Article
Multidisciplinary Sciences
Tzu-Hui Pao, Ying-Yuan Chen, Wei-Lun Chang, Jeffrey Shu-Ming Chang, Nai-Jung Chiang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen, Ta-Jung Chung, Forn-Chia Lin
Summary: The study found that T4 and esophageal stenosis at baseline were independent risk factors for esophageal fistula in ESCC patients treated with definitive CCRT with IMRT. Patients who received repair or stenting for esophageal perforation appeared to have a trend towards improved survival.
Article
Oncology
Koichi Ogawa, Hitoshi Ishikawa, Katsuji Hisakura, Yuichi Hiroshima, Toshikazu Moriwaki, Takeshi Yamada, Yoshiyuki Yamamoto, Yoshimasa Akashi, Yohei Owada, Yusuke Ohara, Tsuyoshi Enomoto, Kinji Furuya, Manami Doi, Osamu Shimomura, Kazuhiro Takahashi, Shinji Hashimoto, Hideyuki Sakurai, Tatsuya Oda
Summary: This study compared long-term outcomes between neoadjuvant chemotherapy + surgery and definitive chemoradiotherapy with proton beam therapy for locally advanced esophageal squamous cell carcinoma. The results showed that long-term outcomes were comparable between the treatments, but the choice of treatment according to cT classification might affect survival.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Article
Oncology
James R. Janopaul-Naylor, Yichun Cao, Neal S. McCall, Jeffrey M. Switchenko, Sibo Tian, Haijian Chen, William A. Stokes, Aparna H. Kesarwala, Mark W. McDonald, Joseph W. Shelton, Jeffrey D. Bradley, Kristin A. Higgins
Summary: Definitive IMPT re-irradiation for lung cancer can prolong disease control with limited toxicity, particularly in the immunotherapy era.
FRONTIERS IN ONCOLOGY
(2023)
Review
Engineering, Biomedical
Wenhua Cao, Humberto Rocha, Radhe Mohan, Gino Lim, Hadis M. Goudarzi, Brigida C. Ferreira, Joana M. Dias
Summary: This article discusses the importance of beam configuration optimization (BCO) in intensity-modulated proton radiotherapy (IMPT). It highlights the challenges posed by the unique properties and requirements of protons in IMPT and the need to modify or develop new effective and efficient BCO algorithms specifically for IMPT.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wing-Keen Yap, Ming-Chieh Shih, Yu-Chen Chang, Chia-Hsin Lin, Shih-Ming Huang, Tsung-You Tsai, Ching-Fu Chang, Chih-Chung Hsu, Chen-Kan Tseng, Miao-Fen Chen, Din-Li Tsan, Chi-Ting Liau, Ming-Mo Hou, Yin-Kai Chao, Chien-Hung Chiu, Tsung-Min Hung
Summary: This study found that adjuvant chemoradiotherapy was associated with improved clinical outcomes in patients with resected esophageal squamous cell carcinoma staged as ypT3/T4 and/or ypN+ after undergoing neoadjuvant chemoradiotherapy.
Article
Oncology
Sehhoon Park, Dongryul Oh, Yoon-La Choi, Sang Ah Chi, Kyunga Kim, Myung-Ju Ahn, Jong-Mu Sun
Summary: Durvalumab and tremelimumab combined with definitive concurrent chemoradiotherapy showed promising efficacy in patients with locally advanced esophageal squamous cell carcinoma (ESCC), and PD-L1 expression had strong predictive value in predicting survival outcomes for these patients.
Article
Oncology
Christopher Nutting, Laura Finneran, Justin Roe, Mark A. Sydenham, Matthew Beasley, Shree Bhide, Cheng Boon, Audrey Cook, Emma De Winton, Marie Emson, Bernadette Foran, Robert Frogley, Imran Petkar, Laura Pettit, Keith Rooney, Tom Roques, Devraj Srinivasan, Justine Tyler, DARS Trialist Grp
Summary: The study found that dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) improved swallowing function and reduced radiation dose-related damage in patients with oropharyngeal and hypopharyngeal cancers. Therefore, DO-IMRT should be considered as a new standard treatment for patients receiving radiotherapy for pharyngeal cancers.
