Review
Oncology
P. Filis, D. Mauri, G. Markozannes, M. Tolia, N. Filis, K. Tsilidis
Summary: Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with interval cytoreductive surgery (CRS) and neoadjuvant chemotherapy significantly improves overall survival (OS) and disease-free survival (DFS) in primary ovarian cancer.
Article
Biochemistry & Molecular Biology
Wei-Chun Chen, Huei-Jean Huang, Lan-Yan Yang, Yu-Bin Pan, Kuan-Gen Huang, Cheng-Tao Lin, Min-Yu Chen, Yun-Hsin Tang, Ting-Chang Chang, Chyong-Huey Lai, Hung-Hsueh Chou
Summary: Secondary cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has potential benefits for patients with recurrent ovarian cancer, with factors such as previous chemotherapy, chemotherapy-free interval, and CA125 levels before HIPEC contributing to prognosis. However, there are also associated toxicities.
BIOMEDICAL JOURNAL
(2022)
Editorial Material
Obstetrics & Gynecology
Aliyah B. Conley, Keith F. Fournier, Anil K. Sood, Michael Frumovitz
Summary: Standard chemotherapy has limited effectiveness for advanced or recurrent primary mucinous ovarian cancer. This case report demonstrates that secondary cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) can lead to complete and durable responses in these patients. No additional chemotherapy was required postoperatively.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Surgery
Myong Cheol Lim, Suk-Joon Chang, Boram Park, Heon Jong Yoo, Chong Woo Yoo, Byung Ho Nam, Sang-Yoon Park
Summary: The study aimed to evaluate the clinical benefit of HIPEC in patients with ovarian cancer. The results showed that adding HIPEC to cytoreductive surgery did not improve survival rates for patients with advanced ovarian cancer. However, in the subgroup of interval cytoreductive surgery, the addition of HIPEC improved progression-free and overall survival.
Review
Oncology
Amine Souadka, Hajar Essangri, Mohammed Anass Majbar, Amine Benkabbou, Saber Boutayeb, Benoit You, Olivier Glehen, Raouf Mohsine, Naoual Bakrin
Summary: The umbrella review summarized the outcomes of heated intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) association in ovarian cancer. The study found that the combination of CRS and HIPEC significantly improved overall survival, disease-free survival, and progression-free survival for both primary and recurrent ovarian cancers. This suggests that HIPEC at the end of CRS may be an effective complementary asset for managing ovarian cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
S. Lot Aronson, Marta Lopez-Yurda, Simone N. Koole, Jules H. Schagen van Leeuwen, Hendrik W. R. Schreuder, Ralph H. M. Hermans, Ignace H. J. T. de Hingh, Mignon D. J. M. van Gent, Henriette J. G. Arts, Maaike A. P. C. van Ham, Peter A. van Dam, Peter Vuylsteke, Arend G. J. Aalbers, Victor J. Verwaal, Koen K. Van de Vijver, Neil K. Aaronson, Gabe S. Sonke, Willemien van Driel
Summary: This study confirms the long-term survival benefit of HIPEC in patients with primary stage III epithelial ovarian cancer undergoing interval cytoreductive surgery.
Article
Biochemistry & Molecular Biology
Dominika Flasarova, Katerina Urban, Ondrej Strouhal, Dusan Klos, Radmila Lemstrova, Pavel Dvorak, Pavel Soucek, Beatrice Mohelnikova-Duchonova
Summary: DNA repair pathways are crucial for maintaining genome stability and understanding their regulation can contribute to the development of new treatment strategies, prevention of chemoresistance, and enhancement of patient survival in ovarian cancer. The study aimed to compare the expression levels of 84 genes involved in DNA repair pathways in tumors and peritoneal metastatic tissue of ovarian cancer patients treated with cytoreductive surgery and platinum-based HIPEC, in relation to patient survival, peritoneal carcinomatosis, treatment response, and alterations in BRCA1 and BRCA2 genes. The findings revealed significant gene interactions and correlations between gene expression and overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Olivia G. Huffman, Danielle B. Chau, Andreea I. Dinicu, Robert DeBernardo, Ofer Reizes
Summary: This review examines the impact of hyperthermic intraperitoneal chemotherapy (HIPEC) on ovarian cancer and discusses its effects on the immune response, DNA damage, DNA damage repair pathways, and synergy with chemotherapy. It provides important insights for the development of new therapeutic strategies for ovarian cancer patients.
