Article
Clinical Neurology
Thibaut Gelle, Rayhanatou Altine Samey, Brigitte Plansont, Barbara Bessette, Marie-Odile Jauberteau-Marchan, Fabrice Lalloue, Murielle Girard
Summary: This study found that BDNF levels were decreased and proBDNF levels were increased in both serum and exosomes in patients with Major Depression (MD). During antidepressant treatment, there was an inverse relationship in the levels of BDNF and proBDNF in serum and exosomes. However, these levels were not related to clinical improvement or depression scales.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Marion Psomiades, Marine Mondino, Filipe Galvao, Nathalie Mandairon, Mikail Nourredine, Marie-Francoise Suaud-Chagny, Jerome Brunelin
Summary: This study found that the level of mature BDNF (mBDNF) is associated with the efficacy of electroconvulsive therapy (ECT) for patients with treatment-resistant depression. Patients with higher baseline mBDNF levels were more likely to achieve remission after ECT sessions.
Article
Oncology
Xilin Xiong, Meiling Zeng, Xiaomin Peng, Chuchu Feng, Chunmou Li, Wenjun Weng, Yang Li
Summary: This study investigates the relationship between serum BDNF concentration and the risk of recurrence in neuroblastoma patients. The findings show that healthy children have a gradual decrease in serum BDNF concentration from newborn to childhood, while children with neuroblastoma have relatively high levels. After comprehensive treatment, the BDNF levels gradually increase in the recurrence group and decrease in the remission group. Therefore, serum BDNF concentration is associated with neuroblastoma recurrence.
Article
Biochemistry & Molecular Biology
Elisa Maffioli, Elisa Angiulli, Simona Nonnis, Francesca Grassi Scalvini, Armando Negri, Gabriella Tedeschi, Ivan Arisi, Flavia Frabetti, Salvatore D'Aniello, Enrico Alleva, Carla Cioni, Mattia Toni
Summary: Experimental evidence suggests that environmental stress conditions can alter the expression of BDNF, which in turn influences the brain proteome and behavioural responses in zebrafish. The absence of BDNF expression leads to changes in protein expression related to synapse functioning, as well as alterations in behavior and response to thermal treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Andrew Want, James E. E. Morgan, Yves-Alain Barde
Summary: This study quantifies and validates the levels of BDNF in mouse serum and plasma using a sensitive immunoassay. The study finds that BDNF levels in mouse serum and plasma are indistinguishable, and are much lower than those in human serum. Pre-adsorption with anti-BDNF effectively reduces the BDNF signal. These findings suggest that BDNF levels can be explored as a biomarker in accessible body fluids using mouse models.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Takahiro Ogawa, Sven P. Hoekstra, Yoshi-Ichiro Kamijo, Victoria L. Goosey-Tolfrey, Jeremy J. Walsh, Fumihiro F. Tajima, Christof A. Leicht
Summary: Whole-body heating significantly increases circulating BDNF concentration, while local heating does not have the same effect and requires a larger increase in physiological measures to induce an acute BDNF response.
Article
Biochemistry & Molecular Biology
Elisa Maffioli, Simona Nonnis, Francesca Grassi Scalvini, Armando Negri, Gabriella Tedeschi, Mattia Toni
Summary: This study demonstrates that temperature variations can induce neurotoxic effects in adult zebrafish. The proteomic analysis identified proteins that serve as hallmarks of neurotoxic processes and revealed protein panels associated with different temperatures and BDNF depletion, which are linked to anxiety-like or boldness behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
L. M. C. Puhlmann, R. Linz, S. L. Valk, P. Vrticka, R. Vos de Wael, A. Bernasconi, N. Bernasconi, B. Caldairou, I Papassotiriou, G. P. Chrousos, B. C. Bernhardt, T. Singer, V Engert
Summary: The study found no significant relationship between serum BDNF levels and hippocampal structure volumes in healthy middle-aged adults, and age does not moderate this relationship.
Article
Psychiatry
Xu Zhu, Dachun Chen, Meihong Xiu, Shen Li, Xiang Yang Zhang
Summary: This study compared serum BDNF and glycolipid profiles between patients with deficit schizophrenia (DS) and non-deficit schizophrenia (NDS), and found that BDNF levels were lower in DS patients and triglyceride levels were an independent predictor for DS. Furthermore, serum BDNF levels were negatively associated with the severity of deficit syndrome in schizophrenia patients, and the differences in glycolipid metabolism patterns between DS and NDS patients indicate that deficit syndrome is an independent endophenotype of schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Water Resources
Sebastian Granitzer, Raimund Widhalm, Simon Atteneder, Mariana F. Fernandez, Vicente Mustieles, Harald Zeisler, Markus Hengstschlaeger, Claudia Gundacker
Summary: BDNF and KISS-1 play a regulatory role in placental development and fetal growth. The predictive value of maternal serum BDNF and KISS-1 concentrations for placental and umbilical cord levels has not been explored. Prenatal lead (Pb) and cadmium (Cd) exposure and maternal iron status have an unclear impact on BDNF and KISS-1 levels. The study found strong correlations between maternal and umbilical serum levels of pro-BDNF, mature BDNF, and KISS-1, as well as their gene expression in placental tissue. Pb exposure and low iron status were associated with alterations in BDNF and KISS-1 levels, but further research is needed for confirmation.