Article
Oncology
Maarten C. C. M. Hulshof, Elisabeth D. Geijsen, Tom Rozema, Vera Oppedijk, Jeroen Buijsen, Karen J. Neelis, Joost J. M. E. Nuyttens, Maurice J. C. van der Sangen, Paul M. Jeene, Jannie G. Reinders, Mark I. van Berge Henegouwen, Adriana Thano, Jeanin E. van Hooft, Hanneke W. M. van Laarhoven, Ate van der Gaast
Summary: In definitive chemoradiation for esophageal cancer, escalating radiation dose up to 61.6 Gy to the primary tumor did not significantly improve local tumor control compared to 50.4 Gy. The absence of a dose-effect was observed in both adenocarcinoma and squamous cell carcinoma.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Tzu-Ting Huang, Shau-Hsuan Li, Yen-Hao Chen, Hung- Lu, Chien-Ming Lo, Fu-Min Fang, Shang-Yu Chou, Yi-Chun Chiu, Yeh-Pin Chou, Yu-Ming Wang
Summary: The study demonstrated that long-term survival is achievable for patients with cT4b thoracic esophageal cancer treated with dCRT, with a 3-year survival rate exceeding 20%. Locoregional recurrence was the most common failure pattern. Significant prognosticators for patient survival included age, BMI, N stage, and tumor length.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Hiroyasu Tamamura, Kenkei Hasatani, Sae Matsumoto, Satoko Asahi, Hitoshi Tatebe, Yoshitaka Sato, Keiichiro Matsusita, Yuji Tameshige, Yoshikazu Maeda, Makoto Sasaki, Shigeyuki Takamatsu, Kazutaka Yamamoto
Summary: Early-stage esophageal cancer with extensive lymph node metastasis requires elective nodal irradiation for chemoradiotherapy. Determining the appropriate dose for prophylactic irradiation is important. This study found that a dose of 36 Gy was effective in preventing lymph node metastasis and reducing adverse events.
Article
Oncology
Yoon Young Jo, Jesang Yu, Kye Jin Song, Jeong Yun Jang, Ye Jin Yoo, Sung-Bae Kim, Sook Ryun Park, Yong-Hee Kim, Hyeong Ryul Kim, Jong Hoon Kim
Summary: For clinical T1bN0 esophageal squamous cell carcinoma, definitive chemoradiotherapy (DCRT) and radical esophagectomy showed similar survival rates, recurrence patterns, and complication rates.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Jing You, Shuchai Zhu, Jiancheng Li, Jie Li, Junyue Shen, Yidian Zhao, Xiaomin Li, Lin Jia, Qingshan Li, Jun Yang, Yiqun Wu, Wenbin Shen, Haishan Wu, Xueqin Wu, Xiaomin Wang, Yaqiong Ren, Jun He, Pingping Lin, Guangying Zhu, Anhui Shi
Summary: This study aimed to investigate whether a high dose of 59.4 Gy using intensity-modulated radiation therapy (IMRT) would improve survival without increasing toxicities in patients with esophageal cancer. The results showed that a high dose of radiation did not improve survival compared to the standard dose in patients with inoperable thoracic esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Olsi Gjyshi, Ting Xu, Adnan Elhammali, David Boyce-Fappiano, Stephen G. Chun, Saumil Gandhi, Percy Lee, Aileen B. Chen, Steven H. Lin, Joe Y. Chang, Anne Tsao, Carl M. Gay, X. Ronald Zhu, Xiaodong Zhang, John V. Heymach, Frank V. Fossella, Charles Lu, Quynh-Nhu Nguyen, Zhongxing Liao
Summary: This study compared the toxicity and clinical outcomes of IMPT and PSPT in the treatment of LA-NSCLC, showing that IMPT delivers lower radiation doses to the lung, heart, and esophagus, with lower rates of grade 3 or higher toxicity. Additional clinical studies will be needed to assess potential differences in survival between the two techniques.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Oncology
J. M. Alberga, J. Meijer, G. M. Raghoebar, J. A. Langendijk, A. Korfage, R. J. H. M. Steenbakkers, T. W. H. Meijer, H. Reintsema, A. Vissink, M. J. H. Witjes
Summary: This study compared the radiation dosimetrics of tooth-bearing regions in head and neck cancer patients using IMPT and VMAT, and found that IMPT significantly reduces the radiation dose to these regions.
