Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 12, Issue -, Pages 1341-1352Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S124965
Keywords
bone cements; nanoporous lithium doping magnesium silicate; degradability; vascularization; osteogenesis
Funding
- National Natural Science Foundation of China [31271031, 31100680]
- Natural Science Fund of Shanghai [15ZR1412500]
- Major International Joint Research Project between China and Korea [81461148033]
- National Research Foundation of Korea (NRF) [NRF-2014K2A2A7066637]
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Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone cements. The introduction of nl-MS improved the in vitro degradability of nl-MSC cements, which could neutralize acidic degradable products of calcium sulfate and prevented the pH from dropping. The cements were implanted into the bone defects of femur bone of rabbits, and the results of histological and immunohistochemical analysis revealed that massive new bone tissue formed in the defects while the cements were degradable, indicating that the osteogenesis and degradability of the nl-MSC cements were much better than the control calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression of vascular endothelial growth factor and collagen type I for nl-MSC cements was higher than CSD, indicating that addition of nl-MS into the cements enhanced vascularization and osteogenic differentiation. The results suggested that the nl-MSC cements with good biocompatibility and degradability could promote vascularization and osteogenesis, and had great potential to treat bone defects.
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