Article
Medicine, General & Internal
Boglarka Soos, Miklos Fagyas, Agnes Horvath, Edit Vegh, Anita Pusztai, Monika Czokolyova, Alexandra Csongradi, Attila Hamar, Zsofia Petho, Nora Bodnar, Gyoergy Kerekes, Katalin Hodosi, Eva Szekanecz, Szilvia Szamosi, Sandor Szanto, Gabriella Szucs, Zoltan Papp, Zoltan Szekanecz
Summary: The study revealed that anti-TNF therapy may increase ACE and ACE2 levels in the sera of RA and AS patients, and these levels are associated with disease duration, markers of inflammation, and vascular pathophysiology. The changes in ACE and ACE2 are influenced by treatment and other factors such as RF or FMD.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Vandana Bhushan, Susan Lester, Liz Briggs, Raif Hijjawi, E. Michael Shanahan, Eliza Pontifex, Jem Ninan, Catherine Hill, Fin Cai, Jennifer Walker, Fiona Goldblatt, Mihir D. Wechalekar
Summary: Similar retention rates of the second and third compared to the first b/tsDMARD in RA, PsA, and AS support a differential b/tsDMARDs use strategy based on patient presentation. The risk of b/tsDMARD failure was halved in PsA patients, and covariates were not associated with the risk of bDMARD failure. The most common reason for switching was treatment failure.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Pilar Peris, Ana Monegal, Nuria Guanabens
Summary: In addition to their well-recognized antiresorptive capacity, bisphosphonates (BPs) also have immunomodulatory and anti-inflammatory abilities, which can prevent structural joint damage in inflammatory rheumatic diseases. More studies are needed to further understand the potential use of BPs in treating inflammatory-mediated diseases and preventing structural damage in these disorders.
Review
Pharmacology & Pharmacy
Ju Li, Zhongyuan Zhang, Xinhua Wu, Jie Zhou, Deqian Meng, Ping Zhu
Summary: This meta-analysis found that treatment with anti-TNF alpha agents may increase the risk of infectious adverse events while the risk of tuberculosis was not significantly different. The use of anti-TNF agents should be carefully considered based on the risk-benefit ratio suggested by the meta-analysis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Bogunia-Kubik, Wojciech Wojtowicz, Jerzy Swierkot, Karolina Anna Mielko, Badr Qasem, Joanna Wielinska, Renata Sokolik, Lukasz Pruss, Piotr Mlynarz
Summary: RA, AS, and PsA are comprehensive immunological disorders with treatment focused on symptom relief. Metabolite changes were most significant in AS, with the shortest time to remission, potentially influenced by ethanol as a common metabolite negatively correlated with healing processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Balazs Juhasz, Katalin Gulyas, Agnes Horvath, Edit Vegh, Anita Pusztai, Agnes Szentpetery, Zsofia Petho, Nora Bodnar, Attila Hamar, Levente Bodoki, Harjit Pal Bhattoa, Eva Szekanecz, Katalin Hodosi, Andrea Domjan, Szilvia Szamosi, Csaba Horvath, Sandor Szanto, Gabriella Szucs, Hennie G. Raterman, Willem F. Lems, Oliver FitzGerald, Zoltan Szekanecz
Summary: BMD as determined by QCT did not change over one year of anti-TNF treatment. Disease activity, CATHK, RANKL and VITD may be associated with the effects of anti-TNF treatment on QCT BMD changes. RA and AS may differ in this respect.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Editorial Material
Rheumatology
Juergen Braun, Dietmar Krause, Uta Kiltz
Summary: This editorial discusses the impact evaluation of a nurse-led program for patient self-assessment and self-management in axial spondyloarthritis, presented in a prospective, multicenter, randomized, controlled trial (COMEDSPA) conducted by Anna Molto et al.
