Article
Immunology
Onyema Ogbuagu, Peter J. Ruane, Daniel Podzamczer, Laura C. Salazar, Keith Henry, David M. Asmuth, David Wohl, Richard Gilson, Yongwu Shao, Ramin Ebrahimi, Stephanie Cox, Alexander Kintu, Christoph Carter, Moupali Das, Jared M. Baeten, Diana M. Brainard, Gary Whitlock, Jason M. Brunetta, Gitte Kronborg, Christoph D. Spinner
Summary: The study shows that emtricitabine and tenofovir alafenamide is non-inferior and even superior in some aspects compared to emtricitabine and tenofovir disoproxil fumarate in preventing HIV infection among adult cisgender men and transgender women at high risk. Additionally, it demonstrates the safety and efficacy of long-term pre-exposure prophylaxis with emtricitabine and tenofovir alafenamide.
Article
Endocrinology & Metabolism
Alexandra Krez, Sanchita Agarwal, Mariana Bucovsky, Donald J. McMahon, Yizhong Hu, Marc Bessler, Beth Schrope, Angela Carrelli, Shannon Clare, Xiang-Dong Edward Guo, Shonni J. Silverberg, Emily M. Stein
Summary: The study revealed that African American and Latina women experienced substantial and progressive bone loss, deterioration of microarchitecture, and trabecular morphology following Roux-en-Y gastric bypass (RYGB) surgery. This study emphasizes the importance of further research to understand the long-term skeletal consequences of bariatric surgery in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Zhihong Liu, Qinglong Jin, Yuexin Zhang, Guozhong Gong, Guicheng Wu, Lvfeng Yao, Xiaofeng Wen, Zhiliang Gao, Yan Huang, Daokun Yang, Enqiang Chen, Qing Mao, Shide Lin, Jia Shang, Huanyu Gong, Lihua Zhong, Huafa Yin, Fengmei Wang, Peng Hu, Ling Xiao, Chuan Li, Qiong Wu, Chang'an Sun, Junqi Niu, Jinlin Hou
Summary: This study compared the efficacy and safety of TMF and TDF in patients with chronic hepatitis B for 48 weeks. Results showed that TMF was non-inferior to TDF in terms of anti-HBV efficacy and demonstrated better bone and renal safety after 48 weeks of treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Infectious Diseases
Todd T. Brown, Krista Yuhas, Kenneth H. Mayer, Raphael J. Landovitz, Mark A. Marzinke, Craig W. Hendrix, Ying Q. Chen, Karen L. Klingman, Wairimu Chege, Marybeth B. Mccauley, Roy M. Gulick, Timothy J. Wilkin
Summary: This study found that Tenofovir disoproxil fumarate-containing PrEP was associated with greater bone loss in the hip compared to maraviroc +/- emtricitabine PrEP, but there was no difference in LS BMD changes. The changes in hip BMD were similar in magnitude for both men and women.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Yu-Shan Huang, Chien-Yu Cheng, Hsin-Yun Sun, Shu-Hsing Cheng, Po-Liang Lu, Chen-Hsiang Lee, Yuan-Ti Lee, Hung-Chin Tsai, Chia-Jui Yang, Chun-Eng Liu, Bo-Huang Liou, Shih-Ping Lin, Sung-Hsi Huang, Mao-Wang Ho, Hung-Jen Tang, Chien-Ching Hung
Summary: Data on the durability of TAF-containing antiretroviral therapy in maintaining HBV viral suppression among HIV/HBV-coinfected patients are limited. This study filled the gap by enrolling 274 participants and assessing viral loads and serology markers through 96 weeks. Results showed high rates of viral suppression and improvements in renal parameters, while fasting lipids increased and BMD stabilized at 96 weeks after the switch.