Article
Oncology
Fan Li, Yan Xu, Bovey Liu, Pankaj Kumar Singh, Wei Zhao, Jiankang Jin, Guangchun Han, Ailing W. Scott, Xiaochuan Dong, Longfei Huo, Lang Ma, Melissa Pool Pizzi, Ying Wang, Yuan Li, Kazuto Harada, Min Xie, Heath D. Skinner, Sheng Ding, Linghua Wang, Sunil Krishnan, Randy L. Johnson, Shumei Song, Jaffer A. Ajani
CLINICAL CANCER RESEARCH
(2019)
Review
Pharmacology & Pharmacy
Anthony Lopez, Kazuto Harada, Maria Vasilakopoulou, Namita Shanbhag, Jaffer A. Ajani
Article
Cardiac & Cardiovascular Systems
Scott M. Atay, Arlene Correa, Wayne L. Hofstetter, Stephen G. Swisher, Jaffer Ajani, Nassar K. Altorki, Shanda H. Blackmon, Eugene H. Blackstone, Thomas W. Rice, Traves D. Crabtree, Thomas A. D'Amico, Gail E. Darling, Steven R. DeMeester, Thomas R. DeMeester, Stephanie G. Worrell, Lorenzo E. Ferri, Henning A. Gaissert, Mark J. Krasna, Antoon Lerut, Phillippe Nafteux, Johnny Moons, Alex G. Little, Donald E. Low, Phillip W. Carrott, Henner M. Schmidt, Daniel Miller, Katie S. Nason, James D. Luketich, Mark B. Orringer, Andrew C. Chang, Nabil P. Rizk, Jarmo A. Salo, Paul M. Schneider, Bernard Mark Smithers, Daniel Vallboehmer, J. J. van Lanschot, Thomas K. Varghese, Thomas J. Watson, Jeff H. Peters, Stephen C. Yang
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2019)
Editorial Material
Oncology
Kazuto Harada, Ahmed A. F. Abdelhakeem, Jaffer A. Ajani
NATURE REVIEWS CLINICAL ONCOLOGY
(2019)
Article
Oncology
Yuki Koga, Masaaki Iwatsuki, Kohei Yamashita, Yuki Kiyozumi, Junji Kurashige, Toshiro Masuda, Kojiro Eto, Shiro Iwagami, Kazuto Harada, Takatsugu Ishimoto, Yoshifumi Baba, Naoya Yoshida, Nobutomo Miyanari, Hiroshi Takamori, Jaffer A. Ajani, Hideo Baba
Article
Oncology
Jane E. Rogers, Lianchun Xiao, Fatemeh G. Amlashi, Elena Elimova, Mariela A. Blum Murphy, Elizabeth Sanders, Namita Shanbhag, Irene Thomas, Jaffer A. Ajani
Article
Oncology
Hector G. van den Boom, Ameen Abu-Hanna, Emil ter Veer, Jessy Joy van Kleef, Florian Lordick, Michael Stahl, Jaffer A. Ajani, Rosine Guimbaud, Se Hoon Park, Susan J. Dutton, Yung-Jue Bang, Narikazu Boku, Nadia Haj Mohammad, Mirjam A. G. Sprangers, Rob H. A. Verhoeven, Aeilko H. Zwinderman, Martijn G. H. van Oijen, Hanneke W. M. van Laarhoven
Article
Oncology
Yuping Yin, Weizhen Liu, Qian Shen, Peng Zhang, Lulu Wang, Ruikang Tao, Hang Li, Xianxiong Ma, Xiangyu Zeng, Jae-Ho Cheong, Shumei Song, Jaffer A. Ajani, Gordon B. Mills, Kaixiong Tao, Guang Peng
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Oncology
Alexander P. Stark, Naruhiko Ikoma, Yi-Ju Chiang, Jeannelyn S. Estrella, Prajnan Das, Bruce D. Minsky, Mariela M. Blum, Jaffer A. Ajani, Paul Mansfield, Brian D. Badgwell
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Kohei Yamashita, Masaaki Iwatsuki, Kazuto Harada, Yuki Koga, Yuki Kiyozumi, Kojiro Eto, Yukiharu Hiyoshi, Takatsugu Ishimoto, Shiro Iwagami, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Yoshihiro Komohara, Jaffer A. Ajani, Hideo Baba
BRITISH JOURNAL OF CANCER
(2019)
Article
Gastroenterology & Hepatology
Ruiping Wang, Shumei Song, Kazuto Harada, Fatemeh Ghazanfari Amlashi, Brian Badgwell, Melissa Pool Pizzi, Yan Xu, Wei Zhao, Xiaochuan Dong, Jiangkang Jin, Ying Wang, Ailing Scott, Lang Ma, Longfei Huo, Diego Vicente, Mariela Blum Murphy, Namita Shanbhag, Ghia Tatlonghari, Irene Thomas, Jane Rogers, Makoto Kobayashi, Jody Vykoukal, Jeannelyn Santiano Estrella, Sinchita Roy-Chowdhuri, Guangchun Han, Shaojun Zhang, Xizeng Mao, Xingzhi Song, Jianhua Zhang, Jian Gu, Randy L. Johnson, George Adrian Calin, Guang Peng, Ju-Seog Lee, Samir M. Hanash, Andrew Futreal, Zhenning Wang, Linghua Wang, Jaffer A. Ajani
Review
Oncology
Jaffer A. Ajani, Thomas A. D'Amico, David J. Bentrem, Joseph Chao, Carlos Corvera, Prajnan Das, Crystal S. Denlinger, Peter C. Enzinger, Paul Fanta, Farhood Farjah, Hans Gerdes, Michael Gibson, Robert E. Glasgow, James A. Hayman, Steven Hochwald, Wayne L. Hofstetter, David H. Ilson, Dawn Jaroszewski, Kimberly L. Johung, Rajesh N. Keswani, Lawrence R. Kleinberg, Stephen Leong, Quan P. Ly, Kristina A. Matkowskyj, Michael McNamara, Mary F. Mulcahy, Ravi K. Paluri, Haeseong Park, Kyle A. Perry, Jose Pimiento, George A. Poultsides, Robert Roses, Vivian E. Strong, Georgia Wiesner, Christopher G. Willett, Cameron D. Wright, Nicole R. McMillian, Lenora A. Pluchino
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2019)
Article
Oncology
Kohei Yamashita, Masaaki Iwatsuki, Kazuto Harada, Kojiro Eto, Yukiharu Hiyoshi, Takatsugu Ishimoto, Yohei Nagai, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Yoshihiro Komohara, Jaffer A. Ajani, Hideo Baba
Correction
Immunology
Vesteinn Thorsson, David L. Gibbs, Scott D. Brown, Denise Wolf, Dante S. Bortone, Tai-Hsien Ou Yang, Eduard Porta-Pardo, Galen F. Gao, Christopher L. Plaisier, James A. Eddy, Elad Ziv, Aedin C. Culhane, Evan O. Paull, I. K. Ashok Sivakumar, Andrew J. Gentles, Raunaq Malhotra, Farshad Farshidfar, Antonio Colaprico, Joel S. Parker, Lisle E. Mose, Nam Sy Vo, Jianfang Liu, Yuexin Liu, Janet Rader, Varsha Dhankani, Sheila M. Reynolds, Reanne Bowlby, Andrea Califano, Andrew D. Cherniack, Dimitris Anastassiou, Davide Bedognetti, Younes Mokrab, Aaron M. Newman, Arvind Rao, Ken Chen, Alexander Krasnitz, Hai Hu, Tathiane M. Malta, Houtan Noushmehr, Chandra Sekhar Pedamallu, Susan Bullman, Akinyemi I. Ojesina, Andrew Lamb, Wanding Zhou, Hui Shen, Toni K. Choueiri, John N. Weinstein, Justin Guinney, Joel Saltz, Robert A. Holt, Charles S. Rabkin, Alexander J. Lazar, Jonathan S. Serody, Elizabeth G. Demicco, Mary L. Disis, Benjamin G. Vincent, Ilya Shmulevich
Article
Oncology
Zhimin Tong, Alicia Mejia, Omkara Veeranki, Anuj Verma, Arlene M. Correa, Rashmi Dokey, Viren Patel, Luisa Maren Solis, Barbara Mino, Riham Kathkuda, Jaime Rodriguez-Canales, Steven H. Lin, Sunil Krishnan, Scott Kopetz, Mariela Blum, Jaffer A. Ajani, Wayne L. Hofstetter, Dipen M. Maru
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2019)