguchi, Kanae Kubo, Tomohisa Okamura, Kazuhiko Yamamoto, Hirofumi Shoda, Keishi Fujio
Summary: RNA-seq of immune cells indicated the dysregulation of Fr. II eTregs in early SSc with increased proportion of the activated subpopulation.
Article
Immunology
Shahrzad Bakhtiar, Celia Kaffenberger, Emilia Salzmann-Manrique, Sabine Donhauser, Leon Lueck, Neslihan Edeer Karaca, Luis Gonzalez-Granado, Esra Hazar, Sevgi Keles, Markus G. Seidel, Julia Fekadu, Christoph Koenigs, Ralf Schubert, Peter Bader, Sabine Huenecke
Summary: This study investigated the Breg profile and CD21low expressing B cells in patients with inborn errors of immunity (IEI) and overlapping clinical symptoms. The results showed significant alterations in B cell/Breg subpopulations in LRBA deficient patients and a tendency towards higher CD21low B cells in non-LRBA deficient patients. Abatacept treatment was effective in decreasing CD21low B cells in LRBA deficient patients. The findings suggest that aberrant maturation of Breg subsets and expansion of CD21low B cells may have therapeutic implications in IEI patients.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Multidisciplinary Sciences
Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Shirin Hafezi, Hawra Ali Hussain Alsayed, Balachandar Selvakumar, Mariam Wed Abdelaziz Eladham, Bushra Mdkhana, Ola Salam Bayram, Mohamad-Hani Temsah, Rabih Halwani
Summary: The levels of regulatory T and B cells are altered in severe COVID-19, especially in the presence of autoantibodies to type I IFNs. Treatment with tocilizumab and/or high dose of Vitamin D can increase the levels of these regulatory cells and improve control of inflammation.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Nigel Sharfe, Ilan Dalal, Zahra Naghdi, Diane Lefaudeux, Linda Vong, Harjit Dadi, Hector Navarro, Diana Tasher, Adi Ovadia, Tzili Zangen, Dorit Ater, Bo Ngan, Alexander Hoffmann, Chaim M. Roifman
Summary: This study identified the genetic defect causing progressive severe autoimmunity and immunodeficiency in three patients through whole exome sequencing. The unique characteristics of this defect provide insights into the interactions of the NFicB pathway and the pathogenesis of autoimmunity.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Multidisciplinary Sciences
Andrew C. Yang, Fabian Kern, Patricia M. Losada, Maayan R. Agam, Christina A. Maat, Georges P. Schmartz, Tobias Fehlmann, Julian A. Stein, Nicholas Schaum, Davis P. Lee, Kruti Calcuttawala, Ryan T. Vest, Daniela Berdnik, Nannan Lu, Oliver Hahn, David Gate, M. Windy McNerney, Divya Channappa, Inma Cobos, Nicole Ludwig, Walter J. Schulz-Schaeffer, Andreas Keller, Tony Wyss-Coray
Summary: This study found that patients with COVID-19 exhibited widespread cellular perturbations in the brain, including the relay of peripheral inflammation into the brain by choroid plexus barrier cells and infiltration of peripheral T cells. Additionally, COVID-19 affected synaptic signaling of upper-layer excitatory neurons linked to cognitive function.
Review
Immunology
Suran L. Fernando, Helena S- Jang, Jamma Li
Summary: CVID is a heterogeneous collection of immune dysregulation disorders, with majority of patients experiencing non-infectious complications such as autoimmunity, enteropathy, polyclonal lymphocytosis, and malignancy. Advances in next generation sequencing have led to a better understanding of the genetic basis of CVID disorders, allowing for improved diagnosis and targeted therapies. The identification of cellular abnormalities in T-cell and B-cell compartments, along with the role of innate lymphoid cells in promoting inflammation, provides valuable insights into the immune dysregulation seen in CVID patients.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Celine Maquet, Jerome Baiwir, Pauline Loos, Lucia Rodriguez-Rodriguez, Justine Javaux, Remy Sandor, Fabienne Perin, Padraic G. Fallon, Matthias Mack, Didier Cataldo, Laurent Gillet, Benedicte Machiels
Summary: Gammaherpesviruses have evolved together with their hosts to establish high infection prevalence and latency. Research shows that pulmonary infection with Murid herpesvirus 4 leads to recruitment of Ly6C(hi) monocytes into airways, modulating host immune response. The absence of Ly6C(hi) MOs is associated with severe virus-induced immunopathology and systemic release of inflammatory mediators.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q. Gabrielski, Lixin Zheng, Tovah E. Markowitz, Waipan Chan, Jian Song, Arun K. Boddapati, Keita Saeki, Bjoern Haupl, Ann Y. Park, Yan H. Cheng, Jing Cui, Thomas Oellerich, Michael J. Lenardo
Summary: Apoptosis is a genetically regulated program of cell death that plays a key role in immune disease processes. The transcription factor EBF4 was identified as a regulator of T cell death and cytotoxic immune function in humans, suggesting its importance in immune responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Yanyun Hao, Hui Li, Xiaoyan Ge, Yang Liu, Jialin Yin, Xia Li, Yutong Liu, Hongfei Chen, Lingling Huang, Jing Zou, Shiying Zhang, Hao Wu, Zhiyue Zhang
Summary: The researchers developed a redox-activatable polymeric nanoswitch that can switch on after entering the tumor, enhancing the infiltration of T lymphocytes and priming of T lymphocytes for cancer treatment. The nanoswitch releases immune agonists and inhibitors to strengthen the immune response against tumors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Viswajit Mulpuru, Nidhi Mishra
Summary: The study aims to identify potential CTL epitopes in the SARS-CoV-2 Indian isolate for Indian population, analyze their immunogenicity and foreignness, and investigate their interactions with HLA system to confirm their candidacy as epitope candidates for vaccine development.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jia-Nan Cheng, Wen Luo, Chengdu Sun, Zheng Jin, Xianghua Zeng, Peter B. Alexander, Zhihua Gong, Xin Xia, Xiaofang Ding, Shouxia Xu, Ping Zou, Yisong Y. Wan, Qingzhu Jia, Qi-Jing Li, Bo Zhu
Summary: Cancer immunotherapy efficacy can be improved by enhancing eosinophil infiltration through radiation, which also boosts the effectiveness of CD8(+) T cells and adoptive T cell therapy. Eosinophil mobilization may serve as a mechanistically relevant biomarker for predicting the effectiveness of pre-immunotherapy radiation and enhancing T cell-mediated immunotherapy against cancers.
Article
Medicine, General & Internal
Rossella Cifaldi, Francesco Salton, Paola Confalonieri, Liliana Trotta, Mariangela Barbieri, Luca Ruggero, Gianmaria Valeri, Riccardo Pozzan, Rossana Della Porta, Metka Kodric, Elisa Baratella, Mattia Bellan, Selene Lerda, Michael Hughes, Marco Confalonieri, Maria Assunta Cova, Ilaria Gandin, Lucrezia Mondini, Barbara Ruaro
Summary: This study aimed to evaluate whether immune system alterations detected by lymphocyte typing in peripheral blood correlate with the severity of sarcoidosis. The results showed that lymphocyte subpopulation values at the time of diagnosis do not appear to correlate with disease severity at onset.
Article
Immunology
Roos-Marijn Berbers, Julia Drylewicz, Pauline M. Ellerbroek, Joris M. van Montfrans, Virgil A. S. H. Dalm, P. Martin van Hagen, Baerbel Keller, Klaus Warnatz, Annick van de Ven, Jaap M. van Laar, Stefan Nierkens, Helen L. Leavis
Summary: This study used serum proteomics to differentiate patients with immune dysregulation in CVID, identified relevant signaling pathways, and provided insights into potential biomarker development.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wenfeng Liu, Yang Liu, Cheng Hu, Cuiying Xu, Jiehong Chen, Yinting Chen, Jing Cai, Guangmei Yan, Wenbo Zhu
Summary: Oncolytic virotherapy can increase the number of Treg cells in the tumor microenvironment, while targeting Treg cells can enhance the anti-tumor effect of M1-based oncolytic virotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Correction
Oncology
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca Maria Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmen, Diether Lambrechts, Pascal Merchiers, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
Review
Allergy
Mathijs Willemsen, Frederik Staels, Margaux Gerbaux, Julika Neumann, Rik Schrijvers, Isabelle Meyts, Stephanie Humblet-Baron, Adrian Liston
Summary: Inborn errors of immunity are a group of diverse monogenic immunologic disorders caused by mutations in genes involved in the immune system. Some mutations occur in genes with restricted expression and/or function in immune cells, while others affect genes that are ubiquitously expressed. These genetic defects can lead to deficiencies in DNA replication, repair, or damage response factors, resulting in immunodeficiency. Understanding the mechanistic insights of these DNA replication-associated inborn errors of immunity is crucial for comprehending the observed heterogeneity in clinical manifestations and immunologic defects.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Immunology
Adrian Liston, Lidia Yshii
Summary: Aging is often associated with cognitive decline caused by brain degeneration. Recent research provides further evidence of the connection between CD8(+) T cells, interferon-gamma production in the brain, and neurodegeneration.
