Review
Neurosciences
Haoyang Tian, Haozheng Zhu, Chenhao Gao, Mingxia Shi, Dekun Yang, Mingyu Jin, Fenghua Wang, Xiaohong Sui
Summary: During the past decades, the potential effects of extremely low-frequency electromagnetic fields (ELF-EMFs) on human health have gained significant attention worldwide. While there have been guidelines for magnetic field limits, further research is needed to explore the long-term effects of ELF-EMFs on organisms and systems, particularly the induced electrotherapy and potential impacts on human health under different frequencies and fields. This article systematically reviews the in vivo experimental outcomes and corresponding mechanisms to provide insights into the safety considerations of ELF-EMFs and advance the future application of electrotherapy in human health.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Hanne Herssens, David Toribio, Eline De Borre, Arno Thielens
Summary: This study used numerical simulations to investigate the far-field absorption of radio frequency electromagnetic fields (RF-EMFs) by different types of insects at frequencies ranging from 2 to 120 GHz, which are expected to be used in future wireless communication. The results showed that the absorbed power is related to the size and frequency, and a log-linear model was developed to estimate the absorbed power in insects. In addition, there was a high correlation between the absorbed power predicted by anatomically accurate insect models and those predicted by spheroid models within a certain frequency range.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2022)
Article
Physics, Multidisciplinary
J. Misek, J. Jakus, K. Hamza Sladicekova, L. Zastko, M. Veternik, V. Jakusova, I. Belyaev
Summary: Cell phones expose significant parts of the human brain and head to extremely low frequency (ELF) magnetic fields (MF) classified by the IARC as a 2B carcinogen. Measurements and simulations showed that the ELF MF emitted by cell phones can reach levels comparable to those known to induce biological and health effects, including carcinogenesis. Understanding the exposure and combined effects of radiofrequency and ELF electromagnetic fields is important for future studies.
FRONTIERS IN PHYSICS
(2023)
Review
Oncology
Mengqian Huang, Parker Li, Feng Chen, Zehao Cai, Shoubo Yang, Xiaohong Zheng, Wenbin Li
Summary: This review summarizes the five significant underlying mechanisms and applications of ELF-PEMF in the treatment of gliomas, as well as discusses the prospects of combining ELF-PEMF with conventional therapy for treating gliomas.
Article
Biology
Sebastian Shepherd, Christopher W. Jackson, Suleiman M. Sharkh, Hitoshi Aonuma, Eugenio E. Oliveira, Philip L. Newland
Summary: Research shows that exposure to 50 Hz electromagnetic fields can significantly impact the wingbeat frequency of locusts in a field strength-dependent manner, with effects varying based on the locust's initial frequency. During exposure to 50 Hz EMFs, locusts had their wingbeat frequencies entrained to a 2:5 ratio of the applied EMF cycles. Moreover, exposure to ELF EMFs near normal wingbeat frequency caused locusts to synchronize with the exact frequency of the applied field.
BIOELECTROMAGNETICS
(2021)
Article
Computer Science, Information Systems
Sumou Hu, Hui Xie, Zhangming Li
Summary: This paper addresses the challenge of Sommerfeld numerical integration in the near-field region by introducing a quasi-static approximation method. It examines the propagation of electromagnetic fields using a horizontal electric dipole model and provides approximations for electromagnetic field propagation in the near region. Experimental findings highlight the presence of lateral waves as the primary mode of electromagnetic wave propagation at the seawater-air boundary.
