Article
Chemistry, Medicinal
Xin Deng, Ruiyao Mai, Chenyu Zhang, Dianbao Yu, Yichang Ren, Gang Li, Binbin Cheng, Ling Li, Zhiqiang Yu, Jianjun Chen
Summary: A novel PDC was synthesized to intelligently deliver paclitaxel, showing higher cellular uptake and cytotoxicity in experiments, with less toxicity to normal cells and the ability to overcome paclitaxel resistance. The results demonstrated that this new PDC had better in vivo anti-tumor efficacy than paclitaxel.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Mo'ath Yousef, Ildiko Szabo, Jozsef Muranyi, Francoise Illien, Dora Soltesz, Csaba Bato, Gabriella Toth, Gyula Batta, Peter Nagy, Sandrine Sagan, Zoltan Banoczi
Summary: This study demonstrates the preparation and investigation of efficient cell-penetrating peptides (CPPs) and explores the possibility of using unnatural aromatic amino acids to mimic the properties of tryptophan. These highly active CPPs have been successful in delivering antitumor drugs into specific cell lines.
Article
Nanoscience & Nanotechnology
Yuping Wei, Man Zhang, Pengfei Jiao, Xin Zhang, Ganggang Yang, Xia Xu
Summary: A novel positive CPP carrier P9 was developed to enhance PTX translocation and increase intracellular concentration of PTX, leading to a significant decrease in tumor cell viability.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biology
Ghulam Abbas, Alfredo E. Cardenas, Ron Elber
Summary: We conducted molecular dynamics simulations to study model heterogeneous membranes and their interactions with an anticancer peptide, NAF-1(44-67). The organization of the peptide in the membrane depends on nearby phospholipid types and is influenced by the charge and size of the head groups.
Article
Pharmacology & Pharmacy
Quim Pena, Sergi Rodriguez-Calado, A. Jalila Simaan, Merce Capdevila, Pau Bayon, Oscar Palacios, Julia Lorenzo, Olga Iranzo
Summary: The study investigates the application of copper-based metal compounds in cancer treatment, enhancing their anticancer activity by modifying their solubility and cellular uptake through functionalization. Results show that copper complexes conjugated with cell-penetrating peptides exhibit improved anticancer activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ildiko Szabo, Mo'ath Yousef, Dora Soltesz, Csaba Bato, Gabor Mezo, Zoltan Banoczi
Summary: Cell-penetrating peptides (CPPs) are a diverse group of molecules with promising potential for transporting compounds into cells, but face challenges such as non-specific internalization and rapid elimination from the body. Despite growing understanding of the mechanisms involved, predicting and designing the cell-penetrating properties of CPPs remains a complex task. Efforts are being made to modify well-known CPPs in order to overcome their limitations and enhance their internalization capabilities and penetration mechanisms.
Review
Pharmacology & Pharmacy
Yingke Liu, Zhihe Zhao, Man Li
Summary: Cell penetrating peptides (CPPs), a class of short peptides capable of translocating drugs across cell membranes, have shown significant potential in drug delivery, particularly in the treatment of cancer, myocardial ischemia, ocular posterior segment disorders, etc. Recent research has focused on CPP-functionalized nano-drug delivery systems, highlighting their promising clinical translation.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Longkun Wang, Chunqian Zhao, Lu Lu, Honglei Jiang, Fengshan Wang, Xinke Zhang
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis, and the current treatment mainly relies on surgery and chemotherapy. However, the application of paclitaxel (PTX) is limited due to its hydrophobicity and side effects. To overcome these problems, a novel PTX conjugate called PTX-SM-TAR was constructed, which improved the specificity and penetrability of PTX at the tumor site. PTX-SM-TAR exhibited receptor-targeting and endocytosis-mediated cell uptake, as well as great transvascular transport and tumor penetration ability. In vivo experiments showed that PTX-SM-TAR had higher antitumor effects compared to PTX, suggesting its potential as a targeted delivery system for TNBC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yoshiyuki Hakata, Kazuma Yamashita, Sonoko Hashimoto, Takashi Ohtsuki, Masaaki Miyazawa, Mizuki Kitamatsu
Summary: The connection between a functional peptide and a cell-penetrating peptide (CPP) using a heterodimeric coiled-coil as a molecular zipper can enhance the intracellular delivery and activity of the functional peptide. In this study, we investigated the optimal length of the K/E zipper for effective intracellular delivery and autophagy induction by conjugating an autophagy-inducing peptide (AIP) with CPP via heterodimeric coiled-coils consisting of 1 to 4 repeating units (K/E zipper; AIP-Kn and En-CPP). The results showed that K/E zippers with n = 3 and 4 formed stable hybrids and effectively induced autophagy, with the former being more intensive.
