Article
Oncology
Jacques A. Greenberg, Maureen D. Moore, Jessica W. Thiesmeyer, Caitlin E. Egan, Yeon Joo Lee, Paul Christos, Rasa Zarnegar, Toni Beninato, Thomas J. Fahey, Brendan M. Finnerty
Summary: The prognosis of patients with coexisting papillary thyroid cancer (PTC) and anaplastic thyroid carcinoma (ATC) depends on the presence of aggressive clinicopathologic features and lies between that of PTC and ATC. Adjuvant radioactive iodine (RAI) and external beam radiation therapy (EBRT) may improve survival, even after complete surgical resection.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Zhen Xu, Hyo Shik Shin, Yoo Hyung Kim, Seong Yun Ha, Jae-Kyung Won, Su-jin Kim, Young Joo Park, Sareh Parangi, Sun Wook Cho, Kyu Eun Lee
Summary: This study aimed to establish a novel orthotopic ATC model in C57BL/6 mice and characterize the tumor microenvironment focusing immunity in the model. The results showed that compared with the B6129SF1 mouse model, this new model exhibited more aggressive tumor cell behaviors and strong immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Laetitia Gheysen, Laura Soumoy, Anne Trelcat, Laurine Verset, Fabrice Journe, Sven Saussez
Summary: The study demonstrated that OTX008 significantly inhibited proliferation, migration, and invasion in thyroid cancer cell lines expressing high levels of Gal-1, showing promising anti-cancer effects. Further investigation of the molecular mechanisms and future clinical trials in patients with anaplastic thyroid cancer are warranted.
Article
Geriatrics & Gerontology
Wouter R. P. H. van de Worp, Jan Theys, Alba Sanz Gonzalez, Brent van der Heyden, Frank Verhaegen, Duncan Hauser, Florian Caiment, Hubertus J. M. Smeets, Annemie M. W. J. Schols, Ardy van Helvoort, Ramon C. J. Langen
Summary: A syngeneic, orthotopic lung cancer mouse model was evaluated to see if it replicates the systemic and muscle-specific alterations associated with human lung cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Kun Wang, Shiyang Liu, Yao Tian, Chenguang Liu, Zhengwei Gui, Tianyao Yu, Lin Zhang
Summary: This study identified 39 differentially expressed genes (DEGs) associated with the progression of papillary thyroid cancer (PTC), among which PDZK1IP1 was found to be upregulated both at the mRNA and protein levels. High expression of PDZK1IP1 was associated with poor progression-free survival, lymph node metastasis, and other clinical characteristics in PTC. Functionally, PDZK1IP1 promoted proliferation and inhibited apoptosis of PTC cells, suggesting its role as an oncogene and potential therapeutic target in PTC.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Rozita Bagheri-Yarmand, Naifa L. Busaidy, Elena McBeath, Brian P. Danysh, Kurt W. Evans, Tyler J. Moss, Argun Akcakanat, Patrick K. S. Ng, Christina M. Knippler, Jalyn A. Golden, Michelle D. Williams, Asha S. Multani, Maria E. Cabanillas, Kenna R. Shaw, Funda Meric-Bernstam, Manisha H. Shah, Matthew D. Ringel, Marie Claude Hofmann
Summary: This study identified a novel RAC1 (P34R) mutation acquired during dabrafenib treatment, as well as revealed that an increase in RAC1 copy numbers and polyploidy of chromosome 7 may contribute to drug resistance.
Article
Oncology
Chunpeng Lv, Yanhui Gao, Jinyin Yao, Yan Li, Qun Lou, Meichen Zhang, Qiushi Tian, Yanmei Yang, Dianjun Sun
Summary: The study demonstrates that high iodine induces proliferation of thyroid cancer cells by accelerating cell cycle progression, with involvement of factors such as CDK1, AKT and Wee1.
FRONTIERS IN ONCOLOGY
(2021)
Correction
Biochemical Research Methods
Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, Charles Lee
Summary: An amendment to the paper has been published and can be accessed through the original article.
BIOLOGICAL PROCEDURES ONLINE
(2021)
Article
Endocrinology & Metabolism
Hao Yang, Qingzhuang Liang, Jian Zhang, Jinkun Liu, Hao Wei, Haibo Chen, Wei Wei, Dong Chen, Yongsheng Zhao
Summary: Papillary thyroid cancer (PTC) is a common malignancy with increasing morbidity and mortality. Traditional culture methods lack tissue structure and fail to reflect tumor heterogeneity. Mouse models are time-consuming and inefficient for large-scale application. Clinical relevant patient-derived organoids have been successfully established from PTC clinical specimens, showing high consistency with parental tumors in histopathological and genome analysis. A detailed method for deriving PTC organoids from clinical specimens is presented, with a success rate of 77.6% (38/49) so far.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Peng Zhang, Changjuan Tao, Takaya Shimura, Andrew C. Huang, Nana Kong, Yujie Dai, Shili Yao, Yun Xi, Xing Wang, Jianmin Fang, Marsha A. Moses, Peng Guo
Summary: Through bioinformatic expression analyses and immunohistochemistry staining, we identified ICAM1 as an attractive target for ATC and PTC. We developed ICAM1-directed antibody-drug conjugates, I1-MMAE and I1-DXd, which effectively eliminated ATC and PTC cells without affecting non-cancerous cells in vitro. In vivo studies demonstrated significant tumor regression in ATC and PTC xenograft models. Additionally, we explored MRI as a non-invasive biomarker detection method for ICAM1 antigen expression in heterogeneous thyroid tumors. This study provides a strong rationale for the further development of I1-MMAE and I1-DXd as promising therapeutic candidates for advanced PTC and ATC.
Article
Endocrinology & Metabolism
Keith C. Bible, Electron Kebebew, James Brierley, Juan P. Brito, Maria E. Cabanillas, Thomas J. Clark, Antonio Di Cristofano, Robert Foote, Thomas Giordano, Jan Kasperbauer, Kate Newbold, Yuri E. Nikiforov, Gregory Randolph, M. Sara Rosenthal, Anna M. Sawka, Manisha Shah, Ashok Shaha, Robert Smallridge, Carol K. Wong-Clark
Summary: The guidelines for the management of anaplastic thyroid cancer (ATC) aim to provide evidence-based recommendations to inform clinical decision-making, encompassing diagnosis, treatment goals, locoregional and advanced disease approaches, palliative care, surveillance, and ethical considerations.
Article
Endocrinology & Metabolism
Sarika N. Rao, Robert C. Smallridge
Summary: Anaplastic thyroid cancer (ATC) is a highly malignant cancer with a low survival rate, especially in older women. It spreads rapidly to nearby structures and distant sites outside the neck. Despite the introduction of newer treatment strategies, further research is needed to improve survival outcomes.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biotechnology & Applied Microbiology
Jing He, Mingxia Zhou, Jie Yin, Junhu Wan, Jie Chu, Jinlin Jia, Jinxiu Sheng, Chang Wang, Huiqing Yin, Fucheng He
Summary: The RNA modification N6-methyladenosine (m6A) plays a crucial role in papillary thyroid carcinoma (PTC) by regulating the tumor-suppressive effects of METTL3 on c-Rel and RelA. Additionally, METTL3 disruption leads to IL-8 secretion and altered recruitment of tumor-associated neutrophils (TANs), affecting tumor growth and metastasis.
Article
Cell Biology
Jianing Tang, Yongwen Luo, Liang Xiao
Summary: This study identified USP26 as a deubiquitinating enzyme for TAZ in anaplastic thyroid cancer (ATC) and demonstrated its significant influence on cell proliferation, migration, and invasion in ATC. Depletion of USP26 resulted in decreased TAZ protein level and affected the expression of TAZ/TEAD target genes in ATC.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Qin Yang, Xiang-Cheng Shi, Li -Qin Zhai, Hong Bi, Jie Wang, Li-Zhu Yang, Chong-Xiao Qu
Summary: This study investigated the effect of interfering expression of the galectin-3 gene on the expression of TGF-beta 1/Smad3 and EMT-related proteins in papillary thyroid carcinoma (PTC). The results showed that interfering with galectin-3 gene expression can reduce the migration and invasion capacity of TPC-1 cells, and galectin-3 can promote the incidence of EMT in PTC through the TGF-beta 1/Smad3 signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biology
Luigi Angelo Vaira, Claudia Gessa, Giovanna Deiana, Giovanni Salzano, Fabio Maglitto, Jerome R. Lechien, Sven Saussez, Pasquale Piombino, Andrea Biglio, Federico Biglioli, Paolo Boscolo-Rizzo, Claire Hopkins, Valentina Parma, Giacomo De Riu
Summary: Persistent olfactory and gustatory dysfunctions are common symptoms of long-COVID-19 syndrome and significantly impact the mental health component of patients' quality of life.
Editorial Material
Computer Science, Interdisciplinary Applications
Adrien Foucart, Olivier Debeir, Christine Decaestecker
Summary: The MoNuSAC 2020 challenge hosted at the ISBI 2020 conference has been analyzed, revealing three problems in the computation of the metric used for ranking. The incorrect code version was used to rank the algorithms in the challenge. The results can be replicated using the code provided on GitHub.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Oncology
Corentin Martens, Antonin Rovai, Daniele Bonatto, Thierry Metens, Olivier Debeir, Christine Decaestecker, Serge Goldman, Gaetan Van Simaeys
Summary: This research proposed a deep learning-based approach to address problems in glioma growth models. By training deep neural networks, it is possible to reconstruct the cell-density distribution of the tumor and accurately evaluate model parameters. This approach has significant potential application value for glioma characterization and therapy planning.
Article
Cell Biology
Sonia Furgiuele, Geraldine Descamps, Jerome R. Lechien, Didier Dequanter, Fabrice Journe, Sven Saussez
Summary: By assessing immune cell infiltrates, an immunoscore can be developed for prognosis in head and neck cancer patients, with the combination of CD8, FoxP3, and CD68 immunoscore showing a significant association with overall survival.
Review
Biochemistry & Molecular Biology
Julie Marin, Fabrice Journe, Ghanem E. Ghanem, Ahmad Awada, Nadege Kindt
Summary: This review explores the involvement of cytokines in different stages of brain metastases and their interaction with cells from the brain microenvironment. The gut-brain axis and its role in cytokine release during this process are also discussed.
Article
Biochemistry & Molecular Biology
Alessandro Scalia, Nadege Kindt, Anne Trelcat, Amandine Nachtergael, Pierre Duez, Fabrice Journe, Stephane Carlier
Summary: This study successfully produced oxidized low-density lipoproteins (oxLDL) and found that exposure to oxLDL can decrease the migration of head and neck cancer cells, as well as increase the expression of CD36 and LOX-1 receptors associated with lipid uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Laura Soumoy, Ghanem E. Ghanem, Sven Saussez, Fabrice Journe
Summary: Bufalin has a wide range of anti-cancer effects both in vitro and in vivo, reducing cancer cell proliferation by affecting the cell cycle and inducing different cell death mechanisms. Additionally, it moderates metastasis formation by blocking migration and invasion, inhibiting angiogenesis, inducing phenotype switch, and reducing cancer cell stemness.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Oncology
Geraldine Descamps, Sonia Furgiuele, Nour Mhaidly, Fabrice Journe, Sven Saussez
Summary: This study improves the classification of oropharyngeal squamous cell carcinomas (OPSCCs) associated with poor outcomes by evaluating the recruitment levels of immune cells. The combination of immune criteria with p16 status or TNM staging showed powerful prognostic values in OPSCC patients. These results encourage further studies on the use of immune criteria in the classification of OPSCCs.
Article
Cell Biology
Pashalina Kehagias, Nadege Kindt, Mohammad Krayem, Ahmad Najem, Giulia Agostini, Elena Acedo Reina, Giacomo Bregni, Francesco Sclafani, Fabrice Journe, Ahmad Awada, Ghanem E. Ghanem, Alain Hendlisz
Summary: This study explores potential resistance mechanisms to regorafenib in CRC cells. Short-term exposure led to senescence-like features, while long-term exposure resulted in acquired resistance. Different cell lines displayed different senescence states and phenotype changes. HCT-116 cells acquired a more aggressive phenotype through EMT, while SW480 cells showed cell arrest and senescence features.
Editorial Material
Microbiology
Sven Saussez, Luigi Angelo Vaira, Giacomo De Riu, Jerome R. Lechien
Article
Pharmacology & Pharmacy
Barbara Freis, Maria De Los Angeles Ramirez, Celine Kiefer, Sebastien Harlepp, Cristian Iacovita, Celine Henoumont, Christine Affolter-Zbaraszczuk, Florent Meyer, Damien Mertz, Anne Boos, Mariana Tasso, Sonia Furgiuele, Fabrice Journe, Sven Saussez, Sylvie Begin-Colin, Sophie Laurent
Summary: Functionalized iron oxide nanoparticles (IONPs) with different shapes and sizes are synthesized and coated with dendron molecules to ensure biocompatibility and colloidal stability. These IONPs show promise in combining magnetic hyperthermia (MH) and photothermia (PTT) for cancer therapy. The 22 nm nanospheres and the 19 nm nanocubes exhibit the most promising theranostic properties, including efficient MRI contrast and hyperthermia abilities.
Article
Computer Science, Artificial Intelligence
Adrien Foucart, Olivier Debeir, Christine Decaestecker
Summary: Biomedical image analysis competitions often use a single metric to rank participants, which makes it difficult to assess the strengths and weaknesses of algorithms. The MoNuSAC 2020 challenge provides an interesting opportunity to study the information lost by using entangled metrics by involving multiple capabilities and releasing prediction masks from different teams. The results analysis using Panoptic Quality (PQ) and disentangled metrics shows that PQ hides interesting aspects of the results and is sensitive to small changes in prediction masks, making it hard to interpret and draw insights from the results. Access to raw predictions from participating teams is necessary for better analysis and usefulness to the research community.
PATTERN RECOGNITION
(2023)
Review
Medicine, General & Internal
Cyril Bouland, Xavier Vanden Eynden, Martin Lalmand, Thibaut Buset, Antoine Yanni, Rokneddine Javadian, Alexandra Rodriguez, Isabelle Loeb, Jerome R. Lechien, Fabrice Journe, Sven Saussez, Didier Dequanter
Summary: This systematic review examines the role of metformin in the prevention and treatment of head and neck cancer (HNC). The results suggest a protective effect of metformin in reducing HNC incidence. However, there is no consensus on its therapeutic effects. Metformin appears to improve cancer-related survival rates in diabetic patients, but no advantages were found compared to non-diabetic population. Further studies are needed to evaluate the effect of metformin on cancer-related survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)