Article
Peripheral Vascular Disease
Lingyan Fei, Minze Xu, Honghong Wang, Cheng Zhong, Shan Jiang, Falk-Bach Lichtenberger, Cem Erdogan, Han Wang, Julia S. Bonk, En Yin Lai, Pontus B. Persson, Richard Kovacs, Zhihua Zheng, Andreas Patzak, Pratik H. Khedkar
Summary: Acute hyperglycemia is a risk factor for acute kidney injury, and our study suggests that hyperglycemia-induced hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Our findings indicate that inhibiting Piezo1 and CaMKII can prevent the vasodilation induced by hyperglycemia and hyperosmotic mannitol solution.
Review
Peripheral Vascular Disease
Jing Liu, Yong Liu, Feng Wang, Mingyu Liang
Summary: miR-204 is a high-value microRNA that plays a critical role in regulating cardiovascular and renal physiology, exhibiting tissue-specific expression patterns and being influenced by multiple regulatory mechanisms. It attenuates pulmonary arterial hypertension and renal injury while promoting hypertension and endothelial dysfunction, potentially impacting disease processes through targeting various biological pathways. Dysregulation of miR-204 in cardiovascular and renal diseases highlights its unequivocal functional roles and clinical relevance.
Article
Biochemistry & Molecular Biology
Soha Sohail, Gabriella Akkawi, Taylor Rechter, Maurice B. Fluitt, Carolyn M. Ecelbarger
Summary: Insulin receptor (InsR) signaling in renal tubules shows sex differences, with distinct effects on sodium reabsorption and gluconeogenesis. Knocking out InsR in adult male and female mice resulted in reduced kidney weight and altered renal cellular structures. Protein levels related to sodium channels and transporters were downregulated in both sexes, but with different patterns. Glucose clearance and blood glucose levels were faster and lower in knockout mice, but only male knockout mice showed enhanced renal gluconeogenesis. These findings highlight the importance of intact renal tubular InsR signaling in metabolic disorders like type 2 diabetes and obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Lu Wang, Yiqian Wu, Zhanjun Jia, Jing Yu, Songming Huang
Summary: PGE2 exerts its effects through four different receptors, influencing the functions of the kidney and blood vessels, and playing a significant role in fluid metabolism and blood pressure homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Reetu R. Singh, Zoe M. McArdle, Lindsea C. Booth, Clive N. May, Geoff A. Head, Karen M. Moritz, Markus P. Schlaich, Kate M. Denton
Summary: The study showed that renal denervation (RDN) in sheep with hypertensive chronic kidney disease normalized NO bioavailability and restored the contribution of NO to renal hemodynamics. This improvement in NO levels may promote enhancements in kidney function and sustained blood pressure lowering after RDN in hypertensive CKD.
Article
Peripheral Vascular Disease
Kunihiko Aizawa, Alun D. Hughes, Francesco Casanova, Phillip E. Gates, David M. Mawson, Kim M. Gooding, Mark Gilchrist, Isabel Goncalves, Jan Nilsson, Faisel Khan, Helen M. Colhoun, Carlo Palombo, Kim H. Parker, Angela C. Shore
Summary: This study demonstrates that baseline reservoir pressure integral is associated with the decline in renal function in older adults, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.
Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Article
Geriatrics & Gerontology
Lixia Liu, Yangong Chao, Xiaoting Wang
Summary: Improving organ blood perfusion is crucial in shock resuscitation, and the kidney, with its excellent ability to autoregulate blood flow and vulnerability to poor perfusion, requires priority evaluation in shock. Critical-care ultrasonography provides the best assessment of renal perfusion.
Article
Geriatrics & Gerontology
Lixia Liu, Yangong Chao, Xiaoting Wang
Summary: Improving organ blood perfusion is crucial for shock resuscitation, especially in the case of the kidney which has excellent autoregulatory ability and is vulnerable to poor perfusion. Critical-care ultrasonography provides the best evaluation of renal perfusion.
Review
Physiology
Jessica R. Ivy, Matthew A. Bailey
Summary: Blood pressure follows a daily rhythm, dipping during nocturnal sleep, and attenuation of this dip is associated with increased risk of cardiovascular disease. Renal control of sodium homeostasis is crucial for long-term blood pressure control, as sodium reabsorption and excretion involve predictive/circadian as well as reactive adaptations. These rhythms may contribute to blood pressure rhythm in health and disease.
Article
Urology & Nephrology
Elaine Ku, Charles E. E. McCulloch, Lesley A. A. Inker, Hocine Tighiouart, Franz Schaefer, Elke Wuehl, Piero Ruggenenti, Giuseppe Remuzzi, Barbara A. A. Grimes, Mark J. J. Sarnak
Summary: This pooled analysis of seven trials shows that intensive blood pressure control can delay the onset of kidney replacement therapy in patients with CKD stages 4-5, but does not necessarily have an effect in CKD stage 3 patients. Therefore, future trials focusing on blood pressure targets in populations with advanced kidney disease are needed.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Transplantation
Christian Ott, Felix Mahfoud, Giuseppe Mancia, Krzysztof Narkiewicz, Luis M. Ruilope, Martin Fahy, Markus P. Schlaich, Michael Bohm, Roland E. Schmieder
Summary: The blood pressure lowering effects of renal denervation (RDN) were compared between hypertensive patients with or without chronic kidney disease (CKD). The results showed that the reduction in 24-hour systolic and diastolic blood pressure was similar in both groups after RDN, but the reduction in office systolic blood pressure was less in patients with CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Peripheral Vascular Disease
Maria Korogiannou, Pantelis Sarafidis, Marieta P. Theodorakopoulou, Maria Eleni Alexandrou, Efstathios Xagas, Antonis Argyris, Athanase Protogerou, Charles J. Ferro, Ioannis N. Boletis, Smaragdi Marinaki
Summary: Blood pressure control in male and female kidney transplant recipients is similar according to office criteria, but significantly different according to ambulatory blood pressure monitoring criteria. Worse ambulatory blood pressure control in males may interfere with renal and cardiovascular outcomes.
JOURNAL OF HYPERTENSION
(2022)
Article
Medicine, General & Internal
Chun Yin See, Chien-Tzu Tseng, Wei-Ren Lin, Jo-Yen Chao, Te-Hui Kuo, Ming-Cheng Wang
Summary: This study found that seasonal blood pressure changes were associated with outcomes in patients with chronic kidney disease in southern Taiwan. Patients with elevated blood pressure in wintertime were older and had a higher prevalence of diabetic nephropathy, leading to worse outcomes. Home blood pressure monitoring was shown to be crucial for better outcomes in these patients.
FRONTIERS IN MEDICINE
(2021)
Review
Urology & Nephrology
Soline Bourgeois, Carsten A. Wagner
Summary: Pendrin plays a critical role in renal salt handling and blood pressure regulation, being regulated by various hormones. Drugs blocking pendrin are currently in development to target its activity.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