Article
Neurosciences
Wenjun Zhao, Lei Dong, Lei Tian, Ling Zhao, Yuhan Zhao, Yu Zheng
Summary: This study investigates the regulation of 15 Hz/2 mT ELF-EMFs on long-term potentiation (LTP) persistence in the hippocampal CA1 region of Sprague-Dawley rats at different early developmental stages. The results show that ELF-EMFs differentially inhibit LTP persistence depending on the age, with a stronger inhibitory effect in younger rats. The inhibitory effect is associated with intracellular calcium stores mediated by inositol-1,4,5-trisphosphate receptors (IP(3)Rs), and can be modulated by adjusting extracellular calcium concentration.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Environmental Sciences
Raffaella Lazzarini, Maria Elexpuru-Zabaleta, Francesco Piva, Matteo Giulietti, Gianluca Fulgenzi, Maria Fiorella Tartaglione, Laura Zingaretti, Adriano Tagliabracci, Matteo Valentino, Lory Santarelli, Massimo Bracci
Summary: This study analyzed the effects of exposure to extremely low-frequency electromagnetic fields (ELF-MF) on breast cancer cells. The results showed that ELF-MF increased cell viability, cellular morphology, oxidative stress response, and altered proteomic profile in breast cancer cells. Moreover, ELF-MF exposure also affected cell adhesion, migration, and invasion abilities, as well as induced changes in mitochondrial function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Masoud Khosravipour, Masoud Ghanbari Kakavandi, Faramarz Gharagozlou, Farshad Nadri, Akbar Barzegar, Khosro Emami, Hossein Valadi Athar
Summary: A four-year repeated measures study was conducted to quantify the long-term effects of noise, extremely low-frequency electromagnetic fields (ELF-EMFs), and shift work on liver enzymes. The study found that an increase in noise and ELF-EMFs was significantly associated with changes in liver enzymes. Shift work, especially 3-rotating night shifts, also had a significant impact on liver enzymes. Furthermore, significant interaction effects were observed among noise, ELF-EMFs, and shift work.
ENVIRONMENTAL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Maryam Sadat Nezamtaheri, Bahram Goliaei, Seyed Peyman Shariatpanahi, Alireza Madjid Ansari
Summary: The impact of extremely low-frequency electromagnetic field (ELF-EMF) on living cells is specific and depends on the biological state of the cell. Long-term exposure to ELF-EMF inhibits proliferation and induces cell death and morphological changes in adherent cells. Suspended cells differentiate and decrease in number after exposure to ELF-EMF.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Irit Markus, Evyatar Ohayon, Keren Constantini, Keren Geva-Kleinberger, Rawan Ibrahim, Angela Ruban, Yftach Gepner
Summary: Previous investigations have shown the therapeutic advantages of extremely low frequency electromagnetic fields (ELF-EMFs) in reducing inflammation and impacting biological processes. However, this study suggests that ELF-EMF has no significant overall effects on recovery rate following high-intensity exercise among athletes. Post-hoc analysis reveals modest benefits of ELF-EMF for younger athletes under certain conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Electrochemistry
Chun-Hong Chen, Hsiang-Pin Huang, Ling-Sheng Jang, Min-Haw Wang
Summary: The study presented an electrical equivalent model with microtubules for analyzing the division process of human breast cancer cells under ELF-EMF. It was found that ELF-EMF influences the assembly of microtubules, which in turn affects cell spreading, mitosis, and division stages.
ELECTROCHIMICA ACTA
(2021)
Article
Public, Environmental & Occupational Health
Muhammad Waseem Khan, Jukka Juutilainen, Jonne Naarala, Paivi Roivainen
Summary: The study found an association between childhood exposure to extremely low frequency magnetic fields and adult melanoma. This is in line with previous findings suggesting that the carcinogenic effects of ELF magnetic fields may be particularly associated with childhood exposure.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Biology
Henry Lai
Summary: This article reviews studies on the neurological effects of static/extremely-low frequency (ELF) electromagnetic fields (EMF), including the impact on neurotransmitters, behavioral effects, pathological effects, and treatment potential for neurological diseases. The results suggest that the effects of electromagnetic fields depend on the conditions of exposure.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2022)
Article
Computer Science, Information Systems
Sumou Hu, Hui Xie, Jianchen Feng
Summary: In this study, the propagation characteristics of extremely low frequency electromagnetic waves excited by horizontal electric dipoles in the polar sea-sea ice half-space were accurately calculated using an improved parallel TSS-FDTD electromagnetic field calculation method. The results showed that certain electric and magnetic field components were more suitable for receiving underwater signals near the interface between seawater and sea ice. The effectiveness and accuracy of the proposed method were verified through comparison with other methods.
Article
Otorhinolaryngology
Sima Farpour, Majid Asadi-Shekaari, Afshin Borhani Haghighi, Hamid Reza Farpour
Summary: This study aimed to investigate the effectiveness of stimulating the supramarginal gyrus (SMG) in improving post-stroke dysphagia. The results showed that the real group, which received anodal stimulation on the intact SMG, had significantly higher improvements in swallowing function compared to the sham group. After one-month follow-up, most of the patients in the real group reached a higher level of swallowing ability.