Article
Oncology
Carolyn N. Krasner, Susana M. Campos, Chantay L. Young, Karan R. Chadda, Hang Lee, Michael J. Birrer, Neil S. Horowitz, Panagiotis A. Konstantinopoulos, Antonella M. D'Ascanio, Ursula A. Matulonis, Richard T. Penson
Summary: CRLX101, as a novel cyclodextrin-containing polymer conjugate of camptothecin, shows promising efficacy in treating recurrent epithelial ovarian cancer, with good tolerability. When combined with bevacizumab, it can improve clinical benefit rates and overall response rates without severe adverse events.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Reproductive Biology
Xin-Ru Li, Yi Zhu, Guo-Nan Zhang, Jian-Ming Huang, Li-Xia Pei
Summary: This study found through meta-analysis that in recurrent ovarian cancer, pegylated liposomal doxorubicin plus carboplatin was more effective than paclitaxel plus carboplatin, while pegylated liposomal doxorubicin monotherapy showed similar survival outcomes to other monotherapies. Both treatment regimens were well tolerated in terms of side effects.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Snita Sinukumar, Dileep Damodaran, Mukurdipi Ray, Sanket Mehta, Lista Paul, Aditi Bhatt
Summary: This study evaluated the patterns of recurrence and factors affecting recurrence after interval cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in primary stage IIIC/IVA epithelial ovarian cancer. The results showed a higher incidence of systemic recurrences in these patients, with nodal involvement, selective peritonectomy, and residual disease being significant factors influencing recurrence risk. Extent of peritonectomy and nodal clearance impacted patterns of recurrence and progression free survival.
Article
Oncology
Ji Hyun Kim, Dong-eun Lee, Yumi Lee, Hyeong In Ha, Yoon Jung Chang, Suk-Joon Chang, Sang-Yoon Park, Myong Cheol Lim
Summary: This study investigated the impact of hyperthermic intraperitoneal chemotherapy (HIPEC) on the health-related quality of life (HRQOL) of patients with primary ovarian cancer. The results showed that the implementation of HIPEC during cytoreductive surgery did not significantly affect HRQOL outcomes.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
S. Kim, J-W Kim
Summary: Ovarian cancer is often diagnosed at an advanced stage, but combining surgery with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) can improve patients' survival outcomes.
Article
Oncology
Cascales Campos Pedro Antonio, Gonzalez Gil Alida, Gil Gomez Elena, Gonzalez Sanchez Rocio, Martinez Garcia Jeronimo, Alonso Romero Jose Luis, Nieto Diaz Anibal, Barcelo Valcarcel Francisco, Gomez Ruiz alvaro Jesus, Ramirez Romero Pablo, Gil Martinez Jose
Summary: In this study, for patients with advanced ovarian cancer treated with neoadjuvant systemic chemotherapy, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) were associated with improved disease-free survival and overall survival. However, there were no differences in postoperative morbidity, mortality, or quality of life evaluation between the CRS with or without HIPEC groups.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Bjorg Jonsdottir, Marta Lomnytska, Inger Sundstrom Poromaa, Ilvars Silins, Karin Stalberg
Summary: The study found PCI to be an excellent predictor of incomplete CRS, suggesting consideration of neoadjuvant chemotherapy if the PCI is higher. The reason for open-close surgery was mainly massive carcinomatosis on the small bowel.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Sport Sciences
Maike G. Sweegers, Teatske M. Altenburg, Johannes Brug, Anne M. May, Jonna K. van Vulpen, Neil K. Aaronson, Gill Arbane, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvao, Rachel Garrod, Kathleen A. Griffith, Wim H. Van Harten, Sandra C. Hayes, Fernando Herrero-Roman, Marie J. Kersten, Alejandro Lucia, Alex McConnachie, Willem van Mechelen, Nanette Mutrie, Robert U. Newton, Frans Nollet, Karin Potthoff, Martina E. Schmidt, Kathryn H. Schmitz, Karl Heinz Schulz, Gabe Sonke, Karen Steindorf, Martijn M. Stuiver, Dennis R. Taaffe, Lene Thorsen, Jos W. Twisk, Miranda J. Velthuis, Jennifer Wenzel, Kerri M. Winters-Stone, Joachim Wiskemann, Mai J. Chin A. Paw, Laurien M. Buffart
BRITISH JOURNAL OF SPORTS MEDICINE
(2019)
Article
Oncology
Marissa C. van Maaren, Linda de Munck, Luc J. A. Strobbe, Gabe S. Sonke, Pieter J. Westenend, Marjolein L. Smidt, Philip M. P. Poortmans, Sabine Siesling
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Nayef A. Alzahrani, Sarah J. Valle, Oliver M. Fisher, Paul H. Sugarbaker, Yutaka Yonemura, Olivier Glehen, Dianne Goere, Charles Honore, Cecile Brigand, Ignace de Hingh, Vic J. Verwaal, Marcello Deraco, Dario Baratti, Shigeki Kusamura, Mark Pocard, Pompiliu Piso, Loreen Maerz, Frederic Marchal, Brendan Moran, Edward A. Levine, Frederic Dumont, Denis Pezet, Karine Abboud, Mathew A. Kozman, Winston Liauw, David L. Morris
JOURNAL OF SURGICAL ONCOLOGY
(2019)
Article
Medicine, General & Internal
K. Moore, N. Colombo, G. Scambia, B. -G. Kim, A. Oaknin, M. Friedlander, A. Lisyanskaya, A. Floquet, A. Leary, G. S. Sonke, C. Gourley, S. Banerjee, A. Oza, A. Gonzalez-Martin, C. Aghajanian, W. Bradley, C. Mathews, J. Liu, E. S. Lowe, R. Bloomfield, P. DiSilvestro
NEW ENGLAND JOURNAL OF MEDICINE
(2018)
Article
Oncology
S. N. Koole, J. M. Kieffer, K. Sikorska, J. H. Schagen van Leeuwen, H. W. R. Schreuder, R. H. Hermans, I. H. de Hingh, J. van der Velden, H. J. Arts, M. A. P. C. van Ham, A. G. Aalbers, V. J. Verwaal, K. K. Van de Vijver, G. S. Sonke, W. J. van Driel, N. K. Aaronson
Summary: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery (CRS) does not negatively impact the health-related quality of life (HRQoL) in patients with stage III ovarian cancer.
Article
Oncology
Simone N. Koole, Christiaan van Lieshout, Willemien J. van Driel, Evi van Schagen, Karolina Sikorska, Jacobien M. Kieffer, Jules H. Schagen van Leeuwen, Henk W. R. Schreuder, Ralph H. Hermans, Ignace H. de Hingh, Jacobus van der Velden, Henriette J. Arts, Leon F. A. G. Massuger, Arend G. Aalbers, Victor J. Verwaal, Koen K. Van de Vijver, Neil K. Aaronson, Harm van Tinteren, Gabe S. Sonke, Wim H. van Harten, Valesca P. Retel
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Gastroenterology & Hepatology
Charlotte E. L. Klaver, Daniel D. Wisselink, Cornelis J. A. Punt, Petur Snaebjornsson, Johannes Crezee, Arend G. J. Aalbers, Alexandra Brandt, Andre J. A. Bremers, Jacobus W. A. Burger, Hans F. J. Fabry, Floris Ferenschild, Sebastiaan Festen, Wilhelmina M. U. van Grevenstein, Patrick H. J. Hemmer, Ignace H. J. T. de Hingh, Niels F. M. Kok, Gijsbert D. Musters, Lotte Schoonderwoerd, Jurriaan B. Tuynman, Anthony W. H. van de Ven, Henderik L. van Westreenen, Marinus J. Wiezer, David D. E. Zimmerman, Annette A. van Zweeden, Marcel G. W. Dijkgraaf, Pieter J. Tanis
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Sissel Ravn, Christian F. Christiansen, Rikke H. Hagemann-Madsen, Victor J. Verwaal, Lene H. Iversen
CLINICAL EPIDEMIOLOGY
(2020)
Article
Oncology
Vincent C. J. van de Vlasakker, Robin J. Lurvink, Peter H. Cashin, Wim Ceelen, Marcello Deraco, Diane Goere, Santiago Gonzalez-Moreno, Kuno Lehmann, Yan Li, Brendan Moran, David L. Morris, Pompiliu Piso, Claudio A. Quadros, Beate Rau, S. P. Somashekhar, Antonio Sommariva, Kurt van der Speeten, John Spiliotis, Paul H. Sugarbaker, Melissa C. C. Teo, Vic J. Verwaal, Yutaka Yonemura, Olivier Glehen, Ignace H. J. T. de Hingh
Summary: The results of PRODIGE 7 have had a major impact on CRS-HIPEC practice worldwide, leading to adjustments in HIPEC regimens, a decrease in referral rates, a reduction in national consensus, and other changes in practice.
Article
Oncology
Victor Jilbert Verwaal, Jonas Amstrup Funder, Mette Moller Sorensen, Lene Hjerrild Iversen
Summary: This study evaluated the impact of postoperative complications on survival in patients with peritoneal metastases of colorectal origin treated with CRS + HIPEC. The results showed that complications had a negative impact on survival.
Article
Oncology
Jesper Nors, Jonas Amstrup Funder, David Richard Swain, Victor Jilbert Verwaal, Tom Cecil, Soren Laurberg, Brendan John Moran
PLEURA AND PERITONEUM
(2020)
Article
Surgery
S. Ravn, U. Heide-Jorgensen, C. E. Christiansen, V. J. Vervvaal, R. H. Hagemann-Madsen, L. H. Iversen
Review
Obstetrics & Gynecology
Samira Zirak-Schmidt, Victor J. Verwaal
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
(2018)
Letter
Medicine, General & Internal
Willemien J. van Driel, Simone N. Koole, Gabe S. Sonke
NEW ENGLAND JOURNAL OF MEDICINE
(2018)
Article
Economics
Hanna van Waart, Johanna M. van Dongen, Wim H. van Harten, Martijn M. Stuiver, Rosalie Huijsmans, Jeannette A. J. H. Hellendoorn-van Vreeswijk, Gabe S. Sonke, Neil K. Aaronson
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2018)