Review
Immunology
Uday Raj Sharma, Akhila Nediyedath Rathnakaran, B. P. Prudhvi Raj, Gayathry Padinjakkara, Akanksh Das, Surendra Vada, Manjunatha P. Mudagal
Summary: Rheumatoid arthritis is an autoimmune inflammatory disorder characterized by joint destruction and symmetrical symptoms. Pregnancy has a positive effect on RA, with different hypotheses explaining this. Treatment options for RA include the use of DMARDs and NSAIDs.
INFLAMMOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Polina Kagan, Noy Horesh, Howard Amital, Avishai M. M. Tsur, Abdulla Watad, Arnon D. D. Cohen, Niv Ben-Shabat
Summary: AS patients in Israel have a higher overall risk of cancer compared to controls, especially for solid malignancies, CNS, kidney, and malignancy of unknown primary. Older age, comorbidity of diabetes and IBD, and treatment with DMARDs were associated with a higher risk of solid malignancies within AS patients, while NSAIDs treatment alone had a protective effect.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Milena Iwaszko, Joanna Wielinska, Jerzy Swierkot, Katarzyna Kolossa, Renata Sokolik, Bartosz Bugaj, Monika Chaszczewska-Markowska, Slawomir Jeka, Katarzyna Bogunia-Kubik
Summary: The IL-33 gene polymorphisms are closely associated with clinical parameters, disease activity, and response to TNF inhibitor treatment in patients with RA and AS, with the rs16924159 AA genotype potentially linked to higher disease activity and poor treatment response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Walter Reinisch, Wayne Hellstrom, Radboud J. E. M. Dolhain, Suresh Sikka, Rene Westhovens, Rajiv Mehta, Timothy Ritter, Ursula Seidler, Oleksandr Golovchenko, Vladimir Simanenkov, Olena Garmish, Slawomir Jeka, Radka Moravcova, Vijay Rajendran, Franck-Olivier Le Brun, Sarah Arterburn, Timothy R. Watkins, Robin Besuyen, Dirk Vanderschueren
Summary: The phase 2 MANTA and MANTA-RAy studies aimed to determine the impact of the oral Janus kinase 1 inhibitor filgotinib on semen parameters and sex hormones in men with inflammatory diseases. Results showed that once daily filgotinib 200 mg for 13 weeks had no measurable impact on semen parameters or sex hormones.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Luis Fernando Perez-Garcia, Esther Roder, Robbert J. Goekoop, Johanna M. W. Hazes, Marc R. Kok, Hieronymus T. W. Smeele, Ilja Tchetverikov, Annette H. M. Van der Helm-van Mil, Jos H. van der Kaap, Petra Kok, Bouwe P. Krijthe, Radboud J. E. M. Dolhain
Summary: This study is the first to demonstrate that inflammatory arthritis can impact male fertility. Men diagnosed with IA before and during the peak reproductive years have lower fertility rates, higher rates of childlessness, and more fertility problems.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Soo Min Ahn, Young Bin Joo, Yun Jin Kim, So -Young Bang, Hye-Soon Lee
Summary: This study analyzed the effects of biologic agents on pregnancy outcomes using a nationwide population-based database. The results suggest that biologic agent use may be associated with several adverse pregnancy outcomes, especially in patients who use biologics during pregnancy.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Monika Czokolyova, Anita Pusztai, Edit Vegh, Agnes Horvath, Anita Szentpeteri, Attila Hamar, Szilvia Szamosi, Katalin Hodosi, Andrea Domjan, Sandor Szanto, Gyorgy Kerekes, Ildiko Seres, Mariann Harangi, Gyorgy Paragh, Eva Szekanecz, Zoltan Szekanecz, Gabriella Szucs
Summary: Anti-TNF therapy significantly decreased certain metabolic markers in AS and RA patients and was closely associated with baseline status and other clinical markers. Results suggest that these metabolic parameters are related to changes in lipids, vascular pathophysiology, disease activity, and inflammation.