Correction
Nutrition & Dietetics
Maryam Haghparast Azad, Iman Niktab, Shaghayegh Dastjerdi, Navid Abedpoor, Golbarg Rahimi, Zahra Safaeinejad, Maryam Peymani, Farzad Seyed Forootan, Majid Asadi-Shekaari, Mohammad Hossein Nasr Esfahani, Kamran Ghaedi
NUTRITION & METABOLISM
(2022)
Article
Neurosciences
Hoda Ranjbar, Monavareh Soti, Mahyar Janahmadi, Kristi A. Kohlmeier, Vahid Sheibani, Meysam Ahmadi-Zeidabadi, Mohammad Shabani
Summary: This study suggests that cannabinoid agonists, specifically the CB1R agonist WIN, may not be effective in treating cerebellar ataxia and may even worsen symptoms. However, co-administration of the CB1R antagonist AM251 with WIN can prevent some ataxic symptoms. This indicates that cannabinoid modulation of ataxia symptoms may involve other cannabinoid receptors in addition to CB1Rs.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Review
Medicine, General & Internal
Mohammad Banazadeh, Sepehr Olangian-Tehrani, Melika Sharifi, Mohammadreza Malek-Ahmadi, Farhad Nikzad, Nooria Doozandeh-Nargesi, Alireza Mohammadi, Gary J. Stephens, Mohammad Shabani
Summary: The COVID-19 pandemic caused by SARS-CoV2 has raised significant health concerns, including increased mortality and morbidity. SARS-CoV2 can infect the central nervous system, particularly the cerebellum, leading to various sequelae such as thrombosis, hemorrhage, stroke, autoantibody production, ataxia, and widespread inflammation. These effects should be taken into consideration for disease prognosis.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Article
Neurosciences
Hoda Ranjbar, Monavareh Soti, Kristi A. Kohlmeier, Vahid Sheibani, Meysam Ahmadi-Zeidabadi, Kiana Rafiepour, Mohammad Shabani
Summary: The study suggests that treatment with AM251 can protect cerebellar PCs and improve motor function in a cerebellar ataxic model.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Aliakbar Mariki, Zahra Barzin, Majid Fasihi Harandi, Kimia Karbasi Ravari, Mahboubeh Davoodi, Seyed Mohammad Mousavi, Soheila Rezakhani, Masoud Nazeri, Mohammad Shabani
Summary: This study found that antigen B from hydatid cyst fluid could reduce the levels of anti-inflammatory cytokines in rats with experimental autoimmune encephalomyelitis (EAE)-induced multiple sclerosis (MS) and increase nerve conduction velocity. The results showed that antigen B modulated the immune system and reduced the inflammatory component of the EAE MS animal model, leading to a decrease in symptoms at the behavioral and electrophysiological level. Antigen B could be used as a potential therapeutic agent to regulate the immune system in MS patients.
BRAIN AND BEHAVIOR
(2023)
Article
Developmental Biology
Amin Hassanshahi, Mahyar Janahmadi, Moazamehosadat Razavinasab, Mehran Ilaghi, Kristi A. Kohlmeier, Elham Hassanshahi, Mohammad Shabani
Summary: In this study, the researchers found that prenatal agmatine exposure could ameliorate behavioural and cognitive deficits in female offspring born to prenatally stressed mice. This study contributes to a better understanding of the effects of prenatal stress on newborns and provides a foundation for targeted prenatal treatments.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Developmental Biology
Maysam Fadaei-kenarsary, Khadijeh Esmaeilpour, Mohammad Shabani, Sara Joushi, Vahid Sheibani
Summary: Maternal morphine exposure reduces motivation for cognitive tasks and leads to deficits in attention, accuracy, and executive function. It also induces depression-like behaviors and has negative consequences for learning and memory in offspring. Maternal separation can cause behavioral and neuropsychiatric abnormalities later in life. This study aimed to evaluate the effects of chronic morphine consumption and maternal separation on the cognitive and behavioral performance of male adolescent rats. The results showed that maternal separation increased locomotor activity and movement velocity, while morphine exposure worsened body stretching behavior. Maternal separation also resulted in spatial learning deficits, but recognition and spatial memory were not significantly affected. Overall, these findings suggest that maternal morphine exposure and maternal separation can impair cognitive and behavioral performance in adolescent male rats.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Moein Salari, Seyed Hassan Eftekhar-Vaghefi, Majid Asadi-Shekaari, Khadijeh Esmaeilpour, Somayeh Solhjou, Maryam Amiri, Meysam Ahmadi-Zeidabadi
Summary: In this study, we examined the effects of ketamine and extremely low-frequency electromagnetic fields (ELF-EMF) on depression-like behavior, learning and memory, and the expression of GFAP, caspase-3, p53, BDNF, and NMDA receptor in animals subjected to chronic unpredictable stress (CUS). The results revealed that the combination of ketamine and ELF-EMF had adverse effects on animals under chronic unpredictable stress.
