Article
Oncology
Soumyadeep Sarkar, Kenneth Porter, Panshak P. Dakup, Rajendra P. Gajula, Bala S. C. Koritala, Ryan Hylton, Michael G. Kemp, Kazumasa Wakamatsu, Shobhan Gaddameedhi
Summary: Solar ultraviolet B radiation is a major cause of skin conditions such as photoaging, sunburn erythema, and melanoma. The skin has defense mechanisms including DNA repair, cell cycle, apoptosis, and melanin synthesis, with circadian mechanisms associated with melanin synthesis. BMAL1 protein regulates MITF expression rhythmically to positively influence melanin synthesis, which in turn protects against UVB damage in human melanoma cells.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yusuke Ito, Kazuomi Sato
Summary: Salicylamide, a non-steroidal anti-inflammatory drug, has been shown to enhance melanin content in B16F1 melanoma cells by increasing tyrosinase expression through transcriptional activation of the Mitf gene. This suggests that Salicylamide could be used as an anti-hypopigmentation agent for skin and/or hair.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Dermatology
Qiuyun She, Yingying Dong, Dong Li, Ran An, Ting Zhou, Xiaoqi Nie, Ronghua Pan, Yunhua Deng
Summary: This study investigates the role of ATP-binding cassette subfamily B member 6 (ABCB6) in melanogenesis. The findings suggest that ABCB6 inhibition impairs melanocyte maturation and melanin production in human melanoma and immortalized human melanocyte cell lines. Mechanistically, ABCB6 interacts with and modulates glycogen synthase kinase 3 beta (GSK3-beta) to exert its biological effect on melanogenesis. Further studies are necessary to uncover the relationship between ABCB6 and pigmentation disorders.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Cell Biology
Silvia Muccioli, Valentina Brillo, Tatiana Varanita, Federica Rossin, Elisabetta Zaltron, Angelo Velle, Giorgia Alessio, Beatrice Angi, Filippo Severin, Anna Tosi, Manuela D'Eletto, Luca Occhigrossi, Laura Falasca, Vanessa Checchetto, Roberto Ciaccio, Amelia Fasci, Leonardo Chieregato, Ana Paula Rebelo, Marta Giacomello, Antonio Rosato, Ildiko Szabo, Chiara Romualdi, Mauro Piacentini, Luigi Leanza
Summary: This article investigates the plasticity of melanoma and the role of Transglutaminase Type-2 (TG2) in regulating melanoma formation and invasiveness. The results suggest that TG2 expression can affect melanoma invasiveness and may contribute to unraveling the vulnerabilities of melanoma.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Jung Min Lee, Jung Ok Lee, Yujin Kim, You Na Jang, A. Yeon Park, Su-Young Kim, Hye Sung Han, Beom Joon Kim, Kwang Ho Yoo
Summary: Exosomes derived from BJ-5ta effectively prevent melanogenesis by regulating multiple signaling pathways, inhibiting melanosome transport and have potential clinical applications in treating hyperpigmentation disorders.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Nutrition & Dietetics
Jeong-Hyun Yoon, Kumju Youn, Mira Jun
Summary: Melanogenic effects of pinostrobin, a flavanone found in honey, were evaluated in this study. Pinostrobin was found to increase melanin levels and tyrosinase activity by stimulating the expression of melanogenic regulatory factors. Computational simulations also revealed the potential pharmacokinetic properties of pinostrobin. The study suggests that pinostrobin could be a potent and safe melanogenic agent for depigmentation disorders.
Article
Biochemistry & Molecular Biology
Shilpi Goenka, Francis Johnson, Sanford R. Simon
Summary: This study investigated four novel chemically modified curcumin (CMC) derivatives and compared them to the parent compound curcumin for inhibition of tyrosinase activity and melanin production. The results showed that CMC2.24 exhibited the greatest efficacy as a tyrosinase inhibitor among all the CMCs, surpassing curcumin and kojic acid.
Article
Biochemistry & Molecular Biology
Myra O. Villareal, Thanyanan Chaochaiphat, Rachida Makbal, Chemseddoha Gadhi, Hiroko Isoda
Summary: Plant saponins, particularly the saponins-rich fraction from argan leaves (ALS), have been found to inhibit melanogenesis without cytotoxicity. This inhibitory effect is achieved by downregulating the expression of melanogenesis-associated enzymes and transcription factors, as well as affecting genes involved in cAMP and Wnt signaling pathways. ALS shows potential for use in cosmeceutical preparations for the treatment of hyperpigmentation.
Article
Biochemistry & Molecular Biology
Kyu-Ree In, Mi Ae Kang, Su Dong Kim, Jinho Shin, Sung Un Kang, Tae Jun Park, Seung-Joo Kim, Jong-Soo Lee
Summary: This study demonstrates that anhydrous alum can inhibit melanin synthesis by downregulating the expression of MITF. The mechanism of action of anhydrous alum involves attenuating phosphorylation of the co-activator of MITF gene transcription, cAMP response element-binding protein, and promoting phosphorylation of extracellular signal-regulated kinase to impair the nuclear localization of MITF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xuan T. Truong, Young-Seung Lee, Thuy T. P. Nguyen, Hyun-Jin Kim, Sung-Hak Kim, Changjong Moon, Don-Kyu Kim, Hueng-Sik Choi, Tae-Il Jeon
Summary: SMILE is a transcriptional corepressor that plays a critical role in the regulation of melanogenesis. It is regulated by α-MSH/cAMP/protein kinase A signaling and acts by suppressing the transcriptional activity of the cAMP response element-binding protein. SMILE's decreased expression in melanoma tissues suggests its potential role as a corepressor in skin pigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Jianzeng Liu, Xiaohao Xu, Jingyuan Zhou, Guang Sun, Zhenzhuo Li, Lu Zhai, Jing Wang, Rui Ma, Daqing Zhao, Rui Jiang, Liwei Sun
Summary: This study investigated the regulatory effects of phenolic acid monomers from Panax ginseng Meyer on melanin production. It found that SA, PA, p-CA, and VA inhibited melanin production, while CA had the opposite effects. Furthermore, the phenolic acid monomers reduced the expression of melanin synthesis-related proteins through multiple signaling pathways and affected MITF protein levels through phosphorylation and post-translational modification processes.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Multidisciplinary Sciences
Grace B. Phelps, Hannah R. Hagen, Adam Amsterdam, Jacqueline A. Lees
Summary: This study investigates the oncogenic signaling events and the role of MITF in uveal melanoma (UM) using zebrafish models. The findings suggest that YAP signaling is the major mediator of UM and MITF acts as a tumor suppressor in UM.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Qiong Ding, Lin Luo, Lan Yu, Si-lu Huang, Xiao-qin Wang, Bo Zhang
Summary: Vitiligo is a depigmented disease with a simple diagnosis but difficult cure. Ermanin, a flavonoid extracted from bee glue used in traditional Chinese medicine, has been found to promote melanin production and regulate glutathione redox balance to assist in treating vitiligo.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Applied
Jaeho Kim, Moon-Moo Kim
Summary: This study found that emodin derived from Polygonum multiflorum can promote melanin production in B16F1 cells by increasing the expression levels of tyrosinase, tyrosine related protein, MITF, and SIRT1 proteins. These findings suggest that emodin may have the potential to prevent graying of hair.
NATURAL PRODUCT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hyun Jeong Lee, Sungkwan An, Seunghee Bae, Jae Ho Lee
Summary: DPN inhibits melanogenesis through downregulation of the PKA/CREB/MITF signaling pathway, and its suppression of melanin production is not related to the estrogen signaling pathway.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Young Min Lee, In Sook Kim, Beong Ou Lim
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Chemistry, Medicinal
Yon-Suk Kim, Eun-Kyung Kim, Xin Dong, Jin-Su Park, Woen-Bin Shin, Su-Jin Kim, Eun-Ae Go, Pyo-Jam Park, Beong-Ou Lim
JOURNAL OF MEDICINAL FOOD
(2019)
Article
Chemistry, Medicinal
Al B. Bayazid, Jae G. Kim, Seo H. Park, Beong O. Lim
NATURAL PRODUCT COMMUNICATIONS
(2020)
Article
Chemistry, Medicinal
Dong Wook Shin, Beong Ou Lim
JOURNAL OF MEDICINAL FOOD
(2020)
Article
Chemistry, Medicinal
Young Min Lee, Dong Wook Shin, Beong Ou Lim
JOURNAL OF MEDICINAL FOOD
(2020)
Article
Biochemistry & Molecular Biology
Al Borhan Bayazid, Young Ah Jang, Yu Mi Kim, Jae Gon Kim, Beong Ou Lim
Summary: Sodium butyrate (NaB) shows potential therapeutic effects against neurodegenerative diseases (NDDs) by attenuating cell death, inhibiting inflammation, and improving the expression of apoptotic regulators.
