Article
Health Care Sciences & Services
Jose Carlos Benitez, Marc Campayo, Tania Diaz, Carme Ferrer, Melissa Acosta-Plasencia, Mariano Monzo, Luis Cirera, Benjamin Besse, Alfons Navarro
Summary: The study demonstrated that lincRNA-p21 expression levels are associated with response to neoadjuvant CRT in rectal cancer patients, serving as a predictive biomarker. It is also correlated with tumor stage, tumor regression grade, and other indicators.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biology
Jeeyong Lee, Junhye Kwon, DaYeon Kim, Misun Park, KwangSeok Kim, InHwa Bae, Hyunkyung Kim, JoonSeog Kong, Younjoo Kim, UiSup Shin, EunJu Kim
Summary: The standard treatment for locally advanced rectal cancer (LARC) involves chemotherapy, radiotherapy, and surgery. Identifying biomarkers that can discriminate radio-responsiveness before surgery is crucial to improve treatment outcomes and reduce side effects. Research has identified candidate genes involved in radio-responsiveness, such as CTSE, which exhibited differential methylation at the promoter region inversely correlated with radio-resistance. This study aims to develop a gene chip for diagnosing radio-responsiveness in LARC patients, with the potential to improve patient prognosis.
Article
Oncology
Hideaki Bando, Yuichiro Tsukada, Koji Inamori, Yosuke Togashi, Shohei Koyama, Daisuke Kotani, Shota Fukuoka, Satoshi Yuki, Yoshito Komatsu, Shigenori Homma, Akinobu Taketomi, Mamoru Uemura, Takeshi Kato, Makoto Fukui, Masashi Wakabayashi, Naoki Nakamura, Motohiro Kojima, Hiroshi Kawachi, Richard Kirsch, Tsutomu Yoshida, Yutaka Suzuki, Akihiro Sato, Hiroyoshi Nishikawa, Masaaki Ito, Takayuki Yoshino
Summary: The study suggests that consolidation treatment with nivolumab after CRT can increase the pCR rate in patients with rectal cancer. PD-L1 expression and an elevated CD8/eTreg ratio are positive predictors in patients with MSS rectal cancer.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Danxiang Chen, Cong Jin, Xubin Dong, Jialiang Wen, Erjie Xia, Qingxuan Wang, Ouchen Wang
Summary: PSMB8 plays a significant role in various malignancies, being closely associated with immune cell infiltration and its impact on the tumor microenvironment. High expression of PSMB8 is correlated with poor clinical outcomes in most cancer types, while also being related to multiple immune-related pathways.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Jun Woo Bong, Seok-Byung Lim, Hyoseon Ryu, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Chang Sik Yu, Jin Cheon Kim
Summary: This study aimed to evaluate the relationship between anaemia and the response to preoperative chemoradiotherapy for rectal cancer and its effect on oncologic outcomes. Anaemia was associated with less pathologic complete regression but was not a risk factor for worse recurrence-free or overall survival. Haemoglobin levels <= 9 g/dL before or during radiotherapy were risk factors for achieving pathologic complete regression after preoperative chemoradiotherapy for rectal cancer.
ANZ JOURNAL OF SURGERY
(2021)
Review
Oncology
Xiaoyu Hu, Zhuang Xue, Kewen He, Yaru Tian, Yu Chen, Mengyu Zhao, Jinming Yu, Jinbo Yue
Summary: Locally advanced rectal cancer (LARC) is a highly heterogeneous tumor group, and the risk of recurrence can be classified by MRI as low to very high according to ESMO guidelines. In the era of precision medicine, treatment decisions should be based on risk stratification. Not all LARC cases are appropriate for the traditional neoadjuvant sandwich strategy. Treatment modalities for LARC have evolved dramatically in recent years, with multiple clinical trials focused on optimizing strategies to improve outcomes for patients.
Article
Oncology
Myroslav Lutsyk, Tarek Taha, Salem Billan
Summary: The aim of this study is to identify factors that may predict the response of locally advanced rectal cancer tumors to neoadjuvant chemoradiotherapy. The study found that an absolute decrease in the level of circulating lymphocytes is associated with poorer tumor response to treatment, and may serve as a predictive biomarker for treatment resistance.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Zhen Yu, Yuying Hao, Yuhua Huang, Ling Ling, Xigang Hu, Simiao Qiao
Summary: Radiotherapy and chemotherapy are effective treatments for locally advanced rectal cancer. New neoadjuvant treatment options need to be explored for better outcomes. Targeted drugs and immunologic agents have shown efficacy in advanced rectal cancer but have not been commonly used in neoadjuvant therapy for LARC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ioannis M. Koukourakis, Erasmia Xanthopoulou, Theologos I. Sgouras, Maria Kouroupi, Alexandra Giatromanolaki, Vassilios Kouloulias, Dina Tiniakos, Anna Zygogianni
Summary: Preoperative radiotherapy can induce changes in the immune phenotype of rectal cancer cells, resulting in the restoration of HLA-class-I expression and the induction of IFN-beta and PD-L1 expression. This suggests that radiotherapy may enhance the efficacy of immunotherapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Caressa Hui, Richel Baclay, Kevin Liu, Navjot Sandhu, Phoebe Loo, Rie von Eyben, Chris Chen, Vipul Sheth, Lucas Vitzthum, Daniel Chang, Erqi Pollon
Summary: This study aimed to determine the optimal treatment for patients with locally advanced rectosigmoid cancers and explore the role of distance from the anal verge and anatomical landmarks in guiding treatment decisions. The study found that the peritoneal reflection (PR) may be a reliable landmark in addition to the distance from the anal verge to determine the most appropriate treatment option. Patients with tumors below the PR may benefit more from neoadjuvant therapy.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)
Article
Multidisciplinary Sciences
Jing Zhang, Lin Zhang, Yuanyuan Gou, Panya Diao, Yi Hu
Summary: The study explores a new system called the NLM score, which combines neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), and examines its prognostic value in patients with Stage II/III rectal cancer undergoing neoadjuvant chemoradiotherapy. The NLM score is found to be an independent prognostic factor with better predictive values than the individual ratios.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Chen, Li Ding, Zhi-wen Zhang, Xue-han Wu, Yu-tao Que, Yu-ru Ma, Yi-yan Liu, Zi-qiang Wen, Xin-yue Yang, Bao-lan Lu, Yong Bao, Shao-qing Niu, Shen-ping Yu
Summary: This study explored the potential of dynamic contrast-enhanced MRI (DCE-MRI) quantitative parameters in predicting severe acute radiation-induced rectal injury (RRI) in rectal cancer patients. The results showed that K-trans demonstrated moderate diagnostic performance in predicting severe acute RRI, providing important non-invasive and objective evidence for perioperative management and treatment strategies in rectal cancer patients.
EUROPEAN RADIOLOGY
(2023)
Article
Surgery
Philip S. Bauer, William C. Chapman, Chady Atallah, Bilal A. Makhdoom, Aneel Damle, Radhika K. Smith, Paul E. Wise, Sean C. Glasgow, Matthew L. Silviera, Steven R. Hunt, Matthew G. Mutch
Summary: In patients with nonmetastatic rectal cancer undergoing neoadjuvant short-course radiation therapy (SC-TNT) or conventional chemoradiotherapy (CRT) followed by proctectomy, there was no significant difference in perioperative complications between the two treatment regimens. SC-TNT did not significantly increase the risk of perioperative complications compared to CRT.
Article
Gastroenterology & Hepatology
Junichi Mazaki, Shunsuke Tsukamoto, Mototaka Miyake, Konosuke Moritani, Ryohei Sakamoto, Dai Shida, Yukihide Kanemitsu
Summary: This study evaluated the long-term oncologic outcomes of radical surgery without preoperative therapy in advanced lower rectal cancer based on circumferential resection margin status in preoperative MRI. The study found that preoperative MRI-predicted circumferential resection margin was associated with relapse-free survival without preoperative therapy, indicating its potential for use in selecting optimal preoperative therapy.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Oncology
Jin Cheon Kim, Jong Hwan Kim, Ye Jin Ha, Chan Wook Kim, Ka Hee Tak, Yong Sik Yoon, Yi Hong Kwon, Seon Ae Roh, Dong-Hyung Cho, Seon-Kyu Kim, Seon-Young Kim, Yong Sung Kim
Summary: Genomic analysis based on the revised Bethesda guidelines and additional criteria revealed specific somatic alterations related to colorectal cancer subtypes, such as location, early onset, and MSI status. Certain gene mutations were associated with gastric cancer in CRC pedigrees, while further validation is required for surveillance strategies in suspected individuals.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
A-Yeong Yang, Eun-Bee Choi, Mi So Park, Seon-Kyu Kim, Min-Seok Park, Mi-Young Kim
Summary: The cooperative roles of PARP1 and PRC2 in BRCA-proficient TNBC have been shown to accelerate tumor growth, mainly by altering the tumor microenvironment to promote cellular proliferation. Mechanistically, dual depletion of PARP1 and PRC2 activates the NF-kappa B pathway, enhancing responsiveness to external stimuli.
Article
Biochemistry & Molecular Biology
Seon-Kyu Kim, Seong-Hwan Park, Yeong Uk Kim, Young Joon Byun, Xuan-Mei Piao, Pildu Jeong, Kyeong Kim, Hee Youn Lee, Sung Pil Seo, Ho Won Kang, Won Tae Kim, Yong-June Kim, Sang-Cheol Lee, Sung-Kwon Moon, Yung Hyun Choi, Wun-Jae Kim, Seon-Young Kim, Seok Joong Yun
Summary: A molecular signature, MSP888, has been identified for Non-muscle-invasive bladder cancer (NMIBC) that can predict heterogeneity and responses to Bacillus Calmette-Guerin (BCG) therapy. This signature includes three distinct molecular subtypes, with DP.BCG+ related to progression and response to BCG treatment, and REC.BCG+ related to recurrence and response to BCG treatment. These findings enhance understanding of NMIBC prognosis and the effectiveness of BCG therapy, potentially improving clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Dong Hyuck Bae, Hee-Jin Kim, Byoung-Ha Yoon, Jong-Lyul Park, Mirang Kim, Seon-Kyu Kim, Seon-Young Kim, Sang-Il Lee, Kyu-Sang Song, Yong Sung Kim
Summary: Epigenetic changes in chromatin, such as hypomethylation of the STK31 promoter, are associated with gastric carcinogenesis. Upregulation of STK31 promotes the proliferation and migration of gastric cancer cells and may predict a shorter survival time for patients with gastric cancer.
Article
Oncology
Jong-Lyul Park, Seon-Kyu Kim, Sora Jeon, Chan-Kwon Jung, Yong-Sung Kim
Summary: Thyroid nodules are commonly benign, but molecular markers such as miRNAs can help differentiate thyroid cancer from benign tumors and predict the risk of recurrence. High expression levels of specific miRNAs, such as miR-136, miR-21, and miR-127, are associated with poor clinicopathological features and recurrent or persistent disease in patients with thyroid cancer. These miRNAs can serve as diagnostic and prognostic markers for thyroid nodules, aiding in risk stratification and treatment decisions.
Article
Oncology
Sung Gwe Ahn, Seon-Kyu Kim, Jonathan H. Shepherd, Yoon Jin Cha, Soong June Bae, Chungyeul Kim, Joon Jeong, Charles M. Perou
Summary: The SP142 PD-L1 assay is a companion diagnostic for atezolizumab in metastatic triple-negative breast cancer (TNBC). Through studying 149 TNBC samples, it was found that PD-L1-positive TNBC samples had higher levels of CD8+ T cells, stromal tumor-infiltrating lymphocytes, and immunomodulatory TNBCtype compared to PD-L1-negative samples. The SP142-guided gene expression signature consisting of 94 immune-related genes was associated with improved response and survival in multiple TNBC cohorts.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Chan Wook Kim, Ye Jin HA, Ka Hee Tak, Seon Ae Roh, Seon-Kyu Kim, Seon-Young Kim, Yong Sung Kim, Dong-Hyung Cho, Jin Cheon Kim
Summary: This study found that CEA, CKS2, OAS2, and ATG5 in preoperative serum were independent risk factors for recurrence in stage II and III colorectal cancer. The combination of these serum biomarkers effectively predicted tumor recurrence in patients.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Jin C. Kim, Ye J. Ha, In J. Park, Chan W. Kim, Yong S. Yoon, Jong L. Lee, Ka H. Tak, Dong-Hyung Cho, Seong H. Park, Seon-Kyu Kim, Seon-Young Kim, Yong S. Kim
Summary: The study revealed different immune microenvironments in mCRC patients with hepatic metastasis, pulmonary metastasis, or concurrent hepatic and pulmonary metastasis. Through RNA analysis and validation of gene expressions in the primary CRC samples, candidate genes associated with different metastasis patterns were identified. These findings help in identifying immune-related site-specific markers of mCRC.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Sangah Lee, Jiyae Jung, Yu-Jin Lee, Seon-Kyu Kim, Jung-Ae Kim, Bo-Kyung Kim, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Han
Summary: The study identified HSF1 as a potential target protein to overcome EGFR-TKI resistance in NSCLC, demonstrating the efficacy of HSF1 inhibition in vitro and in vivo. This suggests a targetable HSF1 pathway to overcome multiple mechanisms of EGFR-TKI resistance.
Article
Oncology
Seon Ae Roh, Yi Hong Kwon, Jong Lyul Lee, Seon-Kyu Kim, Jin Cheon Kim
Summary: The study identified the association between SLAMF7 and TREM1 with anti-PD-1 drugs, and found that TREM1 inhibitors may enhance anti-PD-1-mediated immunogenic cell death in MSS CRC. The results showed that expression of SLAMF7 and TREM1 is closely associated with immunogenic cell death, providing insights into potential adjuvant therapies for CRC.
ANTICANCER RESEARCH
(2021)
Article
Otorhinolaryngology
Seung-Jin Park, Yea Eun Kang, Jeong-Hwan Kim, Jong-Lyul Park, Seon-Kyu Kim, Seung-Woo Baek, In Sun Chu, Shinae Yi, Seong Eun Lee, Young Joo Park, Eun-Jae Jung, Jin Man Kim, Hye Mi Ko, Je-Ryong Kim, Seung-Nam Jung, Ho-Ryun Won, Jae Won Chang, Bon Seok Koo, Seon-Young Kim
Summary: This study investigated the transcriptomic characteristics of advanced papillary thyroid cancer, revealing associations with immune-escape signaling, specific fusion genes, and a novel molecular biomarker for recurrence.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuan-Mei Piao, Seon-Kyu Kim, Young Joon Byun, Chuang-Ming Zheng, Ho Won Kang, Won Tae Kim, Yong-June Kim, Sang-Cheol Lee, Wun-Jae Kim, Sung-Kwon Moon, Yung Hyun Choi, Seok Joong Yun
Summary: This study compared the utility of different risk assessments in NMIBC patients and found that the molecular signature-based subtype predictor (MSP888) had independent predictive value for NMIBC progression, especially in patients without intravesical BCG immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kwangho Kim, Tae Young Ryu, Eunsun Jung, Tae-Su Han, Jinkwon Lee, Seon-Kyu Kim, Yu Na Roh, Moo-Seung Lee, Cho-Rok Jung, Jung Hwa Lim, Ryuji Hamamoto, Hye Won Lee, Keun Hur, Mi-Young Son, Dae-Soo Kim, Hyun-Soo Cho
Summary: A protein called SMYD2 has been identified as a potential target for novel therapies for non-small-cell lung cancer (NSCLC) due to its role in promoting cancer spread. In laboratory experiments, inhibiting SMYD2 production in lung cancer cells hindered the process of metastasis. This discovery could lead to new treatment options for this form of lung cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mijin Park, Byul Moon, Jong-Hwan Kim, Seung-Jin Park, Seon-Kyu Kim, Kihyun Park, Jaehoon Kim, Seon-Young Kim, Jeong-Hoon Kim, Jung-Ae Kim
Summary: This study found that SETD5 expression is associated with poor prognosis of HCC, and depletion of SETD5 can reduce HCC cell proliferation and invasion, induce cell death, downregulate interferon-mediated inflammatory response, as well as decrease glycolysis activity in HCC cells, ultimately inhibiting tumor growth in xenograft mouse models.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Yong-Soon Park, Jong-Seok Park, Soohyun Lee, Sung-Hee Jung, Seon-Kyu Kim, Choong-Min Ryu
Summary: The study revealed a complex interaction between the marine bacterial pathogen V. vulnificus and the land plant Arabidopsis thaliana. The pathogen actively modulates its virulence factors and potential host immune regulators.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)