Article
Chemistry, Analytical
S. Guerrero, E. Sanchez-Tirado, L. Agui, A. Gonzalez-Cortes, P. Yanez-Sedeno, J. M. Pingarron
Summary: This work presents an amperometric bioplatform for detecting anti-MBP, a relevant biomarker for multiple sclerosis. The method shows competitive analytical performance and provides results consistent with ELISA in serum samples of healthy individuals and MS patients.
Article
Rheumatology
Yuji Hosono, Brandon Sie, Iago Pinal-Fernandez, Katherine Pak, Christopher A. Mecoli, Maria Casal-Dominguez, Blake M. Warner, Mariana J. Kaplan, Jemima Albayda, Sonye Danoff, Thomas E. Lloyd, Julie J. Paik, Eleni Tiniakou, Rohit Aggarwal, Chester Oddis, Siamak Moghadam-Kia, Carmelo Carmona-Rivera, Jose Cesar Milisenda, Josep Maria Grau-Junyent, Albert Selva-O'Callaghan, Lisa Christopher-Stine, H. Benjamin Larman, Andrew Lee Mammen
Summary: A novel autoantibody Sp4 was discovered in patients with dermatomyositis, and it appears to identify a subgroup of anti-TIF1 gamma-positive dermatomyositis patients with lower cancer risk.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jean-Baptiste Vulsteke, Rita Derua, Sylvain Dubucquoi, Frederic Coutant, Sebastien Sanges, David Goncalves, Greet Wuyts, Petra De Haes, Daniel Blockmans, Wim A. Wuyts, Kristl G. Claeys, Ellen De Langhe, Nicole Fabien, Xavier Bossuyt
Summary: New and known antisynthetase autoantibodies (ASAs) were discovered and detected through protein immunoprecipitation combined with gel-free liquid chromatography-tandem mass spectrometry (IP-MS). The dominant cognate ARS autoantigen of the newly discovered anti-Ly ASA specificity was identified. Unbiased and targeted IP-MS are promising methods for discovery and detection of autoantibodies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Rencai Qin, Haiqi Wu, Hui Guan, Chun Tang, Zhihua Zheng, Chong Deng, Chengshun Chen, Qinghua Zou, Liwei Lu, Kongyang Ma
Summary: Anti-phospholipid autoantibodies are associated with various diseases, but their specific mechanisms in disease pathogenesis remain unclear.
CLINICAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
John B. Doyle, Benjamin Lebwohl, Johan Askling, Anders Forss, Peter H. R. Green, Bjorn Roelstraete, Jonas Soderling, Jonas F. Ludvigsson
Summary: This study shows that children with celiac disease (CD) have a nearly threefold increased risk of juvenile idiopathic arthritis (JIA) compared to the general population, while adults with CD have a twofold increased risk of rheumatoid arthritis (RA). Clinicians should be alert to the possibility of JIA or RA in patients with CD who present with joint symptoms.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ekaterina Martynova, Timur Khaibullin, Ilnur Salafutdinov, Maria Markelova, Alexander Laikov, Leonid Lopukhov, Rongzeng Liu, Kritika Sahay, Mehendi Goyal, Manoj Baranwal, Albert A. Rizvanov, Svetlana Khaiboullina
Summary: Multiple sclerosis (MS) is a chronic disease with unknown causes, limited treatment options, and seasonal exacerbation of symptoms. This study used targeted metabolomics analysis to identify seasonal changes in metabolites in MS patients and found that ceramides play a central role in disease pathogenesis, glucose metabolism shifts to glycolysis, and histidine pathways are involved in relapse during spring and fall seasons. The study also revealed a higher number of affected metabolites in spring and fall, potentially relating to symptom relapse in these seasons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Guillaume Dorcet, Marie Benaiteau, Fabienne Ory-Magne, Antoine Blancher, Jeremie Pariente, Francoise Fortenfant, Chloe Bost
Summary: This article describes the clinical cases of three patients who were initially suspected of having autoimmune encephalitis but were eventually diagnosed with neurodegenerative diseases.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Audrey Benyamine, Daniel Bertin, Noemie Resseguier, Xavier Heim, Julien Bermudez, David Launay, Sylvain Dubucquoi, Adrian Hij, Dominique Farge, Alain Lescoat, Isabelle Bahon-Riedinger, Nouria Benmostefa, Luc Mouthon, Jean-Robert Harle, Gilles Kaplanski, Pascal Rossi, Nathalie Bardin, Brigitte Granel
Summary: The study found that AFAs in SSc patients have important clinical associations, especially when patients are negative for conventional antibodies and exhibit a typical IIF pattern. AFAs have diagnostic value in SSc and may serve as an interesting marker of disease severity.
