Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling

The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

(2017) Minh Ngoc Duong et al.   Oncotarget

An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients

(2016) G. Piro et al.   CLINICAL CANCER RESEARCH

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

(2016) J. Incio et al.   Cancer Discovery

Adipocytes WNT5a mediated dedifferentiation: a possible target in pancreatic cancer microenvironment

(2016) Elena Zoico et al.   Oncotarget

TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients

(2015) G Piro et al.   BRITISH JOURNAL OF CANCER

Ror2 as a Therapeutic Target in Cancer

(2015) Zufan Debebe et al.   PHARMACOLOGY & THERAPEUTICS

Metastatic pancreatic cancer: Is there a light at the end of the tunnel?

(2015) Vanja Vaccaro   WORLD JOURNAL OF GASTROENTEROLOGY

High ROR2 expression in tumor cells and stroma is correlated with poor prognosis in pancreatic ductal adenocarcinoma

(2015) Jianfei Huang et al.   Scientific Reports

An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis

(2015) Carmine Carbone et al.   Oncotarget

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Pancreatic Cancer: Systemic Combination Therapies for a Heterogeneous Disease

(2014) Davide Melisi et al.   CURRENT PHARMACEUTICAL DESIGN

Pancreatic ductal adenocarcinoma cell lines display a plastic ability to bi-directionally convert into cancer stem cells

(2014) ELISA DALLA POZZA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Abstract B24: Biomarker analysis in the first-in-human phase 1a study for vantictumab (OMP-18R5; anti-Frizzled) demonstrates pharmacodynamic (PD) modulation of the Wnt pathway in patients with advanced solid tumors.

(2014) D. C. Smith et al.   MOLECULAR CANCER THERAPEUTICS

High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model

(2013) D. W. Dawson et al.   Cancer Prevention Research

Rationale and clinical use of multitargeting anticancer agents

(2013) Davide Melisi et al.   CURRENT OPINION IN PHARMACOLOGY

Prediagnostic Body Mass Index and Pancreatic Cancer Survival

(2013) Chen Yuan et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues

(2013) Mariano Di Trapani et al.   STEM CELLS AND DEVELOPMENT

Obesity and cancer risk: evidence, mechanisms, and recommendations

(2012) Ivana Vucenik et al.   Annals of the New York Academy of Sciences

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Editorial [Hot Topic: Pancreatic Cancer: Between Bench and Bedside (Guest Editors: Davide Melisi and Alfredo Budillon)]

(2012) Davide Melisi et al.   CURRENT DRUG TARGETS

Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis

(2012) H.-Y. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression

(2011) Jiyoung Park et al.   ENDOCRINE REVIEWS

Emerging pathways and future targets for the molecular therapy of pancreatic cancer

(2011) Vanja Vaccaro et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain

(2010) Hsiao-Chun Tseng et al.   BMC CELL BIOLOGY

Subcutaneous adipose tissue classification

(2010) A. Sbarbati et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

Oral Poly(ADP-Ribose) Polymerase-1 Inhibitor BSI-401 Has Antitumor Activity and Synergizes with Oxaliplatin against Pancreatic Cancer, Preventing Acute Neurotoxicity

(2009) D. Melisi et al.   CLINICAL CANCER RESEARCH

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET