Article
Oncology
Oukseub Lee, Maarten C. Bosland, Minhua Wang, Ali Shidfar, Omid Hosseini, Xiaoling Xuei, Priyam Patel, Matthew J. Schipma, Irene Helenowski, J. Julie Kim, Susan E. Clare, Seema A. Khan
Summary: Results show that ulipristal acetate is the most effective among the selective progesterone receptor modulators studied, while mifepristone is ineffective and telapristone acetate is less effective. Ulipristal acetate reduces tumor incidence and delays tumor onset, and also affects gene expression in benign mammary glands.
Article
Medicine, General & Internal
Iwona Szydlowska, Marta Grabowska, Jolanta Nawrocka-Rutkowska, Malgorzata Piasecka, Andrzej Starczewski
Summary: The results of the study suggest that a good response to UPA treatment in fibroids may be associated with a decrease in fibrosis, ER/PR and PCNA and Ki67 immunoexpression, as well as an increase in cell apoptosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Rohan R. Chodankar, Alison Murray, Moira Nicol, H. R. Whitaker, Alistair R. W. Williams, Hilary O. D. Critchley
Summary: This study investigated the impact of the progesterone receptor modulator ulipristal acetate (UPA) on endometrial morphology and function. The results showed that the effects on hormone receptors, cell proliferation, and progesterone-regulated genes were reversible after cessation of treatment.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Yutaka Osuga, Yasuaki Nakano, Yuji Yamauchi, Masaya Takanashi
Summary: The study evaluated the efficacy and safety of ulipristal acetate (UPA) for uterine fibroids (UFs), finding it to be noninferior to leuprorelin (LEU) in inducing amenorrhea for 35 days. The results demonstrate the clinical utility of UPA for Asians, with comparable effects on heavy menstrual bleeding as LEU.
FERTILITY AND STERILITY
(2021)
Article
Surgery
Pasquale De Franciscis, Antonio Schiattarella, Gaetano Riemma, Domenico Labriola, Domenico Ambrosio, Salvatore Giovanni Vitale, Antonio Cianci, Gaspare Cucinella, Gloria Calagna, Nicola Colacurci
Summary: This study found that in premenopausal women, a six-month therapy with ulipristal acetate (UPA) can significantly reduce the size of myomas and increase endometrial thickness. UPA is a safe and effective method for suitable patients.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Medicine, Research & Experimental
Jae Ryoung Hwang, Young-Jae Cho, Ji-Yoon Ryu, Ju-Yeon Choi, Jung-Joo Choi, Jason K. Sa, Hyun-Soo Kim, Jeong-Won Lee
Summary: This study found that ulipristal acetate (UPA) has inhibitory effects on uterine sarcoma in in vitro and in vivo experiments. UPA showed significant anti-tumor effects in uterine sarcoma through the inhibition of the STAT3/CCL2 signaling pathway and could be a potential therapeutic agent for treating this disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Ranka Kanda, Yuko Miyagawa, Osamu Wada-Hiraike, Haruko Hiraike, Kazunori Nagasaka, Eiji Ryo, Tomoyuki Fujii, Yutaka Osuga, Takuya Ayabe
Summary: Ulipristal acetate (UPA) inhibits the growth, migration, and invasion of Ishikawa endometrial cancer cells via apoptosis induction while also activating proinflammatory cytokines. Combining UPA with an estrogen receptor antagonist may be useful in suppressing the secretion of proinflammatory cytokines induced by UPA alone.
Review
Pharmacology & Pharmacy
Stefano Angioni, Maurizio N. D'Alterio, Angelos Daniilidis
Summary: Uterine fibroids are common benign tumors in women, often causing heavy menstrual bleeding and various symptoms. Treatment options for uterine fibroids include surgery and medical therapy, each with its own advantages and disadvantages.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Medicine, General & Internal
David K. Turok, Alexandra Gero, Rebecca G. Simmons, Jennifer E. Kaiser, Gregory J. Stoddard, Corinne D. Sexsmith, Lori M. Gawron, Jessica N. Sanders
Summary: In the United States, more women choose levonorgestrel IUDs over copper IUDs for long-term contraception. This study found that the levonorgestrel IUD is noninferior to the copper IUD for emergency contraception. Adverse events were similar between the two groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Carolyn L. Westhoff, Hua Guo, Zhong Wang, Hanina Hibshoosh, Margaret Polaneczky, Malcolm C. Pike, Richard Ha
Summary: This study found that ulipristal acetate can reduce breast epithelial cell proliferation and decrease background parenchymal enhancement. However, concerns about its liver toxicity prevent further investigation into its potential use in breast cancer chemoprevention.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Medicine, Research & Experimental
Emmanuel Ekanem, Vikram Talaulikar
Summary: Ulipristal acetate (UPA) was introduced as an effective therapy for symptomatic fibroids, but recent reports of liver injury necessitating transplant have led to its suspension. Clinical trials confirmed its effectiveness in managing heavy menstrual bleeding due to uterine leiomyomas, but no significant evidence of harm was initially found. The European Medicines Agency is currently conducting a review of the risk of liver injury with UPA use.
