Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 518, Issue 1-2, Pages 130-137Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.12.003
Keywords
Near-infrared spectroscopy (NIR); Chemical imaging; Tableting; Process analytical technology (PAT); Homogeneity
Categories
Funding
- Austrian COMET Program under the Austrian Federal Ministry of Transport, Innovation and Technology
- Austrian Federal Ministry of Economy, Family and Youth
- State of Styria
Ask authors/readers for more resources
Near-infrared chemical imaging (NIR-CI) with high-speed cameras based on the push-broom acquisition principle is a rapidly-evolving and can be used for a variety of purposes, from classification (and sorting) of products to mapping spatial distribution of materials. The present study examined if NIR-CI is suitable for tablet manufacturing. To that end, the tablets were introduced into the CI system via a flat belt conveyor. A formulation, which consisted of 4 wt.%-6 wt.% caffeine, 5 wt.% crospovidone as a disintegrant, 88 wt.%-90 wt.% lactose as a filler and 1 wt.% magnesium stearate as a lubricator, was tableted at compression forces ranging from 5 kN to 30 kN. The intra-and inter-tablet homogeneity of caffeine and the tablet's hardness were analyzed via NIR-CI. For the homogeneity evaluation, two methods were applied: standard deviation (SD) and distributional homogeneity index (DHI). The results showed that the SD of caffeine in a single tablet increased with an increase in the caffeine content. This was attributed to natural variations in a binary mixture of caffeine and excipients. Overall, the chosen NIR-CI setup has strong potential to be transferred to the production scale to monitor all tablets in a production stream. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available