Circadian Clock, Cell Division, and Cancer: From Molecules to Organism

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway

(2016) Weiliang Jiang et al.   CANCER LETTERS

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

(2016) Selma Masri et al.   CELL

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

MYC inhibits the clock and supports proliferation

(2016) Anton Shostak et al.   CELL CYCLE

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

CRY2 and FBXL3 Cooperatively Degrade c-MYC

(2016) Anne-Laure Huber et al.   MOLECULAR CELL

Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

(2016) Toru Matsu-ura et al.   MOLECULAR CELL

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

The molecular basis of metabolic cycles and their relationship to circadian rhythms

(2016) Jane Mellor   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2

(2016) Tetsuya Gotoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Oscillators: Around the Transcription–Translation Feedback Loop and on to Output

(2016) Jennifer M. Hurley et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Plant Circadian Clock: From a Simple Timekeeper to a Complex Developmental Manager

(2016) Sabrina E. Sanchez et al.   Cold Spring Harbor Perspectives in Biology

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

(2016) Anton Shostak et al.   Nature Communications

The molecular basis of metabolic cycles and their relationship to circadian rhythms

(2016) Jane Mellor   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Comprehensive Phylogeny Reveals Functional Conservation of the UV-B Photoreceptor UVR8 from Green Algae to Higher Plants

(2016) María B. Fernández et al.   Frontiers in Plant Science

Sleep Duration and Cancer in the NIH-AARP Diet and Health Study Cohort

(2016) Fangyi Gu et al.   PLoS One

Distinguishing between stochasticity and determinism: Examples from cell cycle duration variability

(2015) Sivan Pearl Mizrahi et al.   BIOESSAYS

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Metabolic Cycles in Yeast Share Features Conserved among Circadian Rhythms

(2015) Helen C. Causton et al.   CURRENT BIOLOGY

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice

(2015) Kirsten C.G. Van Dycke et al.   CURRENT BIOLOGY

Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signaling

(2015) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

Cancer/Testis Antigen PASD1 Silences the Circadian Clock

(2015) Alicia K. Michael et al.   MOLECULAR CELL

Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo

(2015) YAPING WANG et al.   Molecular Medicine Reports

Lineage correlations of single cell division time as a probe of cell-cycle dynamics

(2015) Oded Sandler et al.   NATURE

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

(2015) Stephanie J Papp et al.   eLife

Coupling between the Circadian Clock and Cell Cycle Oscillators: Implication for Healthy Cells and Malignant Growth

(2015) Celine Feillet et al.   Frontiers in Neurology

Circadian gene variants in cancer

(2014) Nicole M. Kettner et al.   ANNALS OF MEDICINE

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

(2014) S. A. Brown   DEVELOPMENT

Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney

(2014) Sander A. Huisman et al.   INTERNATIONAL JOURNAL OF CANCER

The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells

(2014) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells

(2014) J. Bieler et al.   Molecular Systems Biology

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle

(2014) Céline Feillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation-independent circadian control of the cell cycle in a unicellular photosynthetic eukaryote

(2014) Shin-ya Miyagishima et al.   Nature Communications

Ras-Mediated Deregulation of the Circadian Clock in Cancer

(2014) Angela Relógio et al.   PLoS Genetics

Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis

(2013) Marina P Antoch et al.   CELL CYCLE

Human Epidermal Stem Cell Function Is Regulated by Circadian Oscillations

(2013) Peggy Janich et al.   Cell Stem Cell

Overexpression of the Circadian Clock Gene Bmal1 Increases Sensitivity to Oxaliplatin in Colorectal Cancer

(2013) Z.-l. Zeng et al.   CLINICAL CANCER RESEARCH

A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

(2013) Yusur Al-Nuaimi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

hClock gene expression in human colorectal carcinoma

(2013) LIYING WANG et al.   Molecular Medicine Reports

Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway

(2013) CHAN-HUN JUNG et al.   ONCOLOGY REPORTS

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes

(2013) K. D. Nguyen et al.   SCIENCE

The Circadian Molecular Clock Regulates Adult Hippocampal Neurogenesis by Controlling the Timing of Cell-Cycle Entry and Exit

(2013) Pascale Bouchard-Cannon et al.   Cell Reports

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Association of sleep duration and breast cancer OncotypeDX recurrence score

(2012) Cheryl L. Thompson et al.   BREAST CANCER RESEARCH AND TREATMENT

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Over-expression of circadian clock geneBmal1affects proliferation and the canonical Wnt pathway in NIH-3T3 cells

(2012) Fuwei Lin et al.   CELL BIOCHEMISTRY AND FUNCTION

The circadian clock geneBMAL1is a novel therapeutic target for malignant pleural mesothelioma

(2012) Momen Elshazley et al.   INTERNATIONAL JOURNAL OF CANCER

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes

(2012) F. Sporl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

(2012) M. Geyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NONO couples the circadian clock to the cell cycle

(2012) E. Kowalska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian rhythm of adrenal glucocorticoid: Its regulation and clinical implications

(2011) Sooyoung Chung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Disruption of the circadian clock due to theClockmutation has discrete effects on aging and carcinogenesis

(2011) Marina P. Antoch et al.   CELL CYCLE

The circadian molecular clock creates epidermal stem cell heterogeneity

(2011) Peggy Janich et al.   NATURE

Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer

(2011) Oshima   ONCOLOGY REPORTS

Functional interaction of the circadian clock and UV RESISTANCE LOCUS 8-controlled UV-B signaling pathways in Arabidopsis thaliana

(2011) Balázs Fehér et al.   PLANT JOURNAL

Control of skin cancer by the circadian rhythm

(2011) S. Gaddameedhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perception of UV-B by the Arabidopsis UVR8 Protein

(2011) L. Rizzini et al.   SCIENCE

Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock

(2010) Rohini V. Khapre et al.   ANNALS OF MEDICINE

Elevated ATPase Activity of KaiC Applies a Circadian Checkpoint on Cell Division in Synechococcus elongatus

(2010) Guogang Dong et al.   CELL

Circadian clocks and cell division

(2010) Carl Hirschie Johnson   CELL CYCLE

Tumor growth suppressionin vivoby overexpression of the circadian component, PER2

(2010) Koyomi Miyazaki et al.   GENES TO CELLS

Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity

(2010) Z.-L. Zeng et al.   JOURNAL OF BIOCHEMISTRY

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

(2010) Susie Lee et al.   PLoS One

Circadian-independent cell mitosis in immortalized fibroblasts

(2010) M. Yeom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian TIMELESS Is Required for ATM-dependent CHK2 Activation and G2/M Checkpoint Control

(2009) Xiaoming Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura: The Emerging Gene Portrait of the Mesothelioma Phenotype

(2009) Oluf Dimitri Røe et al.   PLoS One

Loss of cryptochrome reduces cancer risk inp53mutant mice

(2009) Nuri Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Implications of Multiple Circadian Clock Origins

(2009) Michael Rosbash   PLOS BIOLOGY

Phase Resetting of the Mammalian Circadian Clock by DNA Damage

(2008) Małgorzata Oklejewicz et al.   CURRENT BIOLOGY

Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis

(2008) P. A. Wood et al.   MOLECULAR CANCER RESEARCH

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE