Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture

Complex Tissue and Disease Modeling using hiPSCs

(2016) Robert Passier et al.   Cell Stem Cell

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury

(2016) Amranul Haque et al.   Scientific Reports

Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules

(2015) Farah Tasnim et al.   BIOMATERIALS

Periodic harvesting of embryonic stem cells from a hollow-fiber membrane based four-compartment bioreactor

(2015) Fanny Knöspel et al.   BIOTECHNOLOGY PROGRESS

Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactionsin vitro

(2015) Dustin R. Berger et al.   HEPATOLOGY

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

(2015) Patricio Godoy et al.   JOURNAL OF HEPATOLOGY

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

(2015) Melissa Baxter et al.   JOURNAL OF HEPATOLOGY

Stem Cell-Derived Systems in Toxicology Assessment

(2015) Laura Suter-Dick et al.   STEM CELLS AND DEVELOPMENT

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

(2015) Brenton R. Ware et al.   TOXICOLOGICAL SCIENCES

Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics

(2015) Jong Hyun Kim et al.   TOXICOLOGICAL SCIENCES

Engraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation

(2015) Wei Song et al.   Scientific Reports

Induced pluripotent stem cell-derived hepatocytes and endothelial cells in multi-component hydrogel fibers for liver tissue engineering

(2014) Chan Du et al.   BIOMATERIALS

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant

(2014) Takanori Takebe et al.   Nature Protocols

Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture

(2014) Richard L. Gieseck III et al.   PLoS One

Overexpression of microRNA-122 enhances in vitro hepatic differentiation of fetal liver-derived stem/progenitor cells

(2013) Ravi Doddapaneni et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Overexpression of miR-122 promotes the hepatic differentiation and maturation of mouse ESCs through a miR-122/FoxA1/HNF4a-positive feedback loop

(2013) Xiao-Geng Deng et al.   LIVER INTERNATIONAL

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Generation of Functional Hepatocyte-Like Cells from Human Pluripotent Stem Cells in a Scalable Suspension Culture

(2013) Massoud Vosough et al.   STEM CELLS AND DEVELOPMENT

The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets

(2012) Yasuhito Nagamoto et al.   BIOMATERIALS

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

(2012) Kazuo Takayama et al.   BIOMATERIALS

Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies

(2012) Yue Yu et al.   Stem Cell Research

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

(2012) Fei Yi et al.   Protein & Cell

Signals and Cells Involved in Regulating Liver Regeneration

(2012) Liang-I. Kang et al.   Cells

Multiple post-translational modifications in hepatocyte nuclear factor 4α

(2011) Atsushi Yokoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

(2011) A. DeLaForest et al.   DEVELOPMENT

Hepatic Differentiation from Human Embryonic Stem Cells Using Stromal Cells

(2011) Young-Dong Yu et al.   JOURNAL OF SURGICAL RESEARCH

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction

(2011) Kazuo Takayama et al.   MOLECULAR THERAPY

New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes

(2011) Iman Saramipoor Behbahan et al.   Stem Cell Reviews and Reports

Organogenesis and Development of the Liver

(2010) Karim Si-Tayeb et al.   DEVELOPMENTAL CELL

Developmental and Tissue-Specific Regulation of Hepatocyte Nuclear Factor 4-α (HNF4-α) Isoforms in Rodents

(2010) SAMENA DEAN et al.   GENE EXPRESSION

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

In vitro hepatic maturation of human embryonic stem cells by using a mesenchymal cell line derived from murine fetal livers

(2009) Takamichi Ishii et al.   CELL AND TISSUE RESEARCH

Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells

(2009) Zhihua Song et al.   CELL RESEARCH

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

(2009) Gareth J. Sullivan et al.   HEPATOLOGY

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

(2009) Thomas Touboul et al.   HEPATOLOGY

Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage

(2009) Gabriella Brolén et al.   JOURNAL OF BIOTECHNOLOGY

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

FGF2 Specifies hESC-Derived Definitive Endoderm into Foregut/Midgut Cell Lineages in a Concentration-Dependent Manner

(2009) Jacqueline Ameri et al.   STEM CELLS

Vascular Development and Differentiation During Human Liver Organogenesis

(2008) Sophie Collardeau-Frachon et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

NS21: Re-defined and modified supplement B27 for neuronal cultures

(2008) Yucui Chen et al.   JOURNAL OF NEUROSCIENCE METHODS

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

(2008) D. C. Hay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo

(2008) David C. Hay et al.   STEM CELLS