Astrocytic Pathological Calcium Homeostasis and Impaired Vesicle Trafficking in Neurodegeneration

Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease

(2016) Sung Min Son et al.   Autophagy

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   BRAIN

Adrenergic stimulation of single rat astrocytes results in distinct temporal changes in intracellular Ca2+ and cAMP-dependent PKA responses

(2016) Anemari Horvat et al.   CELL CALCIUM

Dominant negative SNARE peptides stabilize the fusion pore in a narrow, release-unproductive state

(2016) Alenka Guček et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Calcium Signalling Toolkits in Astrocytes and Spatio-Temporal Progression of Alzheimer's Disease

(2016) Dmitry Lim et al.   Current Alzheimer Research

Astroglia dynamics in ageing and Alzheimer's disease

(2016) Alexei Verkhratsky et al.   CURRENT OPINION IN PHARMACOLOGY

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Adrenergic activation attenuates astrocyte swelling induced by hypotonicity and neurotrauma

(2016) Nina Vardjan et al.   GLIA

Principles of sodium homeostasis and sodium signalling in astroglia

(2016) Christine R. Rose et al.   GLIA

Subanesthetic doses of ketamine stabilize the fusion pore in a narrow flickering state in astrocytes

(2016) Eva Lasič et al.   JOURNAL OF NEUROCHEMISTRY

Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system

(2016) Douglas L. Feinstein et al.   JOURNAL OF NEUROCHEMISTRY

Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism

(2016) Gerald A. Dienel et al.   JOURNAL OF NEUROCHEMISTRY

Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP

(2016) Y. Hong et al.   JOURNAL OF NEUROSCIENCE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Practical application of the neuroregenerative properties of ketamine: real world treatment experience

(2016) TheodoreA Henderson   Neural Regeneration Research

Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes

(2016) Sara Sanz-Blasco et al.   NEUROREPORT

Activation of β-adrenergic receptors in rat visual cortex expands astrocytic processes and reduces extracellular space volume

(2016) Ang Doma Sherpa et al.   SYNAPSE

The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain

(2016) Mara Mather et al.   TRENDS IN COGNITIVE SCIENCES

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis

(2015) S C Sreetama et al.   CELL DEATH AND DIFFERENTIATION

Pathologic Potential of Astrocytic Vesicle Traffic: New Targets to Treat Neurologic Diseases?

(2015) Nina Vardjan et al.   CELL TRANSPLANTATION

Locus Coeruleus in time with the making of memories

(2015) Susan J Sara   CURRENT OPINION IN NEUROBIOLOGY

How does ketamine elicit a rapid antidepressant response?

(2015) Ege T Kavalali et al.   CURRENT OPINION IN PHARMACOLOGY

Preventing the Spread of Alzheimer’s Disease Neuropathology: A Role for Calcilytics?

(2015) Anna Chiarini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment

(2015) Matjaž Stenovec et al.   GLIA

Loose excitation-secretion coupling in astrocytes

(2015) Nina Vardjan et al.   GLIA

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

Ketamine Inhibits ATP-Evoked Exocytotic Release of Brain-Derived Neurotrophic Factor from Vesicles in Cultured Rat Astrocytes

(2015) Matjaž Stenovec et al.   MOLECULAR NEUROBIOLOGY

Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation

(2015) Junchao Tong et al.   NEUROBIOLOGY OF DISEASE

Excitable Astrocytes: Ca2+- and cAMP-Regulated Exocytosis

(2015) Nina Vardjan et al.   NEUROCHEMICAL RESEARCH

Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death

(2015) Daniela Rossi   PROGRESS IN NEUROBIOLOGY

Role for astroglial α1-adrenoreceptors in gliotransmission and control of synaptic plasticity in the neocortex

(2015) Yuriy Pankratov et al.   Frontiers in Cellular Neuroscience

Alterations of calcium homoeostasis in cultured rat astrocytes evoked by bioactive sphingolipids

(2014) M. Stenovec et al.   Acta Physiologica

Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS

(2014) Virginia Ronco et al.   CELL CALCIUM

Aerobic Glycolysis in the Human Brain Is Associated with Development and Neotenous Gene Expression

(2014) Manu S. Goyal et al.   Cell Metabolism

Locus (Coeruleus) Minoris Resistentiae in Pathogenesis of Alzheimer’s Disease

(2014) Boris Mravec et al.   Current Alzheimer Research

Metabotropic Glutamate Receptor 5 in Down's Syndrome Hippocampus During Development: Increased Expression in Astrocytes

(2014) A.M. Iyer et al.   Current Alzheimer Research

Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer’s Disease

(2014) I. Pra et al.   Current Neuropharmacology

Dynamics of β-adrenergic/cAMP signaling and morphological changes in cultured astrocytes

(2014) Nina Vardjan et al.   GLIA

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

(2014) Javier Sanchez-Padilla et al.   NATURE NEUROSCIENCE

Astrocyte Ca2+ signalling: an unexpected complexity

(2014) Andrea Volterra et al.   NATURE REVIEWS NEUROSCIENCE

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Striatal Astrocytes Act as a Reservoir for L-DOPA

(2014) Masato Asanuma et al.   PLoS One

Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices

(2014) D. J. Chandler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation

(2014) Joshua P. Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drowning stars: reassessing the role of astrocytes in brain edema

(2014) Alexander S. Thrane et al.   TRENDS IN NEUROSCIENCES

The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development

(2014) J. Enrique Salcedo-Sora et al.   TRENDS IN PARASITOLOGY

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

(2013) Elena Alberdi et al.   AGING CELL

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice

(2013) Fengfei Ding et al.   CELL CALCIUM

The multifaceted role of glial cells in amyotrophic lateral sclerosis

(2013) Chiara F. Valori et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors

(2013) Amulya Nidhi Shrivastava et al.   GLIA

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Astrocytic Vesicle Mobility in Health and Disease

(2013) Maja Potokar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synapses lacking astrocyte appear in the amygdala during consolidation of pavlovian threat conditioning

(2013) Linnaea E. Ostroff et al.   JOURNAL OF COMPARATIVE NEUROLOGY

cAMP-Mediated Stabilization of Fusion Pores in Cultured Rat Pituitary Lactotrophs

(2013) A. I. Calejo et al.   JOURNAL OF NEUROSCIENCE

Uptake of environmental toxicants by the locus ceruleus: A potential trigger for neurodegenerative, demyelinating and psychiatric disorders

(2013) Roger Pamphlett   MEDICAL HYPOTHESES

Vesicle size determines unitary exocytic properties and their sensitivity to sphingosine

(2013) Ajda Flašker et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model

(2013) William Lee et al.   NEUROBIOLOGY OF DISEASE

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline

(2013) R. S. Wilson et al.   NEUROLOGY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

Astroglial Excitability and Gliotransmission: An Appraisal of Ca2+ as a Signalling Route

(2012) Robert Zorec et al.   ASN Neuro

Plasmalemmal Na+/Ca2+ Exchanger Modulates Ca2+-Dependent Exocytotic Release of Glutamate from Rat Cortical Astrocytes

(2012) Reno C Reyes et al.   ASN Neuro

Fingolimod-A sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes

(2012) Saša Trkov et al.   GLIA

Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice

(2012) Alexander Froese et al.   JOURNAL OF CLINICAL INVESTIGATION

Aβ leads to Ca2+ signaling alterations and transcriptional changes in glial cells

(2012) Ambra A. Grolla et al.   NEUROBIOLOGY OF AGING

Exocytosis in Astrocytes: Transmitter Release and Membrane Signal Regulation

(2012) Alenka Guček et al.   NEUROCHEMICAL RESEARCH

Intercellular Ca2+ Waves: Mechanisms and Function

(2012) Luc Leybaert et al.   PHYSIOLOGICAL REVIEWS

Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein

(2011) Cristina I. Linde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Munc18-1 Tuning of Vesicle Merger and Fusion Pore Properties

(2011) J. Jorgacevski et al.   JOURNAL OF NEUROSCIENCE

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

The astrocyte excitability brief: From receptors to gliotransmission

(2011) Vladimir Parpura et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of Transmitters and Amyloid-Beta Peptide on Calcium Signals in Rat Cortical Astrocytes: Fura-2AM Measurements and Stochastic Model Simulations

(2011) Eeva Toivari et al.   PLoS One

Ionotropic receptors in neuronal–astroglial signalling: What is the role of “excitable” molecules in non-excitable cells

(2010) Ulyana Lalo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice

(2010) Stephanie L Catus et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intermediate filaments attenuate stimulation-dependent mobility of endosomes/lysosomes in astrocytes

(2010) Maja Potokar et al.   GLIA

Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for α- and β-adrenergic receptors

(2010) M.E. Gibbs et al.   NEUROSCIENCE

Evidence for the Existence of Secretory Granule (Dense-Core Vesicle)-Based Inositol 1,4,5-Trisphosphate-Dependent Ca2+ Signaling System in Astrocytes

(2010) Yong Suk Hur et al.   PLoS One

Amyloid β-Peptide Directly Induces Spontaneous Calcium Transients, Delayed Intercellular Calcium Waves and Gliosis in Rat Cortical Astrocytes

(2009) Siu-Kei Chow et al.   ASN Neuro

Trafficking of astrocytic vesicles in hippocampal slices

(2009) Maja Potokar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide

(2009) Christopher S. Casley et al.   BRAIN RESEARCH

Loss of astrocytic glutamate transporters in Wernicke encephalopathy

(2009) Alan S. Hazell et al.   GLIA

Regulation of exocytotic protein expression and Ca2+-dependent peptide secretion in astrocytes

(2009) Sonia Paco et al.   JOURNAL OF NEUROCHEMISTRY

What learning in day-old chickens can teach a neurochemist: focus on astrocyte metabolism

(2009) Leif Hertz et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytes are a major target in thiamine deficiency and Wernicke's encephalopathy

(2009) Alan S. Hazell   NEUROCHEMISTRY INTERNATIONAL

The locus ceruleus norepinephrine system: Functional organization and potential clinical significance

(2009) E. E. Benarroch   NEUROLOGY

Sphingosine Facilitates SNARE Complex Assembly and Activates Synaptic Vesicle Exocytosis

(2009) Frédéric Darios et al.   NEURON

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Focal degeneration of astrocytes in amyotrophic lateral sclerosis

(2008) D Rossi et al.   CELL DEATH AND DIFFERENTIATION

Ca2+ entry through TRPC1 channels contributes to intracellular Ca2+ dynamics and consequent glutamate release from rat astrocytes

(2008) Erik B. Malarkey et al.   GLIA

Mitochondria Modulate Ca2+-Dependent Glutamate Release from Rat Cortical Astrocytes

(2008) R. C. Reyes et al.   JOURNAL OF NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease

(2008) Verónica Berta Dorfman et al.   NEUROBIOLOGY OF AGING

What Is the Role of Astrocyte Calcium in Neurophysiology?

(2008) Cendra Agulhon et al.   NEURON

Glial Cells as Players in Parkinsonism: The “Good,” the “Bad,” and the “Mysterious” Glia

(2008) Maria A. Mena et al.   NEUROSCIENTIST