Article
Food Science & Technology
Enning Zhou, Qi Wang, Xiangxin Li, Dan Zhu, Qingsheng Niu, Qiangqiang Li, Liming Wu
Summary: Royal jelly, secreted by honeybees, is valued for its bioactive substances and its lipid composition is influenced by the plant source of bee pollen and feeding time. Lipidomic analyses of royal jelly produced by honeybees fed with different sources of bee pollen (BP-Am and BP-Pa) were conducted using UPLC-Q-Exactive Orbitrap mass spectrometry. The results showed differences in phospholipid and fatty acid contents between royal jelly produced by honeybees fed BP-Am and BP-Pa. The study also revealed temporal variations in lipid compounds with a decrease after single-pollen feeding began, followed by a gradual increase and a decrease again after 30 days of feeding. The study provides guidance for the production of high-quality royal jelly.
Article
Food Science & Technology
Shengnan Wang, Yongshi Chen, Yu Chen, Peng Liang, Jie Pang, Beiwei Zhu, Xiuping Dong
Summary: This study analyzed the effects of different low-temperature storage temperatures on the lipidomics of Litopenaeus vannamei, identifying potential biomarkers of lipid oxidation in PC, PE, DG, and TG. The results showed that low storage temperatures had varying effects on the lipidomics profile of L. vannamei, with PC, PE, DG, and TG being potential focuses for further studies on lipid oxidation.
Article
Food Science & Technology
Sebastian Imperiale, Ksenia Morozova, Giovanna Ferrentino, Matteo Scampicchio
Summary: This work developed an optimized workflow for targeted analysis of triacylglycerols (TAGs) in milk using liquid chromatography coupled with a Q-Exactive Orbitrap mass spectrometer. The optimized parameters included resolution, automatic gain control target, and flow rate. The optimized conditions were used to successfully identify up to 14 target triglycerides in milk fat extracts, providing helpful information for MS-based lipidomic workflows and targeted milk lipid analysis.
FOOD ANALYTICAL METHODS
(2022)
Article
Food Science & Technology
Jiawen Yu, Wu Li, Bangyan You, Shiying Yang, Wenyan Xian, Yu Deng, Wei Huang, Ruili Yang
Summary: Plum is a rich source of phenolic compounds, with differences in composition between free and bound phenolics. Following simulated gastrointestinal digestion, certain phenolic compounds in plum were found to have higher bioaccessibility, which correlated positively with the antioxidant capacity of plum.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Qiaoyu Liu, Jianjun Lin, Wenhong Zhao, Menglin Lei, Juan Yang, Weidong Bai
Summary: Dry-cured mackerel, known for its suitable salty flavor, was studied for the changes in volatile compounds and lipids during the dry-curing process using UPLC-Orbitrap/MS technique. The results revealed a decrease in endogenous lipase activities and significant effects on lipid classes and content during the dry-curing of mackerel. The dry-curing process also resulted in an increase in certain fatty acids and the detection of various volatile compounds derived from fatty acid oxidation. Phosphatidylethanolamine and sphingolipid metabolisms were found to be important pathways in the dry-cured processing.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Aslee Tailulu, Ming Li, Binghao Ye, Redhwan Al-qudaimi, Fangqi Cao, Wenbin Liu, Ping Shi
Summary: In this study, the antimicrobial and anticancer activities of alcoholic extracts of Hainan dry noni fruit were investigated. The results showed that the extracts exhibited inhibitory effects against Staphylococcus aureus and Candida albicans, as well as anti-cancer effects on human bladder cancer cells. Ten compounds were identified in the noni extracts, including five known bioactive compounds and five novel compounds.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Zhengjun Li, Wanjian Gu, Yingzhuo Wang, Bin Qin, Wei Ji, Zhongqiu Wang, Shijia Liu
Summary: This study found that lipid deregulation is a crucial hallmark of ankylosing spondylitis (AS), providing new insights into the early diagnosis of AS.
