Article
Psychiatry
Mohamed A. Khalil, Noha M. Khalil, Amanne F. Esmael, Shirin M. El-Makawi, Alia A. Saleh, Doaa R. Ayoub
Summary: The study found that patients with long-term tramadol use had lower retinal thickness compared to healthy non-tramadol users. Retinal nerve fiber layer thickness was not associated with tramadol dosage, duration of use, or age of first use. Differences were observed in retinal nerve fiber layer and ganglion cell complex thickness between the right and left eyes.
MIDDLE EAST CURRENT PSYCHIATRY-MECPSYCH
(2023)
Article
Medicine, General & Internal
Murgova Snezhana, Balchev Georgi
Summary: This study evaluated the changes in RNFL, GCL thickness, and rim and disk areas in myopic eyes before and after OCT examination with refractive correction using contact lenses or glasses. The results showed significant changes in these parameters after correction with glasses or contact lenses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Rino Vicini, Dominik Brugger, Mathias Abegg, Anke Salmen, Hilary Michelle Grabe
Summary: MOG-ON is associated with more severe acute vision loss and pronounced thinning of the pRNFL compared to MS-ON. Both entities result in similar final visual acuity and atrophy of the macular ganglion cell layer.
JOURNAL OF NEUROLOGY
(2021)
Article
Chemistry, Analytical
Rafael Berenguer-Vidal, Rafael Verdu-Monedero, Juan Morales-Sanchez, Inmaculada Selles-Navarro, Oleksandr Kovalyk, Jose-Luis Sancho-Gomez
Summary: The study aimed to analyze the relevance of asymmetry features between both eyes of the same patient for glaucoma screening using optical coherence tomography. Machine learning models were designed and optimized based on retinal nerve fiber layer asymmetry, providing good classification of patients for the early diagnosis of glaucoma. The models offer a good trade-off in classification of patients and simplicity for glaucoma screening in daily clinical practice.
Article
Endocrinology & Metabolism
Fiorenza Ulgiati, Sophie Lhoir, Irina Balikova, Sylvie Tenoutasse, Emese Boros, Catheline Vilain, Claudine Heinrichs, Cecile Brachet
Summary: This study is the first to document retinal layer thicknesses in patients with Triple A syndrome, finding that nearly all retinal thickness and peripapillary RNFL measurements were significantly lower than the reference range, particularly showing more marked thinning at the temporal part of the optic nerve. OCT, as a non-invasive tool, shows promise in assessing the severity of neurodegeneration in Triple A syndrome patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Dejan Jakimovski, Robert Zivadinov, Caila B. Vaughn, Osman Ozel, Bianca Weinstock-Guttman
Summary: This study found that the peripapillary retinal nerve fiber layer in multiple sclerosis patients significantly thinned over a 5-year follow-up period, with the thinning influenced by disease subtype, age, disability progression, history of MS optic neuritis, and treatment regimen.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Nuria Cerda-Fuertes, Marc Stoessel, Gintaras Mickeliunas, Silvan Pless, Alessandro Cagol, Muhamed Barakovic, Aleksandra Maleska Maceski, Cesar alvarez Gonzalez, Marcus D' Souza, Sabine Schaedlin, Pascal Benkert, Pasquale Calabrese, Konstantin Gugleta, Tobias Derfuss, Till Sprenger, Cristina Granziera, Yvonne Naegelin, Ludwig Kappos, Jens Kuhle, Athina Papadopoulou
Summary: This study examined the relative role of optical coherence tomography (OCT) in multiple sclerosis (MS) and compared it with magnetic resonance imaging (MRI) and serum markers of disability. The results showed that OCT measures were associated with cognitive and physical disability, independent of serum and brain MRI markers of neuroaxonal loss.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Psychiatry
Batuhan Ayik, Hatice Kaya, Rumeysa Tasdelen, Neslihan Sevimli
Summary: This study investigated retinal changes in patients with bipolar disorder and their healthy siblings using optical coherence tomography (OCT), and explored these findings as potential endophenotype candidates. The results showed that GCL+IPL thicknesses were significantly correlated with functionality of patients and severity of the disorder.
PSYCHIATRY RESEARCH
(2022)
Review
Psychiatry
Paroma Mitra, Ankit Jain, Katherine Kim
Summary: The purpose of this review is to explore the mood, anxiety, and cognitive changes in older HIV patients, as well as the challenges in their treatment. Recent findings suggest that untreated HIV illness may worsen preexisting neuropsychiatric disorders and cause new behavioral and cognitive symptoms. It is important to screen for potential HIV infections in older adults and to consider HIV as a possible cause for new-onset mood and cognitive changes. Neurobehavioral symptoms should be carefully screened and treated in patients with HIV infection.
