Review
Cell Biology
Belma Turan, Erkan Tuncay
Summary: Mitochondria play a crucial role in maintaining cellular Zn2+ homeostasis and signaling in cardiomyocytes, affecting ROS production and redistribution of Zn2+ transporters under pathological conditions. Understanding the role of mitochondria in regulating Zn2+ levels may highlight the importance of new mitochondria-targeting agents for preventing and treating cardiovascular dysfunction in humans.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Di Liu, Yafen Zhan, Xiaoying Wu, Hongping Qiao, Yeli Zhang, Bo Li
Summary: Developing safe and effective delivery vehicles for intracellular protein drugs is crucial in biomedical research and clinical applications. In this study, an octopus-like self-releasing intracellular protein transporter, LEB5, was designed based on the heat-labile enterotoxin. It showed the ability to transport and release protein medicines into cells safely and effectively.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Cell Biology
Eunhee Kim, Dong Min Lee, Min Ji Seo, Hong Jae Lee, Kyeong Sook Choi
Summary: Paraptosis is a type of programmed cell death characterized by dilation of the endoplasmic reticulum and/or mitochondria. Ca2+ transport has been shown to play an important role in paraptosis induced by various agents, and perturbations of cellular proteostasis and ion homeostasis are believed to contribute critically to the process. The communication between the ER and mitochondria mediated by Ca2+ appears to be crucial in inducing paraptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Na Song, Ming Yang, Hao Zhang, Shi-kun Yang
Summary: Kidney disease is a serious health concern, and understanding the pathogenesis is crucial for precise therapies. Disruption of calcium homeostasis plays a fundamental role in kidney disease development and is a promising therapeutic strategy. The endoplasmic reticulum and mitochondria are key organelles, with pharmacologic modulation of cellular calcium homeostasis as a novel treatment approach.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Nadira Hamid, Ulrich P. Jorde, Mark Reisman, Azeem Latib, D. Scott Lim, Susan M. Joseph, Alena Kurlianskaya, Oleg Polonetsky, Petr Neuzil, Vivek Reddy, Jason Foerst, Hemal Gada, Kendra J. Grubb, Guilherme Silva, Dean Kereiakes, Satya Shreenivas, Sean Pinney, Giedrius Davidavicius, Paul Sorajja, John P. Boehmer, Franz X. Kleber, Patrick Perier, Nicolas M. Van Mieghem, Nicolas Dumonteil, Martin B. Leon, Daniel Burkhoff
Summary: This study evaluated the effectiveness of the AccuCinch Transcatheter Left Ventricular Restoration system in patients with heart failure. The results showed that this technique can reduce left ventricular volume and improve patients' quality of life and exercise endurance.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Multidisciplinary Sciences
Cristine J. Reitz, Marjan Tavassoli, Da Hye Kim, Saumya Shah, Robert Lakin, Allen C. T. Teng, Yu-Qing Zhou, Wenping Li, Sina Hadipour-Lakmehsari, Peter H. Backx, Andrew Emili, Gavin Y. Oudit, Uros Kuzmanov, Anthony O. Gramolini
Summary: The prognosis and treatment outcomes of heart failure patients heavily rely on disease etiology, which is complex and not fully understood. In this study, a combined proteomic and phosphoproteomic approach was used to examine cardiac tissue from patients with dilated cardiomyopathy (DCM) or ischemic cardiomyopathy (ICM). Unique global proteomic and phosphoproteomic profiles were identified, and a role for CTNNA3 phosphorylation in the pathophysiology of DCM was described.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Ananya Rakshit, Samuel E. Holtzen, Maria N. Lo, Kylie A. Conway, Amy E. Palmer
Summary: Zinc is an essential micronutrient for life, required for cell proliferation. This study investigates the changes in labile zinc levels during the cell cycle and the role of the zinc-regulatory transcription factor MTF-1. The results demonstrate that cells experience a zinc pulse in early G1, which is influenced by zinc in the growth media, and that MTF-1 knockdown leads to increased labile zinc and zinc pulse. These findings suggest the importance of a minimum zinc pulse for cell proliferation and the regulation of labile zinc levels.
Article
Biochemistry & Molecular Biology
Jussi Leinonen, Paivi Leinikka, Miikka Tarkia, Milla Lampinen, Avishag K. Emanuelov, Ronen Beeri, Esko Kankuri, Eero Mervaala
Summary: The left atrial appendage (LAA) of the adult heart contains progenitor cells and can be used as a regenerative transplant for myocardial infarction. Transplantation of LAA to mice with MI resulted in improved cardiac function and inhibition of deleterious remodeling. This method combines cell therapy and physical support.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Mizuho Sato, Hiroki Tsumoto, Ayumi Toba, Yurie Soejima, Tomio Arai, Kazumasa Harada, Yuri Miura, Motoji Sawabe
Summary: This study investigated the pathophysiology during the early stage of left ventricular diastolic dysfunction by quantitative proteome analysis of human myocardium. Results showed that reduced endoplasmic reticulum stress responses were involved in the early stage of LV diastolic dysfunction, with 57 differentially expressed proteins identified in the impaired diastolic function group.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Fang-fang Ren, Zuo-yi Xie, Yi-na Jiang, Xuan Guan, Qiao-ying Chen, Teng-fang Lai, Lei Li
Summary: The study reveals the potential therapeutic effect of Dapagliflozin (DAPA) in treating heart failure by inhibiting endoplasmic reticulum stress-related apoptosis. DAPA was found to reduce the expression of key proteins while promoting the expression of cardioprotective proteins in cardiomyocytes in vitro experiments.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Cell Biology
Kouminin Kanwore, Piniel Alphayo Kambey, Xiao-Xiao Guo, Ayanlaja Abdulrahman Abiola, Ying Xia, Dianshuai Gao
Summary: The external and internal factors of the cell play a critical role in glioma initiation, with multiple factors and molecules implicated in brain cancer progression. Glioma stem cells have been identified as the origin, and oncogene overexpression is involved in tumorigenesis, maintenance, and progression. Additionally, defects in cell organelles contribute to cancer cell resistance to drugs, apoptosis, and immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Claudio A. Bravo, Andrew G. Navarro, Karanpreet K. Dhaliwal, Maziar Khorsandi, Jeffrey E. Keenan, Parvathi Mudigonda, Kevin D. O'Brien, Claudius Mahr
Summary: Left ventricular assist device (LVAD) therapy is a life-saving option for patients with advanced heart failure who do not respond to medical treatment. However, a significant percentage of LVAD patients develop right heart failure (RHF), which is associated with poor outcomes. The mechanisms of RHF are complex, involving patient factors, surgical factors, and hemodynamic factors. Despite advances in surgical techniques and LVAD technology, RHF remains a major cause of morbidity and mortality among LVAD patients. Current medical therapies for RHF are limited, and cardiac transplantation or supportive management are the only options for these patients. Efforts to predict the risk of RHF in LVAD patients have been challenging, with varying definitions of RHF in different studies. Additionally, most research in this field has focused on early-onset RHF, while late-onset RHF is increasingly recognized as a significant problem. This review aims to describe the unique physiology of the right ventricle and the changes caused by LVADs that may contribute to both early- and late-onset RHF. The available treatments for RHF, including mechanical circulatory support and medical therapies, will also be analyzed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Aleksha Panwar, Jigme Wangchuk, Meenakshi Kar, Rakesh Lodha, Guruprasad R. Medigeshi
Summary: The intracellular free zinc levels are elevated at early stages of dengue virus (DENV) infection, which is mediated by zinc transporter, ZIP8. ZIP8 plays a crucial role in the early stages of DENV replication. Dengue virus utilizes cellular zinc homeostasis during replication of its RNA.
