☆ 4.4 Review

Computational Drug Repositioning for Cancer Therapeutics

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2015)

Journal

CURRENT TOPICS IN MEDICINAL CHEMISTRY

Volume 15, Issue 8, Pages 767-775

Publisher

BENTHAM SCIENCE PUBL LTD

DOI: 10.2174/1568026615666150302105831

Keywords

Anticancer drugs; Cancer therapeutics; Computational drug repositioning; Drug discovery; Drug repositioning; Drug repurposing

Categories

Chemistry, Medicinal

Funding

Chinese National Science Foundation [81402790]
Shanghai Commission of Science and Technology [14PJ1410700]

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Abstract

Due to ever-increasing failure rates, high cost, unsatisfactory safety profile, and limited efficacy associated with anticancer drug development, the repositioning of established non-cancer drugs for new oncology indications has emerged as an increasingly attractive approach to addressing the unmet cancer-related medical need. With the rapid development of bioinformatics, chemoinformatics as well as high-performance computing, drug repositioning is becoming more intentional than ever, and a significant surge of computational approaches has been well established to greatly facilitate drug repositioning for cancer treatment. In this review, we provide a brief overview of recent advances in the computational drug repositioning for anticancer applications with a specific emphasis on repositioning of non-cancer drugs by use of various computational approaches.

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Article Multidisciplinary Sciences

TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase

Gang Liu, Tatt Jhong Haw, Malcolm R. Starkey, Ashleigh M. Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M. Nair, Henry M. Gomez, Irwan Hanish, Alan CY. Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E. Marshall, Richard Y. Kim, Adam M. Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G. Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H. Chotirmall, Jay C. Horvat, Paul S. Foster, Brian GG. Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S. Sohal, Ken R. Bracke, Peter A. Wark, Ian M. Adcock, Kensuke Miyake, Don D. Sin, Philip M. Hansbro

Summary: TLR7 plays a crucial role in the development of emphysema and COPD through the modulation of mast cell activity. This finding highlights TLR7 as a potential therapeutic target for human lung inflammation.

NATURE COMMUNICATIONS (2023)

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