Article
Rheumatology
Anne Boel, Victoria Navarro-Compan, Annelies Boonen, Philip Mease, Uta Kiltz, Maxime Dougados, Robert Landewe, Desiree van der Heijde
Summary: Through a 3-round Delphi survey, patients and axSpA experts identified the most relevant disease domains to be considered for the core set for axSpA.
JOURNAL OF RHEUMATOLOGY
(2021)
Letter
Rheumatology
Vincent Germain, Marc Scherlinger, Thomas Barnetche, Thierry Schaeverbeke
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Review
Immunology
Marc Scherlinger, Philippe Mertz, Flora Sagez, Alain Meyer, Renaud Felten, Emmanuel Chatelus, Rose-Marie Javier, Christelle Sordet, Thierry Martin, Anne-Sophie Korganow, Aurelien Guffroy, Vincent Poindron, Christophe Richez, Marie-Elise Truchetet, Patrick Blanco, Thierry Schaeverbeke, Jean Sibilia, Herve Devillers, Laurent Arnaud
AUTOIMMUNITY REVIEWS
(2020)
Article
Rheumatology
Vincent Germain, Marc Scherlinger, Thomas Barnetche, Clemence Pichon, Alexandre Balageas, Laurence Lequen, Emilie Shipley, Jennifer Foret, Stephanie Dublanc, Lucile Capuron, Thierry Schaeverbeke
Summary: The primary objective of the study was to assess the stressful life events preceding the onset of symptoms in RA patients. It was found that patients with early RA reported more life events in the year preceding the onset of symptoms compared to controls, with a significant association between cumulative stress and RA only observed in women.
Article
Rheumatology
Marc Scherlinger, Johanna Lutz, Gael Galli, Christophe Richez, Jacques-Eric Gottenberg, Jean Sibilia, Laurent Arnaud, Patrick Blanco, Thierry Schaeverbeke, Emmanuel Chatelus, Marie-Elise Truchetet
Summary: This study found significant differences in clinical characteristics and prognosis in patients with systemic sclerosis who have concomitant autoimmune diseases. Patients with overlap SgS/SSc had a higher risk of mortality, while those with RA/SSc received more medication treatments.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Letter
Rheumatology
Marc Scherlinger, Thierry Schaeverbeke
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Marc Scherlinger, George C. Tsokos
Summary: ROS are reactive oxygen species produced by immune cells in response to antigens, predominantly in the mitochondria and tightly regulated by metabolic processes. While necessary for the development of the immune response, the role of ROS in autoimmune disease requires further clarification. Initial clinical data suggests potential benefits in supplementing with antioxidants or reducing ROS production, prompting the need for more research in this area.
AUTOIMMUNITY REVIEWS
(2021)
Article
Cell Biology
Marc Scherlinger, Vivien Guillotin, Isabelle Douchet, Pierre Vacher, Andrea Boizard-Moracchini, Jean-Philippe Guegan, Anne Garreau, Nathalie Merillon, Agathe Vermorel, Emmanuel Ribeiro, Irene Machelart, Estibaliz Lazaro, Lionel Couzi, Pierre Duffau, Thomas Barnetche, Jean-Luc Pellegrin, Jean-Francois Viallard, Maya Saleh, Thierry Schaeverbeke, Patrick Legembre, Marie-Elise Truchetet, Helene Dumortier, Cecile Contin-Bordes, Vanja Sisirak, Christophe Richez, Patrick Blanco
Summary: This study identified a P-selectin-dependent pathway in patients with systemic lupus erythematosus (SLE) and validated it as a potential therapeutic avenue. Platelets from SLE patients interacted with Treg cells via the P-selectin/PSGL-1 axis, affecting Treg cell function and suppressing immune responses. Blocking P-selectin in a mouse model of SLE improved disease features, indicating its potential as a therapeutic target.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Infectious Diseases
Marc Scherlinger, Renaud Felten, Floriane Gallais, Charlotte Nazon, Emmanuel Chatelus, Luc Pijnenburg, Amaury Mengin, Adrien Gras, Pierre Vidailhet, Rachel Arnould-Michel, Sabrina Bibi-Triki, Raphael Carapito, Sophie Trouillet-Assant, Magali Perret, Alexandre Belot, Seiamak Bahram, Laurent Arnaud, Jacques-Eric Gottenberg, Samira Fafi-Kremer, Jean Sibilia
Summary: COVID-19 long-haulers, representing 10% of COVID-19 patients, remain understudied. In a prospective study, half of patients seeking medical help for post-acute COVID-19 syndrome lack SARS-CoV-2 immunity, which did not have consequences on their clinical or biologic characteristics. Symptoms reported by these patients include severe fatigue, altered quality of life, and psychologic distress.