EXPOSURE AND HEALTH
(2023)
Article
Fisheries
Ahmet Topal, Selcuk Ozdemir, Harun Arslan, Selim Comakli
Summary: Water temperature is a crucial environmental factor for fish growth and survival. High water temperature stress leads to physiological changes in the fish brain, including alterations in transcription levels and oxidative stress.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Psychiatry
Shen Li, Dachun Chen, Meihong Xiu, Jie Li, Xiang Yang Zhang
Summary: This study revealed that patients with schizophrenia comorbid with type 2 diabetes mellitus have higher serum BDNF levels and better performance in delayed memory, suggesting a potential relationship between BDNF levels and cognitive function in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Ondine Adam, Marion Psomiades, Romain Rey, Nathalie Mandairon, Marie-Francoise Suaud-Chagny, Marine Mondino, Jerome Brunelin
Summary: The study investigated the acute effects of tDCS on serum mature BDNF levels in schizophrenia patients and found that active tDCS resulted in a significantly larger decrease in mature BDNF levels compared to sham tDCS. This suggests that mature BDNF may play a role in the beneficial effects of frontotemporal tDCS observed in patients with schizophrenia.
Article
Psychiatry
Chirag M. Vyas, David Mischoulon, Grace Chang, Charles F. Reynolds, Nancy R. Cook, Alison Weinberg, Trisha Copeland, Vadim Bubes, Gary Bradwin, I-Min Lee, Julie E. Buring, Samia Mora, Nader Rifai, JoAnn E. Manson, Olivia I. Okereke
Summary: This study examined the relationship between serum brain-derived neurotrophic factor (BDNF) and late-life depression (LLD) both cross-sectionally and longitudinally. It also investigated the effects of vitamin D3 and omega-3s on changes in BDNF and explored the role of BDNF in the effects of these supplements on LLD. The results showed significant cross-sectional associations between serum BDNF levels and LLD, but no longitudinal associations. Neither vitamin D3 nor omega-3s had an effect on serum BDNF levels over a 2-year period.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Yuanyuan Li, Jiao Chen, Hui Yu, Jiayu Ye, Chunxia Wang, Lingli Kong
Summary: This study aimed to evaluate the relationship between serum levels of mature BDNF (mBDNF) and precursor BDNF (proBDNF) in Alzheimer's disease (AD) and investigate their potential as biomarkers for AD risk. The results showed that serum proBDNF levels were significantly higher in AD patients and were correlated with MMSE scores. The combination of proBDNF and M/P performed best in predicting AD risk.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Leonardo Sandrini, Patrizia Amadio, Alessandro Ieraci, Alessandro Malara, Jose P. Werba, Paolo M. Soprano, Alessandra Balduini, Marta Zara, Alice Bonomi, Fabrizio Veglia, Gualtiero Colombo, Maurizio Popoli, Francis S. Lee, Elena Tremoli, Silvia S. Barbieri
Summary: Depression is associated with thrombotic risk and arterial events, and its management is recommended in coronary artery disease patients. The BDNF Val66Met polymorphism, related to depression, is associated with arterial thrombosis in mice and acute myocardial infarction in humans. Finding show desipramine rescues behavioral impairments and reduces arterial thrombosis risk by normalizing norepinephrine levels in BDNFMet/Met mice, suggesting the potential use of alpha(2A)-ADR inhibitors in treating depression-associated thrombotic conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Banfi, Patrizia Amadio, Marta Zara, Maura Brioschi, Leonardo Sandrini, Silvia S. Barbieri
Summary: The absence of PCYOX1 leads to platelet hypo-reactivity and impaired arterial thrombosis, suggesting PCYOX1 as a potential novel target for antithrombotic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Carla Carnovale, Cristiana Perrotta, Sara Baldelli, Dario Cattaneo, Cristina Montrasio, Silvia S. Barbieri, Giulio Pompilio, Chiara Vantaggiato, Emilio Clementi, Marco Pozzi
Summary: There is a bidirectional relationship between hypertension and psychiatric disorders, and the repurposing of antihypertensive drugs to treat mental disorders is being explored. However, the mechanisms and clinical consequences of the use of these drugs on neuropsychiatric functions are not yet fully understood. This article reviews the potential role of antihypertensive agents in psychiatric disorders, discusses their targets and mechanisms of action, and examines the extent to which specific drug classes/molecules may affect psychiatric symptoms.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Patrizia Amadio, Chiara Macchi, Chiara Favero, Marta Zara, Giulia Solazzo, Laura Dioni, Leonardo Sandrini, Luisella Vigna, Maria Francesca Greco, Massimiliano Buoli, Cesare R. Sirtori, Angela Cecilia Pesatori, Alessandro Ieraci, Massimiliano Ruscica, Silvia Stella Barbieri, Valentina Bollati
Summary: Obesity and depression are often associated with an increased risk of cardiovascular complications. The present study investigated the relationship among peripheral Brain-Derived Neurotrophic Factor (BDNF), depression, and extracellular vesicle (EV)-derived miRNAs related to atherothrombosis in a large Italian cohort of obese individuals. The results revealed a negative association between depression and BDNF levels, which was modified by raised levels of IFN-gamma. BDNF levels were also found to be linked to an increase in EV-derived miRNAs related to atherosclerosis and thrombosis, suggesting a possible link among BDNF, depression, and miRNAs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Andrea Baggiano, Marta Zara, Cristina Banfi, Jeness Campodonico, Calogero Tedesco, Patrizia Amadio, Sebastiano Gili, Gianluca De Dona, Leonardo Sandrini, Riccardo Maragna, Giancarlo Marenzi, Gianluca Pontone, Silvia Stella Barbieri
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Review
Biochemistry & Molecular Biology
Silvia M. G. Trivigno, Gianni Francesco Guidetti, Silvia Stella Barbieri, Marta Zara
Summary: Platelets play a crucial role in hemostasis and thrombosis, but they are also involved in various physiological and pathological processes, including infection. They are among the first responders recruited to sites of inflammation and infection, actively cooperating with the immune system to exert their antimicrobial response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Tiziana Bonifacino, Jessica Mingardi, Roberta Facchinetti, Nathalie Sala, Giulia Frumento, Elona Ndoj, Marta Valenza, Caterina Paoli, Alessandro Ieraci, Carola Torazza, Matilde Balbi, Michele Guerinoni, Nadeem Muhammad, Isabella Russo, Marco Milanese, Caterina Scuderi, Alessandro Barbon, Luca Steardo, Giambattista Bonanno, Maurizio Popoli, Laura Musazzi
Summary: Stress is a major risk factor for psychiatric disorders, but little is known about the mechanisms of vulnerability to acute stressors. In this study, a new animal model of resilience/vulnerability to acute footshock stress in rats was generated and used to identify early determinants of maladaptive response related to behavioral vulnerability to stress.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Federico Ravanelli, Laura Musazzi, Silvia Stella Barbieri, Gianenrico Rovati, Maurizio Popoli, Alessandro Barbon, Alessandro Ieraci
Summary: Alzheimer's disease is a neurodegenerative disease that causes memory loss and cognitive impairment in elderly people. The causes of this disease are not well understood and involve genetic, environmental, and epigenetic factors. In the study, SAMP8 mice were used as a model to investigate epigenetic changes in the dorsal hippocampus. The results showed differential regulation of epigenetic markers between male and female SAMP8 mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marta Zara, Andrea Baggiano, Patrizia Amadio, Jeness Campodonico, Sebastiano Gili, Andrea Annoni, Gianluca De Dona, Maria Ludovica Carerj, Francesco Cilia, Alberto Formenti, Laura Fusini, Cristina Banfi, Paola Gripari, Calogero Claudio Tedesco, Maria Elisabetta Mancini, Mattia Chiesa, Riccardo Maragna, Francesca Marchetti, Marco Penso, Luigi Tassetti, Alessandra Volpe, Alice Bonomi, Giancarlo Marenzi, Gianluca Pontone, Silvia Stella Barbieri
Summary: This study found that the expression of CD41-CD61 in sEVs can reflect the CMR-assessed ischemic damage after STEMI, providing a new strategy for the timely identification of high-risk patients and their treatment optimization.
Letter
Biochemistry & Molecular Biology
Silvia Stella Barbieri, Franca Cattani, Leonardo Sandrini, Magda Maria Grillo, Alessandra Amendola, Carmen Valente, Carmine Talarico, Daniela Iaconis, Gabriele Turacchio, Miriam Lucariello, Lucia Lione, Erika Salvatori, Patrizia Amadio, Gloria Garoffolo, Mariano Maffei, Francesca Galli, Andrea Rosario Beccari, Giuseppe Sberna, Emanuele Marra, Marica Zoppi, Michael Michaelides, Giuseppe Roscilli, Luigi Aurisicchio, Riccardo Bertini, Marcello Allegretti, Maurizio Pesce
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. S. Barbieri, P. Amadio, C. Macchi, M. Zara, C. Favero, G. Solazzo, L. Vigna, M. F. Greco, M. Buoli, C. R. Sirtori, A. Ieraci, M. Ruscica, V. Bollati
Article
Biochemistry & Molecular Biology
Marta Zara, Mauro Vismara, Gianluca De Dona, Silvia M. G. Trivigno, Patrizia Amadio, Leonardo Sandrini, Gianni F. Guidetti, Silvia S. Barbieri
Summary: This study emphasizes the critical impact of the platelet preparation process on PEVs release upon ADP stimulation, particularly in terms of alpha-granule release and protein kinase C activation in response to ADP. Residual plasma contamination seems to be essential for platelets to release PEVs in response to ADP, highlighting the importance of the platelet purification procedure.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
