Review
Clinical Neurology
Hakan Ashina, David W. Dodick
Summary: This review discusses the pharmacologic management of post-traumatic headache and the potential therapeutic benefits of targeting calcitonin gene-related peptide signaling. It suggests using a phenotype-guided approach for treatment based on the primary headache phenotype that the clinical features resemble the most. Additionally, advancements are being made in identifying cellular and molecular drivers of headache persistence.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Medicine, General & Internal
Hee-Jin Im, Yoo-Ha Hong, Soo-Jin Cho
Summary: Neck pain is a common symptom among migraine patients, and its impact on headaches and contributing factors are unclear. This study aimed to investigate the disability caused by neck pain on headaches and factors linked to comorbid neck pain, including sleep-related variables. The study found that neck pain was present in 51.9% of migraine patients, with high disability observed in some patients. Factors such as medication days per month, severe disability of migraine, and excessive daytime sleepiness were significant predictors for the severe impact of headaches. The study also found a positive correlation between neck pain and higher monthly headache days, female gender, and likelihood of obstructive sleep apnea among migraine patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Alberto Herrero Babiloni, Andree-Ann Baril, Camille Charlebois-Plante, Marianne Jodoin, Erlan Sanchez, Liesbet De Baets, Caroline Arbour, Gilles J. J. Lavigne, Nadia Gosselin, Louis De Beaumont
Summary: Sleep disturbances commonly occur after traumatic brain injury (TBI) and can contribute to various chronic physiological, psychological, and cognitive difficulties, including chronic pain. Neuroinflammation, a key pathophysiological mechanism in TBI recovery, may worsen outcomes and exacerbate the consequences of sleep disturbances. There is a bidirectional relationship between neuroinflammation and sleep, where neuroinflammation affects sleep regulation and poor sleep promotes neuroinflammation. This review aims to clarify the role of neuroinflammation in the sleep-TBI relationship and its impact on long-term outcomes, such as pain, mood disorders, cognitive dysfunctions, and increased risk of Alzheimer's disease and dementia. Management strategies and novel treatments targeting sleep and neuroinflammation will also be discussed to mitigate long-term outcomes after TBI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Gabriela F. Carvalho, Kerstin Luedtke, Tibor M. Szikszay, Debora Bevilaqua-Grossi, Arne May
Summary: The study found that migraine patients are more likely to report neck pain and migraine attacks following a neck muscle endurance test. Participants with neck pain referred to the head during manual examination had a greater prevalence of migraine attacks than those without or with only local pain.
Article
Sport Sciences
Kerry Peek, Jordan Andersen, Marnee J. McKay, Theo Versteegh, Ian A. Gilchrist, Tim Meyer, Andrew Gardner
Summary: This pilot trial found that a neck exercise programme can increase neck strength and reduce head impact magnitude during heading in adolescent football players. Female players showed more significant reduction in peak angular velocity compared to male players.
Article
Anesthesiology
Austin Pena, Gina Dumkrieger, Visar Berisha, Katherine Ross, Catherine D. Chong, Todd J. Schwedt
Summary: The study found that individuals with persistent posttraumatic headache (PPTH) experience substantial psychological symptoms and disability related to headaches, with disability severity influenced by age, headache frequency, intensity, and trait anxiety.
Article
Critical Care Medicine
Kelly M. M. Naugle, Tyler Nguyen, Jared A. A. Smith, Jonathan Saxe, Fletcher A. A. White
Summary: Recent research examined race differences in pain-related outcomes following mild traumatic brain injury (TBI). The study found that African Americans with mild TBI reported more severe headache pain, worse pain modulation, higher pain sensitivity, and greater pain catastrophizing compared to Caucasians with mild TBI. These race differences were not observed in the healthy TBI-free control group. The results suggest that psychological and pain modulatory profiles following mild TBI could contribute to intense and persistent headaches among African Americans.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Medicine, General & Internal
Carina F. Pinheiro, Anamaria S. Oliveira, Tenysson Will-Lemos, Lidiane L. Florencio, Cesar Fernandez-de-las-Penas, Fabiola Dach, Debora Bevilaqua-Grossi
Summary: Episodic and chronic migraines were associated with reduced total range of motion and mean angular velocity of neck movements, while muscle activity during active neck movements did not show significant differences. Neck disability and kinesiophobia were weakly correlated with cervical movement parameters.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Pora Kuperman, Yelena Granovsky, Shiri Fadel, Noam Bosak, Chen Buxbaum, Rafi Hadad, Elliot Sprecher, Hany Bahouth, Hen Ben Lulu, David Yarnitsky, Michal Granot
Summary: This study aimed to explore the role of pain and post-traumatic psychological features in explaining head and neck-related symptom variability in post-collision patients. While there is a common explanatory feature between neck- and head-related symptoms, they are not entirely overlapping.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Sport Sciences
Stephan Becker, Joshua Berger, Oliver Ludwig, Daniel Gunther, Jens Kelm, Michael Frohlich
Summary: This study investigated the cumulative effect of purposeful heading and the relationship between head-neck-torso alignment and head acceleration. While no relationship was found for head acceleration among standing, jumping, and running headers, a significant relationship was identified between head acceleration and maximum ball speed specifically for standing headers. Additional research is needed to further explore these relationships and confirm the findings.
JOURNAL OF HUMAN KINETICS
(2021)
Article
Otorhinolaryngology
Punam A. Patel, Lavanya Nagappan, Daohai Yu, Xiaoning Liu, Cecelia E. Schmalbach
Summary: The study revealed that female patients, younger individuals, smokers, and those requiring higher doses of opioids during hospital stay are more likely to experience inadequate pain control postoperatively. These patients could benefit from additional education, earlier follow-up visits, and a comprehensive nonopioid pain management regimen.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Amaal J. Starling, Melissa M. Cortez, Nicholas R. Jarvis, Nan Zhang, Frank Porreca, Catherine D. Chong, Todd J. Schwedt
Summary: This study characterized cutaneous heat and light-induced pain thresholds in people with post-traumatic headache (PTH) compared with healthy controls (HCs). The results showed that participants with PTH had higher photophobia symptom severity score and lower light-induced pain thresholds. Exposure to a bright light stressor reduced heat pain thresholds in participants with PTH immediately post stressor, but not in HCs. The study provides evidence for multimodal sensory dysfunction in people with PTH.
Article
Clinical Neurology
Zachary Leibovit-Reiben, Ryotaro Ishii, David W. Dodick, Gina Dumkrieger, Melissa M. Cortez, Kevin C. Brennan, Kathleen Digre, Todd J. Schwedt
Summary: This study investigated the impact of having headaches prior to traumatic brain injury (TBI) on headache features and long-term patient health outcomes. The findings suggest that patients with pre-TBI headaches are less likely to be diagnosed with post-traumatic headache (PTH) and have more severe symptoms of cutaneous allodynia, cognitive impairment, and generalized anxiety.
Article
Biophysics
Mohammad Homayounpour, Nicholas G. Gomez, Anita N. Vasavada, Andrew S. Merryweather
Summary: This study investigated the relative temporal characteristics of the head following impacts from different directions and found that a warning prior to impact can reduce head kinematics associated with injury.
JOURNAL OF BIOMECHANICS
(2021)
Article
Clinical Neurology
Alicia A. Swan, Eamonn Kennedy, Douglas B. Cooper, Megan E. Amuan, Jamie Mayo, David F. Tate, Kangwon Song, Blessen C. Eapen, Anne C. Van Cott, Maria R. Lopez, Mary Jo Pugh
Summary: The study examined the association between comorbidities (PTSD, depression, and/or headache) and polypharmacy with neurobehavioral symptoms among post-9/11 veterans with a history of mild traumatic brain injury (mTBI). The results showed that comorbidity burden and polypharmacy were associated with neurobehavioral symptom distress.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Sushmita Purkayastha, Mathew Stokes, Kathleen R. Bell
Article
Neurosciences
Sushmita Purkayastha, Benjamin Williams, Megan Murphy, Sydney Lyng, Tonia Sabo, Kathleen R. Bell
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2019)
Article
Rehabilitation
Risa Nakase-Richardson, Daniel J. Schwartz, Leah Drasher-Phillips, Jessica M. Ketchum, Karel Calero, Marie N. Dandah, Kimberley R. Monden, Kathleen Bell, Ulysses Magalang, Jeanne M. Hoffman, John Whyte, Jennifer Bogner, Jamie M. Zeitzer
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2020)
Article
Neurosciences
Anthony H. Lequerica, Erica Weber, Marcel P. Dijkers, Kristen Dams-O'Connor, Stephanie A. Kolakowsky-Hayner, Kathleen R. Bell, Tamara Bushnik, Yelena Goldan, Flora M. Hammond
Article
Neurosciences
Kathleen R. Bell, Donald Fogelberg, Jason Barber, Risa Nakase-Richardson, Jennifer M. Zumsteg, Rosemary Dubiel, Kristen Dams-O'Connor, Jeanne M. Hoffman
Summary: In patients with recent traumatic brain injury (TBI), exposure to bright white light (BWL) did not appear to have a significant impact on sleep quality. Despite common complaints of sleep difficulties after TBI, this study was unable to demonstrate the effectiveness of phototherapy as a treatment. Further research is needed to understand the nature and optimal treatment of sleep disorders following TBI, given the growing evidence of the impact of sleep on neural repair and cognition.
Article
Neurosciences
Kan Ding, Takashi Tarumi, Tsubasa Tomoto, Kathleen R. Bell, Christopher Madden, Marisara Dieppa, C. Munro Cullum, Song Zhang, Rong Zhang
Summary: The study demonstrates the feasibility of conducting aerobic exercise training for individuals with traumatic brain injury (TBI) in a community setting and improving cardiorespiratory fitness. However, exploring ways to enhance adherence is crucial for future exercise clinical trials to improve brain health in this population.