ADVANCES IN THERAPY
(2021)
Review
Clinical Neurology
Todd A. Verdoorn, Tom J. Parry, Graziano Pinna, Jonathan Lifshitz
Summary: Traumatic brain injury (TBI) leads to various pathological effects on multiple biochemical and physiological systems in and outside the brain. The recovery of patients is hindered by early brain edema, inflammation, cell death, and neurovascular disruption. Drug treatments targeting these deficits are being developed, and it is likely that effective therapy would require interruption of the TBI-induced pathological processes by either a combination of drugs or a single pleiotropic drug. The complex neurosteroid system offers potential options for the research and development of pleiotropic drug treatments for TBI.
Article
Endocrinology & Metabolism
Jane Y. Xu, Michele A. O'Connell, Lauren Notini, Ada S. Cheung, Sav Zwickl, Ken C. Pang
Summary: Gender dysphoria is the distress associated with having a gender identity different from one's birth-assigned sex. Hormonal treatment guidelines primarily cater to those transitioning from male to female or vice versa, leaving limited options for non-binary trans individuals seeking an androgynous appearance. There is potential for Selective Estrogen Receptor Modulators (SERMs) to be a gender-affirming treatment for non-binary individuals assigned male at birth (AMAB), but further research is needed on their effects and safety.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Acoustics
Jessica D. Rosenberg, Carolyn L. Westhoff
Summary: This study examined the use of transvaginal sonography in imaging ovarian follicles among non-pregnant reproductive-aged women. The results showed that higher-BMI women were less likely to have identifiable follicles, and there were variations in results among different sites.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Biochemistry & Molecular Biology
Elena I. Solntseva, Julia V. Bukanova, Rodion Kondratenko, Eva Kudova
Summary: The negative impact of corticosteroids on mental illness is still unclear. This study found that corticosterone and other corticosteroids could accelerate the desensitization of glycine receptors, while some corticosteroids could also accelerate the desensitization of GABA-A receptors. The results suggest that increased desensitization of these receptors by corticosteroids may contribute to brain dysfunction under chronic stress and identify potential selective modulators of these receptors.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Emna Ouni, Valerie Nedbal, Marta Da Pian, Hangbao Cao, Kalina T. Haas, Alexis Peaucelle, Olivier Van Kerk, Gaetan Herinckx, Etienne Marbaix, Marie-Madeleine Dolmans, Timo Tuuri, Marjut Otala, Christiani A. Amorim, Didier Vertommen
Summary: The increasing infertility rate in modern society has been attributed to limited knowledge of human ovarian tissue. This study reveals the importance of the extracellular side of the ovarian tissue and creates a proteomic codex for the ovarian matrisome. The research provides valuable insights into healthy ovarian physiology, disease characterization, and tissue development in vitro.
Article
Genetics & Heredity
Luciana Cacciottola, Marie-Madeleine Dolmans, Glenn L. Schattman
Summary: The International Society for Fertility Preservation (ISFP) held its first virtual meeting on November 19, 2021. Eight experts in reproductive medicine presented important updates on their research in the field of fertility preservation and reproductive surgery for absolute uterine factor infertility. The presentations covered various topics, including ovarian stem cell therapy for premature ovarian insufficiency, practical aspects of oocyte vitrification, ovarian stimulation for patients with breast cancer, and more.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Editorial Material
Obstetrics & Gynecology
Jacques Donnez, Marie -Madeleine Dolmans
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Camille Hossay, Francesca Tramacere, Luciana Cacciottola, Alessandra Camboni, Jean-Luc Squiff, Jacques Donnez, Marie-Madeleine Dolmans
Summary: This experimental study investigated the effects of freezing, in vitro culture (IVC), and grafting to the chorioallantoic membrane (CAM) on follicle outcomes in human ovarian tissue. The results showed that IVC led to a decrease in primordial follicles (PF), while FT-CAM tissue maintained a higher proportion of PF. Additionally, grafting to CAM suppressed follicle activation, apoptosis, and autophagy, providing further protection for the follicles. Therefore, enhancing neoangiogenesis and exploring the potential benefits of administering antimullerian hormone are crucial for follicle preservation.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Melody Devos, Paula Diaz Vidal, Jason Bouziotis, Ellen Anckaert, Marie-Madeleine Dolmans, Isabelle Demeestere
Summary: Chemotherapy exposure prior to ovarian tissue cryopreservation increases follicle apoptosis rates but not follicular activation. The PI3K/AKT/mTOR and Hippo signaling pathways are modified in the cortex. However, the consequences of treatment on follicle activation and survival require further investigation.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
L. Cacciottola, A. Camboni, A. Cernogoraz, J. Donnez, M. M. Dolmans
Summary: The size of the ovarian follicle pool is regulated by both apoptosis and autophagy. Apoptosis is responsible for the physiological decline of the follicle pool over time and increases in the event of prior chemotherapy. Autophagy plays a major role in the diminution of the follicle pool before puberty.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Christina Anna Stratopoulou, Sophie Cussac, Marie d'Argent, Jacques Donnez, Marie-Madeleine Dolmans
Summary: This study found that M2 macrophages play an important role in the invasiveness of adenomyosis. M2 macrophages accumulate more in patients with adenomyosis compared to healthy tissue. Co-culture with M2 macrophages significantly enhances the invasion capacity of endometrial cells. The study did not find any gene expression differences indicating epithelial-mesenchymal transition (EMT).