Article
Biochemistry & Molecular Biology
Ana L. Vivinetto, Clara Castanares, Constanza Garcia-Keller, Cristian Falcon, Anabela Palandri, Victoria Rozes-Salvador, Juan I. Rojas, Liliana Patrucco, Clara Monferran, Liliana Cancela, Edgardo Cristiano, Ronald L. Schnaar, Ana Lis Moyano, Pablo H. H. Lopen
Summary: The activation of MAG triggers clearance of Glutamate and induces a protective antioxidant response, safeguarding oligodendrocytes and nearby neurons from damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Clinical Neurology
Osama Khojah, Seraj Makkawi, Saeed Alghamdi
Summary: This study aimed to systematically review reported cases of anti-mGluR1 encephalitis and summarize their clinical presentation, management, outcomes, and case reports. The study found that anti-mGluR1 encephalitis manifests as symptoms of cerebellar pathology, and early diagnosis with prompt initiation of immunotherapy is crucial for patient recovery.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Kaibiao Xu, Dongmei Wang, Yan He, Shengnan Wang, Guanghui Liu, Yue Pan, Haishan Jiang, Yu Peng, Fenliang Xiao, Yihua Huang, Qiqi Wang, Yongming Wu, Suyue Pan, Yafang Hu
Summary: This study discovered a novel anti-CRMP2 antibody associated with suspected AE and suggested its significance for the diagnosis of AE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Weipeng Wei, Denglei Ma, Lin Li, Lan Zhang
Summary: Multiple sclerosis is an autoimmune and chronic inflammatory demyelinating disease of the central nervous system, with no complete cure currently available but drugs that can slow down its progression. Traditional therapies mainly focus on disease-modifying drugs to control severity, while new drugs and treatment strategies are being developed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Gabriel Torres Iglesias, Mireya Fernandez-Fournier, Maripaz Lopez-Molina, Dolores Piniella, Fernando Laso-Garcia, Mari Carmen Gomez-de Frutos, Elisa Alonso-Lopez, Lucia Botella, Beatriz Chamorro, Sara Sanchez-Velasco, Inmaculada Puertas, Antonio Tallon Barranco, Pilar Nozal, Exuperio Diez-Tejedor, Maria Gutierrez-Fernandez, Laura Otero-Ortega
Summary: Using a prospective, observational, and single-center study, we found that extracellular vesicles can mediate the delivery of autoantibodies from peripheral B cells, resulting in demyelination in multiple sclerosis. Additionally, we identified that these myelin antibodies in extracellular vesicles could serve as a diagnostic biomarker for multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Devyn Zaminski, Amit Saxena, Peter Izmirly, Jill P. Buyon, H. Michael Belmont
Summary: This study found discordance in positivity between two different assays for anti-dsDNA antibodies, with EIA positivity having a lower association with LN compared to CLIFT positivity. The use of both CLIFT and EIA assays may be beneficial for the classification and routine monitoring of SLE.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Immunology
Shan Qiao, Shan-Chao Zhang, Zhi-Hao Wang, Lei Wang, Ran-Ran Zhang, Hai-Yun Li, Yang Jin, Ling-Ling Liu, Mei-Ling Wang, Ai-Hua Wang, Xue-Wu Liu
Summary: This study investigated the clinical characteristics and significance of overlapping multiple anti-neuronal antibodies in patients with autoimmune encephalitis (AE). Among the 276 AE antibody-positive patients, 7.97% had two or more antibodies. The main symptoms of patients with coexisting antibodies included fever, seizures, memory impairment, cognitive decline, and sleep disorders. The study also found that the presence of multiple antibodies may indicate an underlying malignancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Philippe Grieshaber, Borros Arneth, Ferdinand Steinsberger, Bernd Niemann, Irina Oswald, Harald Renz, Andreas Boening
Summary: The study examined the influence of left atrial appendage (LAA) amputation on pro-atrial natriuretic peptide and B-type natriuretic peptide plasma levels, as well as clinical severity of heart failure in patients after surgical atrial fibrillation therapy. Results showed that LAA amputation did not have a clinically relevant detrimental effect on natriuretic peptide levels or severity of heart failure up to 2 years postoperatively. This suggests that LAA amputation may not negatively impact hormone production or heart failure symptoms in patients undergoing AF therapy.
THORACIC AND CARDIOVASCULAR SURGEON
(2021)
Review
Clinical Neurology
Borros Arneth
Summary: Multiple sclerosis (MS) is a complex autoimmune disorder characterized by neurologic dysfunction that worsens as the disease progresses. This study aimed to examine the role of T cells in MS pathogenesis, revealing significant link between MS and T cell activity. Targeting T cells is a potential strategy for the development of new therapies to manage MS, indicating the influence of effector T cells and regulatory T cells on MS development and progression.
JOURNAL OF NEUROLOGY
(2021)
Review
Immunology
Borros Arneth
Summary: The innate immune system acts rapidly in a nonspecific way upon exposure to pathogens and lacks the ability to establish immunological memory, while trained immunity is influenced by intracellular metabolic pathways and epigenetic remodeling. Despite limited understanding of the molecular and cellular processes mediating a trained immune response in animals, alterations in cell phenotypes and specific cell numbers may play a critical role. Trained innate immune cells, although short-lived in memory, assist in combating pathogens and providing cross-protection.
