Review
Pediatrics
Colin J. Crilly, Sebastien Haneuse, Jonathan S. Litt
Summary: This article provides an in-depth review of risk prediction models for preterm neonates predicting functional outcomes, highlighting the focus on predicting poor neurodevelopmental outcomes. It suggests future models should aim for consistent outcomes definitions, standardized assessment schedules and measurement tools, and consider risks beyond physiologic antecedents. This review reveals areas for improvement in developing risk prediction tools for this population.
PEDIATRIC RESEARCH
(2021)
Article
Medicine, General & Internal
Yun Cao, Siyuan Jiang, Jianhua Sun, Mingyan Hei, Laishuan Wang, Huayan Zhang, Xiaolu Ma, Hui Wu, Xiaoying Li, Huiqing Sun, Wei Zhou, Yuan Shi, Yanchen Wang, Xinyue Gu, Tongling Yang, Yulan Lu, Lizhong Du, Chao Chen, Shoo K. Lee, Wenhao Zhou
Summary: This cohort study evaluated care practices and outcomes for very preterm infants in Chinese neonatal intensive care units. The findings suggest that survival rates and survival without major morbidity for these infants in China are lower compared to high-income countries, highlighting the need for clinical quality improvement and health services reorganization to enhance outcomes.
Article
Multidisciplinary Sciences
Alice Hoffsten, Laszlo Markasz, Katharina Ericson, Leif D. Nelin, Richard Sindelar
Summary: Autopsy determined the final cause of death in one-third of cases, and necrotizing enterocolitis as a cause of death increased significantly during the study period. The autopsy rate did not change significantly between the two study periods.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Anne R. Synnes, Julie Petrie, Ruth E. Grunau, Paige Church, Edmond Kelly, Diane Moddemann, Xiang Ye, Shoo K. Lee, Karel O'Brien
Summary: According to this study, FICare did not have a significant impact on cognitive and language delay in very preterm infants, but did show improvements in motor development.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Juan D. Rios, Prakesh S. Shah, Marc Beltempo, Deepak Louis, Amit Mukerji, Shahirose Premji, Vibhuti Shah, Shoo K. Lee, Petros Pechlivanoglou
Summary: The study developed and validated an itemized costing algorithm for in-patient neonatal intensive care unit (NICU) costs for prematurely born infants. Results showed that NICU costs for preterm infants increase as gestational age decreases and length of stay increases. The cost estimates provided are easily accessible, transparent, and consistent with previous estimates.
JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Jessica Liu, Emily M. Pang, Alexandra Iacob, Aida Simonian, Ciaran S. Phibbs, Jochen Profit
Summary: This study aimed to compare the characteristics and clinical outcomes between safety net and non-safety net neonatal intensive care units (NICUs) in California. The study found that safety net NICUs performed similarly to non-safety net NICUs in terms of quality of care, except for small but significant differences in human milk nutrition, infection, hypothermia, necrotizing enterocolitis, and mortality.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Elizabeth G. Salazar, Sara C. Handley, Lucy T. Greenberg, Erika M. Edwards, Scott A. Lorch
Summary: This study analyzed 433,814 premature infants born in 465 US hospitals and found that the level of care in the neonatal intensive care unit (NICU) is associated with care quality for moderate and late preterm (MLP) infants but not for extremely and very preterm infants. MLP infants in type C NICUs had lower care quality scores. This study suggests that providing less complex subspecialty services in NICUs may improve the care quality for MLP infants.