INFECTIOUS DISEASES AND THERAPY
(2021)
Editorial Material
Immunology
Marc Scherlinger, George C. Tsokos
Summary: In patients with rheumatoid arthritis, a shortage of aspartate in the mitochondria can lead to the production of transmembrane TNF by the endoplasmic reticulum of T cells, contributing to synovial inflammation.
Article
Immunology
Marc Scherlinger, Luc Pijnenburg, Emmanuel Chatelus, Laurent Arnaud, Jacques-Eric Gottenberg, Jean Sibilia, Renaud Felten
Summary: This study suggests that SARS-CoV-2 vaccination is well tolerated and immunogenic in the majority of patients with long-COVID or post-acute sequelae of COVID-19 (PASC). Disseminating these reassuring data might prove crucial to increasing vaccine coverage in patients with PASC.
Article
Immunology
Wenliang Pan, Marc Scherlinger, Nobuya Yoshida, Maria G. Tsokos, George C. Tsokos
Summary: This study demonstrates that PPP2R2D, a regulatory subunit of protein phosphatase 2A, acts as a negative regulator of immune checkpoint receptors. Its absence exacerbates effector T cell exhaustion and promotes regulatory T cell expansion. The expression levels of PPP2R2D are positively correlated with the infiltration of immune cells in melanoma patients.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Marc Scherlinger, Naimah Zein, Jacques-Eric Gottenberg, Marianne Riviere, Jean-Francois Kleinmann, Jean Sibilia, Laurent Arnaud
Summary: This study evaluated the difficulties faced by systemic lupus erythematosus (SLE) patients during the early COVID-19 pandemic and their impact on mental health. The findings showed that many patients experienced challenges in accessing healthcare and treatment, and had high levels of psychological distress.
Article
Rheumatology
Renaud Felten, Marc Scherlinger, Aurelien Guffroy, Vincent Poindron, Alain Meyer, Margherita Giannini, Anne-Sophie Korganow, Christelle Sordet, Emmanuel Chatelus, Rose-Marie Javier, Aurore Meyer, Luc Pijnenburg, Jean-Francois Kleinmann, Jacques-Eric Gottenberg, Jean Sibilia, Thierry Martin, Laurent Arnaud
Summary: This study aimed to assess the prevalence of COVID-19 infection in patients with rare autoimmune diseases, and found a low prevalence of proven SARS-CoV-2 infection and very rare severe infections among these patients, which may be attributed to good compliance with prophylactic measures.
ARTHRITIS RESEARCH & THERAPY
(2021)
Meeting Abstract
Rheumatology
M. Scherlinger, J. Lutz, J. Sibilia, J. E. Gottenberg, T. Schaeverbeke, C. Richez, E. Chatelus, M. E. Truchetet
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Medicine, General & Internal
dos Santos Rocha Andre, Scherlinger Marc, Ostermann Laura, Marc David, Mehler Anton, Nadiradze Aleksandra, Schulze Friederike, Feldmeyer Laurence, de Koning Myrthe, Berbecar T. Vlad, Buijs Ruben, Kijlstra Jan David, Jawaid Ali
SWISS MEDICAL WEEKLY
(2020)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.