Article
Chemistry, Multidisciplinary
Margarida L. Ferreira, Nicole S. M. Vieira, Ana L. S. Oliveira, Joao M. M. Araujo, Ana B. Pereiro
Summary: This study investigates the influence of IFN-alpha 2b on the aggregation behavior of fluorinated ionic liquids (FILs) and the interactions between them. The results show that the presence of IFN-alpha 2b affects the aggregation behavior of FILs and strong interaction occurs between them. FILs can be tailored to carry IFN-alpha 2b and prevent protein aggregation through the formation of a conjugate.
Article
Chemistry, Physical
Onajite T. Diejomaoh Abafe, Muhammad Mohsin Azim, Bice S. Martincigh, Annegret Stark
Summary: This study investigates the physicochemical properties of a series of cation-fluorinated ionic liquids and provides experimental evidence for nanosegregation and triphilicity in these liquids. The introduction of fluoroalkyl chains enhances hydrogen bond interactions between anions and cations and leads to structural rearrangements. The study also demonstrates the use of a group contribution method to predict the density of the liquids.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Iuliana Spiridon, Iuliana-Marilena Andrei, Narcis Anghel, Maria Valentina Dinu, Bianca-Iulia Ciubotaru
Summary: The mechanical performances of composite materials can be improved by adding fillers to the matrix. Different fillers used in the study have an impact on bioadhesion and mucoadhesion parameters. The incorporation of lignin and ferrite-lignin hybrid into the matrix influences the in vitro release rate of ketoconazole.
Review
Medicine, Research & Experimental
Chunxia Liu, Bin Chen, Wei Shi, Wenlong Huang, Hai Qian
Summary: Ionic liquids (ILs) are nonmolecular compounds composed only of ions, which have a wide range of applications in various fields including pharmaceuticals. ILs have advantages such as wide chemical space, adjustable structures, and high thermal stability, making them potential candidates for drug delivery systems.
MOLECULAR PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Polina G. Rudakovskaya, Roman A. Barmin, Pavel S. Kuzmin, Elena P. Fedotkina, Alexander N. Sencha, Dmitry A. Gorin
Summary: This review provides a comprehensive summary and critical evaluation of known protein microbubbles over decades, aiming to optimize their safety and imaging efficiency, as well as exploring biomedical applications beyond ultrasound imaging.
Review
Chemistry, Multidisciplinary
Alexander M. Curreri, Samir Mitragotri, Eden E. L. Tanner
Summary: Ionic liquids and deep eutectic solvents have seen a significant growth in biomedical applications, particularly in drug solubilization, formulation, delivery, protein stabilization, and new biosensors. Overcoming current challenges in these applications will require considerations of biocompatibility, impurities, and a comprehensive understanding of microscopic interactions within ionic liquids.
Review
Pharmacology & Pharmacy
Monu Kumar Shukla, Harshita Tiwari, Rachna Verma, Wen-Liang Dong, Shavkatjon Azizov, Brajesh Kumar, Sadanand Pandey, Deepak Kumar
Summary: Advancements in the field of ionic liquids have led to increased interest from scientists in their applications in pharmaceutical and biomedical fields, particularly in drug delivery systems for poorly soluble medicines. The modularity of their physicochemical properties makes them effective in different applications.
Article
Chemistry, Multidisciplinary
Yi Lu, Jianping Qi, Wei Wu
Summary: Ionic liquids (ILs) as a novel platform have great potential in drug delivery. They can liquidize or solubilize active pharmaceutical ingredients, act as green solvents or permeation enhancers, but also face challenges.
PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Rahman Md Moshikur, Masahiro Goto
Summary: Ionic liquids (ILs) have been extensively used in drug formulation and delivery, addressing challenges such as drug solubility, permeability, formulation instability, and in vivo systemic toxicity associated with conventional solvents. They have also shown potential in addressing issues related to crystalline drugs, such as polymorphism, limited solubility, poor permeability, instability, and low bioavailability. This account discusses the progress and strategies in designing biocompatible ILs and explores their potential biomedical applications in solubilization, active pharmaceutical ingredient creation, and drug delivery.
Article
Chemistry, Medicinal
Daniela A. S. Agostinho, Ana R. Jesus, Ana B. P. Silva, Jose M. S. S. Esperanca, Alexandre Paiva, Ana R. C. Duarte, Patricia M. Reis
Summary: New dianionic phosphonate anion based ionic liquids significantly improved the water solubility of piroxicam and ibuprofen with low cytotoxicity, potentially beneficial for oral drug formulation studies.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Giuseppe Francesco Racaniello, Patrick Knoll, Arne Matteo Joergensen, Ilaria Arduino, Valentino Laquintana, Angela Assunta Lopedota, Andreas Bernkop-Schnurch, Nunzio Denora
Summary: This study aimed to develop thiolated self-emulsifying drug delivery systems (SEDDS) and nano-structured lipid carriers (NLCs) with improved mucoadhesive properties. Thiolated PSE surfactants were found to be promising excipients for the design of highly mucoadhesive drug delivery systems.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Chemistry, Applied
B. N. Kumara, R. Shambhu, Ashwini Prabhu, K. Sudhakara Prasad
Summary: This study reports the design of highly efficient and biocompatible nanocomposites for drug delivery and tracking. A proof-of-concept was demonstrated for the delivery of an anti-glaucoma drug using a novel nanocomposite, with successful drug delivery and intercellular tracking observed. The nanocomposite also showed excellent cell viability and protected cells from oxidative injury.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Marcia M. S. Alves, Manuel N. Melo, Haydyn D. T. Mertens, Ana B. Pereiro, Margarida Archer
Summary: Proteins can be stabilized and have improved properties in the presence of ionic liquids (ILs) as cosolvents or surfactants. By using techniques such as small-angle X-ray scattering (SAXS), fluorescence microscopy, and coarse-grained molecular dynamics (CG-MD) simulations, the interaction between ILs and proteins like lysozyme and bovine serum albumin has been studied. The results show that ILs help maintain the globular structures of proteins and can be used for formulating protein-based pharmaceuticals.
Article
Chemistry, Physical
Rizwan Safdar, Muhammad Nawaz, Asim Mushtaq, Thien Khanh Tran, Abdul Aziz Omar
Summary: This article conducts a bibliometric analysis to assess the applicability of ionic liquids (ILs) in drug delivery. The study shows the continued use of ILs in drug delivery applications and suggests that further investigation is needed to advance drug delivery systems.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Owen J. Curnow, Rathiga Senthooran
Summary: A series of highly-fluorinated triaminocyclopropenium salts were prepared and their properties as ionic liquids were investigated. Different cations were obtained by reacting pentachlorocyclopropane or tetrachlorocyclopropene with bis(2,2,2-trifluoroethyl)amine and a trialkylamine. The salts were characterized by thermal measurements, solubility properties, density, viscosity, and conductivity, and X-ray diffraction studies showed the formation of fluorous and hydrophilic regions.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Thermodynamics
Margarida L. Ferreira, Joao M. M. Araujo, Lourdes F. Vega, Ana B. Pereiro
Summary: This study investigates the solubility of fluorinated gases (F-gases) in fluorinated ionic liquids (FILs) using the soft-Statistical Associating Fluid Theory (soft-SAFT) Equation of State. The results show that the FIL model with a perfluoroalkyl chain in the imidazolium cation has superior solubility for F-gases, indicating that the addition of one carbon atom to the two anionic symmetric fluorinated chains contributes to the gas-philicity of FILs.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2022)
Article
Chemistry, Multidisciplinary
Margarida L. Ferreira, Nicole S. M. Vieira, Ana L. S. Oliveira, Joao M. M. Araujo, Ana B. Pereiro
Summary: This study investigates the influence of IFN-alpha 2b on the aggregation behavior of fluorinated ionic liquids (FILs) and the interactions between them. The results show that the presence of IFN-alpha 2b affects the aggregation behavior of FILs and strong interaction occurs between them. FILs can be tailored to carry IFN-alpha 2b and prevent protein aggregation through the formation of a conjugate.
Article
Chemistry, Multidisciplinary
Marcia M. S. Alves, Paula Leandro, Haydyn D. T. Mertens, Ana B. Pereiro, Margarida Archer
Summary: This study reveals that a biocompatible fluorinated ionic liquid can serve as a delivery system for human phenylalanine hydroxylase, increasing its enzymatic activity but impacting its thermostability.
Article
Multidisciplinary Sciences
Julio E. Sosa, Carine Malheiro, Paulo J. Castro, Rui P. P. L. Ribeiro, Manuel M. Pineiro, Frederic Plantier, Jose P. B. Mota, Joao M. M. Araujo, Ana B. Pereiro
Summary: Research on porous materials for the selective capture of fluorinated gases is crucial for reducing their emissions. This study investigates the adsorption of three fluorinated gases in different materials and finds that MOF-177 exhibits the highest adsorption capacity. This suggests that MOFs are promising for developing new approaches for selectively capturing and separating fluorinated gases.
Article
Thermodynamics
Grata Martinho, Paulo J. Castro, Pedro Santos, Ana Alves, Joao M. M. Araujo, Ana B. Pereiro
Summary: Compliance with international agreements and regulations to reduce emissions of high GWP gases requires involvement of all stakeholders in refrigeration equipment value chain, especially technicians involved in installation, maintenance, and dismantling, whose awareness about F-gases' impact on global warming is critical. This study surveyed 586 technicians from Portugal, Spain, and France to assess their behaviors, knowledge, and risk perception regarding refrigeration gases and global warming. The results reveal the predominant use of HFCs and suggest the need for more efficient information campaigns and improved training to enhance awareness and individual responsibility among technicians.
INTERNATIONAL JOURNAL OF REFRIGERATION
(2023)
Article
Thermodynamics
Rui P. P. L. Ribeiro, Julio E. Sosa, Joao M. M. Araujo, Ana B. Pereiro, Jose P. B. Mota
Summary: This study evaluates the performance of a four-step Vacuum Swing Adsorption (VSA) process for the recovery of R-32 from a R410A refrigerant blend. The results demonstrate the feasibility and efficiency of using VSA processes for the recovery of high purity R-32.
INTERNATIONAL JOURNAL OF REFRIGERATION
(2023)
Article
Pharmacology & Pharmacy
Marcia M. S. Alves, Manuel N. Melo, Haydyn D. T. Mertens, Ana B. Pereiro, Margarida Archer
Summary: Proteins can be stabilized and have improved properties in the presence of ionic liquids (ILs) as cosolvents or surfactants. By using techniques such as small-angle X-ray scattering (SAXS), fluorescence microscopy, and coarse-grained molecular dynamics (CG-MD) simulations, the interaction between ILs and proteins like lysozyme and bovine serum albumin has been studied. The results show that ILs help maintain the globular structures of proteins and can be used for formulating protein-based pharmaceuticals.
Article
Chemistry, Physical
Isabelle F. T. Viana, Carlos H. B. Cruz, Diogo Athayde, W. Camilla S. Adan, Licya S. S. Xavier, Margarida Archer, Roberto D. D. Lins
Summary: The development of therapeutics against Zika virus involves the design of molecules that can neutralize the virus and prevent cell infection. In this study, small synthetic proteins were computationally engineered to bind to a specific epitope in the Zika virus envelope protein. The most promising candidate was synthesized and shown to have high affinity for its target, as well as cross-reactive neutralizing capacity against both Zika virus and dengue virus in vitro. X-ray crystallography was used to validate the computational design and provide insights into the structural basis of flavivirus neutralization.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Marguerita E. Rosa, Ana M. Ferreira, Catarina M. S. S. Neves, Mafalda R. Almeida, Rafael Barros, Ana C. Cristovao, Ana C. A. Sousa, Patricia M. Reis, Luis Paulo N. Rebelo, Jose M. S. S. Esperanca, Joao A. P. Coutinho, Mara G. Freire
Summary: Globally, a large amount of root crops, fruits, and vegetables are wasted, including beetroot stems and leaves. A new integrated process has been developed to extract and separate pigments from red beet stems and leaves, contributing to the valorisation of waste biomass.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