CELLULAR MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Vlad-Sabin Ivan, Roxana Buzas, Adina-Flavia Cutina Morgovan, Paul Ciubotaru, Melania Ardelean, Daniel Goje, Ilie Rosca Ciprian, Romulus Timar, Daniel Lighezan
Summary: The study examined the direct relationship between serum uric acid and ejection fraction in 303 heart failure patients, concluding that higher uric acid levels are associated with a lower ejection fraction of the left ventricle.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ruxandra-Nicoleta Horodinschi, Camelia Cristina Diaconu
Summary: This study analyzed diastolic dysfunction in patients with heart failure (HF) and atrial fibrillation (AF) depending on left ventricle ejection fraction (LVEF). The results showed that patients with HF with reduced ejection fraction (HFrEF) and AF had more severe diastolic dysfunction and higher left ventricular filling pressures compared to those with HF with preserved ejection fraction (HFpEF) and AF.
Article
Cardiac & Cardiovascular Systems
Feyza Alyu, Yusuf Olgar, Sinan Degirmenci, Belma Turan, Yusuf Ozturk
Summary: The study demonstrated the toxic effects of sibutramine on cardiovascular system, showing alterations in intracellular Ca2+, H+, and ROS levels, as well as the mechanical activity of isolated hearts. Acute sibutramine applications induced concentration-dependent changes in action potentials and potassium channel currents, leading to negative alterations in contractility and cardiac parameters. These findings have implications for clinical approaches and drug design studies.
CARDIOVASCULAR TOXICOLOGY
(2021)
Review
Cell Biology
Belma Turan, Erkan Tuncay
Summary: Mitochondria play a crucial role in maintaining cellular Zn2+ homeostasis and signaling in cardiomyocytes, affecting ROS production and redistribution of Zn2+ transporters under pathological conditions. Understanding the role of mitochondria in regulating Zn2+ levels may highlight the importance of new mitochondria-targeting agents for preventing and treating cardiovascular dysfunction in humans.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Correction
Cell Biology
Belma Turan, Erkan Tuncay
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Diana Bou-Teen, Nina Kaludercic, David Weissman, Belma Turan, Christoph Maack, Fabio Di Lisa, Marisol Ruiz-Meana
Summary: Excessive mitochondrial ROS production is linked to aging-related heart pathologies, but also serves as a fundamental function in orchestrating signaling pathways that have cardioprotective effects. Mitochondria in cardiac myocytes are abundant and specialized in subcellular populations, with interactions with other organelles influencing their function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Julian Zayas-Arrabal, Amaia Alquiza, Erkan Tuncay, Belma Turan, Monica Gallego, Oscar Casis
Summary: This study utilized a metabolic model of T2D and found that T2D animals exhibited symptoms of insulin resistance, hyperglycemia, and dyslipidemia, along with bradycardia and prolonged QTc interval. The results indicate that elevated levels of circulating TNFa and IL-1b are responsible for impaired ventricular repolarization and increased susceptibility to cardiac arrhythmia in T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yusuf Olgar, Aysegul Durak, Sinan Degirmenci, Erkan Tuncay, Deniz Billur, Semir Ozdemir, Belma Turan
Summary: The study showed that treatment with Tica reversed alterations in ventricular cardiomyocytes from MetS rats, affecting sarcolemmal ion-channel activities, cytosolic Ca2+ levels, and mitochondria structure and function, while also preventing ER stress and mitochondrial dysfunction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Deniz Billur, Yusuf Olgar, Belma Turan
Summary: This study demonstrated a correlation between long-QT and connexin 43 (Cx43) status and localization in elderly rats, showing the important role of insulin resistance (I-R), ischemia-reperfusion, aging, and heart dysfunction. Alterations in Cx43 protein level and localizations in aging heart were found to lead to abnormal ventricular repolarization in I-R heart.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Cell Biology
Belma Turan, Aysegul Durak, Yusuf Olgar, Erkan Tuncay
