Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 127, Issue 12, Pages 1096-1103Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207454.2017.1337014
Keywords
CUS; behavior; learning and memory; IGF-II; ERK
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Funding
- Shandong Provincial Natural Science Foundation of China [ZR2009DL009]
- Excellent Young and Middle-Aged Scientists Foundation of Shandong Province, China [BS2012SW021]
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Aim: To investigate the behavioral deficits, cognitive impairment and possible mechanisms induced by chronic unpredictable stress (CUS) in mice of different ages.Methods: The behaviors and cognition were tested using the open field test, tail suspension test and the Morris water maze. The changes in the insulin-like growth factor II (IGF-II) and the extracellular signal-regulated kinase (ERK) and phosphorylation (p-ERK) in the hippocampus (HP) and prefrontal cortex (PFC) were evaluated by immunohistochemistry.Results: The 15-month-old mice revealed a significant decline in spontaneous behavior and the learning-memory function and showed a decrease in IGF-II and p-ERK expression levels in HP and PFC. Four weeks of CUS exposure induced significant anxiety- and depression-like behavior and learning-memory function impairment in 3- to 15-month-old mice, and reduced IGF-II and p-ERK expression levels in HP and PFC, compared with control group mice, respectively.Conclusions: The behavioral deficits and cognitive impairment induced by CUS and aging in mice could be associated with the down-regulated expression of IGF-II and p-ERK in HP and PFC. This role seems to be dependent on the intracellular ERK pathway.
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