Article
Materials Science, Multidisciplinary
Youyun Zeng, Yiding Shen, Shuyi Wu, Lei Cai, Zhen Wang, Kexin Cai, Jiating Shen, Kendrick Hii Ru Yie, Hualin Zhang, Lihua Xu, Jinsong Liu
Summary: In this study, a bone targeting drug delivery system was developed to enhance the effectiveness of anti-osteoporotic drugs, showing potential for the treatment of osteoporosis.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Liqiao Zhang, Xiuhua Pan, Lixing Xu, Linlin Zhang, Haiqin Huang
Summary: This study developed mitochondria-targeted curcumin loaded micelles for the treatment of liver fibrosis, showing extended systemic circulation of Cur, enhanced bioavailability, and improved anti-fibrosis effects. The micelles exhibited good dispersion, low CMC, and high encapsulation efficiency, and were more effective in treating liver fibrosis compared to traditional Cur formulations.
Article
Biotechnology & Applied Microbiology
Abdullrahman M. Al-Bishari, Bilal A. Al-Shaaobi, Aisha A. Al-Bishari, Mohammed A. Al-Baadani, Liang Yu, Jiating Shen, Lei Cai, Yiding Shen, Zhennan Deng, Peng Gao
Summary: In this study, a multifunctional nanofiber membrane loaded with vitamin D and curcumin was successfully fabricated. It showed potential for enhancing osteoblast proliferation and differentiation, as well as exhibiting superior anti-inflammatory activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ehsan Ansari Dezfouli, Seyed Hossein Kiaie, Hossein Danafar, Alireza Nomani, Majid Sadeghizadeh
Summary: This study synthesized ligand-targeted micelle nanoparticles CUR-BTN-PEG-PCL and demonstrated its potential in improving CUR uptake in tumor cells, pointing to its promising role in cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Busra Yedekci, Aysen Tezcaner, Bengi Yilmaz, Teyfik Demir, Zafer Evis
Summary: The study successfully synthesized B-Sr-Mg multi-doped HA and PCL-PEG-PCL copolymer, and produced PCL-PEG-PCL composite scaffolds containing different amounts of hydroxyapatite (HA) with desired porosity through compression-molding and particulate leaching method.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Cell Biology
Weiyi Gong, Wenxuan Zhao, Gang Liu, Lei Shi, Xia Zhao
Summary: BDDD-721, a curcumin analogue, exhibits stronger anti-tumor activity than curcumin on medulloblastoma. It effectively inhibits the proliferation, migration, invasion, and promotes apoptosis of medulloblastoma cells. The study also discovered that BDDD-721 targets the Shh/Gli1 signaling pathway to exert its anticancer effects.
Article
Polymer Science
Abbas Rezaei, Abolfazl Khanzadeh, Hossein Behniafar
Summary: In this study, PEG-based hydrophilic branches were grafted onto PCL-based hydrophobic chains to synthesize amphiphilic macromolecules with bioactive disulfide linkages. The structure of the PEG-grafted PCL chains was confirmed by spectroscopy techniques. The resulting micellar aggregates showed a spherical shape and had a critical micelle concentration of 7.1x10(-3) mg/mL. The size of the micelles was measured to be 150 nm with a low heterogeneity index of 0.18 using dynamic light scattering.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhuoran Wang, Shuai Zhang, Ruofei Zhang, Xuehui Chen, Guoming Sun, Meng Zhou, Qiubai Han, Baoli Zhang, Yue Zhao, Bing Jiang, Yili Yang, Xiyun Yan, Kelong Fan
Summary: The Am-PNCage is a novel protein nanocarrier with dual-targeting properties, allowing for effective drug loading and promoting drug penetration and accumulation in tumors in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Asim Mushtaq, Li Li, Lisbeth Grondahl, A. Anitha
Summary: The development of targeted nanoparticles for the delivery of siRNA and chemotherapeutic drugs shows potential as an effective therapeutic system for bone metastasized breast cancer, with demonstrated targeting ability and in vitro cytotoxicity.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jong-Won Kim, Kyung-Kwan Lee, Kyoung-Woo Park, Moonil Kim, Chang-Soo Lee
Summary: This study reported the synthesis of bone-targeting ferritin nanoparticles for bone imaging, using bone-targeting peptides genetically fused to the human ferritin to achieve specific binding with osteoblasts and hydroxyapatite. The promising results demonstrate the specific binding ability of the nanoscale targeting system to bone tissue, potentially for future clinical applications in bone disease therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Rui Ni, Dongyu Duan, Bin Li, Ziwei Li, Li Li, Yue Ming, Xianfeng Wang, Jianhong Chen
Summary: The PCL-PEG-based nanoparticles showed sustained-release characteristics, high cellular uptake efficiency, and superior tumor targeting ability, demonstrating promising potential as an anticancer drug delivery system.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Neurosciences
Guanghai Zhao, Yongqiang Shi, Chaoyang Gong, Taicong Liu, Wei Nan, Lin Ma, Zuolong Wu, Chaoming Da, Kaisheng Zhou, Haihong Zhang
Summary: The research demonstrated that curcumin attenuates cancer-induced bone pain by producing significant analgesic activity and promoting the release of beta-endorphin and enkephalin in primary cultured rat dorsal root ganglion neurons. The analgesic effect of curcumin may be mediated by the up-regulation of proopiomelanocortin (Pomc) expression in DRG neurons.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Miguel Gisbert-Garzaran, Maria Natividad Gomez-Cerezo, Maria Vallet-Regi
Summary: Bone diseases have become a global public concern, affecting millions of people. Although current treatments are effective, they come with side effects. To address this, the development of biocompatible nanoparticles and macroscopic scaffolds has shown promise in improving bone regeneration while reducing side effects. This review highlights the emerging trend of materials that specifically recognize agents in the bone microenvironment, showcasing examples of modified nanoparticles and scaffolds. The potential of these bone-targeting agents to revolutionize the treatment of bone-related diseases is discussed, providing a comprehensive overview of the field's state-of-the-art.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Di Zhao, Kai Jiang, Yuqi Wang, Jin Cheng, Fangli Mo, Tao Luo, Yuanyuan Guo, Chuan Zhang, Jie Song
Summary: Nanocapsules provide an effective platform for targeted drug delivery, overcoming challenges in anticancer drug solubility, toxicity, and multidrug resistance. Their simple design allows for high drug loading efficiency and synergy therapy, with capabilities of enzyme-triggering and lung targeting. This system demonstrates effective tumor inhibition and vascular proliferation without systemic toxicity, offering a universal strategy for targeted lung delivery, enzyme triggering, and synergy therapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemical Research Methods
Lijuan Yang, Guanghui Yang, Zhitong Bing, Yuan Tian, Liang Huang, Yuzhen Niu, Lei Yang
Summary: In this study, a framework combining WAE generative model and PSO forward search algorithm was developed for generating anticancer peptides (ACPs) with desired properties. The WAE-based generative model showed better training performance compared to other models and successfully captured semantic connections in the latent space. The pipeline was validated on breast cancer and lung cancer targets, resulting in the discovery of candidate compounds with higher binding affinity and novel structures.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Liping Wang, Janak L. Pathak, Dongliang Liang, Ningying Zhong, Hongbing Guan, Mianjia Wan, Guohou Miao, Zhengmao Li, Linhu Ge
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Dentistry, Oral Surgery & Medicine
QingBin Zhang, ShanShan Yuan, KaiTong Deng, XingYang Li, Ye Liang, AnTong Wu, Janak L. Pathak, HongChen Liu
Summary: This study investigated the correlation between basic characteristics and clinical features of patients with temporomandibular disorders (TMD). The highest incidence of TMD was observed in the age group of 20 to 30 years, with approximately 2/3 of the patients showing pain symptoms. Joint noises, abnormal mouth opening patterns, and temporomandibular joint synovitis (TMJS) were commonly observed clinical features.
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2023)
Review
Materials Science, Multidisciplinary
Xingnan Lin, Jiping Chen, Ying Liao, Janak Lal Pathak, Huang Li, Yuelian Liu
Article
Dentistry, Oral Surgery & Medicine
ShanShan Yuan, YaRui Liu, KaiTong Deng, XingYang Li, Astrid D. Bakker, Jenneke Klein-Nulend, Janak L. Pathak, QingBin Zhang, ZhaoJian Wang
Summary: This study investigated the correlation between condylar morphology and clinical manifestations in patients with degenerative joint disease. The results showed that the anteroposterior diameter and height of the condyle were correlated with pain, while the shape of the condyle in the sagittal plane was associated with joint noise.
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Wei Cao, Jianfeng Jin, Gang Wu, Nathalie Bravenboer, Marco N. Helder, Janak L. Pathak, Behrouz Zandieh-Doulabi, Jolanda M. A. Hogervorst, Shingo Matsukawa, Lester C. Geonzon, Rommel G. Bacabac, Engelbert A. J. M. Schulten, Jenneke Klein-Nulend
Summary: K-carrageenan promoted adhesion, spreading, metabolic activity, proliferation, and osteogenic differentiation of MC3T3-E1 pre-osteoblasts, indicating its potential as an osteogenic inductive factor for enhancing bone regeneration.
Article
Medicine, General & Internal
Sujuan Zeng, Yuhang Huang, Wenyan Huang, Janak L. Pathak, Yanbing He, Weijian Gao, Jing Huang, Yiqing Zhang, Jian Zhang, Huixian Dong
Summary: The study explored the feasibility of real-time monitoring and quantitative guiding the repair of enamel white spot lesions with resin infiltration using OCT. Results showed that OCT can accurately image the repair process and effectively guide the clinical use of resin infiltrant to repair enamel WSLs.