Article
Medicine, Research & Experimental
Pierre Lemaitre, Samar H. K. Tareen, Emanuela Pasciuto, Loriana Mascali, Araks Martirosyan, Zsuzsanna Callaerts-Vegh, Suresh Poovathingal, James Dooley, Matthew G. Holt, Lidia Yshii, Adrian Liston
Summary: Inflammation and neurodegeneration are common pathological outcomes during aging. Recent studies have shown that T cells accumulate in the brain with age and contribute to inflammatory processes leading to cognitive decline. Researchers have successfully prevented neurological decline in aging mice by delivering IL2 specifically to the brain, restoring cognitive function and spatial learning ability.
EMBO MOLECULAR MEDICINE
(2023)
Article
Allergy
Mathijs Willemsen, John S. Barber, Erika Van Nieuwenhove, Frederik Staels, Margaux Gerbaux, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Vasiliki Lagou, Nancy Boeckx, Jessica Filtjens, Amber De Visscher, Patrick Matthys, Rik Schrijvers, Thomas Tousseyn, Mark O'Driscoll, Giorgia Bucciol, Susan Schlenner, Isabelle Meyts, Stephanie Humblet-Baron, Adrian Liston
Summary: This study reported a patient with severe congenital neutropenia and syndromic features, and a homozygous missense mutation in the DBF4 gene was identified using whole exome sequencing. This mutation caused defects in granulocyte differentiation and DNA replication, resulting in impaired immune system function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Margaux Gerbaux, Evelyne Roos, Mathijs Willemsen, Frederik Staels, Julika Neumann, Leoni Bucken, Jeason Haughton, Lidia Yshii, James Dooley, Susan Schlenner, Stephanie Humblet-Baron, Adrian Liston
Summary: This study compares the efficacy of three main therapeutic candidates (rapamycin, nondepleting anti-CD4 antibody, and CTLA4-Ig) in treating FOXP3-deficient mice, and suggests that CTLA4-Ig may be a superior therapeutic option for FOXP3-deficient patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Frederik Staels, Willem Roosens, Simone Giovannozzi, Leen Moens, Jan Bogaert, Cecilia Iglesias-Herrero, Rik Gijsbers, Xavier Bossuyt, Glynis Frans, Adrian Liston, Stephanie Humblet-Baron, Isabelle Meyts, Lucas Van Aelst, Rik Schrijvers
Summary: Autosomal dominant Signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) mutations cause an inborn error of immunity with chronic mucocutaneous candidiasis, recurrent infections, and autoimmune manifestations. Treatment includes antifungal therapy, antibiotics, and immunosuppressive therapy. A case of STAT1 GOF patient with elevated cardiac troponins leading to a diagnosis of idiopathic myocarditis is described. Treatment with a JAK-inhibitor mitigated inflammation but failed to alter fibrosis, leading to fatal arrhythmia.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Adrian Liston, Lydia E. Makaroff
Summary: PhD training offers a wide range of career opportunities, and this article provides a strategic framework to help PhD researchers build their career options. It emphasizes the importance of self-direction, adaptability, and resilience in navigating a rapidly changing job market. By establishing early markers of multiple career pathways and building professional networks, PhD researchers can maximize their chances of success in academia and beyond.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Editorial Material
Cell Biology
Adrian Liston, Anne C. La Flamme, Gabrielle T. Belz, Christopher R. Parish, Judith M. Greer
Summary: This editorial recounts the history of Immunology & Cell Biology journal, from its founding in 1924 to its current focus on immunology research.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Editorial Material
Cell Biology
Adrian Liston
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Editorial Material
Neurosciences
Magda Ali, Adrian Liston
Summary: In vivo CRISPR screen identifies genetic modules that control T cell infiltration in multiple sclerosis, shedding light on the immunopathology of the disease.