CURRENT PSYCHIATRY REPORTS
(2022)
Article
Ophthalmology
K. Vonor, R. A. Kuaovi Koko, K. Dzidzinyo, M. A. K. Santos, K. D. Ayena, M. Banta, K. P. Balo
Summary: This study aimed to determine the features of the macular ganglion cell complex and its correlations in normal black subjects. The results showed a strong correlation between the thickness of the superior and inferior macular GCC, while showing weaker correlations with age, gender, optic nerve head surface area, and RNFL thickness.
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2022)
Article
Ophthalmology
Mousumi Banerjee, Swati Phuljhele, Gunjan Saluja, Pawan Kumar, Rohit Saxena, Pradeep Sharma, Deepti Vibha, Awadh Kishor Pandit
Summary: The study investigates the correlation between functional parameters and OCT features in patients with idiopathic intracranial hypertension. The results suggest that different parameters have correlations, with GCL-IPL serving as a valuable tool for evaluating the integrity of the optic nerve.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Clinical Neurology
Amy S. Garrett, Kiki D. Chang, Manpreet K. Singh, Casey C. Armstrong, Patricia D. Walshaw, David J. Miklowitz
Summary: This study used fMRI to investigate the impact of FFT-HR treatment on emotion processing networks in youth at high risk for bipolar disorder. The results showed increased activation in the dorsolateral prefrontal cortex in the FFT-HR group post-treatment, while activation decreased in the EC group. Additionally, decreasing activation in the hippocampus and amygdala was correlated with improvement in hypomania, while increasing activation in the DLPFC was correlated with improvement in depression.
Review
Biochemistry & Molecular Biology
Paloma T. Birmann, Angela M. Casaril, Laura Abenante, Filipe Penteado, Cesar A. Bruning, Lucielli Savegnago, Eder J. Lenardao
Summary: This review summarizes recent preclinical studies on organoselenium compounds as therapeutic agents for the treatment of mental and neurodegenerative diseases. Diaryl diselenides, Ebselen-derivatives, and Se-containing heterocycles are identified as the most representative organoselenium molecules. The review aims to provide disease-oriented information that can be useful for the development of novel bioactive molecules with potential clinical viability.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Lais Murta, Daniela Seixas, Luana Harada, Rodolfo Furlan Damiano, Marcus Zanetti
Summary: Recent studies have shown positive effects of Intermittent Fasting (IF) on metabolic parameters, cognition, and mood. However, the effect of IF on depressive symptoms is still unclear. This review assessed the available evidence on IF interventions for depression in both clinical and preclinical studies. Studies on rodents suggest that IF acts as a circadian regulator, improving neurotransmitter availability and increasing neurotrophic factors in the brain. However, studies on humans mainly evaluated healthy volunteers and showed heterogeneity in both the IF regimens studied and the effects on mood. Better designed studies and controlled evaluations are needed to assess the efficiency of IF in treating major depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Darryl Nousome, Roberta Mckean-Cowdin, Grace M. Richter, Bruce Burkemper, Mina Torres, Rohit Varma, Xuejuan Jiang
Summary: This study compared peripapillary retinal nerve fiber layer (RNFL) thickness among healthy adults by race and ethnicity, and identified determinants of RNFL thickness. Significant differences in RNFL thickness were found among different racial and ethnic groups of healthy adults 50 years of age or older, with Black Americans showing the lowest RNFL thickness. Age and race were the main factors influencing RNFL thickness.
Article
Psychiatry
Elina J. Reponen, Ingrid Dieset, Martin Tesli, Ragni H. Morch, Monica Aas, Trude S. J. Vedal, Elisabeth Haug, Ole Kristian Drange, Nils Eiel Steen, Sigrun Hope, Attila Szabo, Sherif M. Gohar, Kirsten Wedervang-Resell, Srdjan Djurovic, Ingrid Melle, Pal Aukrust, Ole A. Andreassen, Thor Ueland
FRONTIERS IN PSYCHIATRY
(2020)
Article
Clinical Neurology
Mohamed Nasreldin, Sherif M. Gohar, Mai Abdel Samie, Nagwan Madbouly
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2020)
Article
Clinical Neurology
Mohamed A. Khalil, Hend Ibrahim Shousha, Saeed M. El-Nahaas, Mohamed Ibrahim Negm, Kariman Kamal, Nagwan Mohamed Madbouly
Summary: This study aimed to evaluate the incidence and potential risk factors of depression and psychological distress following DAAs therapy in CHC euthymic Egyptian patients with no previous or current diagnosis of any psychiatric disorders. The results showed that about one third of patients had moderate to severe depression following treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Ophthalmology
Ibrahim Rezkallah Moussa, Rehab Rashad Kassem, Noha Ahmed Edris, Dalia Hamed Khalil
Summary: The mean intraocular pressure in a group of normal Egyptian children was 11.5 +/- 2.34mm Hg, with positive correlation to age and central corneal thickness. This mean intraocular pressure was lower than that previously reported in any other population.
Article
Psychiatry
Ola Shahin, Sherif M. Gohar, Walaa Ibrahim, Shirin M. El-Makawi, Walaa Fakher, Dina Badie Taher, Mai Abdel Samie, Mohamed A. Khalil, Alia A. Saleh
Summary: This study found that Electroconvulsive Therapy (ECT) has a significant impact on plasma BDNF levels in patients with resistant schizophrenia, increasing BDNF levels and improving symptoms. Patients in both groups showed significant improvement in PANSS subscales after ECT treatment.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2022)
Article
Clinical Neurology
Doaa R. Ayoub, Sherif M. Gohar, Mohamed A. Khalil, Hoda M. Abdel-Hamid, Shirin Mostafa El-Makawi
Summary: Stigma and uncertainty are observed among healthcare providers during global pandemics. A study found that frontline physicians who treated patients with COVID-19 experienced higher levels of stigma and lower resilient coping strategies compared to physicians who did not treat patients with COVID-19.
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2022)
Article
Psychiatry
Nancy Elgizy, Aref Khoweiled, Mohamed A. Khalil, Rehab Magdy, Dalia Khalifa
Summary: This study examined the prevalence of comorbid migraine in patients with bipolar disorder and schizophrenia, and found that patients with schizophrenia had a higher frequency and intensity of migraine attacks compared to those with bipolar disorder.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
(2023)
Article
Psychiatry
Sherif M. Gohar, Wenche ten Velden Hegelstad, Bjorn Auestad, Ulrik Helt Haahr, Inge Joa, Jan Olav Johannessen, Tor Ketil Larsen, Stein Opjordsmoen, Bjorn Rishovd Rund, Jan Ivar Rossberg, Erik Simonsen, Svein Friis, Ingrid Melle
Summary: This study examined the trajectories and predictors of suicidality in first-episode psychosis over a 2-year follow-up. Four distinct trajectories were identified, including stable non-suicidal, stable suicidal ideation, decreasing suicidal thoughts and behaviors, and worsening suicidal thoughts and behaviors. The findings highlight the need for early and targeted interventions for individuals at risk of persistent or worsening suicidality.
Article
Psychiatry
Mohamed A. Khalil, Noha M. Khalil, Amanne F. Esmael, Shirin M. El-Makawi, Alia A. Saleh, Doaa R. Ayoub
Summary: The study found that patients with long-term tramadol use had lower retinal thickness compared to healthy non-tramadol users. Retinal nerve fiber layer thickness was not associated with tramadol dosage, duration of use, or age of first use. Differences were observed in retinal nerve fiber layer and ganglion cell complex thickness between the right and left eyes.
MIDDLE EAST CURRENT PSYCHIATRY-MECPSYCH
(2023)
Article
Psychiatry
Mohammed Ezzat, Mohammed Atef Younis, Mohammed A. Khalil, Maged E. Gomaa, Dina Yosri Afifi, Doaa R. Ayoub
Summary: This study found that OCD is commonly comorbid in youth with bipolar I disorder, and it may be associated with a higher risk of suicide. Additionally, this comorbidity may be linked to a younger age of onset and more severe symptoms.
MIDDLE EAST CURRENT PSYCHIATRY-MECPSYCH
(2023)
Article
Substance Abuse
Noha Shamseldin, Abdelrahman A. Asal, Dalia A. Enaba, Mohamed A. Khalil, Somaya H. Shaheen
Summary: This study found that female patients with tramadol dependence are more likely to experience emotional dysregulation and deliberate self-harm compared to male patients. Additionally, there was a significant positive correlation between overall emotional dysregulation and overall DSH in both groups of patients.
ADDICTIVE DISORDERS & THEIR TREATMENT
(2021)
Article
Substance Abuse
Hanan El-Shinnawy, Radwa H. Sayed, Mohamed A. Khalil, Doaa R. Ayoub
Summary: Research shows that patients with substance dependence and mental disorders have higher levels of impairment and disability in addiction severity index and self-esteem. They are more likely to have psychopathologic factors, such as childhood abuse. However, there was no significant difference in the presence of comorbid personality disorders or a history of stressful life events.
ADDICTIVE DISORDERS & THEIR TREATMENT
(2021)
Article
Clinical Neurology
Arif Musa, Jahanzeb Ashraf, Feng-Jen Tsai, Samir Abolmagd, Ciny Liu, Hajra Hussain, Eva Voslarova, Mohamed A. Khalil, Kate B. Wolitzky-Taylor, Danny Lee, Jeffrey Sugar, Kasim Pendi, Joshua Lee, Reham Abdelmaksoud, Noha Adel, David Baron
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2020)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)