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Jacques Donnez, Marie-Madeleine Dolmans
Summary: IVF cannot replace reproductive surgery because reproductive surgery can heal or harm the organs involved in reproduction. This paper explores different diseases and conditions that affect fertility, and highlights the potential benefits of technological innovations, novel applications, and the expertise of reproductive surgeons. The promise of restoring functional anatomy for enhanced pregnancy chances keeps reproductive surgery alive, and it is our responsibility to properly train young residents to provide the right treatment at the right time.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Ronald Peek, Sapthami Nadesapillai, Thu Yen Thi Nguyen, Sarah Vassart, Dominique Smeets, Guillaume van de Zande, Alessandra Camboni, Didi Braat, Janielle van der Velden, Jacques Donnez, Kathrin Fleischer, Marie-Madeleine Dolmans
Summary: The impact of aneuploid granulosa and stromal cells on folliculogenesis of small ovarian follicles from patients with mosaic Turner syndrome (TS) was studied using a murine xenograft model. It was found that despite the presence of aneuploid cells, small follicles from TS patients were able to undergo normal development, suggesting that ovarian tissue cryopreservation could be a valid option to preserve fertility in young TS patients, especially before the age of 12.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
F. Vitale, L. Cacciottola, F. S. Yu, M. Barretta, C. Hossay, J. Donnez, M. M. Dolmans
Summary: There is a difference in viability and quality of human follicles cultured in ovarian cortex between 20% and 5% oxygen tension. The viability and quality of follicles are higher under 5% oxygen tension after 6 days of in vitro culture (IVC).
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
Lara Houeis, Marie-Madeleine Dolmans
Summary: The 7th International Congress of the ISFP took place in Brussels in November 2022, attracting hundreds of attendees from around the world. Distinguished leaders in the field discussed the latest advances and participants had the opportunity to attend workshops guided by skilled practitioners. Topics covered included fertility preservation approaches in cancer and benign pathologies, male factor infertility, in vitro maturation and poor responders, the impact of chemotherapy on the ovary, and future perspectives.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Chemistry, Medicinal
Jacques Donnez, Luciana Cacciottola, Jean-Luc Squifflet, Marie-Madeleine Dolmans
Summary: Estrogens play a critical role in the pathogenesis of endometriosis, and lowering estradiol levels with oral GnRH antagonists, such as linzagolix, can be an effective option for managing symptomatic endometriosis in premenopausal women. Linzagolix is an orally administered GnRH receptor antagonist that reduces LH and FSH production, leading to a dose-dependent decline in estrogen. Phase 2 and 3 trials have shown promising results for the use of linzagolix in the treatment of endometriosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Genetics & Heredity
Marta Barretta, Luciana Cacciottola, Camille Hossay, Jacques Donnez, Marie-Madeleine Dolmans
Summary: The impact of processing human ovarian tissue on follicle activation dynamics was investigated in this study. It was found that ovarian tissue manipulation significantly affected follicle dynamics by stimulating the PI3K and Hippo signaling pathways involved in primordial follicle activation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Oncology
Matthieu de Codt, Pascale Jadoul, Mathieu Luyckx, Jean-Luc Squifflet, Marie-Madeleine Dolmans, Charlotte Maillard, Jean-Francois Baurain, Etienne Marbaix, Amandine Gerday
Summary: This study presents the results of hysteroscopic resection for the management of hydatidiform mole in 36 patients. The main complications encountered during the surgery were uterine perforation and glycine resorption. Retained product of conception was found in six patients during the ultrasound control one month after the intervention. In conclusion, hysteroscopic resection is a feasible procedure for the treatment of molar pregnancy.
Review
Obstetrics & Gynecology
L. Cacciottola, F. Vitale, J. Donnez, M. M. Dolmans
Summary: Regenerative medicine with stem cell therapy has shown promising results in protecting ovarian reserve and improving fertility potential.
HUMAN REPRODUCTION OPEN
(2023)