NEUROCHEMICAL RESEARCH
(2021)
Article
Food Science & Technology
Al Borhan Bayazid, Jae Gon Kim, Shofiul Azam, Soo Ah Jeong, Da Hee Kim, Chae Won Park, Beong Ou Lim
Summary: The study evaluated the neuroprotective effects of sodium butyrate (NaB) on high-fat diet (HFD)-fed mice. The results showed that NaB restored bodyweight and attenuated oxidative stress, inflammation, and dysregulation in the brains of HFD-fed mice. NaB also enhanced the expression of endogenous antioxidants and exhibited potential as a therapeutic agent for neurodegenerative diseases (NDDs).
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Al Borhan Bayazid, Soo Ah Jeong, Chae Won Park, Da Hee Kim, Beong Ou Lim
Summary: This study investigates the anti-inflammatory activities of fermented Curcuma, finding that it can alleviate intestinal inflammation, improve the intestinal environment, and help with morphological remodeling.
Review
Nutrition & Dietetics
Al Borhan Bayazid, Beong Ou Lim
Summary: This study discusses the impact of oxidative stress on Alzheimer's disease (AD) and Parkinson's disease (PD), and explores the potential of using nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO1) signaling pathways and quercetin as therapeutic approaches against neurodegenerative diseases (NDDs).
Article
Chemistry, Applied
Al Borhan Bayazid, Eun Mi Chun, Mohammad Al Mijan, Seo Hyun Park, Sung-Kwon Moon, Beong Ou Lim
Summary: Bilberry is known for its high content of beneficial compounds and has been used for various diseases. The study shows that bilberry extract has significant antioxidant and anti-inflammatory properties.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Seo Hyun Park, Jae Gon Kim, Young Ah Jang, Al Borhan Bayazid, Beong Ou Lim
Summary: The study showed that fermented black rice and blueberry with Lactobacillus plantarum (FBBBR) has protective effects against UVB-induced skin damage, improving skin hydration and barrier function.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Jae Gon Kim, Xin Dong, Seo Hyun Park, Al Borhan Bayazid, Soo Ah Jeoung, Beong Ou Lim
Summary: This study investigated the anti-inflammatory and immune-boosting effects of bioconversion material BB made from black rice and blueberry using Lactobacillus plantarum. The results showed that in the presence of LPS, BB inhibited nitric oxide production and reduced cytokine secretion, while in the absence of LPS, its effect was lower compared to LPS stimulation.BB was suggested to have multi-efficacy materials in regulating the immune system.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Young Min Lee, In Sook Kim, Beong Ou Lim
Summary: The study demonstrates that sandalwood oil possesses antioxidant activity and may mitigate inflammation induced by ROS by inhibiting the NF-κB-mediated inflammatory signaling pathway.
Article
Biochemistry & Molecular Biology
Seong Min Hong, Min Cheol Kang, Mirim Jin, Taek Hwan Lee, Beong Ou Lim, Sun Yeou Kim
Summary: The study found that fermented blueberry and black rice extract containing syringic acid and kuromanin significantly reduced skin inflammation induced by PM2.5, suggesting that it may serve as an important functional food for atopic dermatitis (AD).
Article
Chemistry, Applied
Al Borhan Bayazid, Seo Hyun Park, Jae Gon Kim, Beong Ou Lim
FOOD AND AGRICULTURAL IMMUNOLOGY
(2020)