Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 30, Issue -, Pages 112-124Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.02.007
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Funding
- German funding agency (DFG) in Collaborative Research Center [902]
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Riboswitches are structured regions of mRNAs that modulate gene expression in response to specific binding of low molecular-weight ligands. They function by induced transitions between different functional conformations. The standard model assumed that the two functional states, the ligand-bound and ligand-free state, populated only two stable conformations. Recent discoveries of multiple conformations for the apo-state and holo-state of riboswitches challenge this model. Moreover, it becomes evident that detected conformational heterogeneity - mostly in the apo-state provides sensitivity to multiple environmental inputs for riboswitch-based gene-regulation.
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