IMMUNOLOGIC RESEARCH
(2021)
Article
Medicine, General & Internal
Felix Hempel, Martin Roderfeld, Lucas John Muentnich, Jens Albrecht, Ziya Oruc, Borros Arneth, Thomas Karrasch, Joern Pons-Kuehnemann, Winfried Padberg, Harald Renz, Andreas Schaeffler, Elke Roeb
Summary: Bariatric surgery is effective for treating NAFLD in morbidly obese patients, but may lead to worsening NASH and fibrosis. Monitoring ccK18 levels can help track patient progress postoperatively. Significant weight loss and reduced ccK18 levels were observed one year after surgery, but some patients did not respond well to treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Anatomy & Morphology
Borros Arneth
Summary: Significant advances have been made in cell biology, particularly in understanding the role of leftover viruses in human physiology. Research evidence suggests that retroviruses and nonretroviruses can be integrated into the human genome, playing key roles in human evolution and the pathogenesis of viral infections. This study highlights the importance of studying leftover viruses to gain a deeper understanding of human physiology and evolution.
BRAIN STRUCTURE & FUNCTION
(2021)
Review
Medicine, General & Internal
Borros M. Arneth
Summary: Pregnancy has been found to reduce the risk of multiple sclerosis (MS) relapse, but evidence on how pregnancy may affect the long-term progression of MS is lacking. MS does not increase the risk of maternal and fetal complications, and a significant correlation exists between pregnancy and MS relapse rates. The research results provide valuable insights for managing MS during pregnancy and monitoring patients with MS.
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Review
Medical Laboratory Technology
Borros Arneth, Joerg Kraus
Summary: Multiple Sclerosis is a neurological disease affecting the central nervous system, with diagnosis being challenging due to variations among patients. Various biomarkers have been identified for evaluating disease activity, progression, and therapeutic responses, with Oligoclonal bands and magnetic resonance imaging features being the most established biomarkers so far. Further studies are needed to explore the potential of other biomarkers like kappa free light chains, the measles-rubella-zoster reaction, and neurofilament light chains.
CLINICAL BIOCHEMISTRY
(2022)
Article
Urology & Nephrology
Moritz Fritzenwanker, Marcel Oliver Grabitz, Borros Arneth, Harald Renz, Can Imirzalioglu, Trinad Chakraborty, Florian Wagenlehner
Summary: The study showed that UFC is an effective tool for detecting significant bacteriuria in urological patients and generally provides high accuracy in comparison to urine culture and dipstick analysis.
UROLOGIA INTERNATIONALIS
(2022)
Article
Physics, Multidisciplinary
Borros Arneth
Summary: This study attempts to calculate the particle masses for all known elementary particles using the Rydberg equation and the Sommerfeld fine structure constant, revealing the existence of internal and external mass-charge binding energies in elementary particles, which can explain the higher masses of highly charged brother particles in heavier particle triplets.
Article
Physics, Multidisciplinary
Borros Arneth
Summary: The article examines and analyzes the oscillations and potentials of mesons and baryons, which are generated by absorbing energy and describe the fine splitting of the masses of elementary particles, including internal and external mass charge binding energy, as well as Coulomb interaction. These potentials can be derived from experimentally determined masses as coefficients.
Article
Medicine, General & Internal
Borros Arneth, Joerg Kraus
Summary: This article reviews the research progress on biomarkers of multiple sclerosis (MS) and reveals the important role of interactions between environmental and genetic factors in the development of MS. Previous studies have identified multiple biomarkers that can help diagnose MS and manage the disease.
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2022)
Review
Biochemistry & Molecular Biology
Borros Arneth
Summary: The study aims to examine the roles of nucleotide signaling and platelets in inflammation. Analysis of literature evidence shows that nucleotides and platelets play a regulatory role in inflammation in the extracellular environment. Nucleotides activate nucleotide receptors to promote inflammation, while platelets influence inflammatory responses and regulate hemostasis.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2022)
Review
Medicine, General & Internal
Silva Herzog, Paraskevi C. Fragkou, Borros M. Arneth, Samr Mkhlof, Chrysanthi Skevaki
Summary: CD169, also known as Siglec1 or Sialoadhesin, is a surface adhesion molecule on human myeloid cells that acts as a receptor for sialylated molecular structures. Recent data suggest that CD169 may be a novel biomarker for viral infections, such as SARS-CoV-2, RSV, and HIV. CD169 not only functions in pathogen elimination, but also plays a role in connecting innate and adaptive immunity through antigen presentation and pathogen elimination. However, our knowledge about CD169's kinetics, induction mechanisms, signaling pathways, and its precise role in host-pathogen interaction remains limited.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Borros Arneth, Joerg Kraus
Summary: This paper is a systematic review and meta-analysis on the use of free light chains in diagnosing multiple sclerosis. The results indicate that using free light chains has the advantages of being fast and low-cost in the diagnosis of clinically isolated syndrome and multiple sclerosis.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Borros Arneth, Rebekka Arneth
Summary: Research has shown that NETs contribute to the pathogenesis of vasculitis through different mechanisms, including renal failure and vascular damage. The protective effects of NETs have also been highlighted. However, the role of neutrophil hyperactivity in vasculitis is not fully understood. More studies are needed to determine the accurate function of NETs in vasculitis pathogenesis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
