From Lysosomal Storage Diseases to NKT Cell Activation and Back

The Immunology of CD1- and MR1-Restricted T Cells

(2016) Lucia Mori et al.   Annual Review of Immunology

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

(2016) Lydia Lynch et al.   Cell Metabolism

Activation strategies for invariant natural killer T cells

(2016) Ayano C. Kohlgruber et al.   IMMUNOGENETICS

The processing and presentation of lipids and glycolipids to the immune system

(2016) Vincent F. Vartabedian et al.   IMMUNOLOGICAL REVIEWS

CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity

(2016) Catia S. Pereira et al.   Journal of Immunology Research

Adipocyte-specific CD1d-deficiency mitigates diet-induced obesity and insulin resistance in mice

(2016) Masashi Satoh et al.   Scientific Reports

Lysosomal Storage Diseases: From Pathophysiology to Therapy

(2015) Giancarlo Parenti et al.   Annual Review of Medicine

The attenuated/late onset lysosomal storage disorders: Therapeutic goals and indications for enzyme replacement treatment in Gaucher and Fabry disease

(2015) Carla E.M. Hollak et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Non-neuronopathic lysosomal storage disorders: Disease spectrum and treatments

(2015) Gregory M. Pastores et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner

(2015) Catia S. Pereira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

(2015) Marta Monteiro et al.   JOURNAL OF IMMUNOLOGY

Invariant NKT Cells Require Autophagy To Coordinate Proliferation and Survival Signals during Differentiation

(2015) Bo Pei et al.   JOURNAL OF IMMUNOLOGY

Type II NKT Cells in Inflammation, Autoimmunity, Microbial Immunity, and Cancer

(2015) Idania Marrero et al.   Frontiers in Immunology

Gaucher Disease and Its Treatment Options

(2014) Lunawati L. Bennett et al.   ANNALS OF PHARMACOTHERAPY

Biology of CD1- and MR1-Restricted T Cells

(2014) Mariolina Salio et al.   Annual Review of Immunology

Secondary biochemical and morphological consequences in lysosomal storage diseases

(2014) J. Alroy et al.   BIOCHEMISTRY-MOSCOW

Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation

(2014) S. Nair et al.   BLOOD

The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian α-Linked Glycosylceramides

(2014) Lisa Kain et al.   IMMUNITY

Different subsets of natural killer T cells may vary in their roles in health and disease

(2014) Vipin Kumar et al.   IMMUNOLOGY

Impairment of homeostasis in lysosomal storage disorders

(2014) Laura Segatori   IUBMB LIFE

Recognition of Lysophosphatidylcholine by Type II NKT Cells and Protection from an Inflammatory Liver Disease

(2014) Igor Maricic et al.   JOURNAL OF IMMUNOLOGY

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

Essential role for autophagy during invariant NKT cell development

(2014) Mariolina Salio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF-  and IL-1 

(2013) M. Monteiro et al.   JOURNAL OF IMMUNOLOGY

Invariant natural killer T cells are phenotypically and functionally altered in Fabry disease

(2013) Catia S. Pereira et al.   MOLECULAR GENETICS AND METABOLISM

Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition

(2013) C. Paduraru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

(2013) M. Salio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C

(2012) Anneliese O. Speak et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of novel glycolipid ligands activating a sulfatide-reactive, CD1d-restricted, type II natural killer T lymphocyte

(2012) Sara Rhost et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR

(2012) Li Bai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

Natural killer T cells in adipose tissue prevent insulin resistance

(2012) Henk S. Schipper et al.   JOURNAL OF CLINICAL INVESTIGATION

Globosides but Not Isoglobosides Can Impact the Development of Invariant NKT Cells and Their Interaction with Dendritic Cells

(2012) S. Porubsky et al.   JOURNAL OF IMMUNOLOGY

Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model

(2012) Maria Fatima Macedo et al.   MOLECULAR GENETICS AND METABOLISM

Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

(2012) Federica Facciotti et al.   NATURE IMMUNOLOGY

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

(2012) L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory Type II Natural Killer T Lymphocytes in Health and Disease

(2012) S. Rhost et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Novel insights into lipid antigen presentation

(2012) Gennaro De Libero et al.   TRENDS IN IMMUNOLOGY

Globotriaosylceramide is correlated with oxidative stress and inflammation in Fabry patients treated with enzyme replacement therapy

(2011) Giovana B. Biancini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Proinflammatory Environment Dictates the IL-17-Producing Capacity of Human Invariant NKT Cells

(2011) L. Moreira-Teixeira et al.   JOURNAL OF IMMUNOLOGY

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria

(2011) Yuki Kinjo et al.   NATURE IMMUNOLOGY

Fine tuning by human CD1e of lipid-specific immune responses

(2011) F. Facciotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal α-Galactosidase Controls the Generation of Self Lipid Antigens for Natural Killer T Cells

(2010) Alexandre Darmoise et al.   IMMUNITY

Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases

(2010) Einat B. Vitner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

(2010) Smruti Killedar et al.   Journal of Neuroinflammation

Raising the NKT cell family

(2010) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a  -linked self-glycolipid

(2010) P. Arrenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development and maturation of invariant NKT cells in the presence of lysosomal engulfment

(2009) Tiziana Plati et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Invariant NKT cells and CD1d+cells amass in human omentum and are depleted in patients with cancer and obesity

(2009) Lydia Lynch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leukocyte perturbation associated with Fabry disease

(2009) P. Rozenfeld et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

(2009) Lisa M. Fox et al.   PLOS BIOLOGY

Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer

(2008) D. H. Chang et al.   BLOOD

Anomalies in conventional T and invariant natural killer T-cell populations in Fabry mice but not in Fabry patients

(2008) Andrea Balreira et al.   BRITISH JOURNAL OF HAEMATOLOGY