Journal
CYTOKINE
Volume 74, Issue 2, Pages 327-330Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.01.021
Keywords
IL-18; Leishmania amazonensis; Macrophage; Leishmaniasis
Funding
- FAPEMIG [APQ-01599-11]
- NIH [U01 AI088650]
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We evaluated the role of IL-18 during LeishTania amazonensis infection in C57BL/6 mice, using IL-18K0 mice. We showed that IL-18 is involved in susceptibility to L. amazonensis, since IL-18K0 mice presented reduced lesions and parasite loads. Because macrophages are the host cells of the parasite, we investigated if macrophages were involved in IL-18-mediated susceptibility to L. amazonensis. We showed that macrophages obtained from WT or IL-18K0 responded similarly to L. amazonensis infection. Moreover, we showed that C57BL/6 macrophages do not respond to IL-18, since they do not express IL-18R. Therefore, macrophages are not involved in IL-18-mediated susceptibility to L. amazonensis. (C) 2015 Elsevier Ltd. All rights reserved.
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