Article
Cell Biology
Drew J. Schwartz, Nitan Shalon, Kate Wardenburg, Anna DeVeaux, Meghan A. Wallace, Carla Hall-Moore, I. Malick Ndao, Janice E. Sullivan, Paula Radmacher, Marilyn Escobedo, Carey-Ann D. Burnham, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas
Summary: BSI in preterm infants is commonly transmitted through the gut microbiome and is associated with antibiotic exposure. Ampicillin, gentamicin, or vancomycin can increase the abundance of Enterobacteriaceae and Enterococcaceae in the gut of preterm infants. This study suggests that the microbial composition of the gut can be utilized to predict the risk of BSI in hospitalized preterm infants.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Pediatrics
Kayla L. Karvonen, Erica Anunwah, Brittany D. Chambers Butcher, Lydia Kwarteng, Tameyah Mathis-Perry, Monica R. McLemore, Sally Oh, Matthew S. Pantell, Olga Smith, Elizabeth Rogers
Summary: This study aimed to evaluate structural racism in the neonatal intensive care unit (NICU) by examining if there were differences in adverse social events among different racialized groups. A retrospective cohort study was conducted on 3290 infants hospitalized in a single center NICU. The study found racial inequities in adverse social events, with Black and American Indian/Alaskan Native families being more likely to experience such events, while Asian families were less likely.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Katherine A. Gallaway, Kayla Cann, Katherine Oetting, Mary Rothenberger, Andra Raibulet, James E. Slaven, Kristen Suhrie, Emma M. Tillman
Summary: This study evaluated the use of pharmacogenomic (PGx) guidelines in early childhood and found that a significant proportion of patients received PGx drugs during this period. Preterm birth, low birth weight, and the presence of congenital anomalies and/or a primary genetic diagnosis were predictive factors of PGx drug exposure. The study suggests that preemptive PGx testing in the neonatal intensive care unit (NICU) could impact medical management during the NICU stay and early childhood.
JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Noha Gomaa, Chaini Konwar, Nicole Gladish, Stephanie H. Au-Young, Ting Guo, Min Sheng, Sarah M. Merrill, Edmond Kelly, Vann Chau, Helen M. Branson, Linh G. Ly, Emma G. Duerden, Ruth E. Grunau, Michael S. Kobor, Steven P. Miller
Summary: This cohort study of very preterm neonates suggests that biological aging may be associated with impaired brain growth and neurodevelopmental outcomes. The associations between epigenetic aging and adverse neonatal brain health warrant further attention.
Article
Otorhinolaryngology
Diogo Raposo, Joao Orfao, Marco Menezes, Mafalda Trindade-Soares, Ana Guimaraes, Filipe Freire
Summary: This study analyzed the ABR findings of preterm and term infants in the NICU with perinatal problems. The results suggest that perinatal problems significantly impair the ABR threshold and the auditory pathway maturational process in preterm infants, but not in term infants.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Multidisciplinary Sciences
Ayenew Engida Yismaw, Abebaw Addis Gelagay, Malede Mequanent Sisay, Yazacchew Engida Yismaw
Summary: This study aimed to assess the recovery time and predictors in preterm neonates with respiratory distress syndrome admitted to the University of Gondar comprehensive specialized hospital in Northwest Ethiopia in 2020. The results showed that multiple pregnancy, vaginal delivery mode, and neonatal hypothermia at admission were significant predictors of longer recovery time.
Article
Medicine, General & Internal
Brynne A. Sullivan, Ayush Doshi, Pavel Chernyavskiy, Ameena Husain, Alexandra Binai, Rakesh Sahni, Karen D. Fairchild, J. Randall Moorman, Colm P. Travers, Zachary A. Vesoulis
Summary: This study investigates the association between socioeconomic status and hospital outcomes among premature infants. The findings suggest that the Area Deprivation Index (ADI), a measure of neighborhood disadvantage, is associated with neonatal intensive care unit (NICU) mortality and morbidity in extremely premature infants.