BRAIN AND BEHAVIOR
(2023)
Review
Developmental Biology
Sina Motamedi, Reza Saboori Amleshi, Behnoush Akbari Javar, Parisa Shams, Kristi A. Kohlmeier, Mohammad Shabani
Summary: Epidemiological studies have shown that exposure to cannabis during gestation or the perinatal period can lead to mental health issues in childhood, adolescence, and adulthood. There is a high risk of negative outcomes in individuals with specific genetic variants, suggesting an interaction between cannabis usage and genetics. Animal research has also demonstrated long-term effects of prenatal and perinatal exposure to psychoactive components on neural systems relevant to psychiatric and substance use disorders. This article discusses the molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal and perinatal exposure to cannabis.
BIRTH DEFECTS RESEARCH
(2023)
Review
Multidisciplinary Sciences
Marjan Nikbakhtzadeh, Hoda Ranjbar, Khadijeh Moradbeygi, Elham Zahedi, Mahnaz Bayat, Monavareh Soti, Mohammad Shabani
Summary: Addiction is a worldwide problem with significant costs on health care, public security, and the community economic cycle. Stress plays a crucial role in the development of addiction and relapse vulnerability. This review examines the impact of stress on the Hypothalamus-Pituitary-Adrenal (HPA) axis and internal factors, such as neuro-inflammatory, neurotrophic, and neurotransmitter factors, and their effects on drug addiction vulnerability, craving, and relapse susceptibility.
Article
Dentistry, Oral Surgery & Medicine
Robert L. Merrill, Donald Goodman, Goli Chamani, Mohammad Shabani
Summary: Trismus can occur as a symptom of various diseases, with articular disorders being the most common cause. However, in rare cases, the cause may be extra-articular. This report describes a case of non-articular hysterical trismus in an 11-year-old boy, resulting in complete jaw lock and significant pain for 3 months. After three therapy sessions, the patient achieved significant improvement in mouth opening and resumed normal eating. This highlights the importance of comprehensive history taking and thorough clinical examination for accurate diagnosis of trismus, particularly in cases involving conversion disorders.
SPECIAL CARE IN DENTISTRY
(2023)
Article
Developmental Biology
Amin Hassanshahi, Mahyar Janahmadi, Moazamehosadat Razavinasab, Hoda Ranjbar, Narges Hosseinmardi, Gila Behzadi, Kristi A. Kohlmeier, Mehran Ilaghi, Mohammad Shabani
Summary: Prenatal stress (PS) can lead to behavioral disorders in offspring, such as substance abuse and anxiety. This study investigated the effects of agmatine on cognitive outcomes in male mice exposed to PS and molecular changes in the ventral tegmental area (VTA). The results showed that agmatine reduced locomotor activity impairment and conditioned place preference to morphine in PS offspring. Agmatine also improved anxiety-like behavior and drug-seeking behavior induced by PS. The molecular effects were observed in the VTA, with agmatine reducing enhanced brain-derived neurotrophic factor (BDNF) levels. Overall, prenatal treatment with agmatine protected against the negative consequences of PS on the development of affective circuits in offspring.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Neurosciences
Fatemeh Abolhasani, Yaghoub Pourshojaei, Fatemeh Mohammadi, Khadijeh Esmaeilpour, Ali Asadipour, Mehran Ilaghi, Mohammad Shabani
Summary: This study evaluated the effects of a synthetic phenoxyethyl piperidine derivative, compound 7c, as a novel dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), on learning and memory in an animal model of Alzheimer's disease (AD). The findings suggest that compound 7c acts as a central AChE inhibitor and has therapeutic potential in alleviating cognitive deficits in AD dementia.
NEUROSCIENCE LETTERS
(2023)
