Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms18122734
Keywords
brassinosteroids; bean second-internode; 3D-QSAR; CoMFA; CoMSIA; plant steroids; vegetable growth promoters
Funding
- Chilean National Science and Technology Research Fund FONDECYT [11130701, 1160446]
- National Commission for Scientific and Technological Research CONICYT [21170877]
- Universidad Tecnica Federico Santa Maria (PIIC) [051/2015]
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In the present study, we have employed the ligand-based drug design technique, 3D-QSAR, through a comparative molecular field analysis (CoMFA) and a comparative molecular similarity indices analysis (CoMSIA) to determine the key factors for the plant growth promoting activity of brassinosteroids reported in literature, using the bean second-internode bioassay measured on two groups of compounds with different molar concentrations. This is the first 3D-QSAR study using the second internode elongation as biological activity. These results provide useful ideas for the design of new molecules, which could be explored in the future to identify novel vegetable growth promoters with similar or greater biological activity than natural brassinosteroids. The reliability of this study was supported by the robust statistical parameters obtained from CoMFA (Model A, r(pred)(2) = 0.751; Model B, r(pred)(2) = 0.770) and CoMSIA (Model A, r(pred)(2) = 0.946; Model B, r(pred)(2) = 0.923) analysis.
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