Article
Obstetrics & Gynecology
Sarah Saleem, Shiyam Sunder S. Tikmani, Shivaprasad Goudar, Kay Hwang, Sangappa Dhaded, Gowder G. Guruprasad, Naveen B. Nadig, Varun Kusagur, Lingaraja Gowda C. Patil, E. S. Siddartha, S. S. Yogeshkumar, Manjunath Somannavar, Sana Roujani, Mashal Khan, Mehmood Shaikh, Muhammad M. Hanif, Carla M. Bann, Elizabeth L. McClure, Robert Goldenberg, PURPOSE Study Group
Summary: This study investigated the potential reasons for the differences in preterm neonatal mortality between neonatal intensive care units (NICUs) in India and Pakistan. Despite equivalent weights and gestational ages, the neonatal mortality in the Pakistani NICU was twice that of the Indian NICU. Shorter length of stay and fewer diagnostic tests in the Pakistani NICU may explain the higher mortality.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Environmental Sciences
Xueying Zhang, Emily Spear, Chris Gennings, Paul C. Curtin, Allan C. Just, Jennifer B. Bragg, Annemarie Stroustrup
ENVIRONMENTAL RESEARCH
(2020)
Review
Environmental Sciences
Susan L. Schantz, Brenda Eskenazi, Jessie P. Buckley, Joseph M. Braun, Jenna N. Sprowles, Deborah H. Bennett, Jose Cordero, Jean A. Frazier, Johnnye Lewis, Irva Hertz-Picciotto, Kristen Lyall, Sara S. Nozadi, Sharon Sagiv, AnneMarie Stroustrup, Heather E. Volk, Deborah J. Watkins
ENVIRONMENTAL RESEARCH
(2020)
Article
Environmental Sciences
Xueying Zhang, Allan C. Just, Hsiao-Hsien Leon Hsu, Itai Kloog, Matthew Woody, Zhongyuan Mi, Johnathan Rush, Panos Georgopoulos, Robert O. Wright, Annemarie Stroustrup
Summary: The study explores an integrated hybrid approach combining dispersion modeling and land use regression to predict daily NO2 concentrations with high spatial resolution in the New York tri-state area. The mixed model showed good prediction performance and R-LINE outputs significantly improved the CV R-2 in terms of overall, spatial, and temporal aspects. This hybrid approach allows for predicting daily NO2 at extremely high spatial resolution such as city blocks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pediatrics
Jill L. Maron, Stephen F. Kingsmore, Kristen Wigby, Shimul Chowdhury, David Dimmock, Brenda Poindexter, Kristen Suhrie, Jerry Vockley, Thomas Diacovo, Bruce D. Gelb, Annemarie Stroustrup, Cynthia M. Powell, Andrea Trembath, Matthew Gallen, Thomas E. Mullen, Pranoot Tanpaiboon, Dallas Reed, Anne Kurfiss, Jonathan M. Davis
Summary: This study reports on interim findings from the GEMINI study comparing rapid whole-genomic sequencing with a targeted genomic platform for diseases presenting in infancy, with significant implications for clinical care. The study enrolled 113 patients, with 78% of infants with a pathogenic (P) or likely pathogenic (LP) variant experiencing significant alterations in clinical care. Significant limitations in understanding the interpretive challenges of existing genomic sequencing technologies were also highlighted.
Article
Environmental Sciences
Xueying Zhang, Norah Smith, Emily Spear, Annemarie Stroustrup
Summary: The study found that neighborhood socioeconomic status was a major risk factor for COVID-19 incidence in children and working-age adults, but had less impact on seniors. Social demographics and housing conditions were important factors affecting COVID-19 incidence in older age groups, and significant associations were observed between transportation-related variables and COVID-19 incidences in multiple age groups. The study concludes that age modifies the association between neighborhood characteristics and COVID-19 incidence.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Obstetrics & Gynecology
Margaret Pulju, Cassandra Pruitt, Jessica Reid-Adam, Emily Spear, Annemarie Stroustrup, Robert S. Green, Andrea S. Weintraub
Summary: This study identified a high prevalence of renal insufficiency in preterm children, highlighting the importance of routine kidney health assessments in this population. Preterm children with a history of stage 1 AKI had higher serum creatinine levels at follow-up, but were not more likely to have RI compared to children without a history of stage 1 AKI. Large multicenter studies are needed to further understand the impact of premature birth and mild AKI on renal function throughout childhood.
JOURNAL OF PERINATOLOGY
(2021)
Article
Pediatrics
Xueying Zhang, Emily Spear, Hsiao-Hsien Leon Hsu, Chris Gennings, Annemarie Stroustrup
Summary: This study found that stress in the neonatal intensive care unit (NICU) may have an impact on the early neurodevelopment of preterm infants. There is an association between salivary cortisol levels and performance on the neurobehavioral scales, and the association is influenced by the infants' gender. Critical developmental windows were identified based on postmenstrual age and chronological age, providing insight into the factors affecting the neurodevelopment of preterm infants.
PEDIATRIC RESEARCH
(2022)
Editorial Material
Pediatrics
Annemarie Stroustrup
PEDIATRIC RESEARCH
(2022)
Review
Pediatrics
T. Michael O'Shea, Monica McGrath, Judy L. Aschner, Barry Lester, Hudson P. Santos, Carmen Marsit, Annemarie Stroustrup, Crisma Emmanuel, Mark Hudak, Elisabeth McGowan, Simran Patel, Rebecca C. Fry
Summary: The National Institutes of Health's ECHO Program conducts research on the links between children's environment and health, with a focus on very preterm infants. The program utilizes data from three cohorts to study the effects of environmental factors on the health outcomes of preterm infants.
PEDIATRIC RESEARCH
(2023)
Article
Environmental Sciences
Stefanie A. Busgang, Emily A. Spear, Syam S. Andra, Srinivasan Narasimhan, Jennifer B. Bragg, Stefano Renzetti, Paul Curtin, Mia Bates, Manish Arora, Chris Gennings, Annemarie Stroustrup
Summary: In this study, the impact of NICU-based phthalate exposure on extrauterine growth trajectories was assessed using advanced growth modeling techniques and the NICU Hospital Exposures and Long-Term Health (NICU-HEALTH) study. The results showed that phthalate mixtures were associated with the timing and rate of the first growth spurt, and this relationship was modified by infant sex. These findings suggest that exposure to specific phthalates during NICU hospitalization may alter the timing and pattern of growth in a sexually dimorphic manner.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Public, Environmental & Occupational Health
Ruby H. N. Nguyen, Emily A. Knapp, Xiuhong Li, Carlos A. Camargo, Elisabeth Conradt, Whitney Cowell, Karen J. Derefinko, Amy J. Elliott, Alexander M. Friedman, Gurjit K. Khurana Hershey, Julie A. Hofheimer, Barry M. Lester, Cindy T. McEvoy, Jenae M. Neiderhiser, Emily Oken, Steven J. Ondersma, Sheela Sathyanarayana, Meagan E. Stabler, Annemarie Stroustrup, Irene Tung, Monica McGrath
Summary: This study analyzed cross-sectional data from 21,905 pregnancies enrolled in the ECHO program in the United States. The study identified characteristics associated with opioid use during pregnancy, including race, pregnancy period, parity, tobacco use, illegal drug use, and maternal depression.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Obstetrics & Gynecology
Steven J. Ondersma, Amii M. Kress, Annemarie Stroustrup, Robert D. Annett, Lyndsay A. Avalos, Maria Talavera-Barber, Patricia A. Brennan, Carlos A. Camargo, Elisabeth Conradt, Anne L. Dunlop, Amy J. Elliott, Monique M. Hedderson, Ximin Li, Monica McGrath, Ruby H. N. Nguyen, Grier P. Page, Sheela Sathyanarayana, Barry Lester
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Marie Camerota, Elisabeth C. McGowan, Judy Aschner, Annemarie Stroustrup, Margaret R. Karagas, Elisabeth Conradt, Sheila E. Crowell, Patricia A. Brennan, Brian S. Carter, Jennifer Check, Lynne M. Dansereau, Sheri A. DellaGrotta, Todd M. Everson, Jennifer B. Helderman, Julie A. Hofheimer, Jordan R. Kuiper, Cynthia M. Loncar, Carmen J. Marsit, Charles R. Neal, Thomas Michael O'Shea, Steven L. Pastyrnak, Stephen J. Sheinkopf, Lynne M. Smith, Xueying Zhang, Barry M. Lester
Summary: A multi-cohort study of preterm and term-born infants revealed two dysregulated neurobehavioral profiles with distinct perinatal antecedents. Factors such as gender, maternal age, and emotional state were predictive of neurobehavioral profiles. Further understanding of these factors could inform interventions for positive developmental outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Psychiatry
Danielle Roubinov, Rashelle J. Musci, Alison E. Hipwell, Guojing Wu, Hudson Santos, Jennifer N. Felder, Sabrina Faleschini, Elisabeth Conradt, Cindy T. McEvoy, Barry M. Lester, Claudia Buss, Amy J. Elliott, Jose F. Cordero, Annemarie Stroustrup, Nicole R. Bush
Summary: This study examined postpartum depressive symptom trajectories from birth to age 5 in mothers of preterm and full-term infants. It found that one in 5 mothers of preterm infants developed clinically relevant depressive symptoms, compared with 1 in 10 mothers of full-term infants. Women with preterm infants were more likely to have increasing and severe symptoms over time, particularly during the preschool and toddler years.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Letter
Obstetrics & Gynecology
Olivia Janssen, Michael Thompson, Sarah Milburn, Robert Green, Brian Wagner, Angela Bianco, Annemarie Stroustrup
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)