MICROBIOLOGY SPECTRUM
(2023)
Article
Gastroenterology & Hepatology
Eunju Kim, Hyun Woong Lee, Soon Sun Kim, Eileen Yoon, Eun Sun Jang, Jong-In Chang, Young Youn Cho, Gi Hyeon Seo, Hyung Joon Kim
Summary: In this retrospective cohort study, researchers found that patients with chronic hepatitis B treated with TAF had a lower risk of osteoporotic fractures compared to those treated with TDF.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Hematology
Katharina Holstein, Leonora Witt, Anna Matysiak, Constantin Schmidt, Florian Barvencik, Michael Amling, Tim Rolvien, Florian Langer
Summary: Low bone mineral density is common in hemophilia patients, influenced by factors such as bone turnover, body mass index, inflammation, treatment regimen, joint status, and HCV infection. Self-reported sportive activity has a positive effect on bone mineral density.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Endocrinology & Metabolism
Lilian Sewing, Laura Potasso, Sandra Baumann, Denis Schenk, Furkan Gazozcu, Kurt Lippuner, Marius Kraenzlin, Philippe Zysset, Christian Meier
Summary: Type 1 diabetes (T1DM) is associated with an increased risk of nonvertebral fractures, and the influence of glycemic control and microvascular disease on skeletal health in long-standing T1DM is not well understood. This study found that patients with long-standing T1DM had lower bone mineral density (BMD), decreased bone turnover, and weaker bones at the ultradistal tibia compared to non-diabetic controls. The presence of diabetic peripheral neuropathy was found to contribute to the altered cortical microarchitecture and reduced bone strength in T1DM patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Hyung Joon Yim, Ji Hoon Kim, Yong Kyun Cho, Young Oh Kweon, Hyun Chin Cho, Jae Seok Hwang, Changhyeong Lee, Moon Soo Koh, Yang-Hyun Baek, Young-Min Park, Jeong-Hoon Lee, Seung Up Kim, Min-Kyu Kang, Neung Hwa Park, June Sung Lee, Young Eun Chon, Gab Jin Cheon, Hee Bok Chae, Joo Hyun Sohn, Young-Suk Lim
Summary: The study evaluated the antiviral effects and safety of switching from TDF to TD treatment in patients with chronic hepatitis B. TD was non-inferior to TDF in maintaining viral suppression in CHB patients, with less impact on renal function.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Immunology
Yu-Shan Huang, Chien-Yu Cheng, Bo-Huang Liou, Po-Liang Lu, Shu-Hsing Cheng, Yuan-Ti Lee, Chun-Eng Liu, Hsin-Yun Sun, Chia-Jui Yang, Hung-Jen Tang, Shih-Ping Lin, Mao-Wang Ho, Sung-Hsi Huang, Hung-Chin Tsai, Chen-Hsiang Lee, Chien-Ching Hung
Summary: Switching to E/C/F/TAF maintained viral suppression of both HIV and HBV, improved proteinuria and bone mineral density, but led to increased lipid levels in HIV/HBV-coinfected patients at week 48.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Multidisciplinary Sciences
Nathan J. Neeteson, Bryce A. Besler, Danielle E. Whittier, Steven K. Boyd
Summary: High-resolution peripheral quantitative computed tomography (HR-pQCT) is an emerging in vivo imaging modality for quantification of bone microarchitecture. However, the current standard protocol for HR-pQCT image segmentation is laborious and introduces biases into research data. In this study, a fully automated algorithm for HR-pQCT image segmentation was proposed and validated, which significantly improved precision for several outputs.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sabrina K. I. Funke, Cecile Factor, Marlene Rasschaert, Philippe Robert, Natasja W. M. van Dijk, Michelle Hussock, Michael Sperling, Uwe Karst
Summary: This study compared the quantitative distribution of gadolinium retained over time in rodent femur after the administration of gadodiamide and gadobutrol. The results showed that although the gadodiamide group had higher gadolinium concentration, the distribution pattern of gadolinium was similar for both contrast agents. The study also found that gadolinium distribution in bone changed with bone remodeling processes.
Article
Medicine, General & Internal
Yui Ogiso, Tatsunori Hanai, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This cross-sectional study aimed to determine whether TBS can identify patients with liver cirrhosis that are at risk of vertebral fractures. The results showed a significant correlation between TBS and vertebral fractures, indicating that TBS can help identify patients at risk of vertebral fractures in liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Vibha Singhal, Amita Bose, Meghan Slattery, Melanie S. Haines, Mark A. Goldstein, Nupur Gupta, Kathryn S. Brigham, Seda Ebrahimi, Kristin N. Javaras, Mary L. Bouxsein, Kamryn T. Eddy, Karen K. Miller, David Schoenfeld, Anne Klibanski, Madhusmita Misra
Summary: In adolescent girls with anorexia nervosa, the combination of rhIGF-1 administration with estrogen replacement therapy did not provide additional benefits compared to estrogen therapy alone over a 12-month period, and both treatments showed similar effects on bone outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Supritha Nimmala, Snimarjot Kaur, Vibha Singhal, Deborah M. Mitchell, Fatima Cody Stanford, Mary L. Bouxsein, Meghan Lauze, Carolyn Huynh, Clarissa C. Pedreira, Hang Lee, Miriam A. Bredella, Madhusmita Misra
Summary: This study found that sleeve gastrectomy (SG) in youth is associated with impaired bone health, which is related to changes in body composition, sex steroids, sclerostin, and enteric peptides.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
