Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Rischka, Chrysoula Vraka, Verena Pichler, Sazan Rasul, Lukas Nics, Gregor Gryglewski, Patricia Handschuh, Matej Murgas, Godber M. Godbersen, Leo R. Silberbauer, Jakob Unterholzner, Christoph Wotawa, Ahmed Haider, Hazem Ahmed, Roger Schibli, Thomas Mindt, Markus Mitterhauser, Wolfgang Wadsak, Andreas Hahn, Rupert Lanzenberger, Marcus Hacker, Simon M. Ametamey
Summary: This study reports on the performance characteristics of (R)-C-11-Me-NB1, a radioligand used to map GluN2B-enriched NMDARs in the human brain. The radioligand demonstrated high and heterogeneous uptake and a high test-retest reliability. It shows promise in deepening our understanding of the role of GluN2B-containing NMDARs in neurodegenerative and neuropsychiatric diseases such Alzheimer's disease and major depression.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
Summary: The study highlights the role of the glutamate/NMDAR axis in obesity-related metabolic syndrome, with evidence showing that targeting NMDAR can be a promising therapeutic strategy. In obese mice, increased glutamate levels and blockade of NMDAR by Memantine improved insulin sensitivity and reduced hepatic steatosis, while NMDA treatment induced obesity and metabolic disorders. In vitro studies demonstrated that NMDAR activation promoted lipid accumulation and impaired fatty acid oxidation through PPARa signaling, suggesting a potential mechanism for NMDAR-mediated metabolic syndrome in obesity.
Review
Neurosciences
Nirav Yogesh Bhatia, Hemen Sanjay Ved, Pravin Popatrao Kale, Gaurav Mahesh Doshi
Summary: This review article discusses novel approaches for the treatment of depression, including modulation of the glutamatergic and serotonergic systems. The dysfunction of glutamatergic neurotransmission greatly affects the pathogenesis of depression. The development of new and fast-acting antidepressant drugs is important for better treatment options.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Maria S. Hadjiagapiou, George Krashias, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides
Summary: Synaptic dysfunction and disrupted communication between neuronal and glial cells are essential in the mechanisms of multiple sclerosis. Antibodies to the NR2 subunit of NMDAR were detected in MS patients and were correlated with clinical outcome. Furthermore, there may be a link between NR2 reactivity and anti-coagulant antibody levels in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Jilun Feng, Mu Yang, Dingge Cui, Zhi Huang, Tuo Ji, Yajun Lian
Summary: This study aimed to investigate the factors influencing or predicting the probability of recurrence of anti-NMDAR encephalitis in central China. The results showed that brainstem lesions and ≥3 abnormal sites on brain MRI were significantly associated with an increased risk of recurrence.
FRONTIERS IN NEUROLOGY
(2022)
Article
Chemistry, Medicinal
Zhongtang Li, Guanxing Cai, Fan Fang, Wenchao Li, Minghua Fan, Jingjing Lian, Yinli Qiu, Xiangqing Xu, Xuehui Lv, Yiyan Li, Ruqiu Zheng, Yuxi Wang, Zhongjun Li, Guisen Zhang, Zhenming Liu, Zhuo Huang, Liangren Zhang
Summary: A series of furan-2-carboxamide analogues were identified as novel NMDAR-positive allosteric modulators, with FS2921 showing potential antidepressant effects. Compound 32h exhibited increased NMDAR excitability in vitro and significant antidepressant activity, with a favorable PK/PD profile. This study presents a new potential opportunity for discovering new antidepressants through novel NMDAR PAMs.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Andrea de Bartolomeis, Licia Vellucci, Mark C. Austin, Giuseppe De Simone, Annarita Barone
Summary: Schizophrenia is a neurodevelopmental disorder characterized by synaptic alterations and abnormal cortical-subcortical connections. Current treatment options mainly focus on dopamine D2 receptor occupancy, while glutamatergic abnormalities remain untargeted. In recent years, D-amino acids acting as NMDAR modulators have emerged as potential augmentation strategies for treatment-resistant schizophrenia (TRS), which affects around 30-40% of patients and is characterized by cognitive deficits and functional impairment. This systematic review explores the efficacy of D-amino acids and their impact on synaptic architecture, as well as compounds targeting D-amino acid oxidase and D-aspartate oxidase enzymes.
Review
Neurosciences
Taylor M. Benske, Ting-Wei Mu, Ya-Juan Wang
Summary: NMDARs are crucial for synaptic development and plasticity in the mammalian CNS. Proper folding and assembly of the receptors, as well as their trafficking to the plasma membrane, are ensured by protein quality control mechanisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Chemistry, Medicinal
Amir Parsa Abhari, Masoud Etemadifar, Niloufar Yazdanpanah, Nima Rezaei
Summary: N-methyl-D-aspartate receptors (NMDARs) play a crucial role in regulating physiological processes in the brain and nervous system. Dysfunction of NMDARs can contribute to various pathologies, including cell death and brain dysfunction. Research has shown the significant involvement of NMDARs in demyelinating disorders and anti-NMDAR encephalitis.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Behavioral Sciences
Cristina Maria de Arruda, Diego Luiz Doneda, Vinicius Vezzi de Oliveira, Rozielly Aparecida Lemes da Silva, Yohan Alves Victor de Matos, Isadora Luiza Fernandes, Christopher Alecsander Herane Rohden, Giordano Gubert Viola, Fabricio Rios-Santos, Eliangela de Lima, Ziliani da Silva Buss, Samuel Vandresen-Filho
Summary: This study found that vilazodone has antidepressant-like effects, which may be mediated through an interaction with the kynurenine pathway and N-methyl-D-aspartate receptors.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Pharmacology & Pharmacy
Naoki Kotani, Il-Sung Jang, Michiko Nakamura, Kiku Nonaka, Hideaki Nagami, Norio Akaike
Summary: In this study, we investigated how Xe and N2O modulate NMDA receptor-mediated spontaneous and evoked excitatory post-synaptic currents (sEPSC(NMDA) and eEPSC(NMDA)) in a synapse bouton preparation of rat hippocampal CA3 neurons. We found that Xe and N2O significantly decreased the frequency and amplitude of sEPSC(NMDA) without altering its decay time constant, and also decreased the amplitude but increased the Rf and PPR of eEPSC(NMDA) without altering its decay time constant. These results suggest that the inhibitory effects of Xe and N2O on synapse activity are primarily due to presynaptic mechanisms.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Biology
Eui-Ho Park, Nam-Soo Kim, Yeon-Kyung Lee, June-Seek Choi
Summary: Accumulating evidence suggests that the medial prefrontal cortex (mPFC) plays a crucial role in the acquisition of fear memory during trace fear conditioning. Specifically, the prelimbic (PL) subregion within the mPFC is involved in short- and long-term trace fear memory formation. Furthermore, NMDA receptor-mediated neurotransmission in PL is required for the acquisition of trace fear memory.
Article
Biochemistry & Molecular Biology
Shinhui Lee, Sanung Eom, Khoa V. A. Nguyen, Jiwon Lee, Youngseo Park, Hye Duck Yeom, Junho H. Lee
Summary: The study found that ergotamine effectively inhibits the NR1a/NR2A subunit of NMDAR, preventing excessive Ca2+ influx and neuronal death.
Article
Andrology
Hamid Reza Momeni, Tahereh Etemadi, Atieh Alyasin, Najmeh Eskandari
Summary: This study demonstrated the function of N-methyl-D-aspartate (NMDA) glutamate receptors in the acrosome reaction of mouse spermatozoa. The results indicated that the NMDA receptor agonist LG could promote the acrosome reaction and increase intracellular calcium levels in spermatozoa, while the antagonist MK-801 could reverse this effect.
