Scaffolds of polylactic acid/hydroxyapatite coated by plasma with polypyrrole-iodine for the generation of neo-tissue-bone in vivo: Study in rabbit

This paper presents the study scaffolds of polylactic acid (PLA) and hydroxyapatite (HA) processed by electrospinning and covered with polypyrrole with iodine (PPy-I) synthetized by plasma polymerization. Two kinds of samples were prepared: PLA/HA and PLA/HA/PPy-I, each with two different HA concentrations (18.1 and 35.7%). 7-day in vitro test with osteoblasts of autologous mesenchymal stem cells was performed. In vivo test was done in the back of a rabbit for 30 days. After extraction, cell viability, immunohistochemistry, histological, and tension tests were performed. Scaffolds PLA/HA (35.7%)/PPy-I showed higher cell viability. Tension test showed better integration in high HA samples.