Article
Polymer Science
M. Margarida Cardoso, Ines N. Peca, Telma Lopes, Rui Gardner, A. Bicho
Summary: DWNPs were produced with PLGA and PLLA containing doxorubicin as a model drug. Optical and fluorescence microscopy were used to examine the inner morphology and drug distribution of the double-walled microparticles. The study showed that the double-walled nanoparticles exhibited sustained drug release and the PLLA layer acted as a rate control barrier.
Article
Engineering, Biomedical
Lucy Geddes, Efrosyni Themistou, James F. Burrows, Fraser J. Buchanan, Louise Carson
Summary: This study aimed to develop an in vitro protocol for assessing the long-term cytotoxicity of bioresorbable polymers. Results showed that PDLLGA samples exhibited increasing cytotoxicity at later degradation stages, while PLLGA samples demonstrated significantly less cytotoxic behavior. Additionally, a new dynamic flow culture methodology was developed and validated to test the cytotoxicity of these degradable materials, along with profiling of inflammatory cytokines released by cells in response to degraded PDLLGA and PLLGA.
ACTA BIOMATERIALIA
(2021)
Article
Polymer Science
Suyang Dai, Ni Jiang, Zhenbo Ning, Zhihua Gan
Summary: The length of the PDLA block was found to have a significant impact on the degradation behavior of PLLA/4-DL-D blend films.
POLYMER INTERNATIONAL
(2021)
Article
Polymer Science
Jidong Dai, Min Liang, Zhigang Zhang, Katrien Bernaerts, Tianzhu Zhang
Summary: By crosslinking nucleation to prepare crystalline 4arm-PLGA, the degradation rate of PLGA can be effectively controlled, promoting cell growth and potentially having ideal performance in tissue engineering.
Article
Biotechnology & Applied Microbiology
Tiantang Fan, Jingwen Qin, Xiao Meng, Jiafeng Li, Qing Liu, Guannan Wang
Summary: PLPG membranes with sc-PLA improved the crystallizing behavior of PLLA segments, increased thermal stability and degradation ability, and showed low cytotoxicity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Lidong Feng, Xinchao Bian, Gao Li, Xuesi Chen
Summary: The study shows that the compatibility between PLLA and PLDLA-m decreases as the L-lactate unit content in PLDLA-m decreases, impacting the crystallization and compatibility of the blends.
Article
Environmental Sciences
Zainab Safaa Al Hachim, Ali Mousa Ridha, Mohammad N. AL-Baiati, Qusay F. Alsalhy, Hasan Shakir Majdi
Summary: This study successfully synthesized PMG nanoparticles and incorporated them into PES membranes, leading to structural changes and improved performance, showing good water flux and protein retention.
Article
Biochemistry & Molecular Biology
Gianni Pecorini, Simona Braccini, Gianluca Parrini, Federica Chiellini, Dario Puppi
Summary: Polyhydroxyalkanoates are biopolyesters that can be used as unique scaffolding polymer candidates for tissue engineering due to their biocompatibility, biodegradability, environmental sustainability, processing versatility, and mechanical properties. This study explored the fabrication of tissue engineering scaffolds using a solution-extrusion additive manufacturing technique, called Computer-Aided Wet-Spinning (CAWS), by blending poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(D,L-lactide-co-glycolide) (PLGA). The results showed that the blend composition influenced the morphological, physicochemical, and biological properties of the scaffolds, with increasing PLGA content leading to larger pore size, enhanced wettability, and improved thermal stability. In vitro experiments demonstrated the suitability of the scaffolds for cell colonization and differentiation towards an osteoblastic phenotype, particularly with scaffolds richer in PLGA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Anton Iemtsev, Fatima Hassouna, Martin Klajmon, Alex Mathers, Michal Fulem
Summary: This study evaluates the compatibility between biodegradable polyesters and active pharmaceutical ingredients (APIs) and investigates the physical stability of drug carriers using phase diagrams. The results show varying levels of compatibility between different ratios of PLGA and model APIs, with only the IND-PLGA75 formulation remaining stable after storage.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Chemistry, Physical
Jaeik Song, Min-Suk Kook, Byung-Hoon Kim, Young-IL Jeong, Kyung-Jin Oh
Summary: ROS-sensitive nanoparticles were developed for CIP delivery to inhibit UTI, showing potential antibacterial activity in vitro without significant cytotoxicity to cells. Free CIP and CIP-incorporated nanoparticles demonstrated dose-dependent inhibitory effects against bacterial growth, with sustained release properties observed in the nanoparticles. Free CIP and CIP-incorporated nanoparticles showed superior antibacterial activity in a dialysis membrane model compared to free CIP.
Article
Polymer Science
Zemei Fang, Zhihua Zhou, Wei Wu, Wenjuan Liu, Hailin Xie, Hongbo Hu, Yan Gan, Jianjun Fang
Summary: A degradable blend scaffold composed of PLLGC and EMPLGA was prepared and characterized for its morphology and biocompatibility. The blend scaffold exhibited a porous structure and high cell proliferation.
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS
(2022)
Article
Polymer Science
Yuhan Wei, Zhengyue Wang, Shuaining Zhou, Zhibo Li
Summary: A tough and transparent film of poly(L-lactic acid)/poly(D-lactide)-b-poly(butadiene)-b-poly(D-lactide) (PLLA/PDLA-PB-PDLA) with balanced strength was obtained. The film was achieved by synthesizing PDLA-PB-PDLA triblock copolymer using ring-opening polymerization and then blending it with PLLA. The blended films exhibited good transparency even with a high loading of PDLA-PB-PDLA. The enhanced mechanical properties were attributed to the synergistic effect of flexible PB chains and stereocomplex crystals formed between PLLA matrix and PDLA chains.
Article
Polymer Science
Shih-Jyun Shen, Ying-Chao Chou, Shih-Chieh Hsu, Yu-Ting Lin, Chia-Jung Lu, Shih-Jung Liu
Summary: In this study, drug-loaded microparticles were successfully prepared using electrospraying technique, and their release behavior was investigated. The results showed that the drugs were sustainably released at the target region in vivo and maintained low concentrations in the blood. This technique has the potential for postoperative pain control.
Article
Polymer Science
Airong Xu, Fen Wang, Luwei Zhang, Xingmin Xu, Zhihong Xiao, Rukuan Liu
Summary: A simple and feasible preparation approach was presented in this study to fabricate biodegradable and biocompatible composite films, addressing the issue of environmental pollution caused by polymer materials based on fossil resources being difficult to degrade. The composite films displayed good mechanical properties, re-usability, and thermal stability.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Polymer Science
Xiaohua Chang, Dengwen Hu, Liangren Chen, Yaping Wang, Yutian Zhu
Summary: Thermoresponsive block copolymer micelles have potential in biological applications, with studies showing that changes in hydrophobic/hydrophilic block ratio, micelle concentration and addition of salt can alter the cloud point. Increasing the amount of PLGA hydrophobic block significantly decreases the cloud point, while higher micelle concentration and salt addition also lower the cloud point.