Article
Biochemical Research Methods
Yi Ma, Bixia Huang, Weiwei Tang, Ping Li, Jun Chen
Summary: The study identified 76 constituents and their metabolites in rat plasma after oral administration of San Miao Wan using the UPLC-Q-Exactive Orbitrap/MS method, with metabolic pathways involving reduction, demethylation, hydroxylation, methylation, and glucuronide conjunction. This approach provides a useful strategy for analyzing traditional Chinese medicine prescriptions and clarifying the effective components in San Miao Wan.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Analytical
Jialing Liu, Jian Sun, Huan Wei, Hong Yu, Xiangdong Dai, Qing Hu
Summary: A new tadalafil analogue, N-cyclohexyl nortadalafil, was discovered in dietary supplements suspected to be contaminated with an erectile dysfunction drug(s) using UPLC-Q-Exactive Orbitrap/MS. The compound showed a similar MS2 spectrum and UV spectrum to tadalafil, with a cyclohexyl group instead of the N-methyl group on the piperazinedione ring.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Yujing Huang, Zhilin Huang, Yuhui Gan, Juntao Xie, Zhiyun Xia, Tao Liu, Xiangyu Chen, Xiangguang Li, Haibo Zhou, Pinghua Sun, Zhe Ren, Yifei Wang, Junxia Zheng
Summary: This study investigates the chemical composition and molecular mechanism of Artemisia argyi, a traditional Chinese herbal medicine, and finds that its main active components, sesquiterpenoids, have potential antiviral and anti-inflammatory properties. The study suggests that Artemisia argyi could be a natural treatment for COVID-19.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Analytical
Li Ji, Wenjun Shi, Yanling Li, Jing He, Guang Xu, Ming Qin, Yuying Guo, Qun Ma
Summary: In this study, the metabolism of hyperoside in rats was comprehensively analyzed using UPLC-Q-Exactive Orbitrap MS technology. A total of 33 metabolites of hyperoside were identified in rat plasma, urine, and feces. The metabolism of hyperoside in vivo was explored, including phase I and phase II reactions. The study provides a basis for further investigation of the biological activities of hyperoside.
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yuhang Jiang, Mengying Chen, Hongchuan Gang, Xuejiao Li, Chuanjia Zhai, Zhiyang Feng, Gan Luo, Xiaoyan Gao
Summary: This study successfully identified comprehensive and representative quality markers for Hugan tablet using a variety of methods. This not only provides a scientific basis for improving and developing the quality standard of Hugan tablet, but also offers a reference method for discovering and identifying quality markers of traditional Chinese medicine preparations.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Nan Xing, Jing Qin, Dongsheng Ren, Qinyun Du, Yuying Li, Jiao Mi, Fengming Zhang, Li Ai, Sanyin Zhang, Yi Zhang, Shaohui Wang
Summary: This study revealed, for the first time, the potential bioactive components and mechanisms of Rhodiola granules (RG) in improving myocardial ischemia/reperfusion (I/R) injury through a comprehensive research strategy. The study identified 15 chemical components in RG as key active compounds, and found that RG may synergistically improve myocardial I/R injury through anti-inflammatory, regulating energy metabolism, and oxidative stress, improving I/R-induced myocardial apoptosis, which may be related to the HIF-1/VEGF/PI3K-Akt signaling pathway. This study provides new insights into the clinical application of RG and also provides a reference for the development and mechanism research of other Tibetan medicine compound preparations.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Rheumatology
Jiawei Lu, Yunke Guo, Yan Lu, Wei Ji, Lili Lin, Wenjuan Qian, Wenjun Chen, Jue Wang, Xiangyu Lv, Mengying Ke, Deshun Kong, Qiuxiang Shen, Youjuan Zhu, Ping Liu, Jinfeng Su, Lu Wang, Yuhua Li, Pan Gao, Jinjun Shan, Shijia Liu
Summary: The study successfully identified serum biomarkers associated with SS patients through the screening and evaluation of biomarkers, indicating that SS metabolic disturbance might be associated with oxidized lipids, fatty acid oxidation, and energy metabolism.
Article
Food Science & Technology
Jinrong Ning, Kanghui Wang, Wanling Yang, Mengshi Liu, Jingyuan Tian, Minyan Wei, Guodong Zheng
Summary: Ultra-high-performance liquid chromatography-Q-Exactive Orbitrap-mass spectrometry and gas chromatography-mass spectrometry were used for the qualitative and quantitative analyses of Citri Sarcodactylis Fructus (CSF) from different origins. The study identified multiple major components in CSF, with 5,7-dimethoxycoumarin and stachydrine being the highest in content and suggested as key components for quality analysis. Additionally, characteristic compounds were found to distinguish different CSF samples.
FOOD SCIENCE & NUTRITION
(2022)
Article
Chemistry, Applied
Liuwei Zhao, Caijun Ren, Xiaofeng Xue, Huanxian Lu, Kai Wang, Liming Wu
Summary: This study characterized monofloral safflower honey (MSH) from a metabolomic perspective and proposed safflomin A as a reliable chemical marker for its authentication. Commercial non-safflower honeys did not test positive for safflomin A, indicating its potential as a fingerprinting chemical marker for safflower honey authentication.
Review
Engineering, Environmental
Sha Yan, Kai Wang, Yahya Al Naggar, Yvan Vander Heyden, Lingling Zhao, Liming Wu, Xiaofeng Xue
Summary: Consumers often believe that natural food is harmless, however naturally occurring toxins in food represent a health risk to humans. Toxic honey, collected by bees from poisonous plants, contains plant toxins such as grayanotoxins and triptolides that can be fatal if consumed. Understanding the toxicity mechanisms of different toxins, preventing toxic honey from entering the food chain, and developing effective antidotes and treatments are critical challenges.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nutrition & Dietetics
Shuting Yin, Yuxiao Tao, Yusuo Jiang, Lifeng Meng, Liuwei Zhao, Xiaofeng Xue, Qiangqiang Li, Liming Wu
Summary: Researchers identified potential allergens in Brassica napus bee pollen and found that fermentation could decrease their allergenicity while increasing the content of oligopeptides and amino acids. Immunoblot analysis confirmed the decrease in IgE-binding affinity after fermentation. Fermentation also promoted the biosynthesis of important amino acids and their precursors or intermediates. These findings suggest that fermentation has the potential to reduce allergenicity and improve the nutritional properties of bee pollen.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Zixuan Li, Liming Wu, Ce Wang, Yue Wang, Ligang He, Zhijing Wang, Xiaofang Ma, Fuxi Bai, Guizhi Feng, Jihong Liu, Yingchun Jiang, Fang Song
Summary: This study provides a comprehensive analysis of the PME gene family in citrus, revealing the biological functions and regulation patterns of CsPME genes during juice sac granulation. These findings are important for further understanding the development and ripening of citrus fruits.
Article
Food Science & Technology
Yuxiao Tao, Shuting Yin, Linglin Fu, Miao Wang, Lifeng Meng, Fukai Li, Xiaofeng Xue, Liming Wu, Qiangqiang Li
Summary: This study identified potential allergens in bee pollen derived from Brassica campestris and investigated the mechanism of enzymatic desensitization. The findings provide a basis for further development of bee pollen.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Qiangqiang Li, Gang Chen, Dan Zhu, Wenwen Zhang, Suzhen Qi, Xiaofeng Xue, Kai Wang, Liming Wu
Summary: A study found that phosphatidylcholine (PC) has better effects in preventing colitis compared to sphingomyelin (SM), inhibiting colonic tissue lesions and pro-inflammatory cytokines expressions. Furthermore, supplementation of PC and SM can impact gut microbiota abundance and metabolism. These findings provide a scientific foundation for further research in developing more effective dietary intervention strategies.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Food Science & Technology
Qianer Jiang, Suvimol Charoensiddhi, Xiaofeng Xue, Biqi Sun, Yang Liu, Hesham R. El-Seedi, Kai Wang
Summary: Tropical fruits are popular for their unique flavors and nutritional value. Polyphenols, the main bioactive compounds in these fruits, have beneficial effects on gastrointestinal health. This article reviews the characteristics, polyphenol types, and effects on gut health of several representative tropical fruits, and discusses the protective mechanism of polyphenols.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Mostafa H. Baky, Mostafa B. Abouelela, Kai Wang, Mohamed A. Farag
Summary: Functional foods have gained a lot of attention in dietetics due to their nutritional value and health benefits. Consumers' increasing demands for these valuable foods require advancements in production and quality assessment tools. Bee products, such as pollen and honey, are considered important food supplements rich in various nutrients and phytonutrients.
Review
Chemistry, Multidisciplinary
Mohamed A. Farag, Abiodun O. Ajayi, Mohammed Taleb, Kai Wang, Iriny M. Ayoub
Summary: Eurycoma longifolia Jack, commonly known as Tongkat Ali, is a popular traditional herbal medicine native to southeast Asia with aphrodisiac and various other health effects. It is used for sexual dysfunction, aging, anxiety, exercise recovery, increased energy, and osteoporosis. The bioactive compounds in E. longifolia, particularly quassinoids, play a major role in its health effects. This review focuses on the production of bioactives from E. longifolia using biotechnology and extraction optimization, as well as the development of green extraction methods. Analytical approaches for quality control assessment and pharmacokinetics of E. longifolia are also discussed.
Article
Environmental Sciences
Yahya Al Naggar, Christie M. Sayes, Clancy Collom, Taiwo Ayorinde, Suzhen Qi, Hesham R. El-Seedi, Robert J. Paxton, Kai Wang
Summary: In a recent study, the potential toxicity of irregularly shaped polystyrene microplastic fragments on honey bee health was investigated. The findings revealed that chronic exposure to these fragments had no effect on honey bee survival, but did decrease feeding rate and body weight, especially at a concentration of 10μg/mL, which could have long-term consequences for honey bee health. This study's findings could be beneficial for assessing the risk of microplastics on pollinator health.
Article
Chemistry, Applied
Enning Zhou, Xiaofeng Xue, Haoxie Xu, Liuwei Zhao, Liming Wu, Qiangqiang Li
Summary: Studies have found that profilin family members are potential pan-allergens in foods, posing public health hazards. However, research on modifying the allergenicity of profilin allergens is limited. In this study, quercetin and its glycosides were used to modify the allergenicity of a profilin allergen from Brassica campestris bee pollen. The results showed that only quercetin could covalently bind to the allergen, resulting in structural changes that reduced its allergenicity.
Article
Chemistry, Applied
Tong Zhao, Liuwei Zhao, Miao Wang, Suzhen Qi, Xiaofeng Xue, Liming Wu, Qiangqiang Li
Summary: This study identified calycosin and formononetin as reliable chemical markers for MH-Am authentication, and determined their contents in MH-Am, other honeys and P-Am through a targeted quantitative analysis. Free radical scavenging assays showed that calycosin directly contributed to the antioxidative activity of MH-Am.
Article
Chemistry, Applied
Enning Zhou, Weiwei Wang, Xiaofeng Xue, Pianpian Wang, Fan Wu, Liming Wu, Qiangqiang Li
Summary: Protein oxidation with hydrogen peroxide can reduce the allergenicity of bee pollen-derived pan-allergen, Bra c p. This oxidation leads to aggregation and sulfonation of the protein, as well as a transformation of its secondary structure. The oxidized Bra c p shows decreased binding affinity to IgE, indicating reduced allergenicity. This study presents a novel approach to reduce the allergenicity of profilin family members in foods.
Article
Chemistry, Applied
Hazel Corrigan, Aoife Dunne, Niamh Purcell, Yuyang Guo, Kai Wang, Hongzhuan Xuan, Daniel Granato
Summary: Designing functional foods as delivery systems is a customized strategy to reduce noncommunicable diseases risk. The study optimized a combination of t-resveratrol (RES), chlorogenic acid (CHA), and quercetin (QUE) and developed a functional tea formulation enriched with the optimal polyphenol combination (OPM). Experimental results showed that the antioxidant capacity of these compounds varied depending on the assays and compounds. Adding OPM (100 mg/L) to chamomile tea showed increased antioxidant activity and protection against oxidation.