Article
Medicine, Research & Experimental
Marina Buyanova, Ashweta Sahni, Rui Yang, Amar Sarkar, Heba Salim, Dehua Pei
Summary: Cyclic cell-penetrating peptide 12 (CPP12) is highly efficient at delivering cargo molecules into mammalian cells. However, its efficiency is reduced at lower concentrations or in the presence of serum proteins. In this study, CPP12 analogs were prepared with varying hydrophobicity and evaluated for cellular entry. CPP12-2, with a substitution of L-3-benzothienylalanine (Bta) for L-2-naphthylalanine (Nal), showed up to 3.8-fold higher efficiency, especially at low concentrations, due to improved endosomal escape efficiency.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Marina Buyanova, Ashweta Sahni, Rui Yang, Amar Sarkar, Heba Salim, Dehua Pei
Summary: In this study, analogs of cyclic cell-penetrating peptide 12 (CPP12) were prepared and CPP12-2 was found to have higher cytosolic entry efficiency than CPP12 at low concentrations, making it suitable for the delivery of highly potent cargos.
MOLECULAR PHARMACEUTICS
(2022)
Article
Polymer Science
Masahiro Kaneko, Masahito Ishikawa, Shuji Nakanishi, Kazuhiko Ishihara
Summary: Redox phospholipid polymers composed of ferrocene or quinone units were prepared as anticancer redox polymers, which can disrupt intracellular redox state and selectively suppress the viability of cancer cells based on their reactivity with intracellular redox species and O-2. The redox potential of the polymers plays a critical role in determining the impact on the viability of human cancer and normal cells.
Article
Medicine, Research & Experimental
Sorour Khayyatnejad Shoushtari, Khalid Zoghebi, Muhammad Imran Sajid, Rakesh Kumar Tiwari, Keykavous Parang
Summary: A novel series of hybrid cyclic-linear peptides were synthesized through Fmoc solid-phase peptide synthesis and evaluated for cellular uptake efficiency in various cancer and normal cell lines. The results suggest the potential of these peptides as cell-penetrating peptides and molecular transporters.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Tejinder Singh, Dong Hyun Kang, Tae Wan Kim, Hye Jeong Kong, Jae Sung Ryu, Seob Jeon, Tae Sung Ahn, Dongjun Jeong, Moo Jun Baek, Jungkyun Im
Summary: The octaarginine-oxaliplatin conjugate successfully delivered oxaliplatin into colon cancer cells at low concentrations, showing high antitumor activity in both in vitro and in vivo studies. This strategy may provide a new approach for designing oxaliplatin derivatives with improved therapeutic capabilities.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Aldo O. Gonzalez-Cruz, Javier Hernandez-Juarez, Monica A. Ramirez-Cabrera, Isaias Balderas-Renteria, Eder Arredondo-Espinoza
Summary: Peptide-Based Drug-delivery systems (PBDs) are innovative strategies that use peptides to transport compounds with pharmacological activity into cells, providing promising perspectives in the diagnosis and treatment of cancer and other diseases. PBDs can be Cell-Penetrating Peptides that facilitate intracellular delivery of cargos, or Tumor Homing Peptides that target biomarkers on tumor cells. They offer groundbreaking advantages in cancer treatment, including improved drug delivery and efficacy, reduced toxicity, and enhanced selectivity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