Summary: Recent studies suggest that hyperglycemia has a lesser contribution to cardiovascular disease (CVD) compared to impaired glucose tolerance. Glucose intolerance appears to be the biggest risk factor for CVD in individuals with insulin resistance. Abnormal insulin signaling is linked to heart dysfunction in diabetics, as well as cardiac insulin resistance in age-related heart failure (HF). Furthermore, HF is associated with generalized insulin resistance. Clinical outcomes and experimental data show that antihyperglycemic drugs have beneficial effects on the cardiovascular system beyond their ability to lower blood glucose levels, including direct effects on the myocardium. New-class drugs like glucagon-like peptide 1 receptor agonists (GLP-1Ra) and sodium-glucose cotransport 2 inhibitors (SGLT2i) can improve cardiac health. However, there are still many unanswered questions about their therapeutic effects on cardiomyocytes in heart failure, despite various cellular-level studies. Comparative studies on SGLT2i versus GLP-1Ra in patients with and without CVD, as well as with or without hyperglycemia, are also important areas of research.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Duru Aras-Tosun, Canan Onder, Nihan Akdogan, Sivge Kurgan, Irem Aktay, Erkan Tuncay, Kaan Orhan
Summary: This study investigates the effects of astaxanthin on gingival fibroblasts exposed to high glucose, and finds that astaxanthin can enhance gingival wound healing through its antioxidative properties. These findings suggest astaxanthin as a promising candidate for maintaining oral health in chronic wounds of oral tissues related to diabetes.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Aysegul Durak, Belma Turan
Summary: This study demonstrates that the GLP-1R agonist liraglutide has cardioprotective effects in aging hearts by improving cardiovascular dysfunction, blood pressure, and oxidative stress parameters. It also normalizes ion channel and Ca2+ regulation in cardiomyocytes. Furthermore, liraglutide promotes mitochondrial function, reduces ROS and RNS levels, and inhibits oxidative stress-induced injury via the IRS1-eNOS-PKG pathway.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell Biology
Erkan Tuncay, Ivan Gando, Jian-Yi Huo, Gautham Yepuri, Natalie Sampler, Belma Turan, Hua-Qian Yang, Ravichandran Ramasamy, William A. Coetzee
Summary: Sirtuins are beneficial NAD+-dependent deacetylases that play roles in various human health conditions. In this study, researchers investigated the regulation of ATP-sensitive K+ (KATP) channels by sirtuins. They found that increasing NAD+ levels and activating sirtuins led to an increase in KATP channel current and surface expression. This finding has implications for cardiac protection against ischemic damage.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cell Biology
Irem Aktay, Ceylan Verda Bitirim, Yusuf Olgar, Aysegul Durak, Erkan Tuncay, Deniz Billur, Kamil Can Akcali, Belma Turan
Summary: A study found that the magnolia bark extract MAHOC has a protective effect against doxorubicin-induced heart dysfunction, improving heart function, myocardial structure, and redox regulation. The results suggest that MAHOC may serve as a beneficial adjunct to conventional therapies in chronic heart diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Erkan Tuncay, Irem Aktay, Belma Turan
Summary: This study demonstrates the important regulatory role of high expression of ZnT7-OE in cardiomyocytes on [Zn2+]i, [Zn2+]Mit, and [Ca2+]Mit, affecting mitochondrial function in part through histone modification.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deniz Billur, Yusuf Olgar, Aysegul Durak, Ayse Hande Yozgat, Simge Unay, Erkan Tuncay, Belma Turan
Summary: Cardiac conduction abnormalities in metabolic syndrome (MetS) involve a complex interplay between cardiomyocytes and nonmyocytes. This study reveals that early-stage MetS hearts undergo significant electrical and structural changes, characterized by short QT intervals on electrocardiograms. These changes are influenced by factors such as increased intercellular interactions between nonmyocytes and cardiomyocytes, as well as altered expression and localization of connexin 43. The findings provide valuable insights into the mechanisms underlying cardiac remodeling in MetS and highlight the importance of nonmyocyte cells in electrical conduction.
CELL BIOCHEMISTRY AND FUNCTION
(2023)