Article
Psychology, Clinical
Stephen C. Bunt, Nyaz Didehbani, Christian LoBue, Mathew Stokes, Morgan Heinzelmann, Heidi Rossetti, Shane M. Miller, Paul A. Nakonezny, Kathleen Bell, Hunt Batjer, C. Munro Cullum
Summary: This study examines differences in concussion symptom reporting between adult females and males, finding that females report higher levels of symptom severity and an increased risk of developing these symptoms following a concussion.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Rehabilitation
Tri Pham, Rachel Green, Stephanie Neaves, Linda S. Hynan, Kathleen R. Bell, Shannon B. Juengst, Rong Zhang, Simon Driver, Kan Ding
Summary: This study investigated the levels of physical activity and perceived barriers to physical activity in individuals with moderate-to-severe traumatic brain injury (TBI). The results showed that individuals aged 45 and above were less likely to meet the recommended physical activity guidelines compared to younger individuals. The perceived barriers to physical activity varied depending on age and physical activity levels, suggesting the need for individualized approaches to promote physical activity in this population.
Article
Psychology, Clinical
Stephen C. Bunt, Christian LoBue, Linda S. Hynan, Nyaz Didehbani, Mathew Stokes, Shane M. Miller, Kathleen Bell, C. Munro Cullum
Summary: Delay in initial evaluation of concussion may result in persisting and worsening symptoms during recovery. Education and earlier clinical evaluation are important in promoting better recovery and reducing persisting concussion symptoms.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Review
Rehabilitation
Arthur J. De Luigi, Kathleen R. Bell, Joe P. Bramhall, Meeryo Choe, Katherine Dec, Jonathan T. Finnoff, Mark Halstead, Stanley A. Herring, Jason Matuszak, P. B. Raksin, Jennifer Swanson, Carolyn Millett
Summary: Early diagnosis and appropriate management of concussion/mTBI is crucial for preventing poor outcomes and minimizing healthcare burden. This study systematically reviewed the available evidence on therapeutic interventions for concussion/mTBI and developed a consensus statement on their use in clinical practice. The panel found that exercise is an appropriate therapy for acute concussion in adolescents, but there is limited evidence for other interventions. High-quality randomized studies are needed to evaluate the effects of rest, rehabilitation, and return to activity protocols for concussion/mTBI management.
Article
Medicine, Research & Experimental
Brittany Wright, Renie Guilliod, Bhaskar Thakur, Charles Kundig, Jill Morales, Joseph Tessler, James Berry, Rong Zhang, Kathleen R. Bell, Shanti M. Pinto
Summary: Post-Concussion Syndrome (PCS) refers to the persistence of physical, cognitive, and emotional symptoms following mild traumatic brain injury (mTBI)/concussion, occurring in roughly 15-30% of individuals. Hyperbaric oxygen therapy (HBOT) is being studied as a potential treatment for PCS, but the evidence is inconclusive due to inconsistent treatment protocols and focus on a specific population. The HOT-POCS study aims to evaluate the effectiveness and safety of HBOT in treating PCS in the general population.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Psychology, Clinical
Kristin Wilmoth, Alexander Tan, Tahnae Tarkenton, Heidi C. Rossetti, Linda S. Hynan, Nyaz Didehbani, Shane M. Miller, Kathleen R. Bell, C. Munro Cullum
Summary: This study explores the predictive role of post-concussion mood and sleep symptoms on recovery time in adolescent athletes. The results show that concussion symptoms and sleep quality are associated with recovery, and there are differences in symptom presentation between genders. Assessing post-concussion symptoms is useful in identifying individuals at risk for longer recovery.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Psychology, Clinical
Stephen C. Bunt, Tawny Meredith-Duliba, Nyaz Didehhani, Linda S. Hynan, Christian LoBue, Mathew Stokes, Shane M. Miller, Kathleen Bell, Hunt Batjer, C. Munro Cullum
Summary: The study found that lower resilience ratings at the initial visit were associated with a greater number and severity of post-concussion symptoms, as well as higher levels of anxiety and depression symptoms during recovery. Subjects with lower initial resilience ratings were less likely to report feeling back to normal at three months and experienced greater aggravation of symptoms from physical and cognitive activity even after returning to sports/physical activity.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2021)
Article
Medicine, Research & Experimental
Simon Driver, Shannon Juengst, Evan Elizabeth McShan, Monica Bennett, Kathleen Bell, Rosemary Dubiel
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2019)
Article
Psychology, Multidisciplinary
Wesley R. Cole, Jo Ann Brockway, Jesse R. Fann, Angelica P. Ahrens, Samantha Hurst, Tessa Hart, Simona Vuletic, Nigel Bush, Kathleen R. Bell
MILITARY PSYCHOLOGY
(2019)
