Review
Materials Science, Multidisciplinary
Abhishek Tiwari, Prince Sharma, Bhagyashree Vishwamitra, Gaurav Singh
Summary: Surface treatment of metallic implants is crucial in orthopedics and orthodontics to prevent bacterial infections, and using coating processes can reduce bacterial and biofilm adhesion, lowering the risk of infection and providing a solution to reduce medical expenses.
Article
Materials Science, Coatings & Films
M. Kubota, N. Masahashi, Y. Michiyama, K. Ohmura, S. Hanada, H. Inoue
Summary: Titanium and its alloys have poor wear resistance and can lead to complications such as aseptic loosing and bone resorption. Anodization is a promising method to improve wear resistance by controlling the mechanical properties of the surface. The newly developed anodized TiNbSn alloy showed improved wear resistance and reduced wear debris and metal ion elution.
SURFACE & COATINGS TECHNOLOGY
(2023)
Review
Engineering, Biomedical
Divya Chopra, Karan Gulati, Saso Ivanovski
Summary: This review discusses the effectiveness of antibacterial nanotubes in combating bacterial infections and the avoidance of cytotoxicity issues. By controlling nanotopographies and locally eluting antibiotics, tailored antibacterial efficacy of titanium implants can be achieved.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Viviane Staendert, Kai Borcherding, Nicole Bormann, Gerhard Schmidmaier, Ingo Grunwald, Britt Wildemann
Summary: The study demonstrates the creation of a mechanically stable porous structure on a titanium surface and embedding of silver particles to enhance osteointegration and provide antibacterial properties through preoperative loading of antibiotics. The novel surface modification shows good biocompatibility, antibacterial effects, and support for osteointegration without negative impact of the released drug.
BIOACTIVE MATERIALS
(2021)
Article
Polymer Science
Chung-Kai Sun, Cherng-Jyh Ke, Yi-Wen Lin, Feng-Huei Lin, Tung-Hu Tsai, Jui-Sheng Sun
Summary: The study aims to establish an effective antibiotic slow-release system and evaluate its efficacy in preventing implant-related infections through an animal model experiment.
Article
Orthopedics
Akihiro Maruo, Takahiro Oda, Ryowa Mineo, Hidetoshi Miya, Hirotsugu Muratsu, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura
Summary: Continuous local antibiotic perfusion is a novel local drug delivery system that can provide sufficient antibiotic concentrations with minimal systemic side effects, and it has been shown to achieve fracture union in the majority of patients with fracture-related infections.
JOURNAL OF ORTHOPAEDIC SURGERY
(2022)
Article
Materials Science, Multidisciplinary
Jiman Nelson, Sakshi Jain, Pallabi Pal, Haden A. Johnson, Kadie P. Nobles, Amol V. Janorkar, Randall S. Williamson, Michael D. Roach
Summary: This study investigated a two-step combination of mixed-acid electrolyte anodization and subsequent Ca(NO3)(2) hydrothermal treatment to optimize titanium specimens with favorable Ca/P surface ratios. The results showed that specimens anodized to 108 V and soaked in Ca(NO3)(2) solution exhibited favorable surface Ca/P ratios and increased apatite formation and mineralization. This two-step combination shows great promise for future biomaterials applications.
Article
Dentistry, Oral Surgery & Medicine
Tingting Wang, Lina Wang, Qianqian Lu, Zhen Fan
Summary: The clinical study aimed to investigate the color changes of peri-implant soft tissue surrounding differently treated titanium abutments, with results showing that anodized gold and pink titanium abutments achieved better esthetics than untreated titanium abutments, while zirconia was the optimal material for esthetic abutments in the study.
JOURNAL OF PROSTHETIC DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
M. M. Hasani-Sadrabadi, S. Pouraghaei, E. Zahedi, P. Sarrion, M. Ishijima, E. Dashtimoghadam, N. Jahedmanesh, S. Ansari, T. Ogawa, A. Moshaverinia
Summary: This study proposes a new method for surface treatment of titanium implants to improve their osseointegration and antibacterial properties. By layer-by-layer surface treatment, sustained release of osteoinductive peptides mimicking BMP-2 and gentamicin was achieved. Experimental results demonstrate that the surface-functionalized implants show promising outcomes in promoting osteogenic differentiation of periodontal ligament stem cells and antimicrobial activity.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Immunology
Nicolas Cortes-Penfield, Martin Krsak, Laura Damioli, Michael Henry, Jessica Seidelman, Angela Hewlett, Laura Certain
Summary: This narrative review synthesizes the literature on the role of suppressive antibiotic therapy (SAT) to prevent treatment failure after debridement, antibiotics, and implant retention (DAIR) for prosthetic joint infection. It aims to answer three key questions: (1) the identification of patients at highest risk for treatment failure after DAIR, (2) the effectiveness of SAT in reducing treatment failure rate after DAIR, and (3) the rates of treatment failure and adverse events in patients receiving SAT. The review proposes risk-benefit stratification criteria for selecting patients for SAT following DAIR.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Materials Science, Multidisciplinary
Pardis Keikhosravani, Fatemeh Jahanmard, Tim Bollen, Kamran Nazmi, Edwin J. A. Veldhuizen, Prasad Gonugunta, Prasaanth Ravi Anusuyadevi, Bart C. H. van der Wal, Charles Vogely, Floris J. Bikker, Peyman Taheri, Harrie Weinans, Saber Amin Yavari
Summary: An antibacterial coating is developed by layer-by-layer assembly of polymers PDLG and GelMA with the loaded peptide CATH-2. The coating exhibits strong antibacterial activity and biocompatibility, making it suitable for preventing infections associated with implants.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Infectious Diseases
J. W. Timoteus Deelen, W. C. Rottier, A. G. M. Buiting, J. W. Dorigo-Zetsma, J. A. J. W. Kluytmans, P. D. Van der Linden, S. F. T. Thijsen, B. J. M. Vlaminckx, A. J. L. Weersink, H. S. M. Ammerlaan, M. J. M. Bonten, C. H. Van Werkhoven
Summary: The study found that short-course adjunctive aminoglycoside treatment along with beta-lactam antibiotics did not improve 30-day mortality in sepsis patients with Gram-negative bloodstream infection, despite providing better antibiotic coverage of pathogens.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Orthopedics
Anna Stephan, Alexander Thuermer, Ingmar Glauche, Joerg Nowotny, Stefan Zwingenberger, Maik Stiehler
Summary: The study evaluated the impact of prophylactic antibiotics and antibiotic therapy on sonicate fluid cultures in patients with implant-associated infection. The results showed that antibiotic treatment did not significantly affect the detection rate of infectious agents, and sonicate fluid cultures were able to detect pathogens that conventional tissue cultures failed to identify.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
M. Hatakeyama, N. Masahashi, Y. Michiyama, H. Inoue, S. Hanada
Summary: Comparative study reveals that the anodized TiNbSn alloy exhibits superior mechanical properties, with higher hardness, surface roughness, and exfoliation strength compared to Ti6Al4V and pure Ti. Its wear resistance significantly improves under both dry and wet conditions, demonstrating potential as an implant biomaterial.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2021)
Article
Chemistry, Physical
Akbar Esmaeilnejad, Negin Khoshnood, Ali Zamanian, Alirza Rezaei, Masoud Mozafari
Summary: The biological properties of anodized titanium implants decorated with MnO nanoparticles were studied. The effects of anodic oxidation voltage on the microstructure of titanium oxide nanotubes were investigated. MnO nanoparticles were synthesized and their size and morphology were studied. The synthesized MnO nanoparticles were then decorated onto the anodized titanium implants and their biocompatibility was evaluated.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)