Review
Biotechnology & Applied Microbiology
Duraipandy Natarajan, Zhitong Ye, Liping Wang, Linhu Ge, Janak Lal Pathak
Summary: The challenges in bone graft and prosthetic implant designing for clinical application are being addressed with the revolutionary advances of nanotechnology, particularly in the use of rare earth (RE) materials with unique properties for tissue engineering. Researchers have developed smart nano-biomaterials using RE materials for bone tissue engineering and implantology applications, exploring their molecular mechanisms and potential for novel strategies. The biomedical applications of micro or nano-scale RE materials have shown promise in providing cost-effective solutions in bone tissue engineering.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Haiyan Wang, Yongyong Yan, Haifeng Lan, Nan Wei, Zhichao Zheng, Lihong Wu, Richard T. Jaspers, Gang Wu, Janak L. Pathak
Summary: This study analyzed the effect of NGR1 on cellular activities of MSCs. The results showed that NGR1 can promote migration, adhesion, spreading, osteogenic differentiation, and anti-inflammatory properties of hASCs.
Article
Nutrition & Dietetics
Siqi Li, Sishuo Chen, Min Nie, Lijing Wen, Bin Zou, Lingyu Zhang, Jingzhou Xie, Hooi-Leng Ser, Learn-Han Lee, Shunyi Wang, Caixia Lin, Janak L. Pathak, Weijie Zhou, Ji Miao, Lijing Wang, Lingyun Zheng
Summary: This study demonstrated the impact of ANP deficiency on cardiac injury, mainly through the modulation of salt-sensitive ileal microbiota, leading to cardiac hypertrophy and fibrosis. Antibiotic treatment significantly alleviated these effects.
Article
Engineering, Biomedical
Qing Zhang, Dan Hou, Xueying Wen, Mengyu Xin, Ziling Li, Lihong Wu, Janak L. Pathak
Summary: This review focuses on the recent advances in the research and application of gold nanoparticles (AuNPs) for early screening, diagnostic typing, drug delivery, photothermal therapy, radiotherapy sensitivity treatment, and combination therapy of oral cancer. It highlights the importance of AuNPs in reducing clinical intervention-related infections, achieving noninvasive diagnosis, and precise treatment.
MATERIALS TODAY BIO
(2022)
Article
Nutrition & Dietetics
Yue Li, Zhijun Huang, Shuaifei Pan, Yuhui Feng, Haokun He, Shuguang Cheng, Lijing Wang, Liping Wang, Janak Lal Pathak
Summary: The mode and mechanism of diabetic periodontitis-induced alveolar-osteocyte death are still unclear. This study found that diabetic periodontitis triggers alveolar osteocyte ferroptosis and resveratrol has a therapeutic potential to alleviate osteocyte ferroptosis. The effects were observed in both mouse models and in vitro experiments.
Article
Pharmacology & Pharmacy
Antong Wu, Janak Lal. Pathak, Xingyang Li, Wei Cao, Wenchao Zhong, Mingjing Zhu, Qiuyu Wu, Wanyi Chen, Qiao Han, Siqing Jiang, Yuzhuo Hei, Ziyi Zhang, Gang Wu, Qingbin Zhang
Summary: In this study, the efficacy of human salivary peptide histatin-1 (Hst1) in attenuating bone and cartilage damage in osteoarthritis (OA) was investigated. Hst1 was found to significantly attenuate cartilage and bone deconstruction as well as macrophage infiltration. It also triggered M1-to-M2 macrophage phenotype switching and restored the metabolic activity, migration, and chondrogenic differentiation of chondrogenic cells.
Article
Engineering, Biomedical
Qing Zhang, Mengyu Xin, Shuang Yang, Qiuyu Wu, Xi Xiang, Tianqi Wang, Wen Zhong, Marco N. Helder, Richard T. Jaspers, Janak Lal Pathak, Yin Xiao
Summary: Targeting macrophages to regulate the immune microenvironment is a new strategy for bone regeneration with nano-drugs. Nano-drugs have achieved surprising anti-inflammatory and bone-regenerative effects, however, their underlying mechanisms in macrophages remain to be clarified.
MATERIALS TODAY BIO
(2023)
Article
Biotechnology & Applied Microbiology
Xiaojie Tong, Jin Chen, Renqin Wang, Dan Hou, Gang Wu, Chang Liu, Janak Lal Pathak
Summary: This study investigated the direct and indirect effects of hyaluronic acid (HA) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) mediated by BMP-2. The study found that HA inhibited the osteogenic differentiation of BMSCs, while the secretions from HA-treated endothelial cells promoted this process.
BIOENGINEERING-BASEL
(2023)
Article
Materials Science, Biomaterials
Wenchao Zhong, Xingyang Li, Janak L. Pathak, Liangjiao Chen, Wei Cao, Mingjing Zhu, Qianting Luo, Antong Wu, Yunxin Chen, Lingbo Yi, Manyuan Ma, Qingbin Zhang
BIOMATERIALS SCIENCE
(2020)