Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 21, Issue 19, Pages 2629-2642Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612821666150416102058
Keywords
Dendrimers; oral route; surface modification; bioavailability; drug delivery; toxicity
Categories
Funding
- Singapore's Ministry of Education [R-148-000-151-112]
- NUS President Graduate Fellowship
Ask authors/readers for more resources
Dendrimers are emerging as potential novel nano-scaled material in drug delivery applications. An interesting area of application is oral drug delivery. In oral drug delivery, many drugs suffer from low bioavailability due to the presence of various biological barriers. Dendrimers have been shown to modulate tight junctions and the integrity of cellular membranes. This effect gives hope for dendrimer to be applied in oral drug delivery. Based on such properties, dendrimers are further surface-modified so that the system will be more suitable for oral delivery applications. Cationic dendrimers are commonly conjugated with neutral or negatively charged ligands, such as polyethylene glycol (PEG), to reduce potential toxicity in gastrointestinal (G. I.) tract. Dendrimers are also surface-modified to inhibit the efflux effect of P-glycoprotein, which is one of the major drug efflux pumps in G. I. tract. Another interesting strategy is to directly conjugate or mix dendrimer with drugs either to form a dendrimer-drug conjugation or complex to deliver the drug. In this review, application of dendrimers in oral drug delivery will be discussed. The main focus is on the various surface modification strategies to design a more desirable dendrimer-based delivery system that fits the need in oral drug delivery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available