Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors

The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats

(2016) Tito Borner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials

(2016) Jennifer S Temel et al.   LANCET ONCOLOGY

Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial

(2016) Koichi Takayama et al.   SUPPORTIVE CARE IN CANCER

Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15

(2016) Tito Borner et al.   Journal of Cachexia Sarcopenia and Muscle

Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling

(2015) Jvalini T. Dwarkasing et al.   Journal of Cachexia Sarcopenia and Muscle

Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved

(2015) Ji-an Chen et al.   Journal of Cachexia Sarcopenia and Muscle

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

New ghrelin agonist, HM01 alleviates constipation and L-dopa-delayed gastric emptying in 6-hydroxydopamine rat model of Parkinson's disease

(2014) H. Karasawa et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Modeling human cancer cachexia in colon 26 tumor-bearing adult mice

(2014) Erin E. Talbert et al.   Journal of Cachexia Sarcopenia and Muscle

Multiplexed Target Detection Using DNA-Binding Dye Chemistry in Droplet Digital PCR

(2013) Geoffrey P. McDermott et al.   ANALYTICAL CHEMISTRY

Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model

(2013) R. Northrup et al.   SUPPORTIVE CARE IN CANCER

Bone Mineral Density Deficits and Fractures in Survivors of Childhood Cancer

(2013) Carmen L. Wilson et al.   Current Osteoporosis Reports

Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia

(2012) K. T. Murphy et al.   Disease Models & Mechanisms

Understanding the mechanisms and treatment options in cancer cachexia

(2012) Kenneth Fearon et al.   Nature Reviews Clinical Oncology

The receptive function of hypothalamic and brainstem centres to hormonal and nutrient signals affecting energy balance

(2012) Thomas Riediger   PROCEEDINGS OF THE NUTRITION SOCIETY

Ghrelin-induced adiposity is independent of orexigenic effects

(2011) Diego Perez-Tilve et al.   FASEB JOURNAL

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse

(2010) Paola Aulino et al.   BMC CANCER

Cancer induces inflammation and depressive-like behavior in the mouse: Modulation by social housing

(2010) Donald M. Lamkin et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients

(2010) Kent Lundholm et al.   CANCER

Glucose metabolism in cancer cells

(2010) Alessandro Annibaldi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

Ghrelin Induces Abdominal Obesity Via GHS-R-Dependent Lipid Retention

(2009) Jeffrey S. Davies et al.   MOLECULAR ENDOCRINOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study

(2008) F Strasser et al.   BRITISH JOURNAL OF CANCER

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION