Article
Biochemistry & Molecular Biology
Tianlei Kou, Deqian Sha, Fei Wang, Tao He, Xuan He
Summary: TRIM44 plays a role in regulating cell migration and invasion in colorectal cancer cells, with its overexpression enhancing NF-kappa B and CXCR4 expression and binding, while its downregulation inhibiting cell viability, migration, and invasion. It may serve as a potential target for diagnosis and progression of colorectal cancer.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Linchun Wen, Weimin Mao, Lu Xu, Beibei Cai, Liying Gu
Summary: TRIM44 is overexpressed in esophageal squamous cell cancer, while sesamin can inhibit ESCC cell proliferation by regulating TRIM44 and possibly through the NF-κB signaling pathway. Sesamin shows potential for the treatment of esophageal cancer.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Multidisciplinary Sciences
Zhengri Lu, Chunshu Hao, Hao Qian, Yuanyuan Zhao, Xiangwei Bo, Yuyu Yao, Genshan Ma, Lijuan Chen
Summary: TRIM38 plays an important role in cardiac fibrosis by suppressing TAK1/MAPK signaling, which can be a potential therapeutic target for treating and preventing cardiac fibrosis.
Article
Oncology
Fengen Liu, Binhui Xie, Rong Ye, Yuankang Xie, Baiyin Zhong, Jinrong Zhu, Yao Tang, Zelong Lin, Huiru Tang, Ziqing Wu, Heping Li
Summary: In this study, it was found that overexpression of TRIM47 is associated with tumor progression and poor prognosis in triple-negative breast cancer. The researchers demonstrated that TRIM47 directly interacts with BRCA1 and induces proteasome turnover of BRCA1, leading to a decrease in BRCA1 protein levels in TNBC. Additionally, TRIM47 overexpression confers sensitivity to the PARP inhibitor olaparib, while TRIM47 inhibition confers resistance to olaparib in TNBC. Overexpression of BRCA1 also increases resistance to olaparib in TRIM47-overexpression-induced PARP inhibition sensitivity. These findings suggest that targeting the TRIM47/BRCA1 axis may be a promising prognostic factor and therapeutic target for TNBC.
Article
Pathology
Junichiro Sato, Kotaro Azuma, Keiichi Kinowaki, Kazuhiro Ikeda, Takuya Ogura, Yutaka Takazawa, Hidetaka Kawabata, Masanobu Kitagawa, Satoshi Inoue
Summary: The combined immunoreactivity of A20 and TRIM44 predicts the prognosis of patients with invasive breast cancer, with a double-positive status associated with shorter disease-free survival. Additionally, the positive correlation between A20 and TRIM44 immunoreactivities suggests that TRIM44's activation of NF-kappa B signaling may occur in clinical breast cancer tissues.
PATHOLOGY INTERNATIONAL
(2021)
Review
Microbiology
Xiu-Zhong Zhang, Fu-Huang Li, Xiao-Jia Wang
Summary: TRIM proteins play crucial roles in modulating antiviral immune responses, but viruses can evade host immune responses by antagonizing or utilizing TRIMs.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mao-xu Ge, Yi-kang Shi, Dong Liu
Summary: As a critical E3 ubiquitin ligase, TRIM25 is involved in glioma progression and immune regulation, playing a potential therapeutic role in gliomas.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Zhigang Yang, Tao Xu, Tao Xie, Liangliang Yang, Guiping Wang, Yang Gao, Gangming Xi, Xiaobiao Zhang
Summary: This study investigated the role of CDC42EP3 in glioma development and its potential downstream mechanism. It was found that CDC42EP3 overexpression was positively correlated with pathological grading and increased the risk of recurrence. Knocking down CDC42EP3 inhibited cell proliferation and migration while promoting apoptosis. The study also suggested that CDC42EP3 might regulate the expression of CCND1. Overall, CDC42EP3 was found to promote glioma progression through targeting CCND1.
CELL DEATH & DISEASE
(2022)
Article
Orthopedics
Yunshan Guo, Jinzhu Fan, Shuguang Liu, Dingjun Hao
Summary: This study reveals that downregulation of Orai1 may reduce cyclin D1 expression by inactivating the Ras-NF-kappa B signaling pathway, thus blocking osteoblast proliferation and cell cycle.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Neurosciences
Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto, Koichi Ichimura
Summary: The study revealed that C11orf95-RELA fusion genes are the hallmark of supratentorial ependymomas, with a close association with aberrant NF-kappa B activity. Through ChIP-seq analysis, RNA-Seq data, and transcription factor motif analysis, the study identified the oncogenic pathways orchestrated by both C11orf95 and RELA target genes in ependymoma formation. Further anti-cancer drug screening with mouse ependymoma cells identified potential anti-ependymoma drugs related to the oncogenic mechanism of RELA(FUS).
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Qing-Hua Li, Li-Ping Sui, Yun-Hua Zhao, Bao-Gang Chen, Jian Li, Zhi-Hong Ma, Zhi-Hong Hu, Yan-Li Tang, You-Xin Guo
Summary: The study showed that overexpressed TRIM44 in laryngeal squamous cell carcinoma could be inhibited effectively by knockdown or nuciferine, leading to suppressed tumor growth. This suggests that targeting TRIM44 could be a potential therapeutic strategy for laryngeal squamous cell carcinoma.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Virology
Haitao Liu, Ji Xi, Jianming Hu
Summary: The docking motifs on the HBc NTD play a crucial role in recruiting and packaging CDK2, which is essential for various stages of HBV infection. Mutations of these motifs affect CDK2 packaging into HBV capsids, impair capsid protein phosphorylation, and block HBV infection, providing insights for the development of antiviral drugs targeting the HBV capsid protein.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manli Zong, Chun Chang, Rameesha Anjum, Hai Xu, Yuxing Guo, Daodong Pan, Zhen Wu
Summary: The anti-inflammatory effect of LPxTG-motif surface protein (LMP) derived from Limosilactobacillus reuteri SH 23 was evaluated in a mouse model of colitis induced by DSS. LMP inhibited DSS-induced ulcerative colitis via the MAPK-dependent NF-κB pathway. It suppressed inflammatory factors TNF-α and IL-6, enhanced IL-10 secretion, and influenced the diversity of intestinal microbiota.
Article
Biochemistry & Molecular Biology
Manli Zong, Chun Chang, Rameesha Anjum, Hai Xu, Yuxing Guo, Daodong Pan, Zhen Wu
Summary: This study found that LMP derived from L.reuteri SH 23 has the potential to alleviate inflammatory diseases by inhibiting inflammatory factors and influencing the balance of intestinal microbiota.
Article
Oncology
Ya Zheng, Haiyan Zhang, Hong Sun
Summary: This study revealed that TRIM37 expression is significantly increased in ovarian cancer tissues and is closely associated with proliferation and metastasis of ovarian cancer. Metformin inhibits the proliferation and invasion of ovarian cancer cells by suppressing TRIM37-induced TRAF2 ubiquitination.
Article
Biochemistry & Molecular Biology
Shin-Chih Lin, Chia-Hung Lin, Nien-Chu Shih, Hsin-Ling Liu, Wen-Chao Wang, Kun-Yang Lin, Zih-Yu Liu, Yu-Jhen Tseng, Hsueh-Kai Chang, Yi-Cheng Lin, Yi-Chen Yeh, Hiroshi Minato, Takeshi Fujii, Yu-Chung Wu, Mei-Yu Chen, Teh-Ying Chou
Article
Multidisciplinary Sciences
Yoichi Oshima, Keiichi Sumida, Masayuki Yamanouchi, Noriko Hayami, Akinari Sekine, Hiroki Mizuno, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Takeshi Fujii, Kenmei Takaichi, Yoshifumi Ubara
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Tsukasa Kadota, Yusuke Yoshioka, Yu Fujita, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Atsushi Miyamoto, Souichiro Suzuki, Sakashi Fujimori, Tadasu Kohno, Takeshi Fujii, Kazuma Kishi, Kazuyoshi Kuwano, Takahiro Ochiya
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Hiroki Mizuno, Junichi Hoshino, Masatomo So, Yuta Kogure, Takeshi Fujii, Yoshifumi Ubara, Kenmei Takaichi, Tetsuko Nakaniwa, Hideaki Tanaka, Genji Kurisu, Fuyuki Kametani, Mayuko Nakagawa, Tsuneaki Yoshinaga, Yoshiki Sekijima, Keiichi Higuchi, Yuji Goto, Masahide Yazaki
Summary: This study reported a rare case of DRA in a 41-year-old hemodialysis patient with a beta(2)-microglobulin variant (V27M) showing strong amyloidogenic propensity. The findings highlight the unique clinical manifestations and pathomechanical features of this variant compared to previously reported cases.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2021)
Article
Urology & Nephrology
Makoto Fukuda, Hiroki Mizuno, Rikako Hiramatsu, Akinari Sekine, Masahiro Kawada, Eiko Hasegawa, Masayuki Yamanouchi, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Motoaki Miyazono, Yoshifumi Ubara
Summary: A 60-year-old Japanese woman with polymyositis developed hemolytic anemia, thrombocytopenia, and acute kidney injury after starting steroid therapy, leading to a diagnosis of hemolytic uremic syndrome with thrombotic microangiopathy. Despite hemodialysis and plasma exchange treatment, the patient passed away due to hemorrhagic respiratory failure. Renal involvement by polymyositis is rare, but clinicians should be aware of the potential serious renal complications such as HUS/TMA.
CLINICAL NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Kanako Terakawa, Naoki Sawa, Hiroki Mizuno, Akinari Sekine, Noriko Hayami, Daisuke Ikuma, Masahiro Kawada, Rikako Hiramatsu, Keiichi Sumida, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
Summary: This case demonstrates a close relationship between the occurrence of squamous cell carcinoma and the development of polymyositis in a patient with ADPKD. Diagnostic imaging showed an 8 cm mass lesion and a renal stone in the right kidney.
Article
Medicine, General & Internal
Sayako Koga-Kobori, Naoki Sawa, Ryo Kido, Akinari Sekine, Hiroki Mizuno, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
Summary: Fabry disease is a genetic disorder caused by a lack of alpha-galactosidase A activity in lysosomes, leading to multi-organ involvement. Cardiac involvement is a key factor in prognosis, and peritoneal dialysis is the preferred treatment for long-term management.
Article
Urology & Nephrology
Shun Watanabe, Naoki Sawa, Hiroki Mizuno, Masayuki Yamanouchi, Tatsuya Suwabe, Junichi Hoshino, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Yutaka Yamaguchi, Yoshifumi Ubara
Summary: Three cases of acute kidney injury were observed after treatment with a SGLT2 inhibitor, showing osmotic vacuolization in tubules and positive staining for CD138 and CD10 indicating proximal tubules. Patients who are obese and have a body mass index over 30 are at higher risk for AKI due to overdose of sugar in urine and dehydration caused by SGLT2 inhibitor treatment, especially in individuals with type II diabetes mellitus.
Article
Medicine, Research & Experimental
Miho Akabane, Shusuke Haruta, Takeshi Fujii, Masayuki Urabe, Yu Ohkura, Masaki Ueno, Harushi Udagawa
Summary: The treatment strategy for idiopathic retroperitoneal mass is still unclear, while distinguishing between benign and malignant is challenging. This report presents a case of idiopathic retroperitoneal fibrosis that mimicked malignancy, in which partial resection of the mass was performed, and the final pathological findings revealed non-tumorous tissue. The patient had a good postoperative course and remained free of recurrence after 8 years.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Masaaki Nagano, Atsushi Miyamoto, Shinichiro Kikunaga, Souichiro Suzuki, Hisashi Takaya, Takeshi Fujii, Sakashi Fujimori
Summary: Surgical lung biopsy is a safe approach for interstitial lung disease, and an accurate diagnosis of idiopathic pulmonary fibrosis through SLB can aid in appropriate patient management.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Urology & Nephrology
Naoya Toriu, Naoki Sawa, Aya Imafuku, Eiko Hasegawa, Akinari Sekine, Hiroki Mizuno, Masayuki Yamanouchi, Rikako Hiramatsu, Noriko Hayami, Junichi Hoshino, Masahiro Kawada, Tatsuya Suwabe, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
Article
Urology & Nephrology
Natsuki Shima, Naoki Sawa, Masayuki Yamanouchi, Hiroki Mizuno, Masahiro Kawada, Akinari Sekine, Rikako Hiramatsu, Noriko Hayami, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
Article
Respiratory System
Hiroki Ishikawa, Hironori Uruga, Takeshi Fujii, Atsuko Kurosaki, Nasa Morokawa, Hisashi Takaya
RESPIROLOGY CASE REPORTS
(2020)
Article
Respiratory System
Hironori Uruga, Takeshi Fujii, Nobuyuki Nakamura, Shuhei Moriguchi, Kazuma Kishi, Hisashi Takaya
RESPIROLOGY CASE REPORTS
(2020)
Article
Urology & Nephrology
Naoya Toriu, Naoki Sawa, Rikako Hiramatsu, Hiroki Mizuno, Daisuke Ikuma, Akinari Sekine, Noriko Hayami, Keiichi Sumida, Masayuki Yamanouchi, Eiko Hasegawa, Junichi Hoshino, Kenmei Takaichi, Atsushi Wake, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara