Review
Biochemistry & Molecular Biology
Sheiphali Gandhi, Roberto Tonelli, Margaret Murray, Anna Valeria Samarelli, Paolo Spagnolo
Summary: Idiopathic pulmonary fibrosis (IPF) is a common and severe disease that primarily affects middle-aged and elderly males. In addition to aging, occupational and environmental exposures, as well as lifestyle factors such as smoking and diet, have been associated with an increased risk of IPF. Trigger factors may also lead to acute exacerbations and poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Paolo Spagnolo, Christopher J. J. Ryerson, Sabina Guler, Johanna Feary, Andrew Churg, Andrew P. P. Fontenot, Sara Piciucchi, Zarir Udwadia, Tamera J. J. Corte, Wim A. A. Wuyts, Kerri A. A. Johannson, Vincent Cottin
Summary: Millions of workers, especially in developing countries, are exposed to substances that can cause occupational interstitial lung diseases (ILDs), but the burden of the disease could be underestimated due to under-recognition and under-reporting. The diagnosis of occupational ILD requires suspicion and a thorough occupational history, as it can be difficult to distinguish between occupational and non-occupational ILDs. Considering the potential occupational cause of ILD is important, as removing workplace exposure can lead to significant improvement.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Roberto G. Carbone, Assaf Monselise, Emanuela Barisione, Vincenzo Fontana, Paolo Paredi, Francesco Puppo
Summary: This retrospective study compared the risk of pulmonary hypertension in systemic sclerosis (SSc) and non-SSc interstitial lung disease patients with usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP). It found that SSc-UIP patients have a significantly higher risk of pulmonary hypertension, with 60% of patients having pulmonary systolic artery pressure (PAPs) > 25 mmHg compared to the control group.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Respiratory System
Jonathan Keow, Matthew J. Cecchini, Nathashi Jayawardena, Maurizio Zompatori, Mariamma G. Joseph, Marco Mura
Summary: This study found that p16-positive foci can be used to diagnose idiopathic pulmonary fibrosis and are not related to radiographic patterns. High p16 expression is associated with shorter survival time, while antifibrotic therapy has a significant protective effect. Digital spatial profiling showed that fibroblastic foci have distinct gene expression compared to normal and fibrotic areas.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Xiaoping Wu, Yunju Jeong, Sergio Poli de Frias, Imaani Easthausen, Katherine Hoffman, Clara Oromendia, Shahrad Taheri, Anthony J. Esposito, Luisa Quesada Arias, Ehab A. Ayaub, Rie Maurer, Ritu R. Gill, Hiroto Hatabu, Mizuki Nishino, Michelle L. Frits, Christine K. Iannaccone, Michael E. Weinblatt, Nancy A. Shadick, Paul F. Dellaripa, Augustine M. K. Choi, Edy Y. Kim, Ivan O. Rosas, Fernando J. Martinez, Tracy J. Doyle
Summary: The study identified molecular signatures associated with interstitial lung disease in rheumatoid arthritis, providing potential non-invasive diagnostic tools and future therapeutic targets.
Article
Rheumatology
G. Sambataro, C. A. Ferrara, S. E. Torrisi, C. Spadaro, G. Vignigni, A. Vancheri, N. Del Papa, M. Orlandi, M. Colaci, L. Malatino, S. Palmucci, L. Cavagna, D. Sambataro, C. Vancheri
Summary: The study aims to evaluate the rate of progression towards SAD in UIP patients satisfying only one IPAF domain compared to classic IPF, and found that 28.9% of UIPAF patients progressed towards SAD.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Health Care Sciences & Services
Turkey Refaee, Benjamin Bondue, Gaetan Van Simaeys, Guangyao Wu, Chenggong Yan, Henry Woodruff, Serge Goldman, Philippe Lambin
Summary: The study investigates whether a CT-based radiomics approach can accurately identify patients with idiopathic pulmonary fibrosis (IPF) and interstitial lung diseases (ILD) associated with IPF. The results show that radiomic features can discriminate different types of ILD via HRCT, reducing the need for unnecessary lung biopsies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilyes Benlala, Agnes Albat, Elodie Blanchard, Julie Macey, Chantal Raherison, Thomas Benkert, Patrick Berger, Francois Laurent, Gael Dournes
Summary: This study assessed the feasibility of quantifying T-2 interstitial lung disease signal-intensity volume using a semi-automated method and found that T-2-ISIV was significantly correlated with disease severity in IPF patients and higher in IPF patients compared to controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Medicine, General & Internal
Jonathan H. Chung, Ayodeji Adegunsoye, Brenna Cannon, Rekha Vij, Justin M. Oldham, Christopher King, Steven M. Montner, Prahasit Thirkateh, Scott Barnett, Ronald Karwoski, Brian J. Bartholmai, Mary Strek, Steven D. Nathan
Summary: A study comparing quantitative imaging data between IPF and CTD-ILD in a UIP setting found that VRS was higher in IPF patients. VRS showed an inverse correlation with DLCO%, while the total volume of normal lung was associated with both DLCO% and FVC% in multivariable analysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Tsuyoshi Takahashi, Yuriko Terada, Michael K. Pasque, Jingxia Liu, Derek E. Byers, Chad A. Witt, Ruben G. Nava, Varun Puri, Benjamin D. Kozower, Bryan F. Meyers, Daniel Kreisel, G. Alexander Patterson, Ramsey R. Hachem
Summary: CPFE, a characteristic syndrome of smoking-related interstitial lung disease, is associated with higher risks of primary graft dysfunction, acute cellular rejection, and chronic lung allograft dysfunction after lung transplantation. However, the survival rate after transplantation is not significantly different between CPFE and IPF patients.
Review
Cell Biology
Shengnan Yang, Peipei Liu, Yale Jiang, Zai Wang, Huaping Dai, Chen Wang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, and currently the only medications that can slow down the progression of the disease and improve survival rate are pirfenidone and nintedanib. The use of mesenchymal stem cells (MSCs) provides a new hope for treating interstitial lung disease, but optimal treatment protocols are still lacking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roxana-Elena Cirjaliu, Mariana Deacu, Ioana Gherghisan, Angela Stefania Marghescu, Manuela Enciu, Gabriela Izabela Baltatescu, Antonela Anca Nicolau, Doina-Ecaterina Tofolean, Oana Cristina Arghir, Ariadna-Petronela Fildan
Summary: This review provides a comprehensive analysis of the risk factors, clinical, radiologic, and histological features of both post-COVID-19 pulmonary fibrosis (PCPF) and idiopathic pulmonary fibrosis (IPF). It highlights the similarities and differences between these two diseases by gathering relevant articles published in English up until October 2022 using multiple databases. This review aims to assist clinicians, pathologists, and researchers in making accurate diagnoses and selecting patients for anti-fibrotic therapies and future therapeutic perspectives.
Article
Biochemistry & Molecular Biology
Veronica Pulito-Cueto, Fernanda Genre, Raquel Lopez-Mejias, Victor Manuel Mora-Cuesta, David Iturbe-Fernandez, Virginia Portilla, Maria Sebastian Mora-Gil, Javier Gonzalo Ocejo-Vinyals, Oreste Gualillo, Ricardo Blanco, Alfonso Corrales, Ivan Ferraz-Amaro, Santos Castaneda, Jose Manuel Cifrian Martinez, Belen Atienza-Mateo, Sara Remuzgo-Martinez, Miguel Angel Gonzalez-Gay
Summary: The aim of this study was to investigate the role of endothelin-1 (ET-1) as a biomarker of interstitial lung disease (ILD), and to differentiate between idiopathic pulmonary fibrosis (IPF) and ILD associated with autoimmune diseases (AD-ILD). The study included a large cohort of ILD patients and healthy controls, and found that ET-1 levels were increased in IPF and AD-ILD patients compared to controls. However, ET-1 levels could not differentiate between IPF and AD-ILD, and were associated with worse lung function in IPF and RA-ILD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Menglin Zou, Xingxing Hu, Weiwei Song, Han Gao, Changrong Wu, Weishuai Zheng, Zhenshun Cheng
Summary: This study found that plasma LTBP2 levels can serve as a biomarker for differentiating CTD-ILD and IPF, and assessing their fibrotic activity. Additionally, clinical evaluation of LTBP2 may be helpful in identifying the presence of the UIP pattern in RA-ILD and discriminating IPF from CTD-UIP, particularly RA-UIP.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Respiratory System
Aparna C. Swaminathan, Anne S. Hellkamp, Megan L. Neely, Shaun Bender, Luca Paoletti, Eric S. White, Scott M. Palmer, Timothy P. M. Whelan, Daniel F. Dilling
Summary: This study identifies the factors associated with lung transplant or death in patients with idiopathic pulmonary fibrosis (IPF). Age, income, and access to lung transplant centers are found to influence the likelihood of receiving a lung transplant or dying. Interventions are needed to address the socioeconomic disparities in lung transplantation.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)