Article
Oncology
Heleen Bollen, Julie van der Veen, Annouschka Laenen, Sandra Nuyts
Summary: IMRT and VMAT have become standard of care in treating head and neck cancer. By analyzing treatment failure patterns, this study indirectly investigated the quality of target volume delineation and treatment delivery, which were performed accurately with few recurrences outside high-dose regions and no marginal failures observed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kentoku Fujisawa, Yu Ohkura, Masaki Ueno, Yusuke Ogawa, Hayato Shimoyama, Shusuke Haruta, Harushi Udagawa
Summary: Preserving the bronchial artery is associated with a decreased incidence of postoperative pneumonia.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Esteban Brenet, Pierre Philouze, Camille Schiffler, Pascal Pommier, Carole Crozes, Nazim Benzerdjeb, Elodie Monchet, Camille Boulagnon-Rombi, Jean Ton Van, Fabien Podeur, Stephanie Servagi-Vernat, Xavier Liem, Jean-Claude Merol, Philippe Ceruse, Anne-Agathe Serre, Sylvie Chabaud, Morbize Julieron, Sophie Deneuve
Summary: This study compared the impact of two radiation modalities on loco-regional control, survival, and tumor emergence in patients with unilateral head and neck carcinoma of unknown primary. The results showed similar outcomes in terms of locoregional control, contralateral lymph node recurrence, and tumor emergence between the UL-RT and COMP-RT groups.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yong Han, Haofei Hu, Yufei Liu, Qiming Li, Zhiqiang Huang, Zhibin Wang, Dehong Liu, Longning Wei
Summary: Congestive heart failure (CHF) is an independent risk factor for 1-year mortality after surgery, with patients experiencing a 24-54% increased risk of all-cause mortality. This study provides important information for clinical decision-making and improving patient consultations and communication.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Ruben Bellotti, Benno Cardini, Carola J. Strolz, Stefan Staettner, Rupert Oberhuber, Eva Braunwarth, Thomas Resch, Stefan Scheidl, Christian Margreiter, Stefan Schneeberger, Dietmar Ofner, Manuel Maglione
Summary: This study compared three different reconstruction techniques for pancreaticoduodenectomy, and found that they did not significantly affect the rates of postoperative complications. However, pancreatogastrostomy had a higher incidence of post-pancreatectomy hemorrhage, indicating the need for meticulous hemostasis during the surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Fabio Salvatore Macaluso, Marco Ventimiglia, Walter Fries, Anna Viola, Aldo Sitibondo, Maria Cappello, Barbara Scrivo, Anita Busacca, Antonino Carlo Privitera, Salvatore Camilleri, Serena Garufi, Roberto Di Mitri, Filippo Mocciaro, Nunzio Belluardo, Emiliano Giangreco, Carmelo Bertolami, Sara Renna, Rosalba Orlando, Giulia Rizzuto, Mario Cottone, Ambrogio Orlando
Summary: In this study comparing VDZ and ADA in CD using propensity score analysis, the drugs showed comparable effectiveness and a similar safety profile.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Gareth Crouch, Shiba Sinha, Serigne Lo, Robyn P. M. Saw, Kenneth K. Lee, Jonathan Stretch, Kerwin Shannon, Pascale Guitera, Richard A. Scolyer, John F. Thompson, Sydney Ch'ng
Summary: This study assessed clinical outcomes of wide local excision for lentigo maligna in head and neck region, finding that a histological margin of >= 3.0 mm is required to minimize recurrence, which necessitates a surgical margin of >= 6.5 mm. Careful long-term follow-up is necessary for all patients to prevent recurrence.
Article
Nutrition & Dietetics
En-Ying Wang, Mu-Kuan Chen, Ming-Yu Hsieh, Chew-Teng Kor, Yen-Tze Liu
Summary: The nutritional status of cancer patients is closely related to their survival and surgical outcomes. This study investigated the association between preoperative prognostic nutritional index (PNI) and post-operative clinical outcomes in head and neck cancer patients. The results showed that patients with a high PNI had a lower incidence of overall complications, medical complications, and pulmonary complications, but no significant difference in surgical complications. The high PNI group also had a lower risk of mortality. These findings suggest that the PNI score can serve as an independent predictor of postoperative complications in head and neck cancer patients undergoing surgical resection. Preoperative testing and evaluation of PNI may help identify patients at low PNI and high-risk for postoperative surveillance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lin Yan, Mingbo Zhang, Qing Song, Fang Xie, Yukun Luo
Summary: The impact of multifocality on the prognosis after RFA for low-risk PTMC was minimal, indicating that RFA may be a promising treatment for both unifocal and multifocal PTMC in properly selected patients after sufficient preoperative evaluation.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Herbert Riechelmann, Daniel Dejaco, Teresa Bernadette Steinbichler, Anna Lettenbichler-Haug, Maria Anegg, Ute Ganswindt, Gabriele Gamerith, David Riedl
Summary: This study reported the functional outcomes of 681 newly diagnosed head and neck cancer (HNC) patients using the HNC-Functional InTegrity (FIT) Scales. The results showed that 61% of patients had normal or near-normal outcomes in all six functional domains, while clinically relevant impairment in at least one domain was observed in 30% of patients and loss of function in at least one domain was observed in 9% of patients. These findings suggest that clinically relevant persistent functional deficits should be expected in 40% of HNC patients. Treatment of these deficits is an important task of oncologic follow-up.
Article
Immunology
Zixuan Hu, Jiaying Zhou, Yupeng Li, Yizhao Luan, Huan Li, Bo Jia, Zhi Xie, Bin Cheng, Tong Wu
Summary: This study explored the relationship between peripheral immune signatures and the survival of head and neck squamous cell carcinoma (HNSCC) patients. The peripheral neutrophil-to-lymphocyte ratio (pNLR) was identified as a significant prognostic indicator. Analysis of tumor RNA-seq data further confirmed the association between high tissue NLR and poor prognosis, as well as the enrichment of immune-related genes in different prognostic groups. The correlation between peripheral immune signatures and the tumor immune microenvironment (TIME) was confirmed in an independent cohort. Overall, the findings suggest that pNLR is a feasible prognostic signature reflecting the TIME patterns in HNSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Jo Omata, Yushi Ueki, Takeshi Takahashi, Ryusuke Shodo, Keisuke Yamazaki, Kohei Saijo, Hisayuki Ota, Takafumi Togashi, Yuichiro Sato, Arata Horii
Summary: The study compared outcomes and safety of chemoradiotherapy in elderly versus non-elderly patients with head and neck squamous cell carcinoma. While elderly patients received lower doses of cisplatin during treatment and had fewer salvage treatments after recurrence, their overall survival rates were comparable to those of non-elderly patients after adjusting for background factors.
FRONTIERS IN SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lei Xiong, Huajiao Yu, Wei Wei, Chong Wang, Bo Li, Huan Liu, Aoming Cheng, Delong Li, Zhengxue Han, Zhien Feng
Summary: This study investigated the impact of chemotherapy on the risk of second primary head and neck malignancies in patients with locally advanced oral squamous cell carcinoma, as well as the survival outcomes of these patients. The results showed that chemotherapy reduced the incidence of subsequent head and neck malignancies, but did not improve disease-free survival in patients with these malignancies.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Oncology
Min-Young Do, Sung-Ill Jang, Hua-Pyong Kang, Eui-Joo Kim, Kyong-Joo Lee, Go-Eun Park, Su-Jee Lee, Dong-Ki Lee, Sang-Myung Woo, Jae-Hee Cho
Summary: Neuroendocrine neoplasms of the gallbladder are rare and often diagnosed at advanced stages, but patients who undergo surgical resection for GB-NEC have improved progression-free survival. Overall survival and PFS are similar between stage-matched GB-NEC and GB-ADC patients, highlighting the need for early diagnosis and improved survival strategies for GB-NEC.
Article
Oncology
Michael T. Brennan, Nathaniel S. Treister, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Alexander Lin, Linda S. Elting, James S. Hodges, Rajesh Lalla
Summary: This study aimed to investigate tooth failure in head and neck cancer patients after radiation therapy (RT). The results demonstrated that tooth failure occurred within 2 years after RT, and factors such as baseline tooth count, reduction in salivary flow rate, and noncompliance with oral hygiene were associated with a higher risk of tooth failure.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
J. Eber, B. Leroy-Freschini, D. Antoni, G. Noel, C. Pflumio
Summary: Radiation-induced heart disease is a complication that typically occurs years after thoracic irradiation. However, recent studies suggest that it can also be an earlier complication with subclinical cardiac injury. A case study described a patient who had abnormal cardiac metabolism detected incidentally after breast irradiation, but remained asymptomatic with normal angiography, indicating radiation-induced hibernating myocardium.
CANCER RADIOTHERAPIE
(2022)
Article
Oncology
Isaure Roquette, Emilie Bogart, Thomas Lacornerie, Massih Ningarhari, Jean-Emmanuel Bibault, Marie-Cecile Le Deley, Eric F. Lartigau, David Pasquier, Xavier Mirabel
Summary: This study describes the treatment efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC). The analysis of data from 318 patients showed that SBRT is efficient for the management of HCC with a favorable toxicity profile.
Article
Radiology, Nuclear Medicine & Medical Imaging
Arnaud Beddok, Fanny Orlhac, Valentin Calugaru, Laurence Champion, Catherine Ala Eddine, Christophe Nioche, Gilles Crehange, Irene Buvat
Summary: The purpose of this study was to evaluate whether radiomics from [18F]-FDG PET and/or MRI before re-irradiation could predict the occurrence and location of a second locoregional recurrence in patients with recurrent head and neck cancer. Radiomic features extracted from pre-reRT PET and MRI were used to create prediction models. The results showed that the models based on MRI and PET could predict the occurrence and location of recurrence with accuracy rates ranging from 78.5% to 84.5%.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Yungan Tao, Xu-Shan Sun, Yoann Pointreau, Christophe Le Tourneau, Christian Sire, Marie-Christine Kaminsky, Alexandre Coutte, Marc Alfonsi, Benoit Calderon, Pierre Boisselier, Laurent Martin, Jessica Miroir, Jean-Francois Ramee, Jean-Pierre Delord, Florian Clatot, Frederic Rolland, Julie Villa, Nicolas Magne, Olgun Elicin, Elisabeta Gherga, France Nguyen, Cedrik Lafond, Guillaume Bera, Valentin Calugaru, Lionnel Geoffrois, Bruno Chauffert, Lars Damstrup, Philippa Crompton, Abdallah Ennaji, Kathrin Gollmer, Heidi Nauwelaerts, Jean Bourhis
Summary: This study compared the long-term efficacy and overall survival of xevinapant plus standard chemoradiotherapy with placebo plus chemoradiotherapy in patients with unresected locally advanced squamous cell carcinoma of the head and neck. The results showed that xevinapant plus CRT significantly reduced the risk of locoregional failure, death or disease progression, and prolonged overall survival in patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Benoit Lhermitte, Thibaut Wolf, Marie Pierre Chenard, Andres Coca, Julien Todeschi, Francois Proust, Edouard Hirsch, Roland Schott, Georges Noel, Eric Guerin, Damien Reita, Agathe Chammas, Alexandra Salmon, Sophie Martin, Monique Dontenwill, Natacha Entz-Werle
Summary: Drugs targeting activating BRAF mutations have transformed the prognosis and treatment of MAPK-pathway-induced cancers. The better knowledge of the MAPK pathway's involvement in gliomagenesis offers hope in brain cancers where conventional therapies have produced disappointing results. This review summarizes the current literature regarding BRAF-altered gliomas, their molecular diagnosis, prognosis, associated molecular alterations, and potential treatment options.
Article
Oncology
Lucas Geyer, Thibaut Wolf, Marie-Pierre Chenard, Helene Cebula, Roland Schott, Georges Noel, Eric Guerin, Erwan Pencreach, Damien Reita, Natacha Entz-Werle, Benoit Lhermitte
Summary: The 2021 WHO classification of central nervous system tumors is a histomolecular classification system that incorporates molecular data to improve patient prognoses and treatments. CDKN2A homozygous deletion is associated with poor prognosis in various types of gliomas, and its detection requires complex techniques. This study investigates the clinical significance of p16 immunohistochemical expression in gliomas and its correlation with CDKN2A homozygous deletion.
Article
Oncology
Jordan Eber, Cyrille Blondet, Martin Schmitt, David G. Cox, Claire Vit, Clara Le Fevre, Delphine Antoni, Fabrice Hubele, Georges Noel
Summary: Breast radiotherapy can cause radiation-induced cardiac disease, especially in left breast cancers. A prospective single-center study will be conducted to explore alternative approaches, such as deep inspiration breath hold radiotherapy and intensity modulated radiation therapy, to reduce the risk of myocardial perfusion defects in patients with left breast cancer. The study will use stress and resting myocardial scintigraphy to assess myocardial perfusion and aims to demonstrate the effectiveness of reducing cardiac dose in preventing early and medium-term perfusion disorders.
Review
Oncology
Arthur Lebas, Clara Le Fevre, Waisse Waissi, Isabelle Chambrelant, David Brinkert, Georges Noel
Summary: This article provides a systematic review of studies on soft tissue sarcomas of the extremities treated with radiotherapy. The analysis reveals the great heterogeneity among these studies and the difficulty in identifying significant prognostic factors for the benefit of radiotherapy. The review provides valuable insights for optimizing radiotherapy treatment for patients with soft tissue sarcomas of the extremities.
Article
Oncology
Laure Kuntz, Clara Le Fevre, Delphine Jarnet, Audrey Keller, Philippe Meyer, Christophe Mazzara, Helene Cebula, Georges Noel, Delphine Antoni
Summary: This retrospective study analyzed the data of patients who received at least two courses of SRT between 2010 and 2020. The results showed that NDFS and OS after SRT were influenced by various factors, including the number of treatments, patient condition, salvage WBRT, and metastasis velocity.
Review
Oncology
Isabelle Chambrelant, Delphine Jarnet, Jolie Bou-Gharios, Clara Le Fevre, Laure Kuntz, Delphine Antoni, Catherine Jenny, Georges Noel
Summary: Solid tumors often cause brain metastases (BMs), and stereotactic radiotherapy (SRT) plays a major role in their treatment. This systematic review summarizes the dosimetric studies of SRT for single BMs and highlights the challenges in comparing different studies due to variations in factors such as PTV margins and volumes, total dose, number of fractions, and isodose prescription. Optimal dosimetric parameters, such as conformity and gradient indexes, need to be considered to minimize radiation exposure to healthy tissue. Future well-designed studies are needed to establish guidelines for selecting the most suitable SRT technique based on the characteristics of treated BMs.
Article
Biochemistry & Molecular Biology
Anasse Nounsi, Joseph Seitlinger, Charlotte Ponte, Julien Demiselle, Ysia Idoux-Gillet, Erwan Pencreach, Michele Beau-Faller, Veronique Lindner, Jean-Marc Balloul, Eric Quemeneur, Helene Burckel, Georges Noel, Anne Olland, Florence Fioretti, Pierre-Emmanuel Falcoz, Nadia Benkirane-Jessel, Guoqiang Hua
Summary: Radiation therapy and platinum-based chemotherapy are common treatments for lung cancer patients. Factors such as the patient's physical state and tumor heterogeneity contribute to the low overall survival rate in lung cancer. This study demonstrates that a patient-derived tumoroid model can be used to predict the efficacy of radiation therapy and cisplatin-based chemotherapy in non-small-cell lung cancer, and the results are correlated to clinical outcomes.
Article
Automation & Control Systems
Zhihao Peng, Vincent Augusto, Lionel Perrier, Xiaolan Xie
Summary: This paper addresses the problem of optimal process mining of event traces and attributes associated with transitions. It proposes a dynamic programming algorithm and a multi-start local optimization algorithm to solve the problem. Experimental results show that the proposed algorithms outperform benchmark algorithms and can generate near optimal process models.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Article
Oncology
Tan Mai Nguyen, Chloe Bertolus, Paul Giraud, Anita Burgun, Pierre Saintigny, Jean-Emmanuel Bibault, Jean-Philippe Foy
Summary: This study aimed to distinguish hot and cold head and neck squamous cell carcinomas (HNSCCs) using imaging data from computed tomography (CT) scans. A computational model was established to determine the hot/cold status non-invasively, which could help identify patients with HNSCC who may benefit from immunotherapy.
Article
Economics
Marius Huguet, Xavier Joutard, Lionel Perrier
Summary: In specialized care, patients' choice of healthcare provider is influenced by the pre-selection process, but they prioritize factors such as waiting times, hospital quality, and other provider attributes in their final decision-making.
Article
Medicine, General & Internal
Evangeline Pillebout, Isabelle Durand-Zaleski, Louis Farge, Lionel Perrier, Clement de Chaisemartin, J. C. K. Dupont, Luc Behaghel, Lise Rochaix
Summary: This study aims to investigate the effectiveness and cost-effectiveness of adding an interactive web-based platform to patient education, as well as whether enhancing the platform with social functions improves its performance. The study will follow patients for 18 months, assessing the cost utility of app-based therapeutic intervention and other secondary endpoints.