Article
Psychiatry
Ole Kohler-Forsberg, Louisa G. Sylvia, Michael Thase, Joseph R. Calabrese, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, Dan Iosifescu, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Vicki Fung, Michael J. Ostacher, Andrew A. Nierenberg
Summary: This study found that patients with bipolar disorder who used lithium in combination with antipsychotics or anticonvulsants showed worse response compared to those who only used lithium. However, compared to lithium and anticonvulsants, the combined use of lithium and antipsychotics showed slight improvement in general and manic symptoms, but worse development in glucose, triglycerides, and metabolic syndrome.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Environmental Sciences
Mariana Tortorelli, Telma Ramos Trigo, Renata Bolibio, Camila Colas Sabino de Freitas, Floracy Gomes Ribeiro, Mara Cristina Souza de Lucia, Dan Iosifescu, Renerio Fraguas
Summary: This study investigated the association between burnout and life events outside the workplace in nursing assistants. The results showed that an increase in the number of personal changes or difficulties was associated with increased severity of emotional exhaustion, while an increase in the number of changes in familial situation and death of relatives or friends was associated with increased severity of depersonalization.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychiatry
Judy Alper, Rui Feng, Gaurav Verma, Sarah Rutter, Kuang-han Huang, Long Xie, Paul Yushkevich, Yael Jacob, Stephanie Brown, Marin Kautz, Molly Schneider, Hung-Mo Lin, Lazar Fleysher, Bradley N. Delman, Patrick R. Hof, James W. Murrough, Priti Balchandani
Summary: This study aimed to assess volumetric differences in hippocampal subfields between patients with major depressive disorder (MDD), treatment-resistant depression (TRD) and healthy controls (HC) using high-resolution MRI data. The results showed that MDD and TRD patients had reduced volume in the right-hemisphere CA2/3 subfield compared to HC. Negative correlations between subfield volumes and life-stressor checklist scores were also found. This study provides valuable insights into the pathophysiology of depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Sara Costi, Audrey Evers, Manish K. Jha, Matthew Klein, Jessica R. Overbey, Ki A. Goosens, JoColl Burgess, Kelvin Alvarez, Adriana Feder, Dennis S. Charney, James W. Murrough
Summary: Stress exposure is a key risk factor for the development of major depressive disorder and posttraumatic stress disorder. Enhancing stress resilience in at-risk populations could potentially protect against stress-induced disorders. The administration of ketamine one week prior to an acute stressor prevents the development of stress-induced depressive-like behavior in rodents. This study aimed to test if the prophylactic effect of ketamine against stress also applies to humans.
NEUROBIOLOGY OF STRESS
(2023)
Review
Psychology, Clinical
Elizabeth C. Stade, Ayelet Meron Ruscio
Summary: Clinical scientists discuss whether worry and rumination are distinct or represent a unitary construct. A series of meta-analyses were conducted to evaluate their relationship. The analyses showed that worry is closely related but nonredundant to different forms of rumination. Researchers should carefully select and study these constructs together.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Review
Clinical Neurology
Zamfira Parincu, Dan V. Iosifescu
Summary: Major depressive disorder is a leading cause of disability globally. Current pharmacotherapies targeting monoamine receptors are often ineffective and slow-acting, highlighting a need for more rapid and effective treatments. Studies have shown that combining dextromethorphan with quinidine or bupropion can effectively reduce depressive symptoms in MDD, but results are mixed for TRD and bipolar depression, warranting further research.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Letter
Psychiatry
Matthew J. Hoptman, Umit Tural, Molly S. Arnold, Katherine A. Collins, Kathryn T. Evans, Molly K. Irvin, Zamfira Parincu, Danielle N. Rette, Allison M. Sparpana, Elizabeth F. Sullivan, Dan V. Iosifescu
SCHIZOPHRENIA RESEARCH
(2023)
Review
Biology
Umit Tural, Allison Sparpana, Elizabeth Sullivan, Dan V. Iosifescu
Summary: This study conducted a network meta-analysis to investigate the differences in adiponectin levels across eating disorders, obesity, constitutional thinness, and healthy controls. The results showed that participants with anorexia nervosa had significantly higher adiponectin levels, while obesity and binge-eating disorder were associated with significantly lower levels. These findings suggest that adiponectin may be an important marker of metabolic imbalance.
Article
Psychology, Clinical
Elizabeth C. Stade, Lyle Ungar, Shreya Havaldar, Ayelet Meron Ruscio
Summary: Perseverative thinking (PT) is a cross-diagnostic process related to the onset and maintenance of emotional disorders. Existing measures of PT have limitations, leading to the development of a language-based behavioral measure of PT. This measure showed associations between PT and language features, and had predictive power for depression, anxiety, psychiatric comorbidity, and treatment seeking.
BEHAVIOUR RESEARCH AND THERAPY
(2023)
Article
Psychiatry
Willians Fernando Vieira, Dan Iosifescu, Kayla Marie McEachern, Maia Gersten, Paolo Cassano
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2023)
Article
Neurosciences
Katherine R. Meckel, Sierra S. Simpson, Arthur Godino, Emily G. Peck, Jonathon P. Sens, Michael Z. Leonard, Olivier George, Erin S. Calipari, Rebecca S. Hofford, Drew D. Kiraly
Summary: Cocaine use disorder is a public health crisis and there are currently no FDA-approved medications for its treatment. Research has shown the important role of the gut microbiome and its metabolites in modulating drug-seeking behaviors, but their impact on relapse after prolonged abstinence is unknown. This study reveals that depletion of the gut microbiome enhances cocaine-seeking behavior, while restoration of bacterially-derived metabolites reverses this effect, suggesting the potential of the microbiome as a target for translational research.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Dan V. Iosifescu, Xiaotong Song, Maia B. Gersten, Arwa Adib, Yoonju Cho, Katherine M. Collins, Kathy F. Yates, Aura M. Hurtado-Puerto, Kayla M. McEachern, Ricardo S. Osorio, Paolo Cassano
Summary: This study aims to investigate the impact, safety, and mechanisms of transcranial photobiomodulation (t-PBM) on cognition in patients with amnestic mild cognitive impairment (aMCI) and early Alzheimer's disease (AD). The participants will receive 24 sessions of t-PBM treatment over 8 weeks, and the study will explore whether baseline tau burden and changes in mitochondrial function moderate the cognitive changes observed after t-PBM therapy. Additionally, changes in the fMRI blood-oxygenation-level-dependent (BOLD) signal after a single treatment will be examined to demonstrate t-PBM-dependent increases in prefrontal cortex blood flow.
Article
Psychology, Clinical
Elizabeth C. Stade, Lyle Ungar, Johannes C. Eichstaedt, Garrick Sherman, Ayelet Meron Ruscio
Summary: Depression is associated with increased use of first-person pronouns and negative emotion words. However, previous studies have not differentiated between depression and anxiety. This study interviewed individuals with varying levels of depression and anxiety and found that certain language features are specific to depression, while others are specific to anxiety.
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
(2023)
Article
Psychiatry
Russell H. Tobe, Lucia Tu, John R. Keefe, Melissa M. Breland, Benjamin A. Ely, Melissa Sital, Jasmin T. Richard, Umit Tural, Dan V. Iosifescu, Vilma Gabbay
Summary: This study aims to examine the factors influencing the expression of anhedonia. By evaluating physical, developmental, and clinical measures, the study found a correlation between personality traits and anhedonia, while diagnostic and symptom measures were not significant predictors of anhedonia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Dan V. Iosifescu, Richard J. Norton, Umit Tural, David Mischoulon, Katherine Collins, Erin McDonald, Luis De Taboada, Simmie Foster, Cristina Cusin, Albert Yeung, Alisabet Clain, David Schoenfeld, Michael R. Hamblin, Paolo Cassano
Summary: This double-blind, sham-controlled study tested the efficacy of low-dose transcranial photobiomodulation (t-PBM) in individuals with major depressive disorder (MDD). The results showed that low-dose t-PBM did not significantly reduce depression severity. This study provides evidence for determining the optimal dosage of t-PBM for MDD treatment.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)