The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver

Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance

(2017) Hongzhi Chen et al.   FASEB JOURNAL

Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells

(2017) Ying Wan et al.   HEPATOLOGY

The Relationship between the Growth Hormone/Insulin-like Growth Factor System and the Histological Features of Nonalcoholic Fatty Liver Disease

(2017) Sayaka Chishima et al.   INTERNAL MEDICINE

The Association Between IGF-1 Levels and the Histologic Severity of Nonalcoholic Fatty Liver Disease

(2017) Laura E Dichtel et al.   Clinical and Translational Gastroenterology

The Role of Nuclear Receptors in the Pathophysiology, Natural Course, and Drug Treatment of NAFLD in Humans

(2016) Stefano Ballestri et al.   ADVANCES IN THERAPY

Liver fat in adults with GH deficiency: comparison to matched controls and the effect of GH replacement

(2016) Fabian Meienberg et al.   CLINICAL ENDOCRINOLOGY

Growth Hormone Control of Hepatic Lipid Metabolism

(2016) Zhongbo Liu et al.   DIABETES

Fatty liver is associated with an increased risk of diabetes and cardiovascular disease - Evidence from three different disease models: NAFLD, HCV and HIV

(2016) Amedeo Lonardo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

(2016) Hitoshi Nishizawa et al.   Scientific Reports

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice

(2015) Jose Cordoba-Chacon et al.   DIABETES

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

(2015) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

(2015) Ryusaku Matsumoto et al.   PLoS One

Long-term effects of growth hormone replacement therapy on liver function in adult patients with growth hormone deficiency

(2014) Ryusaku Matsumoto et al.   GROWTH HORMONE & IGF RESEARCH

Lower levels of insulin-like growth factor-1 standard deviation score are associated with histological severity of non-alcoholic fatty liver disease

(2014) Yoshio Sumida et al.   HEPATOLOGY RESEARCH

Celecoxib derivative OSU-03012 inhibits the proliferation and activation of hepatic stellate cells by inducing cell senescence

(2014) JUN ZHANG et al.   Molecular Medicine Reports

Cardiovascular Risk in Adult Patients With Growth Hormone (GH) Deficiency and Following Substitution With GH—An Update

(2013) Carmine Gazzaruso et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

(2013) K.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Diagnosis and treatment of growth hormone deficiency in adults

(2013) Atil Y. Kargi et al.   Nature Reviews Endocrinology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model

(2012) Hitoshi Nishizawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IGF-I enhances cellular senescence via the reactive oxygen species–p53 pathway

(2012) Anastasia-Evi Handayaningsih et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Essential roles of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the liver [Review]

(2012) Yutaka Takahashi   ENDOCRINE JOURNAL

Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy

(2012) H. Nishizawa et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Hepatic steatosis, GH deficiency and the effects of GH replacement: a Liverpool magnetic resonance spectroscopy study

(2012) Chris J Gardner et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Inflammation and fibrogenesis in steatohepatitis

(2012) Hideki Fujii et al.   JOURNAL OF GASTROENTEROLOGY

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Insulin-like growth factor-1 receptor activation prevents hydrogen peroxide-induced oxidative stress, mitochondrial dysfunction and apoptosis

(2011) Chang-Ning Hao et al.   APOPTOSIS

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2

(2011) Brandon C. Sos et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of the Insulin Receptor and Type I Insulin-Like Growth Factor Receptor Are Early Events in Hepatocarcinogenesis

(2011) Eiman Aleem et al.   TOXICOLOGIC PATHOLOGY

Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study

(2010) Svetlana Y. Kalinchenko et al.   CLINICAL ENDOCRINOLOGY

GH-Dependent STAT5 Signaling Plays an Important Role in Hepatic Lipid Metabolism

(2010) Johanna L. Barclay et al.   ENDOCRINOLOGY

Lower circulating levels of dehydroepiandrosterone, independent of insulin resistance, is an important determinant of severity of non-alcoholic steatohepatitis in Japanese patients

(2010) Yoshio Sumida et al.   HEPATOLOGY RESEARCH

Metabolic Parameters and Nonalcoholic Fatty Liver Disease in Hypopituitary Men

(2010) J. W. Hong et al.   HORMONE AND METABOLIC RESEARCH

Prevalence, gender, ethnic variations, and prognosis of NASH

(2010) Etsuko Hashimoto et al.   JOURNAL OF GASTROENTEROLOGY

Metabolic Co-Morbidities Revealed in Patients with Childhood-Onset Adult GH Deficiency after Cessation of GH Replacement Therapy for Short Stature

(2009) Izumi FUKUDA et al.   ENDOCRINE JOURNAL

Effects of estrogen and androgen deprivation on the progression of non-alcoholic steatohepatitis (NASH) in male Sprague-Dawley rats

(2009) Yanjun Mu et al.   HEPATOLOGY RESEARCH

Hepatic steatosis is associated with low serum testosterone and high serum DHEAS levels in men

(2009) Henry Völzke et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism

(2009) Yong Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential induction of LRP16 by liganded and unliganded estrogen receptor α in SKOV3 ovarian carcinoma cells

(2009) Liyuan Tian et al.   JOURNAL OF ENDOCRINOLOGY

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Endocrine and liver interaction: the role of endocrine pathways in NASH

(2009) Paola Loria et al.   Nature Reviews Gastroenterology & Hepatology

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Recombinant human growth hormone increases albumin and prolongs survival in patients with chronic liver failure: A pilot open, randomized, and controlled clinical trial

(2008) N. Li et al.   DIGESTIVE AND LIVER DISEASE

Low Doses of Insulin-Like Growth Factor-I Induce Mitochondrial Protection in Aging Rats

(2008) Juan E. Puche et al.   ENDOCRINOLOGY

Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion – Preliminary report

(2008) Zvi Laron et al.   GROWTH HORMONE & IGF RESEARCH

Mitochondrial protection by low doses of insulin-like growth factor-Iin experimental cirrhosis

(2008) Raquel Pérez et al.   WORLD JOURNAL OF GASTROENTEROLOGY