Review
Biology
Mateusz Rybka, Lukasz Mazurek, Marek Konop
Summary: Impaired wound healing is a global problem affecting millions of people, leading to chronic wounds that are susceptible to infections. A shift in the antibacterial treatment paradigm is necessary due to the rising bacterial resistance against antibiotics. Silver nanoparticles have emerged as a promising candidate for the treatment of chronic wounds, with their antimicrobial, anti-inflammatory, and anti-oxidative properties. This review article focuses on experimental and clinical studies on dressings containing silver or silver nanoparticles, highlighting their potential in wound healing.
Article
Dermatology
Indri Lakhsmi Putri, Lavonia Berlina Adzalika, Rachmaniar Pramanasari, Citrawati Dyah Kencono Wungu
Summary: This study reviewed the risks and benefits of negative pressure wound therapy (NPWT) in cancer surgical wounds. The results showed that NPWT can significantly reduce the risk of surgical site infection and seroma, and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Saiqing Tang, Zhen Ruan, Axue Ma, Dong Wang, Jiushe Kou
Summary: Vitamin K has a positive impact on wound healing, but its effects differ in animal models and cell experiments. Larger scale studies are needed to determine the mechanisms and safe dosage of vitamin K for wound healing.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Polymer Science
Benu George, Nitish Bhatia, T. V. Suchithra
Summary: The skin is the largest and essential organ in our body, acting as a defensive layer; proper burn wound management considers patient compliance and provides an environment to accelerate wound closure; research shows that hydrogels in the polymer field play a significant role in treating burn wounds.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Dermatology
Tian Yuan, Li Meijia, Chen Xinyao, Chen Xinyue, Hao Lijun
Summary: Exosomes derived from human adipose-derived stem cells (ADSCs) have shown excellent capability in improving wound healing quality, but their efficacy in clinical applications is still uncertain. This study conducted a systematic review of preclinical studies comparing exosomes from human ADSCs with placebo in animal models of wound closure. The results showed that administration of exosomes derived from human ADSCs significantly improved wound closure compared to controls, with the same effect as ADSCs. The therapeutic effect was further enhanced by modified ADSC-EV. This suggests that exosomes derived from human ADSCs, especially after enrichment for specific non-coding RNA, have promising potential to improve healing efficiency.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Na Zheng, Wenjing He, Siquan Zhu
Summary: This study analyzed reliable research to uncover the occurrence rate of wound dehiscence following keratoplasty. The overall incidence was estimated to be 1.9%, with higher rates observed in developed countries compared to developing countries. Deep anterior lamellar keratoplasty showed a lower incidence of wound dehiscence compared to penetrating keratoplasty. Within the first year post-keratoplasty, approximately 31.4% of patients experienced wound dehiscence and 43.1% exhibited a decline in best-corrected visual acuity.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Xiao-Yan Wang, Xiu-Qin Wang, Zhong-Hua Tian, Wei Li, Ning He, Gui-Qin Zhang
Summary: This meta-analysis found that the application of humanised care during the perioperative period of caesarean section can reduce the incidence of postoperative wound infections and complications, as well as alleviate maternal anxiety and depression. Therefore, the findings of this study are worthy of clinical promotion and application.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Fanni Adel Meznerics, Peter Fehervari, Fanni Dembrovszky, Kata Dorottya Kovacs, Lajos Vince Kemeny, Derso Csupor, Peter Hegyi, Andras Banvolgyi
Summary: Platelet-rich plasma (PRP) is a safe and effective modality to enhance wound healing in chronic wounds, increasing the odds of complete closure and decreasing the burden on healthcare.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Tuan-Ngan Tang, Thu Hai-Anh Nguyen, Chien Minh Tran, Vinh Khanh Doan, Ngoc Thi-Thanh Nguyen, Binh Thanh Vu, Nhi Ngoc-Thao Dang, Thanh Tu Duong, Viet Hung Pham, Lam Dai Tran, Toi Van Vo, Thi-Hiep Nguyen
Summary: This study successfully fabricated a multilayer wound dressing combining silver nanoparticles and chitosan oligosaccharides. Characterisation tests demonstrated its suitable characteristics, including proper tensile strength, fluid-absorbable inner surface, waterproof outer layer, and controlled release. In vitro experiments showed its haemostatic and antibacterial effects, while in vivo experiments confirmed its positive effects on wound healing.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2023)
Article
Dermatology
Ping Li, Junhong Li
Summary: This meta-analysis found that Negative Pressure Wound Therapy (NPWT) was superior to conventional therapy in treating superficial wound infection and wound dehiscence, but showed no statistical difference in deep wound infection and wound exudate. Caution should be exercised when interpreting the results due to small sample sizes, and further high-quality research with larger sample sizes is needed to confirm these findings.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Environmental Sciences
Chloe Way, Malcolm D. Hudson, Ian D. Williams, G. John Langley
Summary: Research on microplastics in the environment is of high interest globally, with a focus on the accuracy and reliability of isolation methods. Recovery studies involve spiking test media with plastics to validate new methods. A meta-analysis of 71 recovery rate studies found variation in recovery rates, indicating a potential underestimation of microplastics in the environment. Recommendations were made to improve the quality, use, and reporting of recovery rate studies for standardization and replication in microplastic research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Dermatology
Guoqi Wang, Haiyan Xu, Gaoxiang Xu, Hao Zhang, Zhirui Li, Daohong Liu
Summary: Comparing negative pressure wound therapy with instillation (NPWTi) and standard negative pressure wound therapy, this study found that NPWTi resulted in fewer surgeries and dressing changes, and smaller wound areas post-treatment compared to NPWT. However, no significant differences were observed in other clinical outcomes between NPWTi and NPWT. Further well-designed RCTs with larger sample sizes are needed to validate these conclusions due to heterogeneity.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Orthopedics
Dexter Seow, Youichi Yasui, John F. Dankert, Wataru Miyamoto, James D. F. Calder, John G. Kennedy
Summary: The study evaluated the efficacy of biological adjuvants in hindfoot arthrodesis and found a lack of data to support their meaningful use compared to autograft/allograft. The meta-analysis favored autograft over allograft and rhPDGF/beta-TCP over autograft in the short term.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Dermatology
Jun-Hong Li, Ping Li, Yao Li
Summary: This study investigates the effects of rapid rehabilitation on surgical site wound infections and pain in patients with intertrochanteric femoral fractures. The meta-analysis of 21 studies involving 2004 patients indicated that rapid rehabilitation significantly reduced postoperative complications, wound infections, and hospital stay, while improving wound pain in patients undergoing surgery for intertrochanteric femoral fractures.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Yumeng Wang, Xintian Shou, Zongjing Fan, Jie Cui, Donghua Xue, Yang Wu
Summary: Phytoestrogens have been found to have significant effects on heart diseases by reducing myocardial infarct size, decreasing creatine kinase and cTnI levels, increasing left ventricular ejection fraction and left ventricular fractional shortening, and lowering heart rate.
FRONTIERS IN PHARMACOLOGY
(2022)