NATURE NEUROSCIENCE
(2023)
Article
Cell Biology
Stefan Naulaerts, Angeliki Datsi, Daniel M. Borras, Asier Antoranz Martinez, Julie Messiaen, Isaure Vanmeerbeek, Jenny Sprooten, Raquel S. Laureano, Jannes Govaerts, Dena Panovska, Marleen Derweduwe, Michael C. Sabel, Marion Rapp, Weiming Ni, Sean Mackay, Yannick Van Herck, Lendert Gelens, Tom Venken, Sanket More, Oliver Bechter, Gabriele Bergers, Adrian Liston, Steven De Vleeschouwer, Benoit J. Van Den Eynde, Diether Lambrechts, Michiel Verfaillie, Francesca Bosisio, Sabine Tejpar, Jannie Borst, Rudiger V. Sorg, Frederik De Smet, Abhishek D. Garg
Summary: Through multiomics analysis of CD8+ T cell features in multiple patient cohorts and tumor types, we have identified different hypofunctional states of tumor-associated CD8+ T cells, including exhausted CD8+ T cells in supportive tumor niches and hypofunctional CD8+ T cells in nonsupportive niches. These two types of hypofunctional states exhibit distinct characteristics, such as different T cell receptor repertoires and immunopeptidomes. Furthermore, dysfunctional CD4+:CD8+ T cell interactions and a wound healing-like chemokine profile were observed in glioblastoma. Immuno-oncology clinical trials showed that anti-programmed cell death protein 1 (PD-1) immunotherapy exacerbated the tolerogenic disparities in glioblastoma, while dendritic cell (DC) vaccines partially corrected them. Recipients of DC vaccines for glioblastoma demonstrated evidence of antigen-specific immunity.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemical Research Methods
Carlos P. Roca, Oliver T. Burton, Julika Neumann, Samar Tareen, Carly E. Whyte, Vaclav Gergelits, Rafael V. Veiga, Stephanie Humblet-Baron, Adrian Liston
Summary: The development of dimensionality-reduction tools is necessary for handling high-dimensional single-cell data. t-SNE and UMAP are frequently used approaches that provide clear visualization of complex single-cell datasets. However, their limited use as visualization tools is due to the lack of robust statistical approaches. In this study, a statistical test based on the Kolmogorov-Smirnov test is proposed to evaluate the difference between dimensionality-reduced datasets. This test utilizes the inter-relationship of single cells for comparison, resulting in a robust statistic that can identify true biological variation and provide a valid distance between single-cell datasets.
CELL REPORTS METHODS
(2023)
Article
Immunology
Julika Neumann, Erika Van Nieuwenhove, Lara E. Terry, Frederik Staels, Taylor R. Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R. Baker, Margaux Gerbaux, Mathijs Willemsen, John S. Barber, Irina I. Serysheva, Liesbeth De Waele, Francois Vermeulen, Susan Schlenner, Isabelle Meyts, David Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston
Summary: Calcium signaling is crucial for lymphocyte activation, and disruptions of store-operated calcium entry can lead to severe immunodeficiency. In this study, genetic variations of the ITPR3 gene were identified in two Caucasian patients with immunodeficiency, indicating a potential link between these variations and impaired immune responses. The findings demonstrate the functional connection between defective endoplasmic reticulum calcium channels and immunodeficiency, highlighting the importance of IP(3)Rs as diagnostic targets for patients with specific inborn errors of immunity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Correction
Immunology
Julika Neumann, Erika Van Nieuwenhove, Lara E. Terry, Frederik Staels, Taylor R. Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R. Baker, Margaux Gerbaux, Mathijs Willemsen, John S. Barber, Irina I. Serysheva, Liesbeth De Waele, Francois Vermeulen, Susan Schlenner, Isabelle Meyts, David I. Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)