Article
Medicine, Research & Experimental
Aysu Kilic, Savas Ustunova, Huri Bulut, Ismail Meral
Summary: This study aimed to investigate the effects of prenatal and/or postnatal exposure to 900 MHz electromagnetic field (EMF) on inflammation, oxidative stress, and renin-angiotensin system components in the brain and kidney tissues of male and female rats. The study found that exposure to 900 MHz EMF led to increased inflammation and oxidative stress, as well as higher expression of renin-angiotensin system components in both male and female brain and kidney tissues. These findings suggest that the activation of the renin-angiotensin system may be related to the inflammation and oxidative stress observed in the offspring.
Article
Medicine, Research & Experimental
Hossein Amiri, Fatemeh Shabkhiz, Parisa Pournemati, Amir Hossein Saffar Kohneh Quchan, Reza Zeighami Fard
Summary: This study investigated the effects of swimming exercise on oxidative stress and liver cell damage caused by electromagnetic radiation in rats. The results showed that swimming exercise attenuated the liver damage caused by electromagnetic radiation. In the electromagnetic radiation group, the activity of superoxide dismutase and catalase decreased significantly, and the concentration of malondialdehyde and liver enzymes increased significantly; while in the swimming exercise and electromagnetic radiation + swimming exercise groups, the activity of superoxide dismutase and catalase increased significantly, and the concentration of malondialdehyde and liver enzymes decreased significantly.
Article
Biochemistry & Molecular Biology
Yasmina M. Abd-Elhakim, Gihan G. Moustafa, Nabela El-Sharkawy, Mohamed M. A. Hussein, Mervat H. Ghoneim, Maha M. El Deib
Summary: The study found that curcumin (CUR) significantly reduced the hepatorenal damage induced by fenitrothion (FNT), by inhibiting the upregulation of hepatic enzymes and reducing the levels of damage indicators in the blood. Additionally, CUR restored antioxidant enzyme levels, reduced oxidative stress-related substances, and minimized pathological abnormalities in liver and kidney tissues caused by FNT exposure.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Environmental Sciences
Octavio Gamaliel Aztatzi-Aguilar, Gabriela Andrea Pardo-Osorio, Marisela Uribe-Ramirez, Juana Narvaez-Morales, Andrea De Vizcaya-Ruiz, Olivier Christophe Barbier
Summary: Exposure to PM2.5 is associated with acute kidney damage, oxidative stress, inflammation, and potential loss of renal function, as evidenced by increased early kidney damage biomarkers and inflammatory markers.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Karolina Sieron, Katarzyna Knapik, Grzegorz Onik, Ewa Romuk, Ewa Birkner, Sebastian Kwiatek, Aleksander Sieron
Summary: The study assessed the influence of electromagnetic fields on prooxidative and antioxidative balances in the gastrointestinal tract of rats. Exposure to low-frequency electromagnetic fields led to significant disturbances in oxidative stress, while antioxidant activity varied in different parts of the digestive system.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Yukiko Minamiyama, Shigekazu Takemura, Hiroshi Ichikawa
Summary: The exposome represents the lifetime exposure of an individual to external genetic influences and their impact on health. Certain food additives may affect sperm function, induce oxidative stress in the testes and brain, resulting in infertility and short-term memory loss.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Environmental Sciences
Anjali Sharma, Sadhana Shrivastava, Asha Singh, Shamli S. Gupte, Arti Rathour, Mohd Salim Reshi, Sangeeta Shukla
Summary: This study demonstrated the oxidative potential of microwave radiation (MWR) causing neurodegeneration in rats. Chronic exposure to 2100 MHz frequency resulted in oxidative stress, neural damage, demyelination, and potentially affecting neural communication.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Environmental Sciences
Anjali Sharma, Sadhana Shrivastava, Asha Singh, Shamli S. Gupte, Arti Rathour, Mohd Salim Reshi, Sangeeta Shukla
Summary: The present study showed that microwave radiation can lead to oxidative stress and neurodegeneration in rats. Chronic exposure to 2100 MHz frequency resulted in increased levels of triglycerides and cholesterol, as well as alterations in glutathione homeostasis and inflammatory response. Histopathological and electron microscopic observations confirmed changes in myelination pattern and cellular organelles in the brain. Overall, chronic exposure to 2100 MHz frequency of microwave radiation can cause oxidative stress, neural damage, and demyelination.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Biology
Arvydas Strazdauskas, Sonata Trumbeckaite, Valdas Jakstas, Justina Kamarauskaite, Liudas Ivanauskas, Rasa Baniene
Summary: This study analyzed the oxidation of cardiolipin during renal ischemia in vivo. The results showed that the levels of the dominant species of cardiolipin decreased after ischemia, and multiple cardiolipin oxidation products were produced. These findings suggest that cardiolipin levels are altered and harmful lipid signaling molecules may induce more damage to mitochondria during ischemia.
Article
Nutrition & Dietetics
Gaizun Hu, Lusi Xu, Osamu Ito
Summary: Chronic exercise has antihypertensive and renoprotective effects in rats on a high fructose diet. The study reveals that the high fructose diet affects the nitric oxide (NO) system and oxidative stress in the kidney, while exercise improves these effects.
Article
Immunology
Pei Zhou, Hongbo Guan, Yanyan Guo, Liangliang Zhu, Xiaomei Liu
Summary: Maternal obesity leads to a reduction in peroxisome number in fetal kidneys, activating oxidative stress and inflammasomes, ultimately leading to inflammation and apoptosis. The antioxidant PQQ plays a protective role by reducing ROS levels and inhibiting ER stress and inflammasome activation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Esmaeil Karami, Zahra Goodarzi, Al Ghanbari, Ahmad Reza Bandegi, Sedighe Yosefi, Alireza Dehdashti
Summary: Atorvastatin can alleviate cadmium chloride-induced nephrotoxicity in a rat model by reducing oxidative stress and improving biochemical markers.
Article
Engineering, Environmental
Huanliang Liu, Wenqing Lai, Xiaohua Liu, Honglian Yang, Yanjun Fang, Lei Tian, Kang Li, Huipeng Nie, Wei Zhang, Yue Shi, Liping Bian, Susu Ding, Jun Yan, Bencheng Lin, Zhuge Xi
Summary: The research investigated the mechanism of hepatotoxicity and apoptosis caused by Nano-CuO through oxidative stress and ER-stress. Both in vivo and in vitro experiments confirmed that Nano-CuO induced oxidative stress, leading to ER-stress pathway activation and subsequently cell death.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Victor Enrique Sarmiento-Ortega, Diana Moroni-Gonzalez, Alfonso Diaz, Miguel Angel Garcia-Gonzalez, Eduardo Brambila, Samuel Trevino
Summary: Metabolic diseases are a global health problem, and insulin resistance is their key characteristic. By administering exogenous insulin, we successfully developed an animal model of insulin resistance and observed its progression and time-dependent molecular modifications. The results showed that this model combined with oxidative conditions at the hepatic level, but without inflammation.
Article
Medicine, Research & Experimental
Moustafa Fathy, Rania Abdel-latif, Yasmeen M. Abdelgwad, Othman Ali Othman, Abdel-Razik H. Abdel-Razik, Thomas Dandekar, Eman M. Othman
Summary: The study showed that eugenol has a potential protective effect against CCl4-induced chronic kidney damage in an experimental model, mainly through its antioxidant, anti-inflammatory, and anti-fibrotic activities.
Article
Obstetrics & Gynecology
Metin Celiker, Fatma Beyazal Celiker, Levent Tumkaya, Fatih Oghan, Abdulkadir Ozgur, Tolga Mercantepe, Suat Terzi, Mehmet Beyazal, Arzu Turan, Seda Cinar, Ertan Zengin, Emine Demir, Engin Dursun
Summary: The study aimed to investigate the effects of new generation Doppler ultrasonography (DUSG) at different frequencies on cochlea and cochlear nucleus (CN) in rats during the prenatal period. The results showed that multiple administrations of new generation DUSG to pregnant rats did not have harmful effects on the cochlear neural tissue. High frequencies were found to be more sensitive in the cochlea when applying DUSG.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ali Ozdemir, Levent Tumkaya, Suleyman Kalcan, Mikail Uyan, Ahmet Karakaya, Gokhan Demiral, Tugba Celik Samanci, Tolga Mercantepe, Medine Cumhur Cure, Erkan Cure
Summary: The study demonstrates that Infliximab can mitigate acute kidney injury induced by CCl4 by reducing the number of apoptotic cells and decreasing lipid peroxidation and oxidative stress. These findings suggest a promising ameliorating role of TNF-alpha inhibitors in acute kidney injury.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Chemistry, Multidisciplinary
Ilkay Bahceci, Levent Tumkaya, Tolga Mercantepe, Nuray Aslan, omer Faruk Duran, Umut Serkan Soztanaci, Zihni Acar Yazici
Summary: This study examined the toxic effects of methotrexate (MTX) on T lymphocytes and macrophages and investigated the regulatory effects of anti-TNF alpha agents on MTX-induced toxicity. The results showed that Adalimumab may be a promising candidate for preventing the deleterious effects of MTX-induced toxicity on T lymphocytes and macrophages.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Biology
Fatma Beyazal Celiker, Levent Tumkaya, Tolga Mercantepe, Ertan Zengin, Mehmet Beyazal, Arzu Turan, Hatice Beyazal Polat, Zehra Topal Suzan, Adnan Yilmaz
Summary: This study investigated the effects of new generation Doppler ultrasound application at different frequencies during pregnancy on postnatal renal development. The results showed that multiple administrations of new generation Doppler ultrasound had deleterious effects on the development of postnatal renal tissue.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Dogus Hemsinli, Levent Tumkaya, Saban Ergene, S. Ozan Karakisi, Tolga Mercantepe, Adnan Yilmaz
Summary: This study examines the potential protective effect of the alpha-2 adrenergic receptor agonist dexmedetomidine (DMT) on aortic occlusion-induced lung injury in a ruptured abdominal aortic aneurysm model. The results show that DMT reduces oxidative stress and apoptosis, protecting against aortic occlusion-induced pulmonary injury.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Medicine, Research & Experimental
Seckin Engin, Elif Nur Barut, Yesim Kaya Yasar, Aysun Celik Soysal, Tugba Arici, Gokcen Kerimoglu, Mine Kadioglu, Sena F. Sezen
Summary: Trimetazidine (TMZ) exerts protective effects in cyclophosphamide (CP)-induced cystitis through inhibiting TLR4/ NF Kappa B signaling. TMZ improves histological disturbances and contraction abnormalities in the bladder by enhancing antioxidant capacity and suppressing inflammation, as indicated by decreased TNF-alpha and IL-1 beta levels. However, TMZ also enhances the cytotoxicity of CP when combined.
Article
Medicine, General & Internal
Sila Ozlem Sener, Merve Badem, Ufuk Ozgen, Nuriye Korkmaz, Seyda Kanbolat, Gokcen Kerimoglu, Rezzan Aliyazicioglu, Engin Yenilmez, Esen Sezen Karaoglan
Summary: This study evaluated the antidiabetic and antioxidant effects of Lysimachia verticillaris extract and its isolated compounds in rats with STZ-induced type 1 diabetes. The results showed that the extract and compounds reduced blood glucose levels and increased insulin and antioxidant enzyme levels. Quercetin 3-O-beta-glucopyranoside exhibited the strongest antidiabetic effect. These findings suggest that Lysimachia verticillaris and its compounds could be potential sources of herbal medicine for treating diabetes.
Article
Biotechnology & Applied Microbiology
Filiz Mercantepe, Levent Tumkaya, Tolga Mercantepe, Sema Rakici
Summary: This study investigates the negative effects of x-ray radiation on the pituitary gland and the potential protective effects of the alpha 2-adrenergic receptor agonist dexmedetomidine. The results show that x-ray irradiation causes necrosis and damage to the pituitary gland, while dexmedetomidine treatment reduces necrotic cells and protects against apoptosis. These findings suggest that dexmedetomidine may be useful in preventing radiation-induced pituitary damage.
Article
Pharmacology & Pharmacy
Ibrahim Turan, Deniz Canbolat, Selim Demir, Gokcen Kerimoglu, Fatih Colak, Nihal Turkmen Alemdar, Ahmet Mentese, Yueksel Aliyazicioglu
Summary: This study evaluated for the first time the protective effect of dimethyl sulfoxide (DMSO) extract of Primula vulgaris leaf (PVE) against cisplatin (CDDP)-induced nephrotoxicity in rats. The results showed that PVE exhibited strong protective effects through its anti-apoptotic, antioxidant, and anti-inflammatory activities against nephrotoxicity and oxidative damage caused by CDDP.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Andrology
Selim Demir, Ilke Onur Kazaz, Gokcen Kerimoglu, Elif Ayazoglu Demir, Fatih Colak, Ayse Firuze Biyik, Yasin Cansever, Ahmet Mentese
Summary: This study evaluated the effect of ethanolic extract of Turkish propolis (EEP) on testicular ischemia/reperfusion (I/R) damage in rats for the first time. The results showed that EEP prevented I/R-induced testicular damage through its antioxidant activity. More comprehensive studies are needed to understand the underlying mechanisms.
REVISTA INTERNACIONAL DE ANDROLOGIA
(2023)
Article
Urology & Nephrology
Gokcen Kerimoglu, Tugba Arici, Ayse Firuze Biyik, Ali Kulaber, Nihal Tuerkmen Alemdar, Selim Demir, Yueksel Aliyazicioglu, Engin Yenilmez
Summary: The purpose of this study was to investigate the potential protective effects of Pterostilbene (Pte) against CYP-induced nephrotoxicity and cystitis in rats. The results showed that Pte could reduce oxidative stress and apoptosis in kidney and bladder tissues caused by CYP, as well as ameliorate histopathological damage.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hamit Yilmaz, Filiz Mercantepe, Levent Tumkaya, Tolga Mercantepe, Adnan Yilmaz, Sema Yilmaz Rakici
Summary: This study demonstrates the damaging effects of X-ray irradiation on the islets of Langerhans in rats, and the beneficial effects of N-acetyl cysteine (NAC) in mitigating this damage.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Meeting Abstract
Neurosciences
Mustafa Y. Aygan, Busra Kuru, Sedef Mumcu, Ayse Akca, Oktay Uzun, Ilknur Erkoseoglu, Mine Kadioglu Duman, Gokcen Kerimoglu, Mehmet A. Osmanagaoglu, Ersin Yaris, Nuri I. Kalyoncu
NEUROTOXICOLOGY AND TERATOLOGY
(2022)
Meeting Abstract
Neurosciences
Sedef Mumcu, Mustafa Y. Aygan, Busra Kuru, Ayse Akca, Oktay Uzun, Ilknur Erkoseoglu, Gokcen Kerimoglu, Mine Kadioglu Duman, Mehmet A. Osmanagaoglu, Ersin Yaris, Nuri I. Kalyoncu
NEUROTOXICOLOGY AND TERATOLOGY
(2022)
Meeting Abstract
Neurosciences
Oktay Uzun, Sedef Mumcu, Mustafa Y. Aygan, Busra Kuru, Ayse Akca, Ilknur Erkoseoglu, Gokcen Kerimoglu, Mine Kadioglu Duman, Mehmet A. Osmanagaoglu, Ersin Yaris, Nuri I. Kalyoncu
NEUROTOXICOLOGY AND TERATOLOGY
(2022)