Journal
INTERNATIONAL JOURNAL OF OBESITY
Volume 41, Issue 6, Pages 986-989Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2017.48
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Funding
- Pediatric Diabetes and Metabolic Disorders Unit of the University Hospital in Verona
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We aimed to assess in obese youths the relationships between interleukin-6 (IL-6), fat meal-induced endotoxemia and glucose homeostasis. Twenty obese children/adolescents (9-17 years old, 11 boys) underwent a standard oral glucose tolerance test and, 714 days later, a 5-h fat meal test (fat = 69% of energy, saturated/monounsaturated/polyunsaturated fatty acids = 31.5%/35%/33.5%), with serial measures of IL-6 and two markers of lipopolysaccharide (LPS) exposure and translocation, LPS-binding protein (LBP) and soluble CD14 (sCD14). IL-6 correlated not only with basal (homeostatic model assessment-insulin resistance) but also with postprandial (Matsuda index) insulin sensitivity (r = 0.61 (0.24-0.82), P = 0.005, r = -0.53 (0.12-0.78), P = 0.03, respectively). IL-6 did not change after the meal whereas LBP and sCD14 decreased significantly, indicating LPS translocation. Neither basal sCD14 and LBP nor their incremental concentrations correlated with IL-6 or glucose homeostasis. In our sample, IL-6 was associated with insulin sensitivity but not with LPS exposure, suggesting that meals with a balanced content of saturated/monounsaturated/polyunsaturated fatty acids may not be associated with LPS-induced inflammation